Cited by 365Microtubule and mitosis dynamicsHereditary Neurological DisordersCellular transport and secretion

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Cytoplasmic Dynein, the Dynactin Complex, and Kinesin Are Interdependent and Essential for Fast Axonal Transport

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Martin, MaryAnn, Iyadurai, Stanley J., Gassman, Andrew, Gindhart, Joseph G., Hays, Thomas S., Saxton, William M.·1999·Molecular Biology of the Cell

DOI 10.1091/mbc.10.11.3717PMC PMC25669

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Abstract

In axons, organelles move away from (anterograde) and toward (retrograde) the cell body along microtubules. Previous studies have provided compelling evidence that conventional kinesin is a major motor for anterograde fast axonal transport. It is reasonable to expect that cytoplasmic dynein is a fast retrograde motor, but relatively few tests of dynein function have been reported with neurons of intact organisms. In extruded axoplasm, antibody disruption of kinesin or the dynactin complex (a dynein activator) inhibits both retrograde and anterograde transport. We have tested the functions of the cytoplasmic dynein heavy chain (cDhc64C) and the p150(Glued) (Glued) component of the dynactin complex with the use of genetic techniques in Drosophila. cDhc64C and Glued mutations disrupt fast organelle transport in both directions. The mutant phenotypes, larval posterior paralysis and axonal swellings filled with retrograde and anterograde cargoes, were similar to those caused by kinesin mutations. Why do specific disruptions of unidirectional motor systems cause bidirectional defects? Direct protein interactions of kinesin with dynein heavy chain and p150(Glued) were not detected. However, strong dominant genetic interactions between kinesin, dynein, and dynactin complex mutations in axonal transport were observed. The genetic interactions between kinesin and either Glued or cDhc64C mutations were stronger than those between Glued and cDhc64C mutations themselves. The shared bidirectional disruption phenotypes and the dominant genetic interactions demonstrate that cytoplasmic dynein, the dynactin complex, and conventional kinesin are interdependent in fast axonal transport.

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Authors: Martin, M., Iyadurai, S. J., Gassman, A., Gindhart, J. G., Hays, T. S., & Saxton, W. M.
Affiliations: Indiana University Bloomington (US)
University of Minnesota (US)
University of Massachusetts Boston (US)
ORCID: Iyadurai, Stanley J.
Gassman, Andrew
Hays, Thomas S.
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 1999-11
Volume: 10
Issue: 11
Pages: 3717-3728
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.10.11.3717
PMC: PMC25669
OpenAlex: W2144151547
Cited by: 365
References: 58
Citations by year: 2026: 3 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 5 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 21 · 2016: 9 · 2015: 11 · 2014: 14 · 2013: 14 · 2012: 26
FWCI: 3.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Biology of the Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
American Heart Association
National Institutes of Health
National Institute of General Medical Sciences (GM-44757, R01GM044757, R56GM044757, R01GM046295, GM-46295)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: cytoplasmic dynein, dynactin, kinesin, fast axonal transport, anterograde transport, retrograde transport, microtubule motor proteins, dynein heavy chain, p150Glued, axonal swellings, Drosophila neurons
MeSH terms: Dynactin Complex, Animals, Axons, Cytoplasm, Drosophila, Dyneins, Microscopy, Electron, Microtubule-Associated Proteins, Mutation, Phenotype, Precipitin Tests, Kinesins, Microscopy, Confocal, Microscopy, Video

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Cytoplasmic Dynein, the Dynactin Complex, and Kinesin Are Interdependent and Essential for Fast Axonal Transport

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