Macrophages in allergic asthma: fine-tuning their pro- and anti-inflammatory actions for disease resolution

Moreira, Ana Paula; Hogaboam, Cory M.

doi:10.1089/jir.2011.0027

Cited by 139Asthma and respiratory diseasesImmune cells in cancerMast cells and histamine

Macrophages in allergic asthma: fine-tuning their pro- and anti-inflammatory actions for disease resolution

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Moreira, Ana Paula, Hogaboam, Cory M.·2011·Journal of Interferon & Cytokine Research

DOI 10.1089/jir.2011.0027

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Abstract

Macrophages exert prominent effects in the defense of the respiratory tract from airborne pathogens. These cells are specialized to recognize, phagocytose, and destroy these infectious agents and then promote appropriate tissue repair after successful pathogen clearance. For reasons that are not presently clear, macrophages appear to be inappropriately activated during asthma responses. Evidence stems from the appearance of either classically (or M1) and alternatively activated (or M2) cells in the alveolar compartment of asthmatic lung. Macrophages localized in the interstitial area of the lung appear to be less prone to polarization toward either the M1 or M2 phenotype as these cells predominately express interleukin-10 and exhibit immunoregulatory properties. Effective treatment of clinical asthma, regardless of severity, might depend on restoring an appropriate balance between M1, M2, and immunoregulatory macrophages in the lung.

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Chronic inflammation and persistent Mp accumulation are often associated with tissue destruction and fibrosis.
“However, chronic inflammation and persistent Mp accumulation are often associated with tissue destruction and fibrosis [6 -8].”
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Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197 · see citing works
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,701 · see citing works
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · see citing works
T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma
Woodruff, P. G., Modrek, B., Choy, D. F., Jia, G., Abbas, A. R., Ellwanger, A., Arron, J. R., Koth, L. L., & Fahy, J. V. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0392oc · Cited by 1,806 · see citing works
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
Roncarolo, M. G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., & Levings, M. K. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00420.x · Cited by 1,174 · see citing works
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
Hammad, H., Chieppa, M., Perros, F., Willart, M. A. M., Germain, R. N., & Lambrecht, B. N. (2009) · Nature Medicine · doi:10.1038/nm.1946 · Cited by 1,141 · see citing works
Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
Zhu, Z., Zheng, T., Homer, R., Kim, Y., Chen, N. Y., Cohn, L. E., Hamid, Q. A., & Elias, J. A. (2004) · Science · doi:10.1126/science.1095336 · Cited by 805 · see citing works
IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation
Kurowska‐Stolarska, M., Stolarski, B., Kewin, P., Murphy, G., Corrigan, C. J., Ying, S., Pitman, N. I., Mirchandani, A. S., Rana, B. M. J., van Rooijen, N., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901575 · Cited by 716 · see citing works
IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages
Gazzinelli, R. T., Oswald, I. P., James, S. L., & Sher, A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.6.1792 · Cited by 694 · see citing works
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
Varol, C., Landsman, L., Fogg, D. K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F., & Jung, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061011 · Cited by 627 · see citing works
TH1 cells control themselves by producing interleukin-10
O’Garra, A., & Vieira, P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2097 · Cited by 614 · see citing works
Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production
Zeyda, M., Farmer, D., Todoric, J., Aszmann, O. C., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 553 · see citing works
A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma
Chupp, G. L., Lee, C. G., Jarjour, N. N., Shim, Y. M., Holm, C. T., He, S., Dziura, J. D., Reed, J., Coyle, A. J., Kiener, P. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073600 · Cited by 546 · see citing works
Death receptor signaling
Lavrik, I. N., Golks, A., & Krammer, P. H. (2005) · Journal of Cell Science · doi:10.1242/jcs.01610 · Cited by 494 · see citing works
IL-10 and the Dangers of Immune Polarization: Excessive Type 1 and Type 2 Cytokine Responses Induce Distinct Forms of Lethal Immunopathology in Murine Schistosomiasis
Hoffmann, K. F., Cheever, A. W., & Wynn, T. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6406 · Cited by 474 · see citing works
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B., Thielen, C., Gustin, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39717 · Cited by 399 · see citing works
Interleukin-10 production by effector T cells: Th1 cells show self control
Trinchieri, G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070104 · Cited by 373 · see citing works
Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung
Landsman, L., Varol, C., & Jung, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2000 · Cited by 322 · see citing works
Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study
Bisgaard, H. F., Hermansen, M. N., Bønnelykke, K., Stokholm, J., Baty, F., Skytt, N. L., Aniscenko, J., Kebadze, T., & Johnston, S. L. (2010) · BMJ · doi:10.1136/bmj.c4978 · Cited by 316 · see citing works
Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype
Villalta, S. A., Rinaldi, C., Deng, B., Liu, G., Fedor, B., & Tidball, J. G. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq523 · Cited by 299 · see citing works
Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung
Nair, M. G., Du, Y., Perrigoue, J., Zaph, C., Taylor, J. J., Goldschmidt, M. H., Swain, G. P., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082048 · Cited by 272 · see citing works
Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6
Mikita, T., Campbell, D., Wu, P., Williamson, K., & Schindler, U. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5811 · Cited by 271 · see citing works
Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages
Landsman, L., & Jung, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3488 · Cited by 258 · see citing works
Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-Presenting Cells
Nair, M. G., Gallagher, I. J., Taylor, M. D., Loke, P., Coulson, P. S., Wilson, R. A., Maizels, R. M., & Allen, J. E. (2004) · Infection and Immunity · doi:10.1128/iai.73.1.385-394.2005 · Cited by 252 · see citing works
Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma
Kim, Y., Oh, S.-Y., Jeon, S. G., Park, H., Lee, S.-Y., Chun, E., Bang, B., Lee, H. S., Oh, M. H., Kim, Y., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5375 · Cited by 229 · see citing works
Resolution of Allergic Inflammation and Airway Hyperreactivity Is Dependent upon Disruption of the T1/ST2–IL-33 Pathway
Kearley, J., Buckland, K. F., Mathie, S. A., & Lloyd, C. M. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200805-666oc · Cited by 228 · see citing works
Phenotypic and functional switch of macrophages induced by regulatory CD4 + CD25 + T cells in mice
Liu, G., Ma, H., Qiu, L., Li, L., Cao, Y., Ma, J., & Zhao, Y. X. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.70 · Cited by 222 · see citing works
Interaction of Alveolar Macrophages and Airway Epithelial Cells Following Exposure to Particulate Matter Produces Mediators that Stimulate the Bone Marrow
Fujii, T., Hayashi, S., Hogg, J. C., Mukae, H., Suwa, T., Goto, Y., Vincent, R., & van Eeden, S. F. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.1.4787 · Cited by 217 · see citing works
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
Pesce, J. T., Ramalingam, T. R., Wilson, M. S., Mentink-Kane, M. M., Thompson, R. W., Cheever, A. W., Urban, J. F., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000393 · Cited by 213 · see citing works
T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma
Trautmann, A., Schmid‐Grendelmeier, P., Krüger, K., Crameri, R., Akdiş, M., Akkaya, A., Bröcker, E., Blaser, K., & Akdiş, C. A. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.121460 · Cited by 209 · see citing works
M1 and M2a Polarization of Human Monocyte-Derived Macrophages Inhibits HIV-1 Replication by Distinct Mechanisms
Cassol, E., Cassetta, L., Rizzi, C., Alfano, M., & Poli, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803447 · Cited by 208 · see citing works
Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro
Nair, M. G., Cochrane, D., & Allen, J. E. (2003) · Immunology Letters · doi:10.1016/s0165-2478(02)00225-0 · Cited by 206 · see citing works
Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion
Varin, A., Mukhopadhyay, S., Herbein, G., & Gordon, S. (2009) · Blood · doi:10.1182/blood-2009-08-236711 · Cited by 187 · see citing works
Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts
Kolodsick, J. E., Toews, G. B., Jakubzick, C., Hogaboam, C. M., Moore, T. A., McKenzie, A. N. J., Wilke, C. A., Chrisman, C. J., & Moore, B. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4068 · Cited by 183 · see citing works
Self-citation
Expression of the Ym2 Lectin-binding Protein Is Dependent on Interleukin (IL)-4 and IL-13 Signal Transduction
Webb, D. C., McKenzie, A. N. J., & Foster, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106223200 · Cited by 175 · see citing works
The molecular phenotype of severe asthma in children
Fitzpatrick, A. M., Higgins, M. K., Holguín, F., Brown, L. A. S., & Teague, W. G. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.01.048 · Cited by 158 · see citing works
Defective Apoptotic Cell Phagocytosis Attenuates Prostaglandin E2 and 15-Hydroxyeicosatetraenoic Acid in Severe Asthma Alveolar Macrophages
Huynh, M.-L. N., Malcolm, K. C., Kotaru, C., Tilstra, J. A., Westcott, J. Y., Fadok, V. A., & Wenzel, S. E. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-035oc · Cited by 151 · see citing works
Hyper-responsiveness of IPF/UIP fibroblasts: Interplay between TGFβ1, IL-13 and CCL2
Murray, L. A., Argentieri, R. L., Farrell, F. X., Bracht, M., Sheng, H., Whitaker, B., Beck, H., Tsui, P., Cochlin, K., Evanoff, H. L., et al. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.016 · Cited by 150 · see citing works
Self-citation
Enhanced Pulmonary Allergic Responses to Aspergillus in CCR2−/− Mice
Blease, K., Mehrad, B., Standiford, T. J., Lukacs, N. W., Gosling, J., Boring, L. F., Charo, I. F., Kunkel, S. L., & Hogaboam, C. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2603 · Cited by 145 · see citing works
Self-citation
Apoptosis: the quiet death silences the immune system
Sun, E., & Shi, Y. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00164-4 · Cited by 139 · see citing works
Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages
Joshi, A., Oak, S. R., Hartigan, A. J., Finn, W. G., Kunkel, S. L., Duffy, K. E., Das, A., & Hogaboam, C. M. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-52 · Cited by 135 · see citing works
Self-citation
Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore-induced allergic airway disease.
Moreira, A., Cavassani, K., Hullinger, R., Rosada, R. S., Fong, D. J., Murray, L., Hesson, D., & Hogaboam, C. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.010 · Cited by 133 · see citing works
Self-citation
IL-27 Activates Human Monocytes via STAT1 and Suppresses IL-10 Production but the Inflammatory Functions of IL-27 Are Abrogated by TLRs and p38
Kalliolias, G. D., & Ivashkiv, L. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6325 · Cited by 132 · see citing works
The Role of Leukotriene B4 in Allergic Diseases
Ohnishi, H., Miyahara, N., & Gelfand, E. W. (2008) · Allergology International · doi:10.2332/allergolint.08-rai-0019 · Cited by 122 · see citing works
The IL-3/IL-/GM-CSF Common B Receptor Plays a Pivotal Role in the Regulation of Th2 Immunity and Allergic Airway Inflammation
Asquith, K. L., Ramshaw, H. S., Hansbro, P. M., Beagley, K. W., Lopez, A. F., & Foster, P. (2008) · QUT ePrints (Queensland University of Technology) · doi:10.4049/jimmunol.180.2.1199 · Cited by 118 · see citing works
Airway Remodeling Is Absent in CCR1−/− Mice During Chronic Fungal Allergic Airway Disease
Blease, K., Mehrad, B., Standiford, T. J., Lukacs, N. W., Kunkel, S. L., Chensue, S. W., Lu, B., Gerard, C. J., & Hogaboam, C. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1564 · Cited by 116 · see citing works
Self-citation
IL-27/IFN-γ Induce MyD88-Dependent Steroid-Resistant Airway Hyperresponsiveness by Inhibiting Glucocorticoid Signaling in Macrophages
Li, J. J., Wang, W., Baines, K. J., Bowden, N. A., Hansbro, P. M., Gibson, P. G., Kumar, R. K., Foster, P. S., & Yang, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001039 · Cited by 107 · see citing works
Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations
Prieto, J., Lensmar, C., Roquet, A., et al. (2000) · Respiratory Medicine · doi:10.1053/rmed.2000.0826 · Cited by 104 · see citing works
IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages
Imamichi, T., Yang, J., Huang, D.-W., Brann, T. W., Fullmer, B. A., Adelsberger, J. W., Lempicki, R. A., Baseler, M., & Lane, H. C. (2008) · AIDS · doi:10.1097/qad.0b013e3282f3356c · Cited by 102 · see citing works
The influence of IgG density and macrophage Fc (gamma) receptor cross-linking on phagocytosis and IL-10 production
Gallo, P. M., Gonçalves, R., & Mosser, D. M. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.07.004 · Cited by 93 · see citing works
Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma
Alexis, N. E., Soukup, J. M., Nierkens, S., & Becker, S. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.2.l369 · Cited by 88 · see citing works
Pathogenesis of Steroid-Resistant Airway Hyperresponsiveness: Interaction between IFN-γ and TLR4/MyD88 Pathways
Yang, M., Kumar, R. K., & Foster, P. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803468 · Cited by 86 · see citing works
Oxidative Stress and Asthma: Proteome Analysis of Chitinase-like Proteins and FIZZ1 in Lung Tissue and Bronchoalveolar Lavage Fluid
Zhang, L., Wang, M., Kang, X., Boontheung, P., Li, N., Nel, A. E., & Loo, J. A. (2009) · Journal of Proteome Research · doi:10.1021/pr800685h · Cited by 84 · see citing works
Lipopolysaccharide Activates Transcription of the Heme Oxygenase Gene in Mouse M1 Cells Through Oxidative Activation of Nuclear Factor κB
Kurata, S., Matsumoto, M., Tsuji, Y., et al. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0566u.x · Cited by 77 · see citing works
Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors
Gosset, P., Tillie‐Leblond, I., Oudin, S., Parmentier, O., Wallaert, B., Joseph, M., & Tonnel, A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70504-x · Cited by 77 · see citing works
Granulocyte-Macrophage Colony-Stimulating Factor Expressed by Recombinant Respiratory Syncytial Virus Attenuates Viral Replication and Increases the Level of Pulmonary Antigen-Presenting Cells
Bukreyev, A. A., Belyakov, I. M., Berzofsky, J. A., Murphy, B. R., & Collins, P. L. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12128-12140.2001 · Cited by 76 · see citing works
Alveolar macrophage interleukin (IL)‐10 and IL‐12 production in atopic asthma
Magnan, A., Pee, D. V., Bongrand, P., et al. (1998) · Allergy · doi:10.1111/j.1398-9995.1998.tb03821.x · Cited by 69 · see citing works
Modulating macrophage function with IgG immune complexes
Anderson, C. F., Gerber, J. S., & Mosser, D. M. (2002) · Journal of Endotoxin Research · doi:10.1179/096805102125001118 · Cited by 69 · see citing works
Concentration- and Time-dependent Upregulation and Release of the Cytokines MIP-2, KC, TNF, and MIP-1 α in Rat Alveolar Macrophages by Fungal Spores Implicated in Airway Inflammation
Shahan, T. A., Sorenson, W. G., Paulauskis, J. D., Morey, R. E., & Lewis, D. M. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.18.3.2856 · Cited by 68 · see citing works
Requirement for Inducible Nitric Oxide Synthase in Chronic Allergen Exposure-Induced Pulmonary Fibrosis but Not Inflammation
Naura, A. S., Zerfaoui, M., Kim, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904214 · Cited by 66 · see citing works
Activation of lung macrophage subpopulations in experimental acute pancreatitis
Gea‐Sorlí, S., Guillamat‐Prats, R., Serrano‐Mollar, A., & Closa, D. (2010) · The Journal of Pathology · doi:10.1002/path.2814 · Cited by 65 · see citing works
Modulating macrophage function with IgG immune complexes
Anderson, C. F., Gerber, J. S., & Mosser, D. M. (2002) · Journal of Endotoxin Research · doi:10.1177/09680519020080060501 · Cited by 64 · see citing works
IL-13 induces a bronchial epithelial phenotype that is profibrotic
Malavia, N. K., Mih, J. D., Raub, C. B., Dinh, B.-T., & George, S. C. (2008) · Respiratory Research · doi:10.1186/1465-9921-9-27 · Cited by 62 · see citing works
IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7–mediated Fas ligand cleavage from bronchial epithelial cells
Wadsworth, S. J., Atsuta, R., McIntyre, J. O., Hackett, T., Singhera, G. K., & Dorscheid, D. R. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.05.015 · Cited by 59 · see citing works
FIZZ1 Plays a Crucial Role in Early Stage Airway Remodeling of OVA-Induced Asthma
Dong, L., Wang, S.-J., Camoretti-Mercado, B., et al. (2008) · Journal of Asthma · doi:10.1080/02770900802126941 · Cited by 51 · see citing works
Corticosteroids enhance CD8+ T cell–mediated airway hyperresponsiveness and allergic inflammation by upregulating leukotriene B4 receptor 1
Ohnishi, H., Miyahara, N., Dakhama, A., Takeda, K., Mathis, S., Haribabu, B., & Gelfand, E. W. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.01.035 · Cited by 51 · see citing works
Priming of Alveolar Macrophages by Leukotriene D4: Potentiation of Inflammation
Ménard, G., & Bissonnette, É. Y. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.23.4.4152 · Cited by 51 · see citing works
Granulocyte-Macrophage Colony-Stimulating Factor Is Required for Bronchial Eosinophilia in a Murine Model of Allergic Airway Inflammation
Su, Y.-C., Rolph, M. S., Hansbro, N. G., Mackay, C. R., & Sewell, W. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2600 · Cited by 50 · see citing works
Alveolar Macrophages from Atopic Asthmatics, But Not Atopic Nonasthmatics, Enhance Interleukin-5 Production by CD4 + T Cells
Tang, C., Rolland, J. M., Li, X., Ward, C., BISH, R., & Walters, E. H. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9706118 · Cited by 46 · see citing works
Interleukin‐6 receptor superantagonist Sant7 inhibits TGF‐β‐induced proliferation of human lung fibroblasts
Gallelli, L., Falcone, D., Pelaia, G., Renda, T., Terracciano, R., Malara, N., Vatrella, A., Sanduzzi, A., D’Agostino, B., Rossi, F., et al. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2008.00538.x · Cited by 42 · see citing works
The role of antibiotics in asthma
Blasi, F., & Johnston, S. L. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2006.11.029 · Cited by 41 · see citing works
Interleukin‐13 acts as an apoptotic effector on lung epithelial cells and induces pro‐fibrotic gene expression in lung fibroblasts
Borowski, A., Kuepper, M., Horn, U., Knüpfer, U., Zissel, G., Höhne, K., Luttmann, W., Krause, S., Virchow, J. C., Jr., & Friedrich, K. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02944.x · Cited by 38 · see citing works
Reduced production of interleukin 12 by interferon gamma primed alveolar macrophages from atopic asthmatic subjects
Plummeridge, M. (2000) · Thorax · doi:10.1136/thorax.55.10.842 · Cited by 36 · see citing works
IFN-γ Potentiates the Release of TNF-α and MIP-1 α by Alveolar Macrophages during Allergic Reactions
Déry, R. E., & Bissonnette, É. Y. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.3.3252 · Cited by 34 · see citing works
Intrapulmonary targeting of RANTES/CCL5‐responsive cells prevents chronic fungal asthma
Schuh, J. M., Blease, K., Brühl, H., et al. (2003) · European Journal of Immunology · doi:10.1002/eji.200323917 · Cited by 33 · see citing works
Acute severe asthma: recent advances
Kaza, V., Bandi, V., & Guntupalli, K. K. (2006) · Current Opinion in Internal Medicine · doi:10.1097/mcp.0b013e328011a91c · Cited by 33 · see citing works
Corticosteroids affect nitric oxide generation, total free radicals production, and nitric oxide synthase activity in monocytes of asthmatic patients
KHANDUJA, K. L., Kaushik, G., Khanduja, S., Pathak, C. M., Laldinpuii, J., & Behera, D. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0588-1 · Cited by 32 · see citing works
Transcriptome profiling of primary murine monocytes, lung macrophages and lung dendritic cells reveals a distinct expression of genes involved in cell trafficking
Zasłona, Z., Wilhelm, J., Cakarova, L., Marsh, L. M., Seeger, W., Lohmeyer, J., & von Wulffen, W. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-2 · Cited by 32 · see citing works
Detection of influenza, parainfluenza, adenovirus and respiratory syncytial virus during asthma attacks in children older than 2 years old
Azevedo, A. M. N., Durigon, E. L., Okasima, V. F. B., et al. (2003) · Allergologia et Immunopathologia · doi:10.1016/s0301-0546(03)79204-0 · Cited by 31 · see citing works
Nitric oxide induces apoptosis in GM-CSF-treated eosinophils via caspase-6-dependent lamin and DNA fragmentation
Ilmarinen, P., Moilanen, E., & Kankaanranta, H. (2010) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2010.04.001 · Cited by 27 · see citing works
Association of Exhaled Nitric Oxide to Asthma Burden in Asthmatics on Inhaled Corticosteroids
Zeiger, R. S., Schatz, M. X., Zhang, F., Crawford, W., Kaplan, M., Roth, R. M., & Chen, W. (2010) · Journal of Asthma · doi:10.3109/02770903.2010.539295 · Cited by 26 · see citing works
Langerin+ dendritic cells are responsible for LPS-induced reactivation of allergen-specific Th2 responses in postasthmatic mice
Ortiz-Stern, A., Kanda, A., Mionnet, C., et al. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.73 · Cited by 25 · see citing works
Endotoxin Induces the Expression of Macrophage Inflammatory Protein 1 α mRNA by Rat Alveolar and Bone Marrow-derived Macrophages
Christman, J. W., Blackwell, T. R., Cowan, H. B., et al. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/7.4.455 · Cited by 24 · see citing works
Found in Inflammatory Zone 1 Induces Angiogenesis in Murine Models of Asthma
Sun, Y., Wang, J., HuaBing, L., & Xiu-zhen, H. (2008) · Lung · doi:10.1007/s00408-008-9099-1 · Cited by 21 · see citing works
[Alveolar macrophages in asthmatic patients: study of their phagocytic function].
Damon, M., Godard, P. H., Chaintreuil, J., et al. (1981) · PubMed · Cited by 3 · see citing works

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Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
Macrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384 · see citing works
Macrophage polarization in pathology
Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673 · see citing works
Macrophage phenotypes during tissue repair
Novak, M. L., & Koh, T. J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012512 · Cited by 658 · see citing works
Mesenchymal stromal cell apoptosis is required for their therapeutic function
Pang, S. H. M., D’Rozario, J., Mendonca, S., Bhuvan, T., Payne, N. L., Zheng, D., Hisana, A., Wallis, G., Barugahare, A., Powell, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26834-3 · Cited by 245 · see citing works
Psychedelics as anti-inflammatory agents
Flanagan, T. W., & Nichols, C. D. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1481827 · Cited by 267 · see citing works

Function of Macrophage Prostaglandins in the Process of Phagocytosis
Razin, E., Zor, U., & Globerson, A. (1980) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3593-1_37 · Cited by 14 · see citing works
The phagocytic role of macrophage following myocardial infarction
Li, J., Chen, Q., Zhang, R., Liu, Z., & Cheng, Y. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10314-5 · Cited by 13 · see citing works
Quantitative analysis of macrophage phagocytosis by uptake of particulate 192iridium
Gersten, D. M., Fogler, W. E., & Fidler, I. J. (1977) · Journal of Immunological Methods · doi:10.1016/0022-1759(77)90117-x · Cited by 7 · see citing works
Artificially induced in situ macrophage polarization: An emerging cellular therapy for immuno-inflammatory diseases
Chatterjee, O., & Sur, D. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176006 · Cited by 19 · see citing works
The influence of Pseudomonas aeruginosa biofilm suspension and alginate on macrophage phagocytosis function in mouse
Li, L.-Q. (2008) · Zhongguo weishengtaixue zazhi

Authors: Moreira, A. P., & Hogaboam, C. M.
Affiliations: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
University of Michigan (US)
ORCID: Hogaboam, Cory M.
Venue: Journal of Interferon & Cytokine Research
Publisher: SAGE Publications
Published: 2011-06
Volume: 31
Issue: 6
Pages: 485-491
ISSN: 1079-9907 (ISSN-L)
1557-7465
DOI: 10.1089/jir.2011.0027
OpenAlex: W2004428166
Cited by: 139
References: 86
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 14 · 2016: 11 · 2015: 16 · 2014: 11 · 2013: 20 · 2012: 10
FWCI: 1.54
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Journal of Interferon & Cytokine Research (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: University of Wisconsin-Madison
National Institutes of Health
Topics: Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Keywords: macrophages, allergic asthma, macrophage polarization, M1 macrophages, M2 macrophages, IL-10, alveolar macrophages, disease resolution, lung interstitium
MeSH terms: Asthma, Homeostasis, Humans, Inflammation, Lung, Macrophage Activation, Macrophages, Alveolar, Interleukin-10, Immunomodulation, Th1-Th2 Balance

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Macrophages in allergic asthma: fine-tuning their pro- and anti-inflammatory actions for disease resolution

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