Medial prefrontal cortical innervation of the intercalated nuclear region of the amygdala
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The projections of the infralimbic area (IL) of the medial prefrontal cortex to the intercalated nuclei (ICNs) of the amygdala are thought to form a critical component of the forebrain circuitry for fear extinction. Despite the importance of these projections, there have been no focussed anatomical studies that have investigated the extent of IL inputs to different portions of the ICN complex. The present investigation used anterograde tract tracing in the rat to study the projections of the ventromedial PFC, including the IL, to the ICNs and surrounding amygdalar regions. Immunohistochemistry for the μ-opioid receptor (MOR) was used to identify the ICNs. At rostral levels of the amygdala there was a very dense projection to a far lateral portion of the capsular subdivision of the central nucleus (CLC) located between the main and medial ICNs, but only very light projections to these ICNs and the lateral ICNs. This distinct portion of the CLC receiving strong IL inputs was termed the capsular infralimbic target zone (CITZ), and was MOR-negative. Likewise, at more caudal levels of the amygdala, IL projections to the medial, lateral, and dorsal ICNs were light to moderate compared with projections to adjacent portions of the basolateral amygdala and amygdalostriatal transitional area. These findings suggest that the putative role of the IL-to-ICN connection in fear inhibition may be mediated by light to moderate projections from the IL to the medial ICN, and that the CITZ may be an equally important amygdalar target for this function.
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The PFC can normally decrease basolateral amygdala activity through projections to the intercalated nucleus.
“and PFC can normally decrease basolateral amygdala activity through projections to the intercalated nucleus (Manko et al., 2011; Pinard et al., 2012).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Pinard et al., 2012
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- Authors
- Pinard, C. R., Mascagni, F., & McDonald, A. J.
- Affiliations
- University of South Carolina (US)
- Corresponding author
- McDonald, A.J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 205
- Pages
- 112-124
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC4586033
- OpenAlex
- W2013792428
- Cited by
- 90
- References
- 49
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 13 · 2017: 5 · 2016: 5 · 2015: 14 · 2014: 9 · 2013: 10 · 2012: 7
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01-DA027305)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- infralimbic cortex, medial prefrontal cortex, amygdala, fear extinction, fear inhibition, basolateral amygdala, mu-opioid receptor, rats
- MeSH terms
- Amygdala, Animals, Behavior, Animal, Brain Mapping, Fear, Male, Neural Inhibition, Neural Pathways, Stereotaxic Techniques, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Opioid, mu, Rats
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