Cited by 39Memory and Neural MechanismsTraumatic Brain Injury ResearchNeuroscience and Neuropharmacology Research

Mild traumatic brain injury reduces spine density of projection neurons in the medial prefrontal cortex and impairs extinction of contextual fear memory

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Zhao, Jing, Huynh, Jonathan, Hylin, Michael J., O'Malley, John J., Perez, Alec, Moore, Anthony N., Dash, Pramod K.·2018·Journal of Neurotrauma

Abstract

Epidemiology studies have found that a comorbidity exists between traumatic brain injury (TBI) and stress-related disorders. However, the anatomical and cellular bases for this association is poorly understood. An inability to extinguish the memory of a traumatic event lies at the core of many stress-related disorders. Experimental studies have shown that the medial pre-frontal cortex (mPFC), especially the infralimbic (IL) cortex, is required for extinction and for storing the memory of extinction. The output from the central nucleus of amygdala projects to the lateral hypothalamus, paraventricular nucleus, and central gray to regulate heart rate, stress hormone release, and freezing behavior, respectively. Projection neurons of the IL (layers II/III pyramidal neurons) are thought to stimulate GABAergic neurons in the amygdala, which, in turn, inhibit central amygdala output and reduce fear expression. Thus, loss and/or altered morphology of projection neurons of IL as a result of a mild TBI (mTBI) can compromise their ability to effectively inhibit the central amygdala, allowing the original fear memory to drive behavior. Using lateral mild fluid percussion injury (mFPI) in rats, we found that mFPI did not reduce neuronal numbers in the IL, but caused a significant reduction in overall dendritic spine density of both basal and apical dendrites on layer II/III pyramidal neurons. Spine numbers on layer V/VI pyramidal neurons were not significantly changed as a result of mFPI.…

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Authors
Zhao, J., Huynh, J., Hylin, M. J., O'Malley, J. J., Perez, A., Moore, A. N., & Dash, P. K.
Affiliations
Department of Neurobiology & Anatomy, The University of Texas McGovern Medical School, Houston, Texas.
Venue
Journal of Neurotrauma
Published
2018-01
Volume
35
Issue
1
Pages
149-156
ISSN
  • 0897-7151 (ISSN-L)
  • 1557-9042
OpenAlex
W2727986884
Cited by
39
References
41
Citations by year
2026: 6 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 3
FWCI
1.41
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurotrauma (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Defense (W81XWH)
  • National Institutes of Health (W81XWH, NS086301)
  • University of California, Davis
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
mild traumatic brain injury, dendritic spine density, medial prefrontal cortex, infralimbic cortex, contextual fear memory, fear extinction, central amygdala, projection neurons, fluid percussion injury, stress-related disorders, freezing behavior, pyramidal neurons
MeSH terms
Animals, Brain Concussion, Extinction, Psychological, Fear, Male, Memory, Rats, Sprague-Dawley, Prefrontal Cortex, Pyramidal Cells, Dendritic Spines, Rats

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