Cited by 41interferon and immune responsesMultiple Sclerosis Research StudiesCytokine Signaling Pathways and Interactions

Induction of a Unique Isoform of the NCOA7 Oxidation Resistance Gene by Interferon β-1b

Open access
Yu, Lijian, Croze, Ed, Yamaguchi, Ken D., Tran, Tiffany, Reder, Anthony T., Litvak, Vladimir, Volkert, Michael R.·2015·Journal of Interferon & Cytokine Research

Abstract

We demonstrate that interferon (IFN)-β-1b induces an alternative-start transcript containing the C-terminal TLDc domain of nuclear receptor coactivator protein 7 (NCOA7), a member of the OXR family of oxidation resistance proteins. IFN-β-1b induces NCOA7-AS (alternative start) expression in peripheral blood mononuclear cells (PBMCs) obtained from healthy individuals and multiple sclerosis patients and human fetal brain cells, astrocytoma, neuroblastoma, and fibrosarcoma cells. NCOA7-AS is a previously undocumented IFN-β-inducible gene that contains only the last 5 exons of full-length NCOA7 plus a unique first exon (exon 10a) that is not found in longer forms of NCOA7. This exon encodes a domain closely related to an important class of bacterial aldo-keto oxido-reductase proteins that play a critical role in regulating redox activity. We demonstrate that NCOA7-AS is induced by IFN and LPS, but not by oxidative stress and exhibits, independently, oxidation resistance activity. We further demonstrate that induction of NCOA7-AS by IFN is dependent on IFN-receptor activation, the Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway, and a canonical IFN-stimulated response element regulatory sequence upstream of exon 10a. We describe a new role for IFN-βs involving a mechanism of action that leads to an increase in resistance to inflammation-mediated oxidative stress.

Integrity signals

Registry

Crossref · 10.1089/jir.2014.0115

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yu, L., Croze, E., Yamaguchi, K. D., Tran, T., Reder, A. T., Litvak, V., & Volkert, M. R.
Affiliations
  • University of Massachusetts Chan Medical School (US)
  • Bayer HealthCare Pharmaceuticals
  • University of California, Los Angeles (US)
  • University of Chicago (US)
Corresponding author
Volkert, Michael R.
Venue
Journal of Interferon & Cytokine Research
Published
2015-03
Volume
35
Issue
3
Pages
186-199
ISSN
  • 1079-9907 (ISSN-L)
  • 1557-7465
OpenAlex
W2084761243
Cited by
41
References
64
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 8 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3
FWCI
1.07
Type
journal article
Language
en
Open access
Locations
  • Journal of Interferon & Cytokine Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Teva Pharmaceutical Industries
  • Cleveland Clinic
  • Veracyte
  • Bayer HealthCare
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
interferon beta-1b, aldo-keto reductase, JAK/STAT signaling, IFN-stimulated response element, oxidative stress resistance, multiple sclerosis, peripheral blood mononuclear cells
MeSH terms
Amino Acid Sequence, Cell Line, Humans, Immunotherapy, Leukocytes, Mononuclear, Molecular Sequence Data, Multiple Sclerosis, Oxidation-Reduction, Signal Transduction, Interferon-beta, Protein Structure, Tertiary, Receptors, Interferon, Oxidative Stress, Protein Isoforms, Regulatory Elements, Transcriptional, STAT Transcription Factors, Janus Kinases, Nuclear Receptor Coactivators

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review