Reduction in Duration of Hypoglycemia by Automatic Suspension of Insulin Delivery: The In-Clinic ASPIRE Study

Garg, Satish; Brazg, Ronald L.; Bailey, Timothy S.; Buckingham, Bruce A.; Slover, Robert H.; Klonoff, David C.; Shin, John; Welsh, John B.; Kaufman, Francine R.

doi:10.1089/dia.2011.0292

Cited by 138Diabetes Management and ResearchDiabetes Management and EducationDiabetes Treatment and Management

Reduction in Duration of Hypoglycemia by Automatic Suspension of Insulin Delivery: The In-Clinic ASPIRE Study

Garg, Satish, Brazg, Ronald L., Bailey, Timothy S., Buckingham, Bruce A., Slover, Robert H., Klonoff, David C., Shin, John, Welsh, John B. +1 more·2012·Diabetes Technology & Therapeutics

DOI 10.1089/dia.2011.0292

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Abstract

Background The efficacy of automatic suspension of insulin delivery in induced hypoglycemia among subjects with type 1 diabetes was evaluated. Subjects and methods In this randomized crossover study, subjects used a sensor-augmented insulin pump system with a low glucose suspend (LGS) feature that automatically stops insulin delivery for 2 h following a sensor glucose (SG) value ≤70 mg/dL. Subjects fasted overnight and exercised until their plasma glucose (measured with the YSI 2300 STAT Plus™ glucose and lactate analyzer [YSI Life Sciences, Yellow Springs, OH]) value reached ≤85 mg/dL on different occasions separated by washout periods lasting 3-10 days. Exercise sessions were done with the LGS feature turned on (LGS-On) or with continued insulin delivery regardless of SG value (LGS-Off). The order of LGS-On and LGS-Off sessions was randomly assigned. YSI glucose data were used to compare the duration and severity of hypoglycemia from successful LGS-On and LGS-Off sessions and to estimate the risk of rebound hyperglycemia after pump suspension. Results Fifty subjects attempted 134 sessions, 98 of which were successful. The mean±SD hypoglycemia duration was less during LGS-On than during LGS-Off sessions (138.5±76.68 vs. 170.7±75.91 min, P=0.006). During LGS-On compared with LGS-Off sessions, mean nadir YSI glucose was higher (59.5±5.72 vs. 57.6±5.69 mg/dL, P=0.015), as was mean end-observation YSI glucose (91.4±41.84 vs. 66.2±13.48 mg/dL, P 250 mg/dL. Conclusions Automatic s…

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When comparing the safety and efficacy of overnight closed-loop delivery of insulin with conventional insulin-pump therapy in adults with type 1 diabetes, closed-loop delivery improved overnight control of glycaemia and reduced the risk of nocturnal hypoglycaemia.
“when comparing the safety and efficacy of overnight closed-loop delivery of insulin with conventional insulin-pump therapy in adults with type 1 diabetes, closed-loop delivery improved overnight control of glycaemia and reduced the risk of nocturnal hypoglycaemia.98,99”
From Type 1 diabetes (2014) · cites this paper as [98]

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works
Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes
Cryer, P. E. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3592 · Cited by 402 · see citing works
Insulin Pump Therapy With Automated Insulin Suspension in Response to Hypoglycemia
Choudhary, P., Shin, J., Wang, Y., Evans, M. L., Hammond, P. J., Kerr, D., Shaw, J. A. M., Pickup, J. C., & Amiel, S. A. (2011) · Diabetes Care · doi:10.2337/dc10-2411 · Cited by 175 · see citing works
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Danne, T., Kordonouri, O., Holder, M., Haberland, H., Golembowski, S., Remus, K., Bläsig, S., Wadien, T., Zierow, S., Hartmann, R., et al. (2011) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0084 · Cited by 150 · see citing works
Duration of Nocturnal Hypoglycemia Before Seizures
Buckingham, B. A., Wilson, D. M., Lecher, T., Hanås, R., Kaiserman, K. B., & Cameron, F. J. (2008) · Diabetes Care · doi:10.2337/dc08-0863 · Cited by 111 · see citing works
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Agrawal, P. K., Welsh, J. B., Kannard, B., Askari, S., Yang, Q., & KAUFMAN, F. R. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500514 · Cited by 86 · see citing works
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Ly, T. T., Hewitt, J., Davey, R. J., Lim, E. M., Davis, E. A., & Jones, T. W. (2011) · Diabetes Care · doi:10.2337/dc10-1042 · Cited by 81 · see citing works
Hypoglycemia Begets Hypoglycemia in IDDM
Cryer, P. E. (1993) · Diabetes · doi:10.2337/diab.42.12.1691 · Cited by 67 · see citing works
The ASPIRE Study: Design and Methods of an In-Clinic Crossover Trial on the Efficacy of Automatic Insulin Pump Suspension in Exercise-Induced Hypoglycemia
Brazg, R., Bailey, T. S., Garg, S. K., Buckingham, B. A., Slover, R. H., Klonoff, D. C., Nguyen, X., Shin, J., Welsh, J. B., & Lee, S. W. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500621 · Cited by 28 · see citing works
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Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
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Grunberger, G., Sherr, J., Allende, M., Blevins, T., Bode, B., Handelsman, Y., Hellman, R., Lajara, R., Roberts, V. L., Rodbard, D., et al. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.04.008 · Cited by 288 · see citing works
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Sherr, J. L., Tauschmann, M., Battelino, T., de Bock, M., Forlenza, G., Roman, R., Hood, K. K., & Maahs, D. M. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12731 · Cited by 197 · see citing works
ISPAD Clinical Practice Consensus Guidelines 2018: exercise in children and adolescents with diabetes
Adolfsson, P., Riddell, M. C., Taplin, C. E., Davis, E. A., Fournier, P. A., Annan, F., Scaramuzza, A. E., Hasnani, D., & Hofer, S. E. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12755 · Cited by 191 · see citing works
Challenges and recent progress in the development of a closed-loop artificial pancreas
Bequette, B. W. (2012) · Annual Reviews in Control · doi:10.1016/j.arcontrol.2012.09.007 · Cited by 182 · see citing works
Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics
Pozzilli, P., Battelino, T., Danne, T., Hovorka, R., Jarosz-Chobot, P. A., & Renard, É. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2653 · Cited by 162 · see citing works
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Outpatient Safety Assessment of an In-Home Predictive Low-Glucose Suspend System with Type 1 Diabetes Subjects at Elevated Risk of Nocturnal Hypoglycemia
Buckingham, B. A., Cameron, F., Calhoun, P. M., Maahs, D. M., Wilson, D. M., Chase, H. P., Bequette, B. W., Lum, J. W., Sibayan, J., Beck, R. W., et al. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0040 · Cited by 103 · see citing works
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Robertson, K. J., Riddell, M. C., Guinhouya, B. C., Adolfsson, P., & Hanås, R. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12176 · Cited by 99 · see citing works
Susceptibility of Interstitial Continuous Glucose Monitor Performance to Sleeping Position
Mensh, B. D., Wisniewski, N. A., Neil, B. M., & Burnett, D. R. (2013) · Journal of Diabetes Science and Technology · doi:10.1177/193229681300700408 · Cited by 97 · see citing works
Current perspectives on physical activity and exercise for youth with diabetes
Pivovarov, J. A., Taplin, C. E., & Riddell, M. C. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12272 · Cited by 96 · see citing works
The PILGRIM Study: In Silico Modeling of a Predictive Low Glucose Management System and Feasibility in Youth with Type 1 Diabetes During Exercise
Danne, T., Tsioli, C., Kordonouri, O., Bläsig, S., Remus, K., Roy, A., Keenan, D. B., Lee, S. W., & KAUFMAN, F. R. (2014) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0327 · Cited by 91 · see citing works
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Vehí, J., Contreras, I., Oviedo, S., Biagi, L., & Bertachi, A. (2020) · Health Informatics Journal · doi:10.1177/1460458219850682 · Cited by 76 · see citing works
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Shah, V. N., Shoskes, A., Tawfik, B., & Garg, S. K. (2014) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2014.0193 · Cited by 74 · see citing works
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Abraham, S. B., Arunachalam, S., Zhong, A., Agrawal, P., Cohen, O., & McMahon, C. M. (2021) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819859334 · Cited by 63 · see citing works
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Defective Counterregulation and Hypoglycemia Unawareness in Diabetes
Reno, C. M., Litvin, M., Clark, A. L., & Fisher, S. J. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.005 · Cited by 53 · see citing works
Ramadan Fasting in Diabetes Patients on Insulin Pump Therapy Augmented by Continuous Glucose Monitoring: An Observational Real-Life Study
Khalil, A., Beshyah, S., Awad, S. A., Benbarka, M., Haddad, M., Al-Hassan, D., Kahwatih, M., & Nagelkerke, N. J. D. (2012) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2012.0061 · Cited by 53 · see citing works
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Stenerson, M. B., Cameron, F., Wilson, D. M., Harris, B., Payne, S. R., Bequette, B. W., & Buckingham, B. A. (2014) · Journal of Diabetes Science and Technology · doi:10.1177/1932296813516208 · Cited by 48 · see citing works
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Self-citation
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Sherr, J. L., Palau Collazo, M., Cengiz, E., Michaud, C., Carria, L., Steffen, A. T., Weyman, K., Zgorski, M., Tichy, E., Tamborlane, W. V., et al. (2014) · Diabetes Care · doi:10.2337/dc13-1608 · Cited by 35 · see citing works
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Abraham, M. B., de Bock, M. I., Paramalingam, N., O'Grady, M. J., Ly, T. T., George, C., Roy, A., Spital, G., Karula, S., Heels, K., et al. (2016) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2015.0364 · Cited by 34 · see citing works
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Current topics in glycemic control by wearable artificial pancreas or bedside artificial pancreas with closed-loop system
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Factors affecting the success of glucagon delivered during an automated closed-loop system in type 1 diabetes
Bakhtiani, P. A., Youssef, J. E., Duell, A. K., Branigan, D. L., Jacobs, P. G., Lasarev, M. R., Castle, J. R., & Ward, W. K. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.09.001 · Cited by 25 · see citing works
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Continuous Glucose Monitoring Adherence
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Tauschmann, M., & Hovorka, R. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.910192 · Cited by 21 · see citing works
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Roberts, A. J. C., Yi‐Frazier, J. P., Aitken, K. E., Mitrovich, C., Pascual, M., & Taplin, C. E. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12402 · Cited by 21 · see citing works
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Automated insulin pump suspension for hypoglycaemia mitigation: development, implementation and implications
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Marçal, D. F. D. S., Alexandrino, E. G., Cortez, L. E. R., & Bennemann, R. M. (2018) · journal of physical education · doi:10.4025/jphyseduc.v29i1.2917 · Cited by 11 · see citing works
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Self-citation
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Aktürk, H. K., Brown, S. A., Beck, R. W., Sherr, J. L., Bergenstal, R. M., Kovatchev, B. P., Vigersky, R. A., Breton, M. D., Hovorka, R., Klonoff, D. C., et al. (2025) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2025.0130 · Cited by 6 · see citing works
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Villafuerte, B., Frías, M. M., Martín, M. B. R., Valverde, R. Y., Gómez, M. Á. Á., & Castellanos, R. B. (2017) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2017.02.009 · Cited by 6 · see citing works
Experience With the Enlite Sensor in a Multicenter Pediatric Study
Evans, K., Richardson, C., Landry, A., Muileboom, J., Cormack, L., & Lawson, M. L. (2014) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721714560589 · Cited by 6 · see citing works
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GALLEN, I. W. (2014) · Medicine and sport science/Medicine and sport · doi:10.1159/000357344 · Cited by 5 · see citing works
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Bode, B. W., & Battelino, T. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.1502 · Cited by 5 · see citing works
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Narrative review of the role of technology in pediatric diabetes: from testing blood glucose to subcutaneous automated therapy and hope for cure
Yafi, M., Shah, A., & Vélez, K. (2023) · Translational Pediatrics · doi:10.21037/tp-23-145 · Cited by 5 · see citing works
De la bomba de insulina y el monitoreo continuo de glucosa al páncreas artificial
Apablaza, P., Néstor Soto, I., & Ethel Codner, D. (2017) · Revista médica de Chile · doi:10.4067/s0034-98872017000500011 · Cited by 5 · see citing works
Refining the Closed Loop in the Data Age: Research-to-Practice Transitions in Diabetes Technology
Forlenza, G. P., Sankaranarayanan, S., & Maahs, D. M. (2015) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2015.0055 · Cited by 5 · see citing works
Erratum to «Clinical recommendations for sport practice in diabetic patients (RECORD Guide). Diabetes Mellitus Working Group of the Spanish Society of Endocrinology and Nutrition (SEEN)».
Gargallo-Fernández, M., Martín, J. E. S., Peralta, F. G., Moreno, P. R., Martínez, A. M., Botella-Serrano, M., Pérez, C. T., & Fernández, J. L. (2016) · PubMed · doi:10.1016/j.endonu.2016.03.002 · Cited by 5 · see citing works
Low glucose suspend systems
Shah, V. N., Rewers, A. H., & Garg, S. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816714-4.00013-2 · Cited by 4 · see citing works
Self-citation

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Brazg, R., Bailey, T. S., Garg, S. K., Buckingham, B. A., Slover, R. H., Klonoff, D. C., Nguyen, X., Shin, J., Welsh, J. B., & Lee, S. W. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500621 · Cited by 28 · see citing works
Self-citation
Significant Reduction in Hypoglycemia with the Low Glucose Suspend (LGS) Feature of the Veo Insulin Pump During Exercise-Induced Hypoglycemia and During Routine In-Home Use
Agrawal, P. K., Shin, J., Lee, S. W., Welsh, J. B., Troub, T., & KAUFMAN, F. R. (2012) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2012.07.071
Self-citation
Clinical care and other categories posters: Lesser known complications
(2019) · Diabetic Medicine · doi:10.1111/dme.34_13883
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Choudhary, P., Shin, J., Wang, Y., Evans, M. L., Hammond, P. J., Kerr, D., Shaw, J. A. M., Pickup, J. C., & Amiel, S. A. (2011) · Diabetes Care · doi:10.2337/dc10-2411 · Cited by 175 · see citing works
Self-citation
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Ly, T. T., Nicholas, J. A., Retterath, A., Lim, E. M., Davis, E. A., & Jones, T. W. (2013) · JAMA · doi:10.1001/jama.2013.277818 · Cited by 411 · see citing works

Authors: Garg, S., Brazg, R. L., Bailey, T. S., Buckingham, B. A., Slover, R. H., Klonoff, D. C., Shin, J., Welsh, J. B., & Kaufman, F. R.
Affiliations: Barbara Davis Center for Childhood Diabetes, Aurora, Colorado.
Rainier Clinical Research Center (US)
AMCR Institute (US)
Stanford Medicine (US)
Mills Peninsula Health Services (US)
Medtronic Inc., Northridge, California.
Corresponding author: Garg, Satish
ORCID: Garg, Satish
Bailey, Timothy S.
Buckingham, Bruce A.
Klonoff, David C.
Shin, John
Welsh, John B.
Kaufman, Francine R.
Venue: Diabetes Technology & Therapeutics
Publisher: SAGE Publications
Published: 2012-03
Volume: 14
Issue: 3
Pages: 205-209
ISSN: 1520-9156 (ISSN-L)
1557-8593
DOI: 10.1089/dia.2011.0292
OpenAlex: W1978849955
Cited by: 138
References: 9
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 11 · 2016: 16 · 2015: 17 · 2014: 16 · 2013: 21 · 2012: 10
FWCI: 16.43
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Diabetes Technology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: type 1 diabetes, hypoglycemia, low glucose suspend, sensor-augmented pump, exercise-induced hypoglycemia, rebound hyperglycemia, hypoglycemia duration, hypoglycemia severity, continuous glucose monitoring
MeSH terms: Adolescent, Adult, Blood Glucose, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Male, Middle Aged, Treatment Outcome, Cross-Over Studies, Monitoring, Ambulatory, Young Adult

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Reduction in Duration of Hypoglycemia by Automatic Suspension of Insulin Delivery: The In-Clinic ASPIRE Study

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