The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Epithelialization in Wound Healing: A Comprehensive Review
Open accessAbstract
Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization. This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing. Recent Advances: Discoveries in epidermal stem cells, keratinocyte immune function, and the role of the epidermis as an independent neuroendocrine organ will be reviewed. Novel mechanisms of gene expression regulation important for re-epithelialization, including microRNAs and histone modifications, will also be discussed. Critical Issues: Epithelialization is an essential component of wound healing used as a defining parameter of a successful wound closure. A wound cannot be considered healed in the absence of re-epithelialization. The epithelialization process is impaired in all types of chronic wounds. Future Directions: A comprehensive understanding of the epithelialization process will ultimately lead to the development of novel therapeutic approaches to promote wound closure.
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Cites
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429
The pig as a model for human wound healing
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Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966
A single type of progenitor cell maintains normal epidermis
Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H. (2007) · Nature · doi:10.1038/nature05574 · Cited by 853
A skin microRNA promotes differentiation by repressing ‘stemness’
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Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury
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Neuroendocrinology of the Skin1
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The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
Cabral-Pacheco, G. A., Garza-Veloz, I., Castruita-De la Rosa, C., Ramirez-Acuña, J. M., Perez-Romero, B. A., Guerrero-Rodriguez, J. F., Martinez-Avila, N., & Martinez-Fierro, M. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249739 · Cited by 1,820
The Role of MSC in Wound Healing, Scarring and Regeneration
Guillamat-Prats, R. (2021) · Cells · doi:10.3390/cells10071729 · Cited by 393
A review on nanoparticle based treatment for wound healing
Rajendran, N. K., Kumar, S. S. D., Houreld, N. N., & Abrahamse, H. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.01.009 · Cited by 389
Pranantyo, D., Yeo, C. K., Wu, Y., Fan, C., Xu, X., Yip, Y. S., Vos, M. I. G., Mahadevegowda, S. H., Lim, P. L. K., Yang, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44968-y · Cited by 380
Chronic wounds: Current status, available strategies and emerging therapeutic solutions
Las Heras, K., Igartua, M., Santos-Vizcaino, E., & Hernandez, R. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.039 · Cited by 370
Metadata
- Authors
- Pastar, I., Stojadinovic, O., Yin, N. C., Ramirez, H., Nusbaum, A. G., Sawaya, A., Patel, S. B., Khalid, L., Isseroff, R. R., & Tomic-Canic, M.
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2014-07
- Volume
- 3
- Issue
- 7
- Pages
- 445-464
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- OpenAlex
- W2045232408
- Cited by
- 1,531
- References
- 34
- FWCI
- 40.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Pastar, I., Stojadinovic, O., Yin, N. C., Ramirez, H., Nusbaum, A. G., Sawaya, A., Patel, S. B., Khalid, L., Isseroff, R. R., & Tomic-Canic, M. (2014). Epithelialization in Wound Healing: A Comprehensive Review. Advances in Wound Care. https://doi.org/10.1089/wound.2013.0473
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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