Nuclear Mechanotransduction in Skeletal Muscle

Jabre, Saline; Hleihel, Walid; Coirault, Catherine

doi:10.3390/cells10020318

Cited by 31Muscle Physiology and DisordersNuclear Structure and FunctionCellular Mechanics and Interactions

Nuclear Mechanotransduction in Skeletal Muscle

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Jabre, Saline, Hleihel, Walid, Coirault, Catherine·2021·Cells

DOI 10.3390/cells10020318PMC PMC7913907

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Abstract

Skeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that are maintained in a quiescent state in homeostatic conditions. Skeletal muscle is remarkable in its ability to adapt to mechanical constraints, a property referred as muscle plasticity and mediated by both MCPs and myofibers. An emerging body of literature supports the notion that muscle plasticity is critically dependent upon nuclear mechanotransduction, which is transduction of exterior physical forces into the nucleus to generate a biological response. Mechanical loading induces nuclear deformation, changes in the nuclear lamina organization, chromatin condensation state, and cell signaling, which ultimately impacts myogenic cell fate decisions. This review summarizes contemporary insights into the mechanisms underlying nuclear force transmission in MCPs and myofibers. We discuss how the cytoskeleton and nuclear reorganizations during myogenic differentiation may affect force transmission and nuclear mechanotransduction. We also discuss how to apply these findings in the context of muscular disorders. Finally, we highlight current gaps in knowledge and opportunities for further research in the field.

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In aged muscle, cytoskeletal stiffness and nuclear lamina disorganization severely impair physical signal transmission.
“In aged muscle, cytoskeletal stiffness and nuclear lamina disorganization severely impair physical signal transmission [107,108].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [107]
The Introduction (page unavailable) says defective cytoskeletal and nuclear architectures are likely to affect the nuclear response, and Section 2 describes the cytoskeleton’s role in transmitting forces to the nucleus. The paper does not establish that cytoskeletal stiffness and nuclear lamina disorganization severely impair signal transmission specifically in aged muscle; its relevant discussion concerns muscle differentiation and disease. (LLM, conf=0.83)
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Authors: Jabre, S., Hleihel, W., & Coirault, C.
Affiliations: Inserm (FR)
Holy Spirit University of Kaslik (LB)
Corresponding author: Coirault, Catherine
ORCID: Jabre, Saline
Hleihel, Walid
Coirault, Catherine
Venue: Cells
Publisher: MDPI AG
Published: 2021-02-04
Volume: 10
Issue: 2
Pages: 318
ISSN: 2073-4409 (ISSN-L)
DOI: 10.3390/cells10020318
PMC: PMC7913907
OpenAlex: W3127378855
Semantic Scholar: e9a16a8f24512c5a0e333a5c77cc7fe12b6c1d3e
Cited by: 31
References: 212
Citations by year: 2026: 6 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 1
FWCI: 0.55
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cells (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords: nuclear mechanotransduction, skeletal muscle, muscle plasticity, muscle fibers, nuclear lamina, chromatin condensation, cytoskeleton, myogenesis, mechanical loading, nuclear deformation, muscle disorders
MeSH terms: Biomechanical Phenomena, Cell Nucleus, Chromatin, Cytoskeleton, Humans, Muscle, Skeletal, Mechanotransduction, Cellular

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Nuclear Mechanotransduction in Skeletal Muscle

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