Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
Open accessAbstract
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. Over the past decade, there has been growing evidence for the use of NAC in treating psychiatric and neurological disorders, considering its role in attenuating pathophysiological processes associated with these disorders, including oxidative stress, apoptosis, mitochondrial dysfunction, neuroinflammation and glutamate and dopamine dysregulation. In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy. Disorders such as anxiety, attention deficit hyperactivity disorder and mild traumatic brain injury have preliminary evidence and require larger confirmatory studies while current evidence does not support the use of NAC in gambling, methamphetamine and nicotine addictions and amyotrophic lateral sclerosis. Overall, NAC treatment appears to be safe and tolerable. Further well designed, larger controlled trials are needed for specific psychiatric and neurological disorders where the evidence is favorable.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cognitive studies of N-acetylcysteine have produced inconsistent results, which may be linked to variations in study design.
“Cognitive studies of NAC have produced inconsistent results, which may be linked to variations in study design [155].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [155]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
The well-built clinical question: A key to evidence-based decisions
(1995) · ACP Journal Club · doi:10.7326/acpjc-1995-123-3-a12 · Cited by 2,931 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667 · see citing works
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,644 · see citing works
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357 · see citing works
Glutathione, oxidative stress and neurodegeneration
Schulz, J. B., Lindenau, J. H., Seyfried, J., & DICHGANS, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01595.x · Cited by 1,215 · see citing works
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works
Self-citationMetaplasticity: tuning synapses and networks for plasticity
Abraham, W. C. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2356 · Cited by 1,119 · see citing works
Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers
Volkow, N. D., Chang, L. L., Wang, G., Fowler, J. S., Leonido–Yee, M., Franceschi, D., Sedler, M. J., Gatley, S. J., HITZEMANN, R. J., Ding, Y. ‐., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.377 · Cited by 984 · see citing works
Mechanism of Oxidative Stress in Neurodegeneration
Gandhi, S., & Abramov, A. Y. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428010 · Cited by 964 · see citing works
James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955 · see citing works
Volkow, N. D., Chang, L., Wang, G.-J., Fowler, J. S., Ding, Y.-S., Sedler, M., Logan, J., Franceschi, D., Gatley, J., Hitzemann, R., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2015 · Cited by 916 · see citing works
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905 · see citing works
McFarland, K., Lapish, C. C., & Kalivas, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03531.2003 · Cited by 884 · see citing works
The chemistry and biological activities of N-acetylcysteine
Samuni, Y., Goldstein, S., Dean, O. M., & Berk, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.016 · Cited by 876 · see citing works
Self-citationLoss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence
Volkow, N. D., Chang, L. L., Wang, G., Fowler, J. S., Franceschi, D., Sedler, M. J., Gatley, S. J., Miller, E. N., HITZEMANN, R. J., Ding, Y., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09414.2001 · Cited by 754 · see citing works
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
Baker, D. L., McFarland, K., LAKE, R. W., Shen, H., Tang, X., Toda, S., & Kalivas, P. W. (2003) · Nature Neuroscience · doi:10.1038/nn1069 · Cited by 740 · see citing works
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
Psychomotor stimulant addiction: a neural systems perspective
Everitt, B. J., & Wolf, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03312.2002 · Cited by 700 · see citing works
Pierce, R. C., Bell, K., Duffy, P., & Kalivas, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01550.1996 · Cited by 624 · see citing works
Gliogenesis and Glial Pathology in Depression
Rajkowska, G., & Miguel-Hidalgo, J. J. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780619326 · Cited by 612 · see citing works
James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., Cutler, P., Bock, K., Boris, M., Bradstreet, J., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30366 · Cited by 605 · see citing works
Glutathione Pathways in the Brain
Dringen, R., & Hirrlinger, J. (2003) · Biological Chemistry · doi:10.1515/bc.2003.059 · Cited by 597 · see citing works
Gawryluk, J. W., Wang, J.-F., Andreazza, A. C., Shao, L., & Young, L. T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000805 · Cited by 594 · see citing works
Dringen, R., Pfeiffer, B., & Hamprecht, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00562.1999 · Cited by 589 · see citing works
The Origin and Neuronal Function ofIn VivoNonsynaptic Glutamate
Baker, D. L., Xi, Z., Shen, H., Swanson, C. J., & Kalivas, P. W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09134.2002 · Cited by 584 · see citing works
Berk, M., Copolov, D., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Judd, F., Katz, F., Katz, P., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.004 · Cited by 552 · see citing works
Self-citationGlutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
Cornish, J. L., & Kalivas, P. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0006.2000 · Cited by 546 · see citing works
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.165 · Cited by 545 · see citing works
Self-citationMolecular Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Cell Death
Sattler, R., & Tymianski, M. (2001) · Molecular Neurobiology · doi:10.1385/mn:24:1-3:107 · Cited by 537 · see citing works
Davidson, C., Gow, A. J., Lee, T. H., & Ellinwood, E. H. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00054-6 · Cited by 521 · see citing works
Berk, M., Copolov, D. L., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., & Bush, A. I. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.022 · Cited by 500 · see citing works
Self-citationRandomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosis
The Idiopathic Pulmonary Fibrosis Clinical Research Network (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401739 · Cited by 499 · see citing works
Molecular Evidence for Mitochondrial Dysfunction in Bipolar Disorder
Konradi, C. L., Eaton, M. E., MacDonald, M. L., Walsh, J. P., Benes, F. M., & Heckers, S. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.300 · Cited by 499 · see citing works
Dean, O., Giorlando, F., & Berk, M. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100057 · Cited by 494 · see citing works
Self-citationBlackwell, T. S., Blackwell, T., Holden, E. P., Christman, B. W., & Christman, J. W. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.4.1630 · Cited by 483 · see citing works
Rose, S., Melnyk, S., Pavliv, O., Bai, S., Nick, T. G., Frye, R. E., & James, S. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.61 · Cited by 480 · see citing works
Self-citationThe promise of N-acetylcysteine in neuropsychiatry
Berk, M., Malhi, G. S., Gray, L. J., & Dean, O. M. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.01.001 · Cited by 434 · see citing works
Self-citationEvidence of linkage between the serotonin transporter and autistic disorder
Cook, E., Yeung-Courchesne, R., Lord, C., Cox, N. J., Yan, S., Lincoln, A. J., Haas, R., Courchesne, E., & LEVENTHAL, B. L. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000266 · Cited by 426 · see citing works
Grant, J. E., Odlaug, B. L., & Won Kim, S. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.60 · Cited by 424 · see citing works
Free radicals, antioxidant defense systems, and schizophrenia
Wu, J. Q., Kosten, T. R., & Zhang, X. Y. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.02.015 · Cited by 420 · see citing works
Moran, M., McFarland, K., Meléndez, R. I., Kalivas, P. W., & Seamans, J. K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1007-05.2005 · Cited by 412 · see citing works
Dopaminergic dysfunction in schizophrenia: Salience attribution revisited
Heinz, A., & Schlagenhauf, F. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq031 · Cited by 412 · see citing works
N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities
Shahripour, R. B., Harrigan, M. R., & Alexandrov, A. V. (2014) · Brain and Behavior · doi:10.1002/brb3.208 · Cited by 412 · see citing works
Sekine, Y., Iyo, M., Ouchi, Y., Matsunaga, T., Tsukada, H., Okada, H., Yoshikawa, E., Futatsubashi, M., Takei, N., & Mori, N. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1206 · Cited by 408 · see citing works
N-Acetylcysteine reverses cocaine-induced metaplasticity
Moussawi, K., Pacchioni, A. M., Moran, M., Olive, M. F., Gass, J. T., Lavı́n, A., & Kalivas, P. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2250 · Cited by 400 · see citing works
Kantrowitz, J. T., & Javitt, D. C. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.04.006 · Cited by 397 · see citing works
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
Berk, M., Dodd, S., Kauer‐Sant’Anna, M., Malhi, G. S., Bourin, M., Kapczinski, F., & Norman, T. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01058.x · Cited by 396 · see citing works
Self-citationAnatomical Substrates for Glutamate‐Dopamine Interactions
Sesack, S., Carr, D. B., Omelchenko, N., & Pinto, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.066 · Cited by 348 · see citing works
Glutamatergic Dysfunction in OCD
Chakrabarty, K., Bhattacharyya, S., Christopher, R., & Khanna, S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300733 · Cited by 344 · see citing works
The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death
Banjac, A., Perisic, T., Sato, H., Seiler, A., Bannai, S., Weiss, N., Kölle, P., Tschoep, K., Issels, R. D., Daniel, P. T., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210796 · Cited by 324 · see citing works
Park, W.-K., Bari, A., Jey, A. R., Anderson, S. M., Spealman, R. D., Rowlett, J. K., & Pierce, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02916.2002 · Cited by 310 · see citing works
The Role of Oxidative Stress in Alzheimer Disease
Markesbery, W. R. (1999) · Archives of Neurology · doi:10.1001/archneur.56.12.1449 · Cited by 307 · see citing works
Gray, K. M., Carpenter, M. J., Baker, N. L., DeSantis, S. M., Kryway, E., Hartwell, K. J., McRae-Clark, A. L., & Brady, K. T. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12010055 · Cited by 306 · see citing works
Mitochondrial involvement in psychiatric disorders
Shao, L., Martin, M. V., Watson, S. J., Schatzberg, A. F., Akil, H., Myers, R., Jones, E. G., Bunney, W. E., & Vawter, M. P. (2008) · Annals of Medicine · doi:10.1080/07853890801923753 · Cited by 303 · see citing works
Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors
Müller, C. P., Carey, R. J., Huston, J. P., & Silva, M. A. D. S. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.001 · Cited by 302 · see citing works
Grant, J. E., Kim, S. W., & Odlaug, B. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.021 · Cited by 302 · see citing works
Capuron, L., Ravaud, A., & Dantzer, R. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.10.2143 · Cited by 293 · see citing works
A randomized controlled pilot trial of oral N-acetylcysteine in children with autism
Hardan, A. Y., Fung, L. K., Libove, R. A., Obukhanych, T. V., Nair, S., Herzenberg, L. A., Frazier, T. W., & Tirouvanziam, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.014 · Cited by 293 · see citing works
Ciano, P. D. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00235-4 · Cited by 287 · see citing works
Cadet, J. L., Jayanthi, S., & Deng, X. (2003) · The FASEB Journal · doi:10.1096/fj.03-0073rev · Cited by 286 · see citing works
Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?
Carlezon, W. A., & Nestler, E. J. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02289-0 · Cited by 281 · see citing works
Astrocytes Provide Cysteine to Neurons by Releasing Glutathione
Wang, X. F., & Cynader, M. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741434.x · Cited by 281 · see citing works
Chronic pain, depression, and quality of life: correlations and predictive value of the SF-36.
Elliott, T. E., Renier, C., & Palcher, J. A. (2003) · Pain medicine (Malden, Mass.) · doi:10.1111/j.1526-4637.2003.03040.x · Cited by 281 · see citing works
N‐acetylcysteine replenishes glutathione in HIV infection
Rosa, S. C. D., Zaretsky, M. D., Dubs, J. G., Roederer, M., Anderson, M., Green, A., Mitra, D. K., Watanabe, N., Nakamura, H., Tjioe, I., et al. (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00736.x · Cited by 278 · see citing works
Piani, D., & Fontana, A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.7.3578 · Cited by 274 · see citing works
Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis
Wu, J., Xiao, H., Sun, H., Zou, L., & Zhu, L.-Q. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8278-5 · Cited by 274 · see citing works
Flora, S. J. S. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03157.x · Cited by 273 · see citing works
Fumagalli, F., Gainetdinov, R. R., Valenzano, K. J., & Caron, M. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-04861.1998 · Cited by 266 · see citing works
Drexhage, R. C., Knijff, E. M., Padmos, R. C., Heul-Nieuwenhuijzen, L. V. D., Beumer, W., Versnel, M. A., & Drexhage, H. A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.144 · Cited by 263 · see citing works
Barger, S. W., & Basile, A. S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00075.x · Cited by 262 · see citing works
The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans
Knackstedt, L. A., LaRowe, S., Mardikian, P., Malcolm, R., Upadhyaya, H., Hedden, S., Markou, A., & Kalivas, P. W. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.040 · Cited by 260 · see citing works
Melnyk, S., Fuchs, G. J., Schulz, E., Lopez, M., Kahler, S. G., Fussell, J. J., Bellando, J., Pavliv, O., Rose, S., Seidel, L., et al. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1260-7 · Cited by 250 · see citing works
Khan, M., Sekhon, B., Jatana, M., Giri, S., Gilg, A. G., Sekhon, C., Singh, I., & Singh, A. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20087 · Cited by 245 · see citing works
Sekine, Y., Minabe, Y., Ouchi, Y., Takei, N., Iyo, M., Nakamura, K., Suzuki, K., Tsukada, H., Okada, H., Yoshikawa, E., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1699 · Cited by 242 · see citing works
Kunz, M., Gama, C. S., Andreazza, A. C., Salvador, M. M., Ceresér, K. M., Gomes, F. A., Belmonte-de-Abreu, P. S., Berk, M., & Kapczinski, F. P. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.07.001 · Cited by 241 · see citing works
Self-citationControlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease
Adair, J. C., Knoefel, J. E., & Morgan, N. (2001) · Neurology · doi:10.1212/wnl.57.8.1515 · Cited by 240 · see citing works
Capuron, L., Ravaud, A., Miller, A. H., & Dantzer, R. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.004 · Cited by 237 · see citing works
Robicsek, O., Karry, R., Petit, I., Kesner, N. S., Müller, F.-J., Klein, E., Aberdam, D., & Ben‐Shachar, D. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.67 · Cited by 229 · see citing works
Repeated<i>N</i>-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine
Madayag, A., Lobner, D., Kau, K. S., Mantsch, J. R., Abdulhameed, O., Hearing, M., Grier, M. D., & Baker, D. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2808-07.2007 · Cited by 225 · see citing works
James, S. J., Rose, S., Melnyk, S., Jernigan, S., Blossom, S. J., Pavliv, O., & Gaylor, D. W. (2009) · The FASEB Journal · doi:10.1096/fj.08-128926 · Cited by 223 · see citing works
Mitochondrial damage and dysfunction in traumatic brain injury.
Lifshitz, J., Sullivan, P., Hovda, D., Wieloch, T., & McIntosh, T. (2004) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2004.07.021 · Cited by 220 · see citing works
N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases
Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Öz, G., Cloyd, J. C., & Tuite, P. J. (2013) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31829ae713 · Cited by 216 · see citing works
Grant, J., Odlaug, B., Chamberlain, S., Keuthen, N., Lochner, C., & Stein, D. J. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12040508 · Cited by 214 · see citing works
Is Cocaine Desire Reduced by N -Acetylcysteine?
LaRowe, S. D., Myrick, H., Hedden, S. L., Mardikian, P. N., Saladin, M. E., McRae‐Clark, A. L., Brady, K. T., Kalivas, P. W., & Malcolm, R. J. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.7.1115 · Cited by 210 · see citing works
Hoffer, M. E., Balaban, C., Slade, M. D., Tsao, J. W., & Hoffer, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054163 · Cited by 207 · see citing works
N-acetylcysteine and neurodegenerative diseases: Basic and clinical pharmacology
Arakawa, M., & Ito, Y. (2007) · The Cerebellum · doi:10.1080/14734220601142878 · Cited by 206 · see citing works
Behr, G. A., Moreira, J. C. F., & Frey, B. N. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/609421 · Cited by 205 · see citing works
Geiler, J., Michaelis, M., Naczk, P., Leutz, A., Langer, K., Doerr, H.-W., & Cinatl, J. J. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.08.025 · Cited by 205 · see citing works
Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Dantzer, R., Maes, M., & Neveu, P. J. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00030-0 · Cited by 201 · see citing works
Lafleur, D. L., Pittenger, C., Kelmendi, B., Gardner, T., Wasylink, S., Malison, R. T., Sanacora, G., Krystal, J. H., & Coric, V. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0246-6 · Cited by 200 · see citing works
Andreazza, A. C., Kapczinski, F. P., Kauer‐Sant’Anna, M., Walz, J. C., Bond, D. J., Gonçalves, C. A., Young, L. T., & Yatham, L. N. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0935 · Cited by 199 · see citing works
The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson’s disease
Hastings, T. G. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9257-z · Cited by 199 · see citing works
A Noradrenergic and Serotonergic Hypothesis of the Linkage Between Epilepsy and Affective Disorders
Jobe, P. C., Dailey, J. W., & Wernicke, J. F. (1999) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v13.i4.10 · Cited by 193 · see citing works
Temporal Characterization of Mitochondrial Bioenergetics after Spinal Cord Injury
Sullivan, P. G., Krishnamurthy, S., Patel, S. P., et al. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0242 · Cited by 191 · see citing works
Randomized, Double-Blind, Controlled Trial of Acetylcysteine in Amyotrophic Lateral Sclerosis
Louwerse, E. S., Weverling, G. J., Bossuyt, P. M., Meyjes, F. E. P., & de Jong, J. M. B. V. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540300031009 · Cited by 186 · see citing works
Berk, M., Dean, O., Cotton, S. M., Gama, C. S., Kapczinski, F., Fernandes, B. S., Kohlmann, K., Jeavons, S., Hewitt, K., Allwang, C., et al. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.005 · Cited by 181 · see citing works
Self-citationSafety and Tolerability of N‐Acetylcysteine in Cocaine‐Dependent Individuals
LaRowe, S. D., Mardikian, P. N., Malcolm, R. J., Myrick, H., Kalivas, P. W., McFarland, K., Saladin, M. E., McRae‐Clark, A. L., & Brady, K. T. (2006) · American Journal on Addictions · doi:10.1080/10550490500419169 · Cited by 181 · see citing works
Amen, S. L., Piacentine, L., Ahmad, M. E., Li, S.-J., Mantsch, J. R., Risinger, R., & Baker, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.226 · Cited by 179 · see citing works
An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: A pilot study
Mardikian, P. N., LaRowe, S. D., Hedden, S., Kalivas, P. W., & Malcolm, R. J. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.10.001 · Cited by 179 · see citing works
Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress
Deng, W., Wang, H., Rosenberg, P. A., Volpe, J. J., & Jensen, F. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307850101 · Cited by 179 · see citing works
Berk, M., Dean, O. M., Cotton, S. M., Jeavons, S., Tanious, M., Kohlmann, K., Hewitt, K., Moss, K., Allwang, C., Schapkaitz, I., et al. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08454 · Cited by 172 · see citing works
Self-citationBloch, M., Panza, K. E., Grant, J., Pittenger, C., & Leckman, J. (2013) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1016/j.jaac.2012.12.020 · Cited by 171 · see citing works
Chen, G., Shi, J., Hu, Z., & Hang, C. (2008) · Mediators of Inflammation · doi:10.1155/2008/716458 · Cited by 170 · see citing works
Cerebral cystine uptake: a tale of two transporters
McBean, G. J. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02060-6 · Cited by 164 · see citing works
S-Nitrosothiols signal hypoxia-mimetic vascular pathology
Palmer, L. A., Doctor, A., Chhabra, P., Sheram, M. L., Laubach, V. E., Karlinsey, M. Z., Forbes, M. S., Macdonald, T. L., & Gaston, B. M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29444 · Cited by 161 · see citing works
Hotsenpiller, G., Giorgetti, M., & Wolf, M. E. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01804.x · Cited by 160 · see citing works
Ghanizadeh, A. J., & Sarani, E. M. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-196 · Cited by 158 · see citing works
Farokhnia, M., Azarkolah, A., Adinehfar, F., Khodaie-Ardakani, M.-R., Hosseini, S.-M.-R., Yekehtaz, H., Tabrizi, M., Rezaei, F., Salehi, B., Sadeghi, S.-M.-H., et al. (2013) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000001 · Cited by 155 · see citing works
A Double-Blind Placebo-Controlled Trial of N-Acetylcysteine in the Treatment of Cocaine Dependence
Larowe, S., Kalivas, P., Nicholas, J. S., Randall, P., Mardikian, P., & Malcolm, R. (2013) · American Journal on Addictions · doi:10.1111/j.1521-0391.2013.12034.x · Cited by 154 · see citing works
Motor Neuron Disease (Amyotrophic Lateral Sclerosis)
WILLIAMS, D. B., & Windebank, A. J. (1991) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)61175-6 · Cited by 153 · see citing works
The Psychiatric Manifestations of Mitochondrial Disorders: A Case and Review of the Literature
Anglin, R. E., Garside, S. L., Tarnopolsky, M. A., Mazurek, M. F., & Rosebush, P. I. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11r07237 · Cited by 150 · see citing works
Schmaal, L., Veltman, D. J., Nederveen, A. J., van den Brink, W., & Goudriaan, A. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.66 · Cited by 147 · see citing works
Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages
Palacio, J. R., Markert, U. R., & Martínez, P. (2011) · Inflammation Research · doi:10.1007/s00011-011-0323-8 · Cited by 145 · see citing works
Uhm, J. H., Dooley, N. P., Oh, L. Y. S., & Yong, V. W. (1998) · Glia · doi:10.1002/(sici)1098-1136(199801)22:1 · Cited by 144 · see citing works
The Effect of N-Acetylcysteine in the Nucleus Accumbens on Neurotransmission and Relapse to Cocaine
Kupchik, Y. M., Moussawi, K., Tang, X., Wang, X., Kalivas, B. C., Kolokithas, R., Ogburn, K. B., & Kalivas, P. W. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.024 · Cited by 141 · see citing works
Baker, D. L., Shen, H., & Kalivas, P. W. (2002) · Amino Acids · doi:10.1007/s00726-001-0122-6 · Cited by 140 · see citing works
Fukami, G., Hashimoto, K., Koike, K., Okamura, N., Shimizu, E., & Iyo, M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.072 · Cited by 138 · see citing works
Afshar, H., Roohafza, H., Mohammad-Beigi, H., Haghighi, M., Jahangard, L., Shokouh, P., Sadeghi, M., & Hafezian, H. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318272677d · Cited by 136 · see citing works
Grant, J. E., Odlaug, B. L., Chamberlain, S. R., Potenza, M. N., Schreiber, L. R. N., Donahue, C. B., & Kim, S. W. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08411 · Cited by 135 · see citing works
Green, J., Heard, K., Reynolds, K., & Albert, D. (2013) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2012.4.6885 · Cited by 135 · see citing works
Altuntaş, İ., Aksoy, H., Coşkun, İ., Çayköylü, A., & Akçay, F. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.201 · Cited by 131 · see citing works
Remington, R., Chan, A., Paskavitz, J., & Shea, T. B. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317508325094 · Cited by 129 · see citing works
The Dynamic Brain: Neuroplasticity and Mental Health
Kays, J. L., Hurley, R. A., & Taber, K. H. (2012) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.12050109 · Cited by 128 · see citing works
Jatana, M., Singh, I., Singh, A. K., & Jenkins, D. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000215045.91122.44 · Cited by 126 · see citing works
Kantrowitz, J. T., & Javitt, D. C. (2010) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.4.3.6 · Cited by 118 · see citing works
The role for N-acetylcysteine in the management of COPD
Dekhuijzen, P., & van Beurden, W. (2006) · International Journal of COPD · doi:10.2147/copd.2006.1.2.99 · Cited by 116 · see citing works
Role of serotonin in obsessive-compulsive disorder
Baumgarten, H. G., & Grozdanovic, Z. (1998) · The British Journal of Psychiatry · doi:10.1192/s0007125000297857 · Cited by 115 · see citing works
Reichel, C. M., Moussawi, K., Do, P. H., Kalivas, P. W., & See, R. E. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.179317 · Cited by 115 · see citing works
Yarema, M. C., Johnson, D. W., Berlin, R. J., Sivilotti, M. L. A., Nettel‐Aguirre, A., Brant, R., Spyker, D. A., Bailey, B., Chalut, D. S., Lee, J. S., et al. (2009) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2009.05.010 · Cited by 114 · see citing works
Kau, K. S., Madayag, A., Mantsch, J. R., Grier, M. D., Abdulhameed, O., & Baker, D. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.010 · Cited by 113 · see citing works
N-acetylcysteine for major depressive episodes in bipolar disorder
Magalhães, P. V. D. S., Dean, O. M., Bush, A. I., Copolov, D., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson‐Hunt, M., & Berk, M. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000400011 · Cited by 113 · see citing works
Self-citationLin, P., Lee, M.-Y., Wang, W.-S., et al. (2006) · Supportive Care in Cancer · doi:10.1007/s00520-006-0018-9 · Cited by 113 · see citing works
Superoxide dismutase and glutathione peroxidase function in progressive myoclonus epilepsies
Ben‐Menachem, E., Kyllerman, M., & Marklund, S. L. (2000) · Epilepsy Research · doi:10.1016/s0920-1211(00)00096-6 · Cited by 113 · see citing works
N-Acetylcysteine as an Adjunctive Therapy to Risperidone for Treatment of Irritability in Autism
Nikoo, M., Radnia, H., Farokhnia, M., Mohammadi, M.-R., & Akhondzadeh, S. (2015) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000063 · Cited by 113 · see citing works
Contribution of Cystine–Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine
Baker, D. L., Madayag, A., Kristiansen, L. V., Meador‐Woodruff, J. H., Haroutunian, V. H., & Raju, I. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301532 · Cited by 112 · see citing works
do Nascimento, M. M., Suliman, M. E., Silva, M., Chinaglia, T., Marchioro, J. C., Hayashi, S. Y., RIELLA, M. C., Lindholm, B., & Anderstam, B. (2010) · Peritoneal Dialysis International · doi:10.3747/pdi.2009.00073 · Cited by 111 · see citing works
<i>N</i>‐Acetylcysteine (NAC) in Young Marijuana Users: An Open‐Label Pilot Study
Gray, K. M., Watson, N. L., Carpenter, M. J., & LaRowe, S. D. (2010) · The American Journal on Addictions · doi:10.1111/j.1521-0391.2009.00027.x · Cited by 109 · see citing works
James, S. J., Melnyk, S., Jernigan, S., Hubanks, A., Rose, S., & Gaylor, D. W. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0614-2 · Cited by 107 · see citing works
Garcia, R. J., Francis, L., Dawood, M., Lai, Z., Faraone, S. V., & Perl, A. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37893 · Cited by 105 · see citing works
Jones, S., & Kauer, J. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09780.1999 · Cited by 102 · see citing works
Magalhães, P. V. D. S., Dean, O. M., Bush, A. I., Copolov, D., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson‐Hunt, M., & Berk, M. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.08.001 · Cited by 100 · see citing works
Self-citationCocaine Sensitization and Craving
Cornish, J. L., & Kalivas, P. W. (2001) · Journal of Addictive Diseases · doi:10.1300/j069v20n03_05 · Cited by 99 · see citing works
Kopke, R. D., Slade, M. D., Jackson, R., et al. (2015) · Hearing Research · doi:10.1016/j.heares.2015.01.002 · Cited by 99 · see citing works
Alterations of Serotonin Transmission in Schizophrenia
Abi‐Dargham, A. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78005-9 · Cited by 98 · see citing works
Accelerated Aging in Schizophrenia Patients: The Potential Role of Oxidative Stress
Okusaga, O. O. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500256 · Cited by 96 · see citing works
Berk, M., Dean, O. M., Cotton, S., Gama, C. S., Kapczinski, F. P., Fernandes, B. S., Kohlmann, K., Jeavons, S., Hewitt, K., Moss, K., et al. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-91 · Cited by 96 · see citing works
Self-citationJames, S. J., Melnyk, S., Jernigan, S., Hubanks, A., Rose, S., & Gaylor, D. W. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0591-5 · Cited by 96 · see citing works
N-Acetyl Cysteine in the Treatment of Grooming Disorders
Odlaug, B. L., & Grant, J. E. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000264976.86990.00 · Cited by 94 · see citing works
Grant, J., Odlaug, B., & Kim, S.-W. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.06.018 · Cited by 93 · see citing works
Rose, S., Melnyk, S., Trusty, T. A., Pavliv, O., Seidel, L., Li, J., Nick, T. G., & James, S. J. (2011) · Autism Research and Treatment · doi:10.1155/2012/986519 · Cited by 93 · see citing works
Schmaal, L., Berk, L., Hulstijn, K. P., Cousijn, J., Wiers, R. W., & van den Brink, W. (2011) · European Addiction Research · doi:10.1159/000327682 · Cited by 93 · see citing works
Sandhir, R., Sood, A., Mehrotra, A., & Kamboj, S. S. (2012) · Neurodegenerative Diseases · doi:10.1159/000334273 · Cited by 88 · see citing works
Does dopamine dysfunction drive depression?
Malhi, G. S., & Berk, M. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00969.x · Cited by 86 · see citing works
Self-citationSmaga, I., Pomierny, B., Krzyżanowska, W., Pomierny-Chamioło, L., Miszkiel, J., Niedzielska, E., Ogorka, A. Z. T., & Filip, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.018 · Cited by 85 · see citing works
Selek, S., Herken, H., Bulut, M., Ceylan, M. F., Çelık, H., SAVAS, H. A., & Erel, Ö. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.10.002 · Cited by 85 · see citing works
Allen, J. W., Knoblach, S. M., & Faden, A. I. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400678 · Cited by 83 · see citing works
Hurd, R. W., Wilder, B. J., Helveston, W. R., & Uthman, B. M. (1996) · Neurology · doi:10.1212/wnl.47.5.1264 · Cited by 82 · see citing works
Varga, V., Jenei, Z., Janáky, R., Saransaari, P., & Oja, S. S. (1997) · Neurochemical Research · doi:10.1023/a:1027377605054 · Cited by 81 · see citing works
Amrouche-Mekkioui, I., & Djerdjouri, B. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.014 · Cited by 81 · see citing works
N-acetylcysteine Protects Mice from Lethal Endotoxemia by Regulating the Redox State of Immune Cells
Víctor, V. M., Rocha, M., & la Fuente, M. D. (2003) · Free Radical Research · doi:10.1080/1071576031000148727 · Cited by 78 · see citing works
The Psychiatric Presentation of Mitochondrial Disorders in Adults
Anglin, R. E., Tarnopolsky, M. A., Mazurek, M. F., & Rosebush, P. I. (2012) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.11110345 · Cited by 77 · see citing works
Gatti, S., Faggioni, R., Echtenacher, B., et al. (1993) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1993.tb05924.x · Cited by 75 · see citing works
Beneficial effects of<i>N-</i>acetylcysteine in treatment resistant schizophrenia
Bulut, M., Savas, H. A., Altindag, A., Virit, O., & Dalkilic, A. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970903144004 · Cited by 73 · see citing works
An open‐label pilot study of N‐acetylcysteine for skin‐picking in Prader–Willi syndrome
Miller, J. L., & Angulo, M. (2014) · American Journal of Medical Genetics. Part A · doi:10.1002/ajmg.a.36306 · Cited by 70 · see citing works
The mitochondrial genome and psychiatric illness
Anglin, R., Mazurek, M. F., Tarnopolsky, M. A., & Rosebush, P. I. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32086 · Cited by 69 · see citing works
System xc− regulates microglia and macrophage glutamate excitotoxicity in vivo
Kigerl, K. A., Ankeny, D. P., Garg, S. K., Wei, P. Y., Guan, Z., Lai, W., McTigue, D. M., Banerjee, R. V., & Popovich, P. G. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.025 · Cited by 69 · see citing works
<i>N</i>-acetylcysteine for therapy-resistant tobacco use disorder: a pilot study
Prado, E., Maes, M., Piccoli, L. G., Baracat, M., Barbosa, D. S., Franco, O., Dodd, S., Berk, M., & Vargas Nunes, S. O. (2015) · Redox Report · doi:10.1179/1351000215y.0000000004 · Cited by 69 · see citing works
Self-citationMousavi, S. G., Sharbafchi, M. R., Salehi, M., Peykanpour, M., Sichani, N. K., & Maracy, M. R. (2015) · PubMed · Cited by 67 · see citing works
N-acetylcysteine in the Treatment of Trichotillomania
Rodrigues-Barata, A. R., Tosti, A., Rodriguez-Pichardo, A., & Camacho-Martínez, F. (2012) · International Journal of Trichology · doi:10.4103/0974-7753.100090 · Cited by 65 · see citing works
Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn
Csontos, C., Rezman, B., Földi, V., Bogár, L., Drenkovics, L., Roth, E. B., Wéber, G., & Lantos, J. (2011) · Burns · doi:10.1016/j.burns.2011.09.011 · Cited by 65 · see citing works
Ghanizadeh, A. J., Derakhshan, N., & Berk, M. (2013) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523011312030003 · Cited by 64 · see citing works
Self-citationBailey, B., Blais, R., & Letarte, A. (2004) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2004.05.014 · Cited by 64 · see citing works
Effects of <scp>N</scp>‐acetyl cysteine on cognitive function in bipolar disorder
Dean, O. M., Bush, A. I., Copolov, D. L., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson‐Hunt, M., & Berk, M. (2012) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2012.02392.x · Cited by 58 · see citing works
Self-citationNail-Biting Stuff? The Effect of N-acetyl Cysteine on Nail-Biting
Berk, M., Jeavons, S., Dean, O. M., Dodd, S., Moss, K., Gama, C. S., & Malhi, G. S. (2009) · CNS Spectrums · doi:10.1017/s1092852900023002 · Cited by 58 · see citing works
Self-citationA preliminary investigation on the efficacy of <i>N</i> -acetyl cysteine for mania or hypomania
Vieira da Silva Magalhães, P., Dean, O. M., Bush, A. I., Copolov, D. L., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., & Berk, M. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413481631 · Cited by 58 · see citing works
Self-citationGilbert, K. R., Aizenman, E., & Reynolds, I. J. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90045-u · Cited by 57 · see citing works
N -acetylcysteine and Unverricht–Lundborg disease Variable response and possible side effects
Edwards, M. J., Hargreaves, I., Heales, S., et al. (2002) · Neurology · doi:10.1212/wnl.59.9.1447 · Cited by 56 · see citing works
Seiva, F. R. F., Amauchi, J. F., Rocha, K. K. R., et al. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.09.028 · Cited by 51 · see citing works
Survival in patients with amyotrophic lateral sclerosis, treated with an array of antioxidants
Vyth, A., Timmer, J. G., Bossuyt, P. M., Louwerse, E. S., & de Jong, J. M. B. V. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00071-8 · Cited by 50 · see citing works
Leslie, S. W., Brown, L. M., Trent, R. D., Lee, Y. H., Morris, J. L., Jones, T. W. A., Randall, P. K., Lau, S. S., & Monks, T. J. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08878-9 · Cited by 48 · see citing works
Venè, R., Castellani, P., Delfino, L., Lucibello, M., Ciriolo, M. R., & Rubartelli, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3830 · Cited by 47 · see citing works
N-acetylcysteine for treatment of autism, a case report.
Ghanizadeh, A. J., & Derakhshan, N. (2012) · PubMed · Cited by 45 · see citing works
Achat‐Mendes, C., Anderson, K. L., & Itzhak, Y. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301119 · Cited by 45 · see citing works
Yang, R., Gallo, D. J., Baust, J., Watkins, S. C., Delude, R. L., & Fink, M. P. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00278.2002 · Cited by 45 · see citing works
Tsai, S., Chung, K., Huang, S., Chen, P., Lee, H., & Kuo, C. (2014) · Bipolar Disorders · doi:10.1111/bdi.12240 · Cited by 43 · see citing works
Mahmoud, K. M., & Ammar, A. (2011) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2011.02492.x · Cited by 40 · see citing works
Liu, X., Xu, C.-Y., & Fan, G.-H. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-52 · Cited by 37 · see citing works
Assessing oxidative pathway genes as risk factors for bipolar disorder
Fullerton, J. M., Tiwari, Y., Agahi, G., Heath, A., Berk, M., Mitchell, P. B., & Schofield, P. R. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00834.x · Cited by 37 · see citing works
Self-citationMarijuana craving trajectories in an adolescent marijuana cessation pharmacotherapy trial
Roten, A. T., Baker, N. L., & Gray, K. M. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.11.003 · Cited by 35 · see citing works
Clinical features and genetics of progressive myoclonus epilepsy of the Unverricht-Lundborg type
Lehesjoki, A., & Koskiniemi, M. (1998) · Annals of Medicine · doi:10.3109/07853899809002489 · Cited by 34 · see citing works
Basha, R. H., & Priscilla, D. H. (2011) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2011.05.002 · Cited by 33 · see citing works
Qualitative Methods in Early-Phase Drug Trials
Berk, M., Munib, A., Dean, O. M., Malhi, G. S., Kohlmann, K., Schapkaitz, I., Jeavons, S., Katz, F., Anderson‐Hunt, M., Conus, P., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05741yel · Cited by 33 · see citing works
Self-citationN-acetylcysteine in the treatment of skin-picking disorder
Silva-Netto, R., de Jesus, G. N., Nogueira, M. S., & Tavares, H. (2014) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1154 · Cited by 33 · see citing works
Cigarette smoking during an N -acetylcysteine-assisted cannabis cessation trial in adolescents
McClure, E. A., Baker, N. L., & Gray, K. M. (2014) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2013.878718 · Cited by 33 · see citing works
Wan, F.-J., Tung, C., Shiah, I., et al. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.07.002 · Cited by 31 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Baker, D.A., Xi, Z.X., Shen, H., Swanson, C.J., Kalivas, P.W., 2002b. The origin and neu- ronal function of in vivo nonsynaptic glutamate. J. Neurosci. 22 (20), 9134-9141.
- Howick, J., Chalmers, I., Glasziou, P., Greenhalgh, T., Heneghan, C., Liberati, A., Moschetti, I., Phillips, B., Thornton, H., Goddard, O., Hodgkinson, M., 2011. The Oxford 2011 Levels of Evidence. http://www.cebm.net/index.aspx?o=5653 (retrieved 03.09.11).
- Kranich, O., Dringen, R., Sandberg, M., Hamprecht, B., 1998. Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine. Glia 22 (1), 11-18.
Cited by
Sorted by citations
N-Acetylcysteine (NAC): Impacts on Human Health
Tenório, M. C. D. S., Graciliano, N. G., Moura, F. A., Oliveira, A. C. M. D., & Goulart, M. O. F. (2021) · Antioxidants · doi:10.3390/antiox10060967 · Cited by 526 · see citing works
Nutritional psychiatry: The present state of the evidence
Marx, W., Moseley, G., Berk, M., & Jacka, F. (2017) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117002026 · Cited by 469 · see citing works
Self-citationCognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
Self-citationPeripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197 · see citing works
Amino acid catabolism in Alzheimer’s disease brain: Friend or foe?
Griffin, J. W. D., & Bradshaw, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5472792 · Cited by 185 · see citing works
Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments
Frye, R. E. (2020) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2020.100829 · Cited by 161 · see citing works
Self-citationFrye, R. E., & Rossignol, D. A. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38337 · Cited by 96 · see citing works
Self-citationThe Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders
Bradlow, R. C. J., Berk, M., Kalivas, P. W., Back, S. E., & Kanaan, R. A. (2022) · CNS Drugs · doi:10.1007/s40263-022-00907-3 · Cited by 87 · see citing works
Self-citationNamba, M. D., Leyrer-Jackson, J. M., Nagy, E. K., Olive, M. F., & Neisewander, J. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.650785 · Cited by 76 · see citing works
Glutamate transport: a new bench to bedside mechanism for treating drug abuse
Spencer, S., & Kalivas, P. W. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx050 · Cited by 71 · see citing works
Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy
Marchezan, J., Winkler dos Santos, E. G. A., Deckmann, I., & Riesgo, R. D. S. (2018) · Neuroimmunomodulation · doi:10.1159/000492225 · Cited by 70 · see citing works
Morbidity in depressive disorders
Baldessarini, R. J., Forte, A., Selle, V., Sim, K., Tondo, L., Undurraga, J., & Vázquez, G. H. (2017) · Psychotherapy and Psychosomatics · doi:10.1159/000448661 · Cited by 63 · see citing works
Clinical Staging for Youth Mental Disorders: Progress in Reforming Diagnosis and Clinical Care
McGorry, P. D., & Mei, C. (2021) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-050620-030405 · Cited by 38 · see citing works
Nery, F. G., Li, W., DelBello, M. P., & Welge, J. A. (2021) · Bipolar Disorders · doi:10.1111/bdi.13039 · Cited by 29 · see citing works
Zhu, C., Li, H., Kong, X., Wang, Y., Sun, T., & Wang, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.819470 · Cited by 26 · see citing works
Slattery, J., MacFabe, D., Kahler, S., & Frye, R. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160905123953 · Cited by 20 · see citing works
Self-citation
- Authors
- Deepmala, Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R.
- Affiliations
- Arkansas Children's Hospital (US)
- Barwon Health (AU)
- MaRS (CA)
- Corresponding author
- Deepmala
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 55
- Pages
- 294-321
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W240506283
- Cited by
- 463
- References
- 218
- Citations by year
- 2026: 28 · 2025: 35 · 2024: 38 · 2023: 38 · 2022: 38 · 2021: 38 · 2020: 49 · 2019: 51 · 2018: 47 · 2017: 50 · 2016: 42 · 2015: 8
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Geelong Region Medical Research Foundation
- Simons Foundation Autism Research Initiative
- Australian Rotary Health
- Beyond Blue
- Servier
- H. Lundbeck A/S
- National Institutes of Health (1059660)
- National Health and Medical Research Council (1078928, 1061043, 1059660)
- Cilag
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- N-acetylcysteine, mental illness, neurological disorders, autism spectrum disorder, Alzheimer's disease, addiction, bipolar disorder, depression, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy, progressive myoclonic epilepsy, oxidative stress, neuroinflammation, glutamate dysregulation, dopamine dysregulation, mitochondrial dysfunction, treatment safety
- MeSH terms
- Acetylcysteine, Adolescent, Adult, Mental Disorders, Clinical Trials as Topic, Female, Humans, Male, Nervous System Diseases, Neurology, Psychiatry, Randomized Controlled Trials as Topic, Treatment Outcome, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review