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Cited by 220Nutritional Studies and DietAdipokines, Inflammation, and Metabolic DiseasesFatty Acid Research and Health

Consumption of a healthy dietary pattern results in significant reductions in C-reactive protein levels in adults: a meta-analysis

Neale, E.P., Batterham, M.J., Tapsell, L.C.·2016·Nutrition Research
DOI 10.1016/j.nutres.2016.02.009
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Abstract

Consumption of healthy dietary patterns has been associated with reduced risk of cardiovascular disease and metabolic syndrome. Dietary intervention targets disease prevention, so studies increasingly use biomarkers of underlying inflammation and metabolic syndrome progression to examine the diet-health relationship. The extent to which these biomarkers contribute to the body of evidence on healthy dietary patterns is unknown. The aim of this meta-analysis was to determine the effect of healthy dietary patterns on biomarkers associated with adiposity, insulin resistance, and inflammation in adults. A systematic search of Scopus, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials (all years to April 2015) was conducted. Inclusion criteria were randomized controlled trials; effects of dietary patterns assessed on C-reactive protein (CRP), total adiponectin, high-molecular-weight adiponectin, tumor necrosis factor-α, adiponectin:leptin, resistin, or retinol binding protein 4. Random effects meta-analyses were conducted to assess the weighted mean differences in change or final mean values for each outcome. Seventeen studies were included in the review. These reflected research on dietary patterns associated with the Mediterranean diet, Nordic diet, Tibetan diet, and the Dietary Approaches to Stop Hypertension diet. Consumption of a healthy dietary pattern was associated with significant reductions in CRP (weighted mean difference, -0.75 [-1.16, -0.35]; P = .0003). Non-significant changes were found for all other biomarkers. This analysis found evidence for favorable effects of healthy dietary patterns on CRP, with limited evidence for other biomarkers. Future research should include additional randomized controlled trials incorporating a greater range of dietary patterns and biomarkers.

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  • Absolute changes in CRP or IL-6 with healthy diet or aerobic exercise are comparable to the absolute difference associated with sleep disturbance.

    “Alternatively, the absolute change in levels of CRP or IL-6 with a healthy diet intervention (Neale et al, 2016), or aerobic exercise (Hayashino et al, 2014), is comparable to the absolute difference found in association with sleep disturbance.”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Neale et al, 2016

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Authors
Neale, E. P., Batterham, M. J., & Tapsell, L. C.
Affiliations
University of Wollongong (AU)
Corresponding author
Neale, E.P.
ORCID
Venue
Nutrition Research
Publisher
Elsevier BV
Published
2016-05
Volume
36
Issue
5
Pages
391-401
ISSN
0271-5317 (ISSN-L)
DOI
10.1016/j.nutres.2016.02.009
OpenAlex
W2287836917
Cited by
220
References
70
Citations by year
2026: 11 · 2025: 17 · 2024: 31 · 2023: 17 · 2022: 16 · 2021: 22 · 2020: 24 · 2019: 30 · 2018: 25 · 2017: 22 · 2016: 4 · 2013: 1
FWCI
4.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nutrition Research (publishedVersion)
  • PubMed (publishedVersion)
  • Research Online (University of Wollongong) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
healthy eating patterns, C-reactive protein, inflammation, Mediterranean diet, Nordic diet, Dietary Approaches to Stop Hypertension diet, adiponectin, TNF-α, resistin, retinol-binding protein 4, adiposity, insulin resistance, metabolic syndrome, cardiovascular disease prevention
MeSH terms
Red Meat, Diet, Healthy, Adult, C-Reactive Protein, Cardiovascular Diseases, Edible Grain, Diet, Fruit, Humans, Inflammation, Obesity, Vegetables, Biomarkers, Metabolic Syndrome

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