The DOI matches its Crossref record.
Engineering Bone Regeneration with Bioabsorbable Scaffolds with Novel Microarchitecture
Abstract
Critical-sized defects (CSDs) were introduced into rat calvaria to test the hypothesis that absorption of surrounding blood, marrow, and fluid from the osseous wound into a bioabsorbable polymer matrix with unique microarchitecture can induce bone formation via hematoma stabilization. Scaffolds with 90% porosity, specific surface areas of approximately 10 m2/g, and median pore sizes of 16 and 32 microm, respectively, were fabricated using an emulsion freeze-drying process. Contact radiography and radiomorphometry revealed the size of the initial defects (50 mm2) were reduced to 27 +/- 11 mm2 and 34 +/- 17 mm2 for CSDs treated with poly(D,L-lactide-co-glycolide). Histology and histomorphometry revealed scaffolds filled with significantly more de novo bone than negative controls (p < 0. 007), more osteoid than both the negative and autograft controls (p < 0.002), and small masses of mineralized tissue (< 15 mm in diameter) observed within the scaffolds. Based on these findings, we propose a change in the current paradigm regarding the microarchitecture of scaffolds for in vivo bone regeneration to include mechanisms based on hematoma stabilization.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The design of scaffolds for use in tissue engineering. Part I. Traditional factors
Yang, S., Leong, K.-F., Du, Z., & Chua, C.-K. (2001) · Tissue Engineering · doi:10.1089/107632701753337645 · Cited by 2,234
Polymeric Scaffolds in Tissue Engineering Application: A Review
Dhandayuthapani, B., Yoshida, Y., Maekawa, T., & Kumar, D. S. (2011) · International Journal of Polymer Science · doi:10.1155/2011/290602 · Cited by 1,773
Scaffolds based bone tissue engineering: the role of chitosan
Costa-Pinto, A. R., Reis, R. L., & Neves, N. M. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2010.0704 · Cited by 355
Choi, J.-W., Wicker, R., Lee, S.-H., Choi, K.-H., Ha, C.-S., & Chung, I. (2009) · Journal of Materials Processing Technology · doi:10.1016/j.jmatprotec.2009.05.004 · Cited by 200
Ji, C., Khademhosseini, A., & Dehghani, F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.003 · Cited by 180
Xia, Z., Yu, X., Jiang, X., Brody, H. D., Rowe, D. W., & Wei, M. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.03.038 · Cited by 178
Burdick, J. A., Frankel, D., Dernell, W. S., & Anseth, K. S. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00538-0 · Cited by 102
PCL‐PEG‐PCL film promotes cartilage regeneration in vivo
Fu, N., Liao, J., Lin, S., Sun, K., Tian, T., Zhu, B., & Lin, Y. (2016) · Cell Proliferation · doi:10.1111/cpr.12295 · Cited by 65
Perpelek, M., Tamburaci, S., Aydemir, S., Tihminlioglu, F., Baykara, B., Karakasli, A., & Havitcioglu, H. (2021) · Biomedical Materials · doi:10.1088/1748-605x/ac2352 · Cited by 27
Metadata
- Authors
- Whang, K., Healy, K. E., Elenz, D. R., Nam, E. K., Tsai, D. C., Thomas, C. H., Nuber, G. W., Glorieux, F. H., Travers, R., & Sprague, S. M.
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 1999-02
- Volume
- 5
- Issue
- 1
- Pages
- 35-51
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W2018595771
- Cited by
- 405
- References
- 0
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
