Biomechanical Analysis of Experimental Diffuse Axonal Injury
Abstract
The purpose of this paper is to present results from methodologies used in our laboratory that are targeted toward identifying specific brain injury thresholds. Results from studying one form of brain injury, diffuse axonal injury, are presented in this report. Physical models, or surrogates, of the skull-brain complex are used to estimate the relationship between inertial loading and brain deformation. A porcine model of diffuse axonal injury, developed with information from these physical models and earlier in vitro tissue modeling studies, is used to correlate histologic and radiologic evidence of axonal injury to predicted regions of injury from the experimental and theoretical analysis. These results form the basis for developing improved diffuse brain injury tolerance levels, as well as identifying new means of diagnostic and treatment techniques for diffuse axonal injury.
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Concussion and subconcussion are produced by acceleration and deceleration forces on the brain, either linear or rotational.
“Concussion and subconcussion are produced by acceleration and deceleration forces on the brain, either linear or rotational [130].”
From The neuropathology of sport (2014) · cites this paper as [130]
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- Authors
- MEANEY, D. F., SMITH, D. H., SHREIBER, D. I., BAIN, A. C., MILLER, R. T., ROSS, D. T., & GENNARELLI, T. A.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 1995-08
- Volume
- 12
- Issue
- 4
- Pages
- 689-694
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W1991799458
- Cited by
- 254
- References
- 17
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 14 · 2019: 7 · 2018: 14 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 12 · 2013: 5 · 2012: 10
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurotrauma (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institutes of Health
- Centers for Disease Control and Prevention
- U.S. Public Health Service (R49 CCR 304684)
- National Institute of Neurological Disorders and Stroke (NS-08803)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- diffuse axonal injury, inertial loads, brain deformation, porcine model, traumatic brain injury
- MeSH terms
- Animals, Axons, Biomechanical Phenomena, Brain Injuries, Models, Neurological, Swine, Swine, Miniature
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