Cited by 70Thyroid Disorders and TreatmentsNeutrophil, Myeloperoxidase and Oxidative MechanismsAdrenal Hormones and Disorders

Type 3 Deiodinase Is Highly Expressed in Infiltrating Neutrophilic Granulocytes in Response to Acute Bacterial Infection

Boelen, Anita, Boorsma, Jeffrey, Kwakkel, Joan, Wieland, Catharina W., Renckens, Rosemarijn, Visser, Theo J., Fliers, Eric, Wiersinga, Wilmar M.·2008·Thyroid

Abstract

BACKGROUND: Macrophages and polymorphonuclear cells (PMNs) play an important role in the first line of defense against bacteria by infiltrating the infected organ in order to clear the harmful pathogen. Our earlier studies showed that granulocytes express type 3 deiodinase (D3) when activated during a turpentine-induced abscess. We hypothesized that D3 expression by granulocytes may also occur during bacterial infection. METHODS: In order to test this hypothesis, we used the following experimental infection models: peritonitis induced by Escherichia coli and acute pneumonia induced by Streptococcus pneumoniae. RESULTS: E. coli-induced peritonitis was characterized by infiltration in the liver by inflammatory cells with abundant immunocytochemical D3 expression while no staining was present in hepatocytes of infected or control mice. Acute pneumonia induced by S. pneumoniae resulted in inflamed lungs characterized by numerous infiltrating granulocytes expressing D3 while no D3 staining was present in lung sections without an infiltrate. Serum thyroid hormones were negatively correlated to bacterial outgrowth in both lung and spleen, and thus to the severity of illness. CONCLUSION: Infiltrating granulocytes during acute bacterial infection express D3. Our work supports the hypothesis that D3 plays an important role during chemical and bacterial inflammation. Whether the resulting decreased local bioavailability of thyroid hormones or rather the increased local availability of iodide is an important element of the innate immune response remains to be studied.

Integrity signals

Registry

Crossref · 10.1089/thy.2008.0090

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • DIO3 protein is highly expressed in infiltrating murine neutrophils during both bacterial infection and sterile inflammation.

    “DIO3 protein is highly expressed in infiltrating murine neutrophils during both bacterial infection and sterile inflammation [32, 33].”

    From An update on non-thyroidal illness syndrome (2021) · cites this paper as [33]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Boelen, A., Boorsma, J., Kwakkel, J., Wieland, C. W., Renckens, R., Visser, T. J., Fliers, E., & Wiersinga, W. M.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Erasmus MC (NL)
Venue
Thyroid
Published
2008-10
Volume
18
Issue
10
Pages
1095-1103
ISSN
  • 1050-7256 (ISSN-L)
  • 1557-9077
OpenAlex
W2030186159
Cited by
70
References
32
Citations by year
2026: 2 · 2025: 6 · 2023: 2 · 2022: 9 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 2
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Locations
  • Thyroid (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
type 3 deiodinase, neutrophils, acute bacterial infection, Escherichia coli peritonitis, pneumococcal pneumonia, inflammatory cell infiltration, iodide, innate immunity, liver inflammation, serum thyroid hormones
MeSH terms
Acute Disease, Animals, Escherichia coli Infections, Female, Iodide Peroxidase, Liver, Mice, Inbred C57BL, Neutrophils, Peritonitis, Pneumonia, Pneumococcal, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review