The DOI matches its Crossref record; 243 of the 244 references it cites were found in a registry or an index.
Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary plaque deposits. AD shows oxidative stress and chronic inflammation. In AD, canonical Wingless-Int (Wnt)/β-catenin pathway is downregulated, whereas peroxisome proliferator-activated receptor γ (PPARγ) is increased. Downregulation of Wnt/β-catenin, through activation of glycogen synthase kinase-3β (GSK-3β) by Aβ, and inactivation of phosphatidylinositol 3-kinase/Akt signaling involve oxidative stress in AD. Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid from Cannabis sativa plant. In PC12 cells, Aβ-induced tau protein hyperphosphorylation is inhibited by CBD. This inhibition is associated with a downregulation of p-GSK-3β, an inhibitor of Wnt pathway. CBD may also increase Wnt/β-catenin by stimulation of PPARγ, inhibition of Aβ and ubiquitination of amyloid precursor protein. CBD attenuates oxidative stress and diminishes mitochondrial dysfunction and reactive oxygen species generation. CBD suppresses, through activation of PPARγ, pro-inflammatory signaling and may be a potential new candidate for AD therapy.
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“In PC12 neuronal cells, CBD has shown protection against oxidative stress, Aβ-induced neurotoxicity, inhibition of tau hyperphosphorylation, prevention of proinflammatory gene transcription, and inhibition of Aβ-induced tau hyperphosphorylation [188,189].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [188]
In the citing paper
“In PC12 neuronal cells, CBD has shown protection against oxidative stress, Aβ-induced neurotoxicity, inhibition of tau hyperphosphorylation, prevention of proinflammatory gene transcription, and inhibition of Aβ-induced tau hyperphosphorylation [188,189].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [188]
In the citing paper
“In PC12 neuronal cells, CBD has shown protection against oxidative stress, Aβ-induced neurotoxicity, inhibition of tau hyperphosphorylation, prevention of proinflammatory gene transcription, and inhibition of Aβ-induced tau hyperphosphorylation [188,189].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [188]
Citations
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Research works printed but not linked: 2
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Cannabidiol Adverse Effects and Toxicity
Huestis, M. A., Solimini, R., Pichini, S., Pacifici, R., Carlier, J., & Busardò, F. P. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190603171901 · Cited by 499
Vallée, A., & Lecarpentier, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00745 · Cited by 380
Self-citationUse of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials
Silvestro, S., Mammana, S., Cavalli, E., Bramanti, P., & Mazzon, E. (2019) · Molecules · doi:10.3390/molecules24081459 · Cited by 249
Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease
Yan, X., Hu, Y., Wang, B., Wang, S., & Zhang, X. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.530219 · Cited by 230
Metadata
- Authors
- Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Acta Biochimica et Biophysica Sinica
- Published
- 2017-10-01
- Volume
- 49
- Issue
- 10
- Pages
- 853-866
- ISSN
- 1672-9145 (ISSN-L)
- OpenAlex
- W2738129635
- Cited by
- 226
- References
- 244
- Citations by year
- 2026: 20 · 2025: 17 · 2024: 26 · 2023: 29 · 2022: 37 · 2021: 37 · 2020: 31 · 2019: 16 · 2018: 9 · 2017: 4
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Biochimica et Biophysica Sinica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- cannabidiol, Alzheimer's disease, Wnt/β-catenin signaling, PPARγ, oxidative stress, neuroinflammation, amyloid-beta, glycogen synthase kinase-3β, tau hyperphosphorylation, phosphatidylinositol 3-kinase/Akt signaling, mitochondrial dysfunction, reactive oxygen species, neuroprotection
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Alzheimer Disease, Animals, Cannabidiol, Inflammation, Models, Biological, Phosphorylation, Amyloid beta-Peptides, PC12 Cells, Neurofibrillary Tangles, tau Proteins, Oxidative Stress, PPAR gamma, Rats, Wnt Signaling Pathway
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