Cited by 90Neurogenesis and neuroplasticity mechanismsNuclear Structure and FunctionNeuroscience and Neuropharmacology Research

Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity

Open access
bin Imtiaz, Muhammad Khadeesh, Jaeger, Baptiste N., Bottes, Sara, Machado, Raquel A.C., Vidmar, Mojca, Moore, Darcie L., Jessberger, Sebastian·2021·Cell Stem Cell

Abstract

Neural stem cells (NSCs) generate neurons throughout life in the hippocampal dentate gyrus. With advancing age, levels of neurogenesis sharply drop, which has been associated with a decline in hippocampal memory function. However, cell-intrinsic mechanisms mediating age-related changes in NSC activity remain largely unknown. Here, we show that the nuclear lamina protein lamin B1 (LB1) is downregulated with age in mouse hippocampal NSCs, whereas protein levels of SUN-domain containing protein 1 (SUN1), previously implicated in Hutchinson-Gilford progeria syndrome (HGPS), increase. Balancing the levels of LB1 and SUN1 in aged NSCs restores the strength of the endoplasmic reticulum diffusion barrier that is associated with segregation of aging factors in proliferating NSCs. Virus-based restoration of LB1 expression in aged NSCs enhances stem cell activity in vitro and increases progenitor cell proliferation and neurogenesis in vivo. Thus, we here identify a mechanism that mediates age-related decline of neurogenesis in the mammalian hippocampus.

Integrity signals

Registry

Crossref · 10.1016/j.stem.2021.01.015

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Expression of lamin B1 declines in old NSCs, and restoration of lamin B1 expression is sufficient to increase old NSC proliferation and neurogenesis.

    “Finally, expression of lamin B1, a key component of the nuclear architecture involved in epigenomic maintenance103, declines in old NSCs, and restoration of lamin B1 expression is sufficient to increase old NSC proliferation and neurogenesis104.”

    From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [104]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
bin Imtiaz, M. K., Jaeger, B. N., Bottes, S., Machado, R. A. C., Vidmar, M., Moore, D. L., & Jessberger, S.
Affiliations
  • University of Zurich (CH)
  • University of Wisconsin–Madison (US)
Corresponding author
  • Moore, Darcie L.
  • Jessberger, Sebastian
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2021-05
Volume
28
Issue
5
Pages
967-977.e8
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W3132495570
Cited by
83
References
60
Citations by year
2026: 13 · 2025: 18 · 2024: 20 · 2023: 14 · 2022: 13 · 2021: 5
FWCI
5.33
Type
journal article
Language
en
Open access
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Foundation for the National Institutes of Health
  • European Research Council
  • Helmut Horten Stiftung
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
lamin B1, SUN1, nuclear lamina, neural stem cells, hippocampal neurogenesis, aging, Hutchinson-Gilford progeria syndrome, stem cell proliferation
MeSH terms
Aging, Animals, Hippocampus, Progeria, Lamin Type B, Mice, Neurogenesis, Neural Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review