Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats
Open accessAbstract
Spinal cord injury (SCI) is a condition with no available cure. The initial physical impact triggers a cascade of molecular and cellular events that generate a nonpermissive environment for cell survival and axonal regeneration. Spinal cord injured patients often arrive at the clinic hours after the initial insult. This indicates the need to study and develop treatments with a long therapeutic window of action and multiactive properties, which target the complex set of events that arise after the initial trauma. We provide evidence that tamoxifen (TAM), a drug approved by the Food and Drug Administration, exerts neuroprotective effects in an animal model when applied up-to 24 h after SCI. We hypothesized that continuous TAM administration will improve functional locomotor recovery by favoring myelin preservation and reducing secondary damage after SCI. Adult female Sprague-Dawley rats (∼230 g) received a moderate contusion to the thoracic (T9–T10) spinal cord, using the MASCIS impactor device. To determine the therapeutic window available for TAM treatment, rats were implanted with TAM pellets (15 mg) immediately or 24 h after SCI. Locomotor function (Basso, Beattie, Bresnahan open field test, grid walk, and beam crossing tests) was assessed weekly for 35 days post-injury. TAM-treated rats showed significant functional locomotor recovery and improved fine movements when treated immediately or 24 h after SCI. Further, TAM increased white matter preservation and reduced secondary damage caused by astrogliosis, axonal degeneration, and cell death after trauma. These results provide evidence for TAM as a potential therapeutic agent to treat SCI up to 24 h after the trauma.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tamoxifen administration immediately after SCI reduces this response in part by promoting cell survival.
“Studies have shown that tamoxifen administration immediately after SCI reduces this response in part by promoting cell survival [39, 41, 55].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [55]
The Abstract (page unavailable) reports that tamoxifen given immediately after SCI reduced secondary damage, including astrogliosis and cell death, in female rats. The Discussion (page unavailable) also reports reduced GFAP levels and cites evidence that tamoxifen attenuates neuronal apoptosis. It does not establish that promoting cell survival is the mechanism by which tamoxifen reduces the response. (LLM, conf=0.83)
Experimental — accuracy not yet measuredTamoxifen is a known repressor of astrocyte reactivity acutely after SCI.
“Tamoxifen is a known repressor of astrocyte reactivity acutely after SCI [42, 43, 55].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [55]
The Results section reports that tamoxifen given immediately or 24 hours after SCI reduced GFAP-mediated reactive gliosis in female rats. However, GFAP was assessed 35 days after injury, so the paper does not establish that astrocyte reactivity was suppressed acutely. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPrevious studies began tamoxifen treatment within 24 hours of injury, then gave low doses of tamoxifen chronically via intraperitoneal injection or intrathecal infusion.
“Previous studies began tamoxifen treatment within 24 hours of injury, then gave low doses of tamoxifen chronically via intraperitoneal injection [39, 41] or intrathecal infusion [40, 55].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [55]
The 'Laminectomy, SCI, and drug administration' section reports treatment immediately or 24 hours after injury, with continuous release of 0.71 mg/day for 21 days. But it says the tamoxifen was delivered by subcutaneous pellets, not intraperitoneal injection or intrathecal infusion. No page number is available in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredIt is possible that giving tamoxifen at 300 mg/kg, compared to 1 mg/kg, was toxic and induced neuronal cell death.
“Tamoxifen is known to be toxic to humans and rodents at high doses [72–74]; therefore, it is possible that giving tamoxifen at 300 mg/kg, compared to 1 mg/kg [39, 55], was toxic and induced neuronal cell death.”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [55]
The Conclusions (page unavailable) report neuroprotective effects at 0.71 mg/day and refer to other studies using 1 mg/day, not 1 mg/kg. The neuronal-survival figure reports more surviving neurons after tamoxifen treatment, but the paper does not test 300 mg/kg or suggest that this dose induced neuronal cell death. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThese results contradict other CNS trauma studies that show tamoxifen improves anatomical and motor recovery in female and male SCI rodents.
“These results contradict other CNS trauma studies that show tamoxifen improves anatomical and motor recovery in female and male SCI rodents [39–41, 55], but this is likely attributed to differences in the timing of dosing.”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [55]
This is opposite of previous reports that suggest tamoxifen is neuroprotective and increases neuron survival.
“This is opposite of previous reports that suggest tamoxifen is neuroprotective and increases neuron survival [39, 41, 42, 55].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [55]
Studies that report a neuroprotective effect of tamoxifen have given it during the acute phase, capitalizing on tamoxifen's ability to reduce inflammation, decrease glial reactivity, and promote cell survival.
“Studies that report a neuroprotective effect of tamoxifen have given it during this acute phase, capitalizing on tamoxifen’s ability to reduce inflammation, decrease glial reactivity, and promote cell survival [39–42, 55].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A Threshold Selection Method from Gray-Level Histograms
Otsu, N. (1979) · IEEE Transactions on Systems Man and Cybernetics · doi:10.1109/tsmc.1979.4310076 · Cited by 43,748 · see citing works
A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats
Basso, D. M., Beattie, M. S., & Bresnahan, J. C. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.1 · Cited by 4,481 · see citing works
Molecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594 · see citing works
Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury
Faulkner, J., Herrmann, J., Woo, M. J., Tansey, K., Doan, N., & Sofroniew, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3547-03.2004 · Cited by 1,600 · see citing works
Basso, D. M., Beattie, M. S., & Bresnahan, J. C. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0098 · Cited by 1,470 · see citing works
Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007 · see citing works
A fast algorithm for multilevel thresholding
Liao, P., Chen, T.-S., & Chung, P. (2001) · doi:10.6688/jise.2001.17.5.1 · Cited by 954 · see citing works
Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
Barnabé-Heider, F., Göritz, C., Sabelström, H., Takebayashi, H., Pfrieger, F. W., Meletis, K., & Frisén, J. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.014 · Cited by 628 · see citing works
Experimental Modeling of Spinal Cord Injury: Characterization of a Force-Defined Injury Device
Scheff, S. W., Rabchevsky, A. G., Fugaccia, I., Main, J. A., & Lumpp, J. E. (2003) · Journal of Neurotrauma · doi:10.1089/08977150360547099 · Cited by 564 · see citing works
Heterogeneity of reactive astrocytes
Anderson, M. A., Ao, Y., & Sofroniew, M. V. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.030 · Cited by 449 · see citing works
Michael, B., Yano, B. L., Sellers, R. S., Perry, R., Morton, D. G., Roome, N. O., Johnson, J. K., & Schafer, K. A. (2007) · Toxicologic Pathology · doi:10.1080/01926230701595292 · Cited by 441 · see citing works
Lien, E. A., Solheim, E., & Ueland, P. M. (1991) · PubMed · Cited by 362 · see citing works
RECENT ADVANCES IN PATHOPHYSIOLOGY AND TREATMENT OF SPINAL CORD INJURY
Hulsebosch, C. E. (2002) · AJP Advances in Physiology Education · doi:10.1152/advan.00039.2002 · Cited by 358 · see citing works
Merkler, D., Metz, G. A. S., Raineteau, O., Dietz, V., Schwab, M. E., & Fouad, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03665.2001 · Cited by 330 · see citing works
Schucht, P., Raineteau, O., Schwab, M. E., & Fouad, K. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7909 · Cited by 307 · see citing works
Tripathi, R. B., Rivers, L. E., Young, K. M., Jamen, F., & Richardson, W. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3411-10.2010 · Cited by 277 · see citing works
Pharmacological Approaches To Repair the Injured Spinal Cord
Baptiste, D. C., & Fehlings, M. G. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.318 · Cited by 268 · see citing works
Robinson, S. P., Langan-Fahey, S. M., Johnson, D. A., & Jordan, V. C. (1991) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07102-8 · Cited by 268 · see citing works
Protective Effects of Estrogen and Selective Estrogen Receptor Modulators in the Brain1
Dhandapani, K. M., & Brann, D. W. (2002) · Biology of Reproduction · doi:10.1095/biolreprod.102.003848 · Cited by 218 · see citing works
Magnuson, D. S. K., Trinder, T. C., Zhang, Y., Burke, D. A., Morassutti, D. J., & Shields, C. B. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7016 · Cited by 216 · see citing works
Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype
Yankaskas, J. R., Haizlip, J. E., Conrad, M., Koval, D., Lazarowski, E. R., Paradiso, A. M., Rinehart, C. A., Sarkadi, B., Schlegel, R., & Boucher, R. C. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.5.c1219 · Cited by 193 · see citing works
Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs
Yang, G., Nowsheen, S., Aziz, K., & Georgakilas, A. G. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.05.005 · Cited by 190 · see citing works
Quick‐and‐clean article figures with FigureJ
Mutterer, J., & ZINCK, E. (2013) · Journal of Microscopy · doi:10.1111/jmi.12069 · Cited by 189 · see citing works
Scott, A. C. (2002) · Springer eBooks · doi:10.1007/b98897 · Cited by 184 · see citing works
Functional Redundancy of Ventral Spinal Locomotor Pathways
Loy, D. N., Magnuson, D. S. K., Zhang, Y. P., Onifer, S. M., Mills, M. D., Cao, Q., Darnall, J. B., Fajardo, L. C., Burke, D. A., & Whittemore, S. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00315.2002 · Cited by 165 · see citing works
Targeting Rho To Stimulate Repair after Spinal Cord Injury
McKerracher, L. J., & Higuchi, H. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.309 · Cited by 149 · see citing works
Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion
Kimelberg, H. K., Feustel, P. J., Jin, Y., Paquette, J., Boulos, A., Keller, R. W., & Tranmer, B. I. (2000) · NeuroReport · doi:10.1097/00001756-200008210-00014 · Cited by 108 · see citing works
Tamoxifen mimics the effects of estradiol on food intake, body weight, and body composition in rats
Wade, G. N., & Heller, H. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.6.r1219 · Cited by 106 · see citing works
The Current Role of Steroids in Acute Spinal Cord Injury
Bydon, M., Lin, J. A., Macki, M., Gokaslan, Z. L., & Bydon, A. (2013) · World Neurosurgery · doi:10.1016/j.wneu.2013.02.062 · Cited by 105 · see citing works
Barreto, G. E., Santos‐Galindo, M., Diz-Chaves, Y., Pernía, O., Carrero, P., Azcoitia, Í., & García‐Segura, L. M. (2009) · Endocrinology · doi:10.1210/en.2009-0352 · Cited by 103 · see citing works
Tian, D., Liu, J., Xie, M., Zhan, Y., Qu, W., Yu, Z., Tang, Z., Pan, D., & Wang, W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06077.x · Cited by 98 · see citing works
Selective Oestrogen Receptor Modulators Decrease the Inflammatory Response of Glial Cells
Arévalo, M., Diz-Chaves, Y., Santos‐Galindo, M., Bellini, M. J., & García‐Segura, L. M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02156.x · Cited by 98 · see citing works
Pharmacological interventions for spinal cord injury: Where do we stand? How might we step forward?
Rabchevsky, A. G., Patel, S. P., & Springer, J. E. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.05.001 · Cited by 90 · see citing works
Neuroprotective actions of selective estrogen receptor modulators
DonCarlos, L. L., Azcoitia, Í., & García‐Segura, L. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.012 · Cited by 86 · see citing works
Neuroprotective activity of tamoxifen in permanent focal ischemia
Kimelberg, H. K., Jin, Y., Charniga, C. J., & Feustel, P. J. (2003) · Journal of neurosurgery · doi:10.3171/jns.2003.99.1.0138 · Cited by 83 · see citing works
Zhang, Y., Milatović, D., Aschner, M., Feustel, P. J., & Kimelberg, H. K. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.01.015 · Cited by 83 · see citing works
Mehta, S. H., Dhandapani, K. M., Sevilla, L. M. D., Webb, R. C., Mahesh, V. B., & Brann, D. W. (2003) · Neuroendocrinology · doi:10.1159/000068332 · Cited by 78 · see citing works
Spinal Cord Injury Causes Chronic Liver Pathology in Rats
Sauerbeck, A. D., Laws, J. L., Bandaru, V. V. R., Popovich, P. G., Haughey, N. J., & McTigue, D. M. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3497 · Cited by 75 · see citing works
Mosquera, L., Colón, J. M., Santiago, J. M., Torrado, A. I., Meléndez, M., Segarra, A. C., Rodríguez-Orengo, J. F., & Miranda, J. D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.002 · Cited by 74 · see citing works
Self-citationOsuka, K., Feustel, P. J., Mongin, A. A., Tranmer, B. I., & Kimelberg, H. K. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00198.x · Cited by 70 · see citing works
Liu, J., Tian, D., Li, Z., Qu, W., Zhan, Y., Xie, M.-J., Yu, Z., Wang, W., & Wu, G. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.055 · Cited by 68 · see citing works
Care of Rats with Complete High-Thoracic Spinal Cord Injury
Ramsey, J. B., Ramer, L. M., Inskip, J. A., Alan, N., Ramer, M. S., & Krassioukov, A. V. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1382 · Cited by 66 · see citing works
Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia
Zhang, Y., JIN, Y., BEHR, M., Feustel, P. J., Morrison, J. B., & Kimelberg, H. K. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.002 · Cited by 61 · see citing works
Robins, H. I., Won, M., Seiferheld, W. F., Schultz, C. J., Choucair, A. K., Brachman, D. G., Demas, W. F., & Mehta, M. P. (2006) · Neuro-Oncology · doi:10.1215/s1522851705000311 · Cited by 59 · see citing works
O’Neill, K. E., Chen, S., & Brinton, R. D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.014 · Cited by 57 · see citing works
Sun, X., Ji, C., Hu, T., Wang, Z., & Chen, G. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-157 · Cited by 57 · see citing works
Figueroa, J. D., Benton, R. L., Velazquez, I., Torrado, A. I., Ortiz, C. M., Hernandez, C. M., Diaz, J. J., Magnuson, D. S. K., Whittemore, S. R., & Miranda, J. D. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21048 · Cited by 55 · see citing works
Self-citationWei, H., & Ma, X. (2014) · Neurological Sciences · doi:10.1007/s10072-014-1828-z · Cited by 44 · see citing works
Biegon, A. R., Brewster, M. E., Degani, H., Pop, E., Sömjen, D., & Kaye, A. M. (1996) · PubMed · Cited by 41 · see citing works
The cancer drug tamoxifen: A potential therapeutic treatment for spinal cord injury
Guptarak, J., Wiktorowicz, J. E., Sadygov, R. G., Zivadinovic, D., Paulucci-Holthauzen, A. A., Vergara, L., & Nesic, O. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3108 · Cited by 38 · see citing works
Molecular, Anatomical, Physiological and Behavioral studies of rats treated with Buprenorphine
Santiago, J. M., Rosas, O. R., Torrado, A. I., González, M. M., Kalyan-Masih, P., & Miranda, J. D. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2007-0502 · Cited by 38 · see citing works
Self-citationNeuroprotective effects of tamoxifen on experimental spinal cord injury in rats
İsmailoğlu, Ö., Oral, B., Görgülü, A., Sütçü, R., & Demır, N. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2010.01.049 · Cited by 35 · see citing works
Tamoxifen favoured the rat sensorial cortex regeneration after a penetrating brain injury
Rodríguez, N. E. F., Jiménez, J. M. D., de la Torre-Valdovinos, B., Ruiz, J. R. L., Hernández, L., & Jiménez, S. H. D. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.07.007 · Cited by 27 · see citing works
Expression and activation of ephexin is altered after spinal cord injury
Rosas, O. R., Figueroa, J. D., Torrado, A. I., Rivera, M., Santiago, J. M., König, F., & Miranda, J. D. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20848 · Cited by 19 · see citing works
Self-citation(2007) · PubMed · Cited by 14 · see citing works
Miranda, J., Salgado, I., Torrado, A. I., & Santiago, J. M. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.153685 · Cited by 12 · see citing works
Self-citationSantiago, J. M., Rosas, O., Torrado, A. I., González, M. M., Kalyan-Masih, P. O., & Miranda, J. D. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2007.0502
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Pajarillo, E. A. B., Rizor, A., Lee, J., Aschner, M., & Lee, E.-S. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.002 · Cited by 477 · see citing works
Báez-Jurado, E., Rincon‐Benavides, M. A., Hidalgo‐Lanussa, O., Guio-Vega, G. P., Ashraf, G. M., Sahebkar, A., Echeverrı́a, V., García‐Segura, L. M., & Barreto, G. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.09.001 · Cited by 62 · see citing works
Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum
Shahheydari, H., Ragagnin, A., Walker, A. K., Toth, R. P., Vidal, M., Jagaraj, C. J., Perri, E. R., Konopka, A., Sultana, J. M., & Atkin, J. D. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00119 · Cited by 59 · see citing works
Microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice
Brennan, F. H., Swarts, E. A., Kigerl, K. A., Mifflin, K. A., Guan, Z., Noble, B. T., Wang, Y., Witcher, K. G., Godbout, J. P., & Popovich, P. G. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adi3259 · Cited by 56 · see citing works
The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury
Shvetcov, A., Ruitenberg, M. J., Delerue, F., Gold, W. A., Brown, D. A., & Finney, C. A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105074 · Cited by 52 · see citing works
Wang, H., Wu, Y., Han, W., Li, J., Xu, K., Li, Z., Wang, Q., Xu, K., Liu, Y., Xie, L., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00858 · Cited by 45 · see citing works
Wu, F., Wei, X., Wu, Y., Kong, X., Hu, A., Tong, S., Liu, Y., Gong, F., Xie, L., Zhang, J., et al. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5414 · Cited by 40 · see citing works
Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery
Miranda, J., & Colón, J. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.189164 · Cited by 35 · see citing works
Self-citationHormonal therapy in traumatic spinal cord injury.
Ludwig, P. E., Patil, A. A., Chamczuk, A. J., & Agrawal, D. K. (2017) · Europe PMC (PubMed Central) · Cited by 35 · see citing works
Effects of endocrine disrupting chemicals on myelin development and diseases
Naffaa, V., Laprévôte, O., & Schang, A. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.12.009 · Cited by 26 · see citing works
Spinal cord injury: pathophysiology, possible treatments and the role of the gut microbiota
Pagán-Rivera, L. H., Ocasio-Rivera, S. E., Godoy‐Vitorino, F., & Miranda, J. D. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1490855 · Cited by 23 · see citing works
Self-citationXu, Y., Zhu, Y., Yue, Y., Pu, S., Wu, J., Lv, Y., & Du, D. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa127 · Cited by 20 · see citing works
Colón, J. M., González, P. A., Cajigas, Á., Maldonado, W. I., Torrado, A. I., Santiago, J. M., Salgado, I. K., & Miranda, J. D. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.006 · Cited by 19 · see citing works
Self-citationKaur, J., & Mojumdar, A. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1912040 · Cited by 18 · see citing works
Xia, X., Zhou, C., Sun, X., He, X., Liu, C., & Wang, G. (2020) · Brain and Behavior · doi:10.1002/brb3.1777 · Cited by 16 · see citing works
Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury
Xiao, Y., He, Y., Zhong, D., Liu, B., Tang, Z., Lan, X., Dong, Y., Du, H., Liu, Y., & Luo, J. F. (2025) · ACS Nano · doi:10.1021/acsnano.4c14140 · Cited by 10 · see citing works
Chen, M., Dai, P., Wang, S., Song, S.-H., Wang, H., Zhao, Y., Wang, T., & Liu, J. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1970-5 · Cited by 10 · see citing works
Pukos, N., & McTigue, D. M. (2020) · PLOS ONE · doi:10.1371/journal.pone.0235232 · Cited by 9 · see citing works
Sánchez‐Torres, S., Orozco-Barrios, C. E., Salgado‐Ceballos, H., Segura-Uribe, J. J., Guerra‐Araiza, C., León-Cholula, Á., Morán, J., & Coyoy-Salgado, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015285 · Cited by 9 · see citing works
Ebrahimzadeh‐Bideskan, A., Mansouri, S., Ataei, M. L., Jahanshahi, M., & Hosseini, M. (2017) · Anatomical Science International · doi:10.1007/s12565-017-0398-6 · Cited by 9 · see citing works
Double‐edged effects of tamoxifen‐in‐oil‐gavage on an infectious murine model for multiple sclerosis
Hülskötter, K., Jin, W., Allnoch, L., Hansmann, F., Schmidtke, D., Röhn, K., Flügel, A., Lühder, F., Baumgärtner, W., & Herder, V. (2021) · Brain Pathology · doi:10.1111/bpa.12994 · Cited by 8 · see citing works
Comprehensive therapeutics targeting the corticospinal tract following spinal cord injury
Xu, A., Gong, Z., He, Y.-Z., Xia, K., & Tao, H. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1800280 · Cited by 8 · see citing works
Colon, J., Torrado-Tapias, A., Salgado, I. K., Santiago, J. M., Ocasio-Rivera, S. E., Bracho-Rincon, D. P., Pagán-Rivera, L. H., & Miranda, J. D. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00035 · Cited by 7 · see citing works
Self-citationWang, X., Niu, X., Wang, Y., Liu, Y., Yang, C., Chen, X., & Qi, Z. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00119 · Cited by 6 · see citing works
Cabrera‐Aldana, E. E., Balderas-Martínez, Y. I., Velázquez‐Cruz, R., Tovar‐y‐Romo, L. B., Sevilla‐Montoya, R., Martínez‐Cruz, A., Martínez-Cordero, C., Valdés‐Flores, M., Santamaría‐Olmedo, M., Hidalgo‐Bravo, A., et al. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45090472 · Cited by 6 · see citing works
Current Developments in Antioxidant Therapies for Spinal Cord Injury
Villa, J., Villamar, D. M. P., Zapien, J. A. T., Blancas-Espinoza, L., García, J. H., & Silva‐García, R. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85424 · Cited by 5 · see citing works
The Effect of Cefazolin on the Gut Microbiome of Female Rats After Spinal Cord Injury
Pagán-Rivera, L. H., Godoy‐Vitorino, F., Meléndez-Vázquez, N. M., Ocasio-Rivera, S. E., Santiago-Gascot, M. E., Santiago, J. M., Salgado, I. K., González, V., Martínez‐Guzmán, O., Cáceres‐Chacón, M., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13102324 · Cited by 4 · see citing works
Self-citationGuo, W., Wu, Y., Zhao, S., & Xu, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1627414 · Cited by 3 · see citing works
Hülskötter, K., Lühder, F., Flügel, A., Herder, V., & Baumgärtner, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168486 · Cited by 3 · see citing works
Veshchitskii, A. A., Shkorbatova, P. Y., Efimova, E. V., & Merkulyeva, N. S. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.25673 · Cited by 3 · see citing works
Developmental Biology in Central America, the northern region of South America and the Caribbean
García‐Arrarás, J. E. (2020) · The International Journal of Developmental Biology · doi:10.1387/ijdb.200232jg · Cited by 1 · see citing works
de Guadalajara, D. D. E. U., José, V. M., Guillen, J. T., de Guadalajara, D. D. E. U., García, M. A., de Guadalajara, D. D. E. U., Franco, N., & Departamento de Farmacobiología, U. D. G. (2018) · Memorias del Congreso Nacional de Ingeniería Biomédica · doi:10.24254/cnib.18.77
Vidaković, E., Bamberg, E., Zörner, B., Ostheim, K., Minder, B., Bertschy, S., Pannek, J., Stute, P., & Glisic, M. (2026) · Spinal Cord · doi:10.1038/s41393-026-01201-5
Tamoxifen Modulates Spinal Cord Injury Repair Via CCL2/CCR2 Axis and its Mechanisms
Wang, X., Liang, X., Lin, Y., Pang, W., Liu, Y., Wang, Z., Liu, B., & Chen, X. (2026) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-026-10314-w
Pagán-Rivera, L. H., Godoy‐Vitorino, F., Ocasio-Rivera, S. E., Santiago-Gascot, M. E., González, V., Santiago, J. M., Salgado, I. K., Torrado-Tapias, A., Colon, J., García-Guay, C., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198729
Self-citation
- Authors
- Colón, J. M., Torrado, A. I., Cajigas, Á., Santiago, J. M., Salgado, I. K., Arroyo, Y., & Miranda, J. D.
- Affiliations
- University of Puerto Rico Medical Sciences Campus
- University of Puerto Rico, Medical Sciences Campus (PR)
- University of Puerto Rico at Río Piedras (PR)
- University of Puerto Rico at Carolina (PR)
- University of Puerto Rico Carolina Campus
- Corresponding author
- Miranda, Jorge D.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2016-09
- Volume
- 33
- Issue
- 18
- Pages
- 1696-1708
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- PMC
- PMC5035917
- OpenAlex
- W2341520224
- Cited by
- 35
- References
- 56
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurotrauma (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (GM103642)
- National Institute of General Medical Sciences (T34GM007821, P20GM103642, R25GM061838, R25GM061151)
- National Institute on Minority Health and Health Disparities (G12MD007600)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Veterinary › Small Animals › Veterinary Orthopedics and Neurology
- Keywords
- spinal cord injury, tamoxifen, therapeutic window, locomotor recovery, neuroprotection, myelin preservation, white matter preservation, astrocyte activation, axonal degeneration, cell death, bruising, female rats
- MeSH terms
- Animals, Female, Locomotion, Spinal Cord Injuries, Tamoxifen, Rats, Sprague-Dawley, Neuroprotective Agents, Recovery of Function, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
