The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation
Open accessAbstract
There is emerging interest in stem cell energy metabolism and its effect on differentiation. Bioenergetic changes in differentiating bone marrow mesenchymal stem cells (MSCs) are poorly understood and were the focus of our study. Using bioenergetic profiling and transcriptomics, we have established that MSCs activate the mitochondrial process of oxidative phosphorylation (OxPhos) during osteogenic differentiation, but they maintain levels of glycolysis similar to undifferentiated cells. Consistent with their glycolytic phenotype, undifferentiated MSCs have high levels of hypoxia-inducible factor 1 (HIF-1). Osteogenically induced MSCs downregulate HIF-1 and this downregulation is required for activation of OxPhos. In summary, our work provides important insights on MSC bioenergetics and proposes a HIF-based mechanism of regulation of mitochondrial OxPhos in MSCs.
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Cites
Hypoxia-inducible factors in physiology and medicine
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Assessing mitochondrial dysfunction in cells
Brand, M. D., & Nicholls, D. G. (2011) · Biochemical Journal · doi:10.1042/bj20110162 · Cited by 2,405
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267
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Hypoxia requires Notch signaling to maintain the undifferentiated cell state
Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., & Bondesson, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.010 · Cited by 1,109
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Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts
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Cited by
The role of osteoblasts in energy homeostasis
Dirckx, N., Moorer, M. C., Clemens, T. L., & Riddle, R. C. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0246-y · Cited by 292
Yan, W., Diao, S., & Fan, Z. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02194-z · Cited by 167
Metadata
- Authors
- Shum, L. C., White, N. S., Mills, B. N., de Mesy Bentley, K. L., & Eliseev, R. A.
- Venue
- Stem Cells and Development
- Publisher
- SAGE Publications
- Published
- 2016-01-15
- Volume
- 25
- Issue
- 2
- Pages
- 114-122
- ISSN
- 1525-8165 (ISSN-L)
- 1547-3287
- 1557-8534
- OpenAlex
- W1766726626
- Cited by
- 281
- References
- 23
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Shum, L. C., White, N. S., Mills, B. N., de Mesy Bentley, K. L., & Eliseev, R. A. (2016). Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation. Stem Cells and Development. https://doi.org/10.1089/scd.2015.0193
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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