The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats
Abstract
Spinal cord injury (SCI) is one of the most common devastating injuries, which causes permanent disabilities such as paralysis and loss of movement or sensation. The precise pathogenic mechanisms of the disease remain unclear, and, as of yet, there is no effective cure. Mesenchymal stem cells (MSCs) show promise as an effective therapy in the experimental models of SCI. MSCs secrete various factors that can modulate a hostile environment, which is called the paracrine effect. Among these paracrine molecules, exosome is considered to be the most valuable therapeutic factor. Thus, exosomes from MSCs (MSCs-exosomes) can be a potential candidate of therapeutic effects of stem cells. The present study was designed to investigate the effect of whether systemic administration of exosomes generated from MSCs can promote the function recovery on the rat model of SCI in vivo. In the present study, we observed that systemic administration of MSCs-exosomes significantly attenuated lesion size and improved functional recovery post-SCI. Additionally, MSCs-exosomes treatment attenuated cellular apoptosis and inflammation in the injured spinal cord. Expression levels of proapoptotic protein (Bcl-2-associated X protein) and proinflammatory cytokines (tumor necrosis factor alpha and interleukin [IL]-1β) were significantly decreased after MSCs-exosomes treatment, whereas expression levels of antiapoptotic (B-cell lymphoma 2) and anti-inflammatory (IL-10) proteins were upregulated. Further, administration of MSCs-exosomes significantly promoted angiogenesis. These results show, for the first time, that systemic administration of MSCs-exosomes attenuated cell apoptosis and inflammation, promoted angiogenesis, and promoted functional recovery post-SCI, suggesting that MSCs-exosomes hold promise as a novel therapeutic strategy for treating SCI.
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Cites
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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis
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Cited by
Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05034-x · Cited by 640
Li, L., Zhang, Y., Mu, J., Chen, J., Zhang, C., Cao, H., & Gao, J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c00929 · Cited by 404
Liu, W., Wang, Y., Gong, F., Rong, Y., Luo, Y., Tang, P., Zhou, Z., Zhou, Z., Xu, T., Jiang, T., et al. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.5835 · Cited by 325
Liu, W.-Z., Ma, Z.-J., Li, J.-R., & Kang, X.-W. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02153-8 · Cited by 252
Kim, H. Y., Kumar, H., Jo, M.-J., Kim, J., Yoon, J.-K., Lee, J.-R., Kang, M., Choo, Y. W., Song, S. Y., Kwon, S. P., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b01816 · Cited by 190
Metadata
- Authors
- Huang, J.-H., Yin, X.-M., Xu, Y., Xu, C.-C., Lin, X., Ye, F.-B., Cao, Y., & Lin, F.-Y.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2017-12-15
- Volume
- 34
- Issue
- 24
- Pages
- 3388-3396
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W2732993379
- Cited by
- 292
- References
- 43
- FWCI
- 16.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, J.-H., Yin, X.-M., Xu, Y., Xu, C.-C., Lin, X., Ye, F.-B., Cao, Y., & Lin, F.-Y. (2017). Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats. Journal of Neurotrauma. https://doi.org/10.1089/neu.2017.5063
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