Neutrophils and Wound Repair: Positive Actions and Negative Reactions

Of Mice and Not Men: Differences between Mouse and Human Immunology

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Neutrophils: Molecules, Functions and Pathophysiological Aspects

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Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9

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Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice

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Accelerated wound closure in neutrophil-depleted mice

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Development of a novel keratin dressing which accelerates full-thickness skin wound healing in diabetic mice: In vitro and in vivo studies

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Bioactive hemostatic materials: a new strategy for promoting wound healing and tissue regeneration

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Healing Properties of Epidermal Growth Factor and Tocotrienol-Rich Fraction in Deep Partial-Thickness Experimental Burn Wounds

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Proteomic characterization of platelet gel releasate from adult peripheral and cord blood

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HMGB1‐induced inflammatory response promotes bone healing in murine tooth extraction socket

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Promotion of chronic wound healing by plant-derived active ingredients and research progress and potential of plant polysaccharide hydrogels

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Immune suppressive activities of low-density neutrophils in sepsis and potential use as a novel biomarker of sepsis-induced immune suppression

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Neutrophils remain detrimentally active in hydroxyurea-treated patients with sickle cell disease

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Development and Characterization of Biointeractive Gelatin Wound Dressing Based on Extract of Punica granatum Linn

do Nascimento, M. F., Cardoso, J. C., Santos, T. S., Tavares, L. A. D. M., Pashirova, T. N., Severino, P. B., Souto, E. B., & Júnior, R. L. C. D. A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121204 · Cited by 26

Wound healing activity of the hydroethanolic extract of the leaves of Maytenus ilicifolia Mart. Ex Reis

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Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders

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Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing

Jung, S. H., Jang, B. H., Kwon, S., Park, S. J., Park, T., & Kang, J. H. (2023) · Advanced Materials · doi:10.1002/adma.202211149 · Cited by 27

A novel diabetic foot ulcer diagnostic model: identification and analysis of genes related to glutamine metabolism and immune infiltration

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Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases

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Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair

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Inflammatory Responses during Tumour Initiation: From Zebrafish Transgenic Models of Cancer to Evidence from Mouse and Man

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Skin wound closure delay in metabolic syndrome correlates with SCF deficiency in keratinocytes

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Myeloid cell diversification during regenerative inflammation: Lessons from skeletal muscle

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Recent Developments in Extracellular Matrix Remodeling for Fat Grafting

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The remarkable effect of menstrual blood stem cells seeded on bilayer scaffold composed of amniotic membrane and silk fibroin aiming to promote wound healing in diabetic mice

Mirzadegan, E., Golshahi, H., Saffarian, Z., Darzi, M., Khorasani, S., Edalatkhah, H., Saliminejad, K., & Kazemnejad, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108404 · Cited by 25

Distinct Roles for Dectin-1 and Dectin-2 in Skin Wound Healing and Neutrophilic Inflammatory Responses

Yamaguchi, K., Kanno, E., Tanno, H., Sasaki, A., Kitai, Y., Miura, T., Takagi, N., Shoji, M., Kasamatsu, J., Sato, K., et al. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.04.030 · Cited by 25

Modulation of Macrophage Function by Bioactive Wound Dressings with an Emphasis on Extracellular Matrix-Based Scaffolds and Nanofibrous Composites

He, T., Xiao, Y., Guo, Z., Shi, Y., Tan, Q., Huang, Y., & Xie, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030794 · Cited by 27

Citrullination regulates wound responses and tissue regeneration in zebrafish

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Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage

Houseright, R. A., Rosowski, E. E., Lam, P., Tauzin, S., Mulvaney, O., Dewey, C. N., Bennin, D., & Anna Huttenlocher, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-72750-9 · Cited by 24

Pirfenidone regulates LPS mediated activation of neutrophils

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Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing

Liu, Y., Xiang, C., Que, Z., Li, C., Wang, W., Yin, L., Chu, C., & Zhou, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1201651 · Cited by 26

The characterization of a full-thickness excision open foot wound model in n5-streptozotocin (STZ)-induced type 2 diabetic rats that mimics diabetic foot ulcer in terms of reduced blood circulation, higher C-reactive protein, elevated inflammation, and reduced cell proliferation

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Learning from Mother Nature: Innovative Tools to Boost Endogenous Repair of Critical or Difficult-to-Heal Large Tissue Defects

Cancedda, R., Bollini, S., Descalzi, F., Mastrogiacomo, M., & Tasso, R. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00028 · Cited by 26

Centrifugation Conditions in the L-PRP Preparation Affect Soluble Factors Release and Mesenchymal Stem Cell Proliferation in Fibrin Nanofibers

de Melo, B. A. G., Luzo, Â. C. M., Lana, J. F., & Santana, M. H. A. (2019) · Molecules · doi:10.3390/molecules24152729 · Cited by 24

YAP/TAZ, beta-catenin, and TGFb pathway activation in medical plasma-induced wound healing in diabetic mice

Schmidt, A., von Woedtke, T., Weltmann, K., & Bekeschus, S. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.07.004 · Cited by 23

The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging

Su, Z. G., Hu, Q., Li, X., Wang, Z., & Xie, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010926 · Cited by 26

Neutrophil Migration is a Crucial Factor in Wound Healing and the Pathogenesis of Diabetic Foot Ulcers: Insights into Pharmacological Interventions

Asunama, A. S. R., Nambi, N., Radhakrishnan, L., Prasad, M. K., & Ramkumar, K. M. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611308960241014155413 · Cited by 25

More Than Just a Bandage: Closing the Gap Between Injury and Appendage Regeneration

Kakebeen, A. D., & Wills, A. E. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00081 · Cited by 24

Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies

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Modulation of the Immune System Promotes Tissue Regeneration

Masoomikarimi, M., & Salehi, M. (2022) · Molecular Biotechnology · doi:10.1007/s12033-021-00430-8 · Cited by 28

Early inflammatory players in cutaneous fibrosis

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The Immunomodulatory Effect of IrSPI, a Tick Salivary Gland Serine Protease Inhibitor Involved in Ixodes ricinus Tick Feeding

Blisnick, A., Šimo, L., Grillon, C., Fasani, F., Brûlé, S., Bonniec, B. L., Prina, E., Marsot, M., Relmy, A., Blaise‐Boisseau, S., et al. (2019) · Vaccines · doi:10.3390/vaccines7040148 · Cited by 23

Silk fibroin nanofibrous mats for visible sensing of oxidative stress in cutaneous wounds

Singh, S. K., Cortes, G., Kumar, U., Sakthivel, T. S., Niemiec, S. M., Louiselle, A. E., Azeltine, M., Zgheib, C., Liechty, K. W., & Seal, S. (2020) · Biomaterials Science · doi:10.1039/d0bm01325k · Cited by 23

Fluorinated methacrylamide chitosan sequesters reactive oxygen species to relieve oxidative stress while delivering oxygen

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Inflammation-Responsive Hydrogels in Perioperative Pain and Wound Management: Design Strategies and Emerging Potential

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Sambucus nigra L. leaves inhibit TNF-α secretion by LPS-stimulated human neutrophils and strongly scavenge reactive oxygen species

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Calreticulin: a multifunctional protein with potential therapeutic applications for chronic wounds

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Microdialysis Sampling from Wound Fluids Enables Quantitative Assessment of Cytokines, Proteins, and Metabolites Reveals Bone Defect-Specific Molecular Profiles

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The impact of biologics in surgical outcomes in ulcerative colitis

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Chemokines and Bone

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Biological solutions activated by cold plasma at atmospheric pressure: A new therapeutic approach for skin wound healing

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Nanoparticle-based approaches for wound healing: a comprehensive review of nanomaterials enhancing tissue regeneration

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Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress Response

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Are TRPA1 and TRPV1 channel-mediated signalling cascades involved in UVB radiation-induced sunburn?

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Immunity‐on‐a‐Chip: Integration of Immune Components into the Scheme of Organ‐on‐a‐Chip Systems

Ramadan, Q., Hazaymeh, R., & Zourob, M. M. (2023) · Advanced Biology · doi:10.1002/adbi.202200312 · Cited by 21

Functional characterization of the dimeric form of PDGF-derived fusion peptide fabricated based on theoretical arguments

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Bacterial Species Involved in Venous Leg Ulcer Infections and Their Sensitivity to Antibiotherapy—An Alarm Signal Regarding the Seriousness of Chronic Venous Insufficiency C6 Stage and Its Need for Prompt Treatment

Matei, S.-C., Dumitru, C. Ș., FAKHRY, A. M., Ilijevski, N. S., Pešić, S., Petrović, J., Crăiniceanu, Z. P., Murariu, M.-S., & Olariu, S. (2024) · Microorganisms · doi:10.3390/microorganisms12030472 · Cited by 21

Non-invasive tracking of injected bone marrow mononuclear cells to injury and implanted biomaterials

Tan, R. P., Lee, B. S. L., Chan, A., Yuen, S. C. G., Hung, J., Wise, S. G., & Ng, M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.02.002 · Cited by 21

Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells

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The Wound Healing Property of N -Methyl-(2 S ,4 R )- trans -4-Hydroxy-L-Proline from Sideroxylon obtusifolium is Related to its Anti-Inflammatory and Antioxidant Actions

de Aquino, P. É. A., de Souza, T. D. F. G., Santos, F. A., Viana, A. F. S. C., Louchard, B. O., Leal, L. K. A. M., Rocha, T. M., Evangelista, J. S. A. M., de Aquino, N. C., de Alencar, N. M. N., et al. (2019) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x19865166 · Cited by 21

Hypochlorous acid-generating electrochemical scaffold eliminates Candida albicans biofilms

Zmuda, H. M., Mohamed, A. H., Raval, Y. S., Call, D. R., Schuetz, A. N., Patel, R., & Beyenal, H. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14656 · Cited by 20

The Effect of Inflammation on the Healing Process of Acute Skin Wounds Under the Treatment of Wounds with Injections in Rats

Stupin, V. A., Manturova, N. E., Silina, E. V., Litvitskiy, P., Vi, V., Artyushkova, E. B., Иванов, А. В., Гладченко, М. П., & Aliev, S. R. (2020) · Journal of Experimental Pharmacology · doi:10.2147/jep.s275791 · Cited by 26

Bio-inspired biomaterial coating for enzyme responsive release of antimicrobial peptides

Böhner, D. A., Mörl, K., & Beck‐Sickinger, A. G. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101958 · Cited by 23

Appreciating the First Line of the Human Innate Immune Defense: A Strategy to Model and Alleviate the Neutrophil Elastase‐Mediated Attack toward Bioactivated Biomaterials

Blum, C., Taskin, M. B., Shan, J., Schilling, T., Schlegelmilch, K., Teßmar, J., & Gröll, J. (2021) · Small · doi:10.1002/smll.202007551 · Cited by 20

Wound-Healing Promotion and Anti-Inflammatory Properties of Carvacrol Prodrugs/Hyaluronic Acid Formulations

Marinelli, L., Cacciatore, I., Costantini, E., Dimmito, M. P., Serra, F., Stefano, A. D., & Reale, M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071468 · Cited by 20

Layered Black Phosphorus Nanoflakes Reduce Bacterial Burden and Enhance Healing of Murine Infected Wounds

Virgo, E. P., Haidari, H., Shaw, Z. L., Huang, L. Z. Y., Kennewell, T. L., Smith, L., Ahmed, T., Bryant, S. J., Howarth, G. S., Walia, S., et al. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300235 · Cited by 20

The role of cathelicidins in neutrophil biology

Yoon, G., Puentes, R., Tran, J., Multani, A., & Cobo, E. R. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae112 · Cited by 22

Cutaneous Wounds in Mice Lacking TSG-6 Exhibit Delayed Closure and an Abnormal Inflammatory Response

Shakya, S., Mack, J. A., Alipour, M., & Maytin, E. V. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.04.015 · Cited by 20

Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion via Mechanisms Similar and Distinct From CTLA-4 and PD-1

Mathew, D., & Torres, R. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.531910 · Cited by 22

Effect of laser therapy on immune cells infiltrate after excisional wounds in diabetic rats

Santana, C. D. L., Silva, D. D. F. T., de Souza, A. S., Jacinto, M. V. G., Bussadori, S., Mesquita-Ferrari, R., Fernandes, K., & França, C. (2016) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22445 · Cited by 16

Efficient and specific Ly6G + cell depletion: A change in the current practices toward more relevant functional analyses of neutrophilsPreprint

Faget, J., Boivin, G., Ancey, P., Gkasti, A., Mussard, J., Engblom, C., Pfirschke, C., Vázquez, J., Bendriss‐Vermare, N., Caux, C., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/498881 · Cited by 20

Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic WoundsPreprint

Bray, E. R., Kirsner, R. S., & Badiavas, E. V. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041227 · Cited by 23

Anti-Inflammatory and Wound Healing Properties of Different Honey Varieties from Romania and Correlations to Their Composition

Iosăgeanu, A., Ștefan, L. M., Crăciunescu, O., & Cîmpean, A. (2024) · Life · doi:10.3390/life14091187 · Cited by 23

Potassium-Doped MnO 2 Nanoparticles Reprogram Neutrophil Calcium Signaling to Accelerate Healing of Methicillin-Resistant Staphylococcus aureus -Infected Diabetic Wounds

Wei, J., Zhang, X., Sui, B., Ding, X., Li, Y., Liu, B., Wang, J., Lv, X., Zhang, Y., Jiang, X., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c14057 · Cited by 22

Decoding wound healing: cellular insights and technological advances

Berthiaume, K. A., Galvin, E. R., Kness-Knezinskis, E., Hostler, A. C., Chen, K., & Gurtner, G. C. (2026) · npj Biomedical Innovations. · doi:10.1038/s44385-025-00046-6 · Cited by 19

Immune Cell Therapies to Improve Regeneration and Revascularization of Non-Healing Wounds

Groppa, E., Colliva, A., Vuerich, R., Kocijan, T., & Zacchigna, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155235 · Cited by 20

Skewing cPLA 2 α activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis

Maus, K. D., Stephenson, D., MacKnight, H. P., Vu, N., Hoeferlin, L. A., Kim, M., Diegelmann, R. F., Xie, X., & Chalfant, C. E. (2023) · Science Signaling · doi:10.1126/scisignal.add6527 · Cited by 19

Modulation of the Osteoimmune Environment in the Development of Biomaterials for Osteogenesis

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Leading edge: emerging drug, cell, and gene therapies for junctional epidermolysis bullosa

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Manuka honey modulates the release profile of a dHL-60 neutrophil model under anti-inflammatory stimulation

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