Oiling the brain: a review of randomized controlled trials of Omega-3 fatty acids in psychopathology across the lifespan

Sinn, Natalie; Milte, Catherine; Howe, Peter R. C.

doi:10.3390/nu2020128

Cited by 115Fatty Acid Research and HealthNutritional Studies and DietAquaculture Nutrition and Growth

Oiling the brain: a review of randomized controlled trials of Omega-3 fatty acids in psychopathology across the lifespan

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Sinn, Natalie, Milte, Catherine, Howe, Peter R. C.·2010·Nutrients

DOI 10.3390/nu2020128PMC PMC3257637

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Abstract

Around one in four people suffer from mental illness at some stage in their lifetime. There is increasing awareness of the importance of nutrition, particularly omega-3 polyunsaturated fatty acids (n-3 PUFA), for optimal brain development and function. Hence in recent decades, researchers have explored effects of n-3 PUFA on mental health problems over the lifespan, from developmental disorders in childhood, to depression, aggression, and schizophrenia in adulthood, and cognitive decline, dementia and Alzheimer's disease in late adulthood. This review provides an updated overview of the published and the registered clinical trials that investigate effects of n-3 PUFA supplementation on mental health and behavior, highlighting methodological differences and issues.

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Combining vitamins C and E with 3-omega fatty acids, which are membrane phospholipid components with anti-inflammatory actions, has shown some success.
“However, these vitamins have also been given with some success together with 3-omega fatty acids which are key components of membrane phospholipids and have anti-inflammatory properties among others (see reviews: Leza et al., 2014; Muller et al., 2013; Sinn et al., 2010).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Sinn et al., 2010

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Authors: Sinn, N., Milte, C., & Howe, P. R. C.
Affiliations: Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Frome Road, Adelaide 5000, Australia
University of South Australia (AU)
ORCID: Milte, Catherine
Howe, Peter R. C.
Venue: Nutrients
Publisher: MDPI AG
Published: 2010-02-09
Volume: 2
Issue: 2
Pages: 128-170
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu2020128
PMC: PMC3257637
OpenAlex: W2141381281
Cited by: 115
References: 180
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 8 · 2021: 8 · 2020: 1 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 15 · 2015: 11 · 2014: 14 · 2013: 14 · 2012: 7
FWCI: 0.90
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
UniSA Research Outputs Repository (University of South Australia) (submittedVersion, other-oa)
Funders: Australian Research Council (LP0776922)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords: omega-3 fatty acids, dietary supplementation, psychopathology, mental health, depression, schizophrenia, aggression, developmental disorders, cognitive decline, dementia, Alzheimer's disease, lifespan
MeSH terms: Adolescent, Adult, Aged, Animals, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Bipolar Disorder, Brain, Child, Child, Preschool, Depressive Disorder, Female, Humans, Male, Middle Aged, Psychopathology, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Young Adult

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Oiling the brain: a review of randomized controlled trials of Omega-3 fatty acids in psychopathology across the lifespan

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