Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583

Wnt/β-catenin signaling and disease

Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554

Oxidative stress, inflammation, and cancer: How are they linked?

Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441

The Global Deterioration Scale for assessment of primary degenerative dementia

Reisberg, ‌., Ferris, S. H., de Leon, M. J., & Crook, T. H. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.9.1136 · Cited by 5,122

Identification of c- MYC as a Target of the APC Pathway

He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580

Signaling to NF-κB by Toll-like receptors

Kawai, T., & Akira, S. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.09.002 · Cited by 2,468

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217

The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 ‐tetrahydrocannabinol, cannabidiol and Δ 9 ‐tetrahydrocannabivarin

Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707442 · Cited by 2,047

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Benilova, I., Karran, E., & De Strooper, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3028 · Cited by 1,962

TLR signaling

Kawai, T., & Akira, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401850 · Cited by 1,894

The PPARs: From Orphan Receptors to Drug Discovery

Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990554g · Cited by 1,816

Biomarkers of Oxidative Damage in Human Disease

Dalle-Donne, I., Rossi, R., Colombo, R., Giustarini, D., & Milzani, A. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.061408 · Cited by 1,703

Secreted antagonists of the Wnt signalling pathway

Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Jagt, D. L. V., Semenza, G. L., & Dang, C. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914433107 · Cited by 1,528

HIF-1: upstream and downstream of cancer metabolism

Semenza, G. L. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.10.009 · Cited by 1,431

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

Hoeflich, K. P., Luo, J., Rubie, E. A., Tsao, M., Jin, O., & Woodgett, J. R. (2000) · Nature · doi:10.1038/35017574 · Cited by 1,401

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., et al. (2001) · Nature · doi:10.1038/35102591 · Cited by 1,388

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

Pascual, G., Fong, A. L., Ogawa, S., Gamliel, A., Li, A. C., Perissi, V., Rose, D. W., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2005) · Nature · doi:10.1038/nature03988 · Cited by 1,287

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Anastasiou, D., Poulogiannis, G., Asara, J. M., Boxer, M. B., Jiang, J., Shen, M., Bellinger, G., Sasaki, A. T., Locasale, J. W., Auld, D. S., et al. (2011) · Science · doi:10.1126/science.1211485 · Cited by 1,218

The GSK3 hypothesis of Alzheimer’s disease

Hooper, C., Killick, R., & Lovestone, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05194.x · Cited by 1,191

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

Lluis Fajas, A., Auboeuf, D., Raspé, E., Schoonjans, K., Lefebvre, A., Saladin, R., Najib, J., Laville, M., Fruchart, J., Deeb, S. S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18779 · Cited by 1,188

Proximal events in Wnt signal transduction

Angers, S., & Moon, R. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2717 · Cited by 1,135

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

Grygiel-Górniak, B. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-17 · Cited by 1,079

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.

Devinsky, O., Cilio, M. R., Cross, H., Fernandez‐Ruiz, J., French, J., Hill, C., Katz, R., Di Marzo, V., Jutras‐Aswad, D., Notcutt, W. G., et al. (2014) · Epilepsia · doi:10.1111/epi.12631 · Cited by 1,000

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

Islam, M. T. (2016) · Neurological Research · doi:10.1080/01616412.2016.1251711 · Cited by 989

Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer’s disease

Reddy, P. H., & Beal, M. F. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.002 · Cited by 975

The Promise and Perils of Wnt Signaling Through β-Catenin

Moon, R. T., Bowerman, B. A., Boutros, M., & Perrimon, N. (2002) · Science · doi:10.1126/science.1071549 · Cited by 970

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Yang, W., Zheng, Y., Xia, Y., Ji, H., Chen, X., Guo, F., Lyssiotis, C. A., Aldape, K., Cantley, L. C., & Lu, Z. (2012) · Nature Cell Biology · doi:10.1038/ncb2629 · Cited by 926

Emerging roles of PPARS in inflammation and immunity

Daynes, R. A., & Jones, D. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri912 · Cited by 926

GSK3: a multifaceted kinase in Wnt signaling

Wu, D., & Pan, W. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.002 · Cited by 862

GSK3 signalling in neural development

Hur, E., & Zhou, F. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2870 · Cited by 841

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

Remijsen, Q., Berghe, T. V., Wirawan, E., Asselbergh, B., Parthoens, E., De Rycke, R., Noppen, S., Delforge, M., Willems, J., & Vandenabeele, P. (2011) · Cell Research · doi:10.1038/cr.2010.150 · Cited by 818

Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling

Essers, M. A. G., Smits, L. M. M., Barker, N., Polderman, P. E., Burgering, B. M. T., & Korswagen, H. C. (2005) · Science · doi:10.1126/science.1109083 · Cited by 759

Peroxisome proliferator-activated receptors in inflammation control

Delerive, P., Fruchart, J., & Staels, B. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690453 · Cited by 755 · cited 1×

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease

Risner, M. E., Saunders, A. M., Altman, J. F. B., Ormandy, G. C., Craft, S., Foley, I. M., Zvartau-Hind, M. E., Hosford, D. A., Roses, A. D., & for the Rosiglitazone in Alzheimer's Disease Study Group (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500369 · Cited by 686

An overview of APP processing enzymes and products.

Chow, V. W., Mattson, M. P., Wong, P. C., & Gleichmann, M. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8104-z · Cited by 684

The NAD metabolome — a key determinant of cancer cell biology

Chiarugi, A., Dölle, C., Felici, R., & Ziegler, M. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3340 · Cited by 660

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

Lv, L., Dong, L., Zhao, D., Lin, R., Chu, Y., Zhang, H., Zha, Z., Liu, Y., Li, Z., Xu, Y., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.025 · Cited by 623

Suppression of canonical Wnt/ -catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy

Garcia-Gras, E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27751 · Cited by 623

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

Jucker, M., & Walker, L. C. (2011) · Annals of Neurology · doi:10.1002/ana.22615 · Cited by 622 · cited 2×

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

Mosconi, L., Pupi, A., & de Leon, M. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.007 · Cited by 616

FoxO proteins in insulin action and metabolism

Barthel, A., Schmoll, D., & Unterman, T. G. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.03.010 · Cited by 615

Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury

Lehnardt, S. (2009) · Glia · doi:10.1002/glia.20928 · Cited by 612

A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol

Russo, E. B., & Guy, G. W. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.08.026 · Cited by 608

The pharmacology of cannabinoid receptors and their ligands: an overview

Pertwee, R. G. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803272 · Cited by 588

Increase of Brain Oxidative Stress in Mild Cognitive Impairment

Praticò, D., Clark, C. M., Liun, F., Lee, V., & Trojanowski, J. Q. (2002) · Archives of Neurology · doi:10.1001/archneur.59.6.972 · Cited by 587

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Sun, Q., Chen, X., Ma, J., Peng, H., Wang, F., Zha, X., Wang, Y., Jing, Y., Yang, H., Chen, R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014769108 · Cited by 586

The Forkhead Transcription Factor FoxO Regulates Transcription of p27 Kip1 and Bim in Response to IL-2

Stahl, M., Dijkers, P. F., Kops, G. J. P. L., Lens, S. M. A., Coffer, P. J., Burgering, B. M. T., & Medema, R. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5024 · Cited by 585

Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D

Schmidt, M., de Mattos, S. F., van der Horst, A., Klompmaker, R., Kops, G. J. P. L., Lam, E. W. ‐., Burgering, B. M. T., & Medema, R. H. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.7842-7852.2002 · Cited by 573

Safety and side effects of cannabidiol, a Cannabis sativa constituent

Machado Bergamaschi, M., Helena Costa Queiroz, R., Waldo Zuardi, A., & Alexandre S. Crippa, J. (2011) · Current Drug Safety · doi:10.2174/157488611798280924 · Cited by 558 · cited 3×

DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway

Niida, A., Hiroko, T., Kasai, M., Furukawa, Y., Nakamura, Y., Suzuki, Y., Sugano, S., & Akiyama, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207892 · Cited by 555

Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

McPartland, J. M., Duncan, M., Marzo, V. D., & Pertwee, R. G. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12944 · Cited by 552

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy

Rajesh, M., Mukhopadhyay, P., Bátkai, S., Patel, V., Saito, K., Matsumoto, S., Kashiwaya, Y., Horváth, B., Mukhopadhyay, B., Becker, L. K., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.07.033 · Cited by 513

Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis

Takada, I., Kouzmenko, A., & Kato, S. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.137 · Cited by 511

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator‐activated receptors

O’Sullivan, S. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707423 · Cited by 509

Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists

Combs, C. K., Johnson, D. E., Karlo, J. C., Cannady, S. B., & Landreth, G. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00558.2000 · Cited by 483

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimarães, F. S. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0389 · Cited by 475

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid ß-protein

Selkoe, D. J. (2001) · Journal of Alzheimer's Disease · doi:10.3233/jad-2001-3111 · Cited by 466

Peroxisome proliferator-activated receptor $gamma; in diabetes and metabolism

Rangwala, S. M., & Lazar, M. A. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.03.012 · Cited by 464

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

Pate, K. T., Stringari, C., Sprowl‐Tanio, S., Wang, K., TeSlaa, T., Hoverter, N. P., McQuade, M. M., Garner, C., Digman, M. A., Teitell, M. A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488598 · Cited by 459

Cannabidiol, neuroprotection and neuropsychiatric disorders

Campos, A. C., Fogaça, M. V., Sonego, A. B., & Guimarães, F. S. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.033 · Cited by 446

Production of Reactive Oxygen Species in Brain Mitochondria: Contribution by Electron Transport Chain and Non–Electron Transport Chain Sources

Adam-Vizi, V. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1140 · Cited by 439

Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling

Molina‐Holgado, E., Vela, J. M., Arévalo‐Martín, Á., Almazán, G., Molina‐Holgado, F., Borrell, J. I., & Guaza, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09742.2002 · Cited by 425

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

Zuardi, A. W. (2008) · Revista Brasileira de Psiquiatria · doi:10.1590/s1516-44462008000300015 · Cited by 421

PPARγ AND G LUCOSE H OMEOSTASIS

Picard, F., & Auwerx, J. H. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102808 · Cited by 412

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease

Martín-Moreno, A. M., Reigada, D., Ramírez, B. G., Mechoulam, R., Innamorato, N. G., Cuadrado, A., & CEBALLOS, M. L. D. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.071290 · Cited by 410

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

Esposito, G., Scuderi, C., Valenza, M., Togna, G. I., Latina, V., De Filippis, D., Cipriano, M., Carratù, M. R., Iuvone, T., & Steardo, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028668 · Cited by 410

Emerging role of the cannabinoid receptor CB 2 in immune regulation: therapeutic prospects for neuroinflammation

Cabral, G. A., & Griffin-Thomas, L. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409000957 · Cited by 408 · cited 2×

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemüller, A. J. M., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C., & Nicoletti, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1381-04.2004 · Cited by 398

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

Liu, Y. M., Liu, F., Iqbal, K., Grundke, I., & Gong, C. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.12.035 · Cited by 396

Molecular Cloning, Expression and Characterization of Human Peroxisome Proliferator Activated Receptors γ1 and γ2

Elbrecht, A., Chen, Y., Cullinan, C. A., Hayes, N. S., Leibowitz, M. D., Moller, D. E., & Berger, J. P. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1044 · Cited by 384

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

Beurel, E., Michalek, S. M., & Jope, R. S. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.007 · Cited by 378

β-catenin interacts with and inhibits NF-κB in human colon and breast cancer

Deng, J., Miller, S. A., Wang, H.-Y., Xia, W., Wen, Y., Zhou, B. P., Li, Y., Lin, S., & Hung, M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00154-x · Cited by 370

Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease

Patterson, K. R., Remmers, C. L., Fu, Y., Brooker, S. M., Kanaan, N. M., Vana, L., Ward, S., Reyes, J. F., Philibert, K., Glucksman, M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237974 · Cited by 369

Role of mitochondrial dysfunction in Alzheimer's disease

Castellani, R. J., Hirai, K., Aliev, G. M., Drew, K. L., Nunomura, A., Takeda, A., Cash, A., Obrenovich, M. E., Perry, G. L., & Smith, M. A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10389 · Cited by 366

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

Fernández‐Ruíz, J., Sagredo, O., Pazos, M. R., García, C., Pertwee, R. G., Mechoulam, R., & Martínez-Orgado, J. A. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04341.x · Cited by 364

Neuroprotective effect of cannabidiol, a non‐psychoactive component from Cannabis sativa, on β‐amyloid‐induced toxicity in PC12 cells

Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M., & Izzo, A. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2003.02327.x · Cited by 361

Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine

Tomar, G. B., Srivastava, R. K., Gupta, N., Barhanpurkar, A. P., Pote, S. T., Jhaveri, H. M., Mishra, G. C., & Wani, M. R. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.126 · Cited by 357

Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo

Jones, N. A., Hill, A. J., Smith, I., Bevan, S. A., Williams, C. M., Whalley, B. J., & Stephens, G. J. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.159145 · Cited by 353

Abnormalities of mitochondrial enzymes in Alzheimer disease

Gibson, G. E., Sheu, K.-F. R., & Blass, J. P. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050099 · Cited by 345

Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease

Gouras, G. K., Almeida, C. G., & Takahashi, R. H. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.022 · Cited by 338

Glucose transporter expression in the central nervous system: relationship to synaptic function

McEwen, B. S., & Reagan, L. P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.041 · Cited by 331

GSK3: a possible link between beta amyloid peptide and tau protein

Hernández, F., Gómez de Barreda, E., Fuster-Matanzo, A., Lucas, J. J., & Avila, J. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.011 · Cited by 327

Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease

de la Monte, S. M., & Wands, J. R. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9209 · Cited by 324

Wnt signaling in the nervous system and in Alzheimer's disease

Inestrosa, N. C., & Varela-Nallar, L. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt051 · Cited by 324

Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells

Kozela, E., Pietr, M., Juknat, A., Rimmerman, N., Levy, R., & Vogel, Z. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.069294 · Cited by 322

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

Pandi-Perumal, S. R., BaHammam, A. S., Brown, G. M., Spence, D. W., Bharti, V. K., Kaur, C., Hardeland, R., & Cardinali, D. P. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9337-4 · Cited by 320

Endocannabinoids and Their Pharmacological Actions

Pertwee, R. G. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_1 · Cited by 317

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., & Van Leuven, F. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-22 · Cited by 309

Cannabidiol in vivo blunts β‐amyloid induced neuroinflammation by suppressing IL‐1β and iNOS expression

Esposito, G., Scuderi, C., Savani, C., Steardo, L., De Filippis, D., Cottone, P., Iuvone, T., Cuomo, V, & Steardo, L. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707337 · Cited by 308

Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation

Bouaboula, M., Hilairet, S., Marchand, J., Fajas, L., Fur, G. L., & Casellas, P. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.05.032 · Cited by 298

Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease

Guan, Y., & Breyer, M. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00766.x · Cited by 292

Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors

Mecha, M., Feliú, A., Iñigo, P. M., Mestre, L., Carrillo-Salinas, F. J., & Guaza, C. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.06.016 · Cited by 285

PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease

Landreth, G. E., Jiang, Q., Mandrekar, S., & Heneka, M. T. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.05.003 · Cited by 283

Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart

Burkart, E. M., Sambandam, N., Han, X., Gross, R. W., COURTOIS, M. R., Gierasch, C. M., Shoghi, K. I., Welch, M. J., & Kelly, D. P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32578 · Cited by 281

S100B/RAGE-dependent activation of microglia via NF-κB and AP-1

Bianchi, R., Giambanco, I., & Donato, R. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.017 · Cited by 280

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

Almeida, M., Ambrogini, E., Li, H., Manolagas, S. C., & Jilka, R. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023572 · Cited by 278

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms

Roche, T. E., Baker, J. C., Yan, X., Hiromasa, Y., Gong, X., Peng, T., Dong, J., Türkan, A., & Kasten, S. A. (2001) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(01)70013-x · Cited by 274

Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

Hoogeboom, D., Essers, M. A. G., Polderman, P. E., Voets, E., Smits, L. M. M., & Burgering, B. M. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706638200 · Cited by 274

WNT signaling in neuronal maturation and synaptogenesis

Rosso, S. B., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00103 · Cited by 272

Aerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox Mechanisms

Hunt, T. K., Aslam, R. S., Beckert, S., Wagner, S., Ghani, Q. P., Hussain, M., Roy, S., & Sen, C. K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1674 · Cited by 263

The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide

Soucek, T., Cumming, R., Dargusch, R., Maher, P., & Schubert, D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00367-2 · Cited by 258

Effects of Cannabinoids on Neurotransmission

Szabó, B., & Schlicker, E. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_11 · Cited by 256

Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

Pan, H., Mukhopadhyay, P., Rajesh, M., Patel, V., Mukhopadhyay, B., Gao, B., Haskó, G., & Pacher, P. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.147181 · Cited by 256

Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier

Erickson, M. A., Dohi, K., & Banks, W. A. (2012) · NeuroImmunoModulation · doi:10.1159/000330247 · Cited by 254

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

Booz, G. W. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.007 · Cited by 254

Does Cannabidiol Protect Against Adverse Psychological Effects of THC?

Niesink, R. J. M., & van Laar, M. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00130 · Cited by 253

The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt/β-catenin pathway rescue in PC12 cells

Esposito, G., Filippis, D. D., Carnuccio, R., Izzo, A. A., & Iuvone, T. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0025-1 · Cited by 252

Vascular PPARγ Controls Circadian Variation in Blood Pressure and Heart Rate through Bmal1

Wang, N., Yang, G., Jia, Z., Zhang, H. E., Aoyagi, T., Soodvilai, S., Symons, J. D., Schnermann, J. B., Gonzalez, F. J., Litwin, S. E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.009 · Cited by 238

Rosiglitazone rescues memory impairment in Alzheimer’s transgenic mice: Mechanisms involving a reduced amyloid and tau pathology

Escribano, L., Simón, A.-M., Gimeno, E., Cuadrado-Tejedor, M., López de Maturana, R., García-Osta, A., Ricobaraza, A., Pérez-Mediavilla, A., Del Río, J., & Frechilla, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.32 · Cited by 235

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

Cho, H., Gladwell, W., Wang, X., Chorley, B. N., Bell, D. A., Reddy, S. P., & Kleeberger, S. R. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1047oc · Cited by 233

Toxicity of Amyloid β Peptide: Tales of Calcium, Mitochondria, and Oxidative Stress

Canevari, L., Abramov, A. Y., & Duchen, M. R. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014834.06405.af · Cited by 227

AKT/GSK3 signaling pathway and schizophrenia

Emamian, E. S. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00033 · Cited by 227

Regulation of PI3K/Akt/GSK‐3 pathway by cannabinoids in the brain

Ozaita, A., Puighermanal, E., & Maldonado, R. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04642.x · Cited by 221

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

Ferreiro, E. B., Oliveira, C. R., & Pereira, C. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.02.003 · Cited by 218

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders

Scuderi, C., Filippis, D. D., Iuvone, T., Blasio, A., Steardo, A., & Esposito, G. (2008) · Phytotherapy Research · doi:10.1002/ptr.2625 · Cited by 217

Cannabidiol: A Promising Drug for Neurodegenerative Disorders?

Iuvone, T., Esposito, G., Filippis, D. D., Scuderi, C., & Steardo, L. (2009) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00065.x · Cited by 217

Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease

Mori, T., Koyama, N., Arendash, G. W., Horikoshi‐Sakuraba, Y., Tan, J., & Town, T. (2009) · Glia · doi:10.1002/glia.20924 · Cited by 212

Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons

Alvarez, A. R., Godoy, J. A., Müllendorff, K., Olivares, G. H., Bronfman, M., & Inestrosa, N. C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.02.028 · Cited by 212

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

Rajesh, M., Mukhopadhyay, P., Bátkai, S., Haskó, G., Liaudet, L., Drel, V. R., Obrosova, I. G., & Pacher, P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00236.2007 · Cited by 211

Glucose Transporters in Brain: In Health and in Alzheimer’s Disease

Szablewski, L. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160841 · Cited by 211

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis

Wolf, S. A., Bick-Sander, A., Fabel, K., Leal-Galicia, P., Tauber, S., Ramirez-Rodriguez, G., Müller, A., Melnik, A., Waltinger, T. P., Ullrich, O., et al. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-12 · Cited by 208

15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.

Shappell, S. B., Gupta, R. A., Manning, S., Whitehead, R. H., Boeglin, W. E., Schneider, C. G., Case, T., Price, J. O., Jack, G. S., Wheeler, T. M., et al. (2001) · PubMed · Cited by 207

Long-Term Cannabidiol Treatment Prevents the Development of Social Recognition Memory Deficits in Alzheimer's Disease Transgenic Mice

Cheng, D., Spiro, A. S., Jenner, A. M., Garner, B., & Karl, T. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140921 · Cited by 196

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss

Purro, S. A., Dickins, E. M., & Salinas, P. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4562-11.2012 · Cited by 195

Wnt Signaling in the Vertebrate Central Nervous System: From Axon Guidance to Synaptic FunctionPreprint

Salinas, P. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008003 · Cited by 195

Wnt Signaling: Role in Alzheimer Disease and Schizophrenia

Inestrosa, N. C., Montecinos-Oliva, C., & Fuenzalida, M. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9417-5 · Cited by 192

Regulation of Inflammatory Response in Neural Cells in Vitro by Thiadiazolidinones Derivatives through Peroxisome Proliferator-activated Receptor γ Activation

Luna‐Medina, R., Cortés‐Canteli, M., Alonso, M., Santos, Á., Martı́nez, A., & Pérez‐Castillo, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414390200 · Cited by 191

Peroxisome proliferator-activated receptor γ is expressed in hippocampal neurons and its activation prevents β-amyloid neurodegeneration: role of Wnt signaling

Inestrosa, N. C., Godoy, J. A., Quintanilla, R. A., KOENIG, C., & Bronfman, M. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.09.032 · Cited by 191

Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease

Lee, T. H., Pastorino, L., & Lu, K. P. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001906 · Cited by 185

Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by β-Catenin and Plakoglobin

Zhurinsky, J., Shtutman, M. S., & Ben‐Ze'ev, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4238-4252.2000 · Cited by 185

Glycation exacerbates the neuronal toxicity of β-amyloid

Li, X.-H., Du, L.-L., Cheng, X.-S., Jiang, X., Zhang, Y., Lv, B.-L., Liu, R., Wang, J.-Z., & Zhou, X.-W. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.180 · Cited by 184

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

Ferrer, I., Barrachina, M., Puig, B., de Lagrán, M. M., Martı́, E., Ávila, J., & Dierssen, M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.020 · Cited by 181

Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice

Cheng, D., Low, J. K., Logge, W., Garner, B., & Karl, T. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3478-5 · Cited by 181

The role of tau kinases in Alzheimer's disease.

Dolan, P. J., & Johnson, G. V. W. (2010) · PubMed · Cited by 178

Phosphatidylinositol 3-Kinase Links the Interleukin-2 Receptor to Protein Kinase B and p70 S6 Kinase

Reif, K., Burgering, B. M. T., & Cantrell, D. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14426 · Cited by 175

Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis

Hao, E., Mukhopadhyay, P., Cao, Z., Erdélyi, K., Holovac, E., Liaudet, L., Lee, W.-S., Haskó, G., Mechoulam, R., & Pacher, P. (2015) · Molecular Medicine · doi:10.2119/molmed.2014.00261 · Cited by 175

NEUROBEHAVIORAL AND NEUROPSYCHIATRIC SYMPTOMS IN ALZHEIMER'S DISEASE

Chung, J. A., & Cummings, J. L. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70228-0 · Cited by 174

Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

del Pulgar, T. G., CEBALLOS, M. L. D., Guzmán, M., & Velasco, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205797200 · Cited by 173

Increased Dickkopf‐1 expression in transgenic mouse models of neurodegenerative disease

Rosi, M. C., Luccarini, I., Grossi, C., Fiorentini, A., Spillantini, M. G., Prisco, A., Scali, C., Gianfriddo, M., Caricasole, A., Terstappen, G. C., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06566.x · Cited by 168

Wnt Signaling and Forebrain DevelopmentPreprint

Harrison-Uy, S. J., & Pleasure, S. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008094 · Cited by 168

Wnt your brain be inflamed? Yes, it Wnt!

Marchetti, B., & Pluchino, S. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.001 · Cited by 167

The role of the Wnt canonical signaling in neurodegenerative diseases

Libro, R., Bramanti, P., & Mazzon, E. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.06.024 · Cited by 166

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162

Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement

Scuderi, C., Steardo, L., & Esposito, G. (2014) · Phytotherapy Research · doi:10.1002/ptr.5095 · Cited by 161

FoxO3a and BCR-ABL Regulate cyclin D2 Transcription through a STAT5/BCL6-Dependent Mechanism

de Mattos, S. F., Essafi, A., Soeiro, I., Pietersen, A. M., Birkenkamp, K. U., Edwards, C. S., Martino, A., Nelson, B. H., Francis, J. M., Jones, M. C., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.10058-10071.2004 · Cited by 161

The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells

Jansson, E. Å., Are, A., Greicius, G., Kuo, I.-C., Kelly, D., Arulampalam, V., & Pettersson, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405928102 · Cited by 156

Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?

Contreras, D. L., Carvajal, K., Toral-Ríos, D., Franco-Bocanegra, D., & Campos‐Peña, V. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/497802 · Cited by 155

Effect of oxidative DNA damage in promoter elements on transcription factor binding

Ghosh, R., & Mitchell, D. L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.3213 · Cited by 152

Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis

Giacoppo, S., Pollastro, F., Grassi, G., Bramanti, P., & Mazzon, E. (2016) · Fitoterapia · doi:10.1016/j.fitote.2016.11.010 · Cited by 151

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

Manolopoulos, K. N., Klotz, L.-O., Korsten, P., Bornstein, S. R., & Barthel, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.17 · Cited by 150

In vivoActivation ofWntSignaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model

Vargas, J., Fuenzalida, M., & Inestrosa, N. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0862-13.2014 · Cited by 149

Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats

Napimoga, M. H., Benatti, B. B., de Lima, F. O., Alves, P. M., Campos, A. C., Pena-dos-Santos, D. R., Severino, F. P., Cunha, F. Q., & Guimarães, F. S. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.11.010 · Cited by 148

Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma

Vallée, A., & Lecarpentier, Y. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00459 · Cited by 147

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively.

Bobba, A., Amadoro, G., Valenti, D., Corsetti, V., Lassandro, R., & Atlante, A. (2013) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2013.03.008 · Cited by 146

Peroxisome Proliferator-Activated Receptors and the Control of Inflammation

Cabrero, À., Laguna, J. C., & Vázquez‐Carrera, M. (2002) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010023344616 · Cited by 143

Toll‐like receptor 4 mediates cross‐talk between peroxisome proliferator‐activated receptor γ and nuclear factor‐κB in macrophages

Necela, B. M., Su, W., & Thompson, E. A. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02849.x · Cited by 140

Oxidative Stress Mediated Mitochondrial and Vascular Lesions as Markers in the Pathogenesis of Alzheimer Disease

Aliev, G., Priyadarshini, M., Reddy, V., Grieg, N. H., Kaminsky, Y., Cacabelos, R., Ashraf, G., Jabir, N. R., Kamal, M. A., Nikolenko, V. N., et al. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131227161303 · Cited by 138

Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2

Kim, E. J., Kwon, K. J., Park, J.-Y., Lee, S., Moon, C., & Baik, E. J. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02480-0 · Cited by 137

Enhanced Expression of the Voltage-Dependent Anion Channel 1 (VDAC1) in Alzheimer's Disease Transgenic Mice: An Insight into the Pathogenic Effects of Amyloid-β

Cuadrado‐Tejedor, M., Vilariño, M., Cabodevilla, F., Río, J. D., Frechilla, D., & Pérez‐Mediavilla, A. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100966 · Cited by 134

Glucose metabolism and Alzheimer's disease

Schubert, D. A. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.02.003 · Cited by 133

The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria

Silva-García, O., Valdez-Alarcón, J. J., & Baizabal-Aguirre, V. M. (2014) · Mediators of Inflammation · doi:10.1155/2014/310183 · Cited by 132

Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders

Chen, Y., Wu, J., Tsai, H.-D., Huang, C., Chen, J.-J., Sun, G. Y., & Lin, T. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8259-8 · Cited by 132

PPAR Regulation of Inflammatory Signaling in CNS Diseases

Bright, J. J., Kanakasabai, S., Chearwae, W., & Chakraborty, S. (2008) · PPAR Research · doi:10.1155/2008/658520 · Cited by 131

Peroxisome Proliferator-activated Receptor γ Activation Can Regulate β-Catenin Levels via a Proteasome-mediated and Adenomatous Polyposis Coli-independent Pathway

Sharma, C., Pradeep, A., Wong, L., Rana, A., & Rana, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403143200 · Cited by 130

Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of D -galactose/AlCl 3 inducing rats model of Alzheimer’s disease

Li, H., Kang, T., Qi, B., Kong, L., Jiao, Y., Cao, Y., Zhang, J., & Yang, J. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.12.020 · Cited by 129

Targeting innate immunity for neurodegenerative disorders of the central nervous system

Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13667 · Cited by 126

The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-βProduction in Alzheimer’s Disease

Zuo, L., Hemmelgarn, B. T., Chuang, C., & Best, T. M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/604658 · Cited by 122

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

Newington, J. T., Pitts, A., Chien, A., Arseneault, R., Schubert, D. A., & Cumming, R. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019191 · Cited by 121

Curcumin activates Wnt/β-catenin signaling pathway through inhibiting the activity of GSK-3β in APPswe transfected SY5Y cells

Zhang, X., Yin, W., Shi, X.-D., & Li, Y. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.02.009 · Cited by 116

Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production

Newington, J. T., Rappon, T., Albers, S. S., Wong, D. Y. L., Rylett, R. J., & Cumming, R. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.366195 · Cited by 115

Trolox and 17β-Estradiol Protect against Amyloid β-Peptide Neurotoxicity by a Mechanism That Involves Modulation of the Wnt Signaling Pathway

Quintanilla, R. A., Muñoz, F. J., Metcalfe, M., Hitschfeld, M., Olivares, G. H., Godoy, J. A., & Inestrosa, N. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411936200 · Cited by 114

Cannabidiol Modulates the Expression of Alzheimer’s Disease-Related Genes in Mesenchymal Stem Cells

Libro, R., Diomede, F., Scionti, D., Piattelli, A., Grassi, G., Pollastro, F., Bramanti, P., Mazzon, E., & Trubiani, O. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010026 · Cited by 110

New Cannabidiol Derivatives: Synthesis, Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity

Ben‐Shabat, S., Hanuš, L. O., Katzavian, G., & Gallily, R. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm050709m · Cited by 108

Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway

Park, K. S., Lee, R. D., Kang, S.-K., Han, S. Y., Park, K. L., Yang, K. H., Song, Y. S., Park, H. J., Lee, Y. M., Yun, Y. P., et al. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.03.034 · Cited by 105

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

Scuderi, C., Esposito, G., Blasio, A., Valenza, M., Arietti, P., Steardo, L., Carnuccio, R., Filippis, D. D., Petrosino, S., Iuvone, T., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01267.x · Cited by 100

From tau phosphorylation to tau aggregation: what about neuronal death?

Buée, L., Troquier, L., Burnouf, S., Bélarbi, K., der Jeugd, A. V., Ahmed, T., Fernández-Gómez, F.-J., Caillierez, R., Grosjean, M., Bégard, S., et al. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380967 · Cited by 99

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

Orellana, A. M., Vasconcelos, A. R., Leite, J. A., Lima, L. D. S., Andreotti, D. Z., Munhoz, C. D., Kawamoto, E. M., & Scavone, C. (2015) · Aging · doi:10.18632/aging.100853 · Cited by 99

Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments

Renard, J., Norris, C., Rushlow, W. J., & Laviolette, S. R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.006 · Cited by 99

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

Chiang, M., Chen, C., Lee, M.-R., Chen, H.-W., Chen, H., Wu, Y.-S., Hung, C.-H., Kang, J.-J., Chang, C., Chang, C., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq322 · Cited by 98

Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction

Lecarpentier, Y., CLAES, V. A., Duthoit, G., & Hébert, J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00429 · Cited by 98

S100B induces tau protein hyperphosphorylation via Dickopff‐1 up‐regulation and disrupts the Wnt pathway in human neural stem cells

Esposito, G., Scuderi, C., Lu, J., Savani, C., Filippis, D. D., Iuvone, T., Steardo, L., Jr., Sheen, V. L., & Steardo, L. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00159.x · Cited by 97

Interruption of β-catenin suppresses the EGFR pathway by blocking multiple oncogenic targets in human glioma cells

Yue, X., Lan, F., Yang, W., Yang, Y., Han, L., Zhang, A., Liu, J., Zeng, H., Jiang, T., Pu, P., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.032 · Cited by 96

The Activity of PPARγ in Primary Human Trophoblasts Is Enhanced by Oxidized Lipids

Schild, R. L., Schaiff, W. T., Carlson, M. G., Cronbach, E. J., Nelson, D. M., & Sadovsky, Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8284 · Cited by 93

Wnt signaling: Role in LTP, neural networks and memory

Oliva, C. A., Vargas, J., & Inestrosa, N. C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.03.006 · Cited by 92

Cannabinoids for the treatment of dementia

Krishnan, S., Cairns, R., & Howard, R. J. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007204.pub2 · Cited by 91

Wnt1, FoxO3a, and NF-κB oversee microglial integrity and activation during oxidant stress

Shang, Y., Chong, Z. Z., Hou, J., & Maiese, K. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.04.009 · Cited by 91

Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics

Silva-Álvarez, C., Arrázola, M. S., Godoy, J. A., Ordenes, D., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00097 · Cited by 91

Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9‐tetrahydrocannabinol in BV‐2 microglial cells

Juknat, A., Pietr, M., Kozela, E., Rimmerman, N., Levy, R., Coppola, G., Geschwind, D. H., & Vogel, Z. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01461.x · Cited by 90

Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry

Yoshimura, Y., Ichinose, T., & Yamauchi, T. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.037 · Cited by 90

Cross-Regulation Between Wnt and NF-κB Signaling Pathways.

Du, Q., & Geller, D. A. (2010) · Forum on Immunopathological Diseases and Therapeutics · doi:10.1615/forumimmundisther.v1.i3 · Cited by 86

The Role of Wnt Signaling in the Development of Alzheimer’s Disease: A Potential Therapeutic Target?

Wan, W., Xia, S., Kalionis, B., Liu, L., & Li, Y. (2014) · BioMed Research International · doi:10.1155/2014/301575 · Cited by 86

Blockade of THC-Seeking Behavior and Relapse in Monkeys by the Cannabinoid CB1-Receptor Antagonist Rimonabant

Justinová, Z., Munzar, P., Panlilio, L. V., Yaşar, S., Redhi, G. H., Tanda, G., & Goldberg, S. R. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.21 · Cited by 86

Crossregulation of NF‐κB by the APC/GSK‐3β/β‐catenin pathway

Deng, J., Xia, W., Miller, S. A., Wen, Y., Wang, H., & Hung, M. (2004) · Molecular Carcinogenesis · doi:10.1002/mc.10169 · Cited by 85

Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease

Harris, R. A., Tindale, L. C., & Cumming, R. C. (2014) · Biogerontology · doi:10.1007/s10522-014-9534-z · Cited by 85

Antioxidative and Anti-Inflammatory Properties of Cannabidiol

Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019) · Antioxidants · doi:10.3390/antiox9010021 · Cited by 889

Cannabidiol Adverse Effects and Toxicity

Huestis, M. A., Solimini, R., Pichini, S., Pacifici, R., Carlier, J., & Busardò, F. P. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190603171901 · Cited by 499

Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis

Vallée, A., & Lecarpentier, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00745 · Cited by 380

Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials

Silvestro, S., Mammana, S., Cavalli, E., Bramanti, P., & Mazzon, E. (2019) · Molecules · doi:10.3390/molecules24081459 · Cited by 249

Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease

Yan, X., Hu, Y., Wang, B., Wang, S., & Zhang, X. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.530219 · Cited by 230

The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt/β-catenin pathway rescue in PC12 cells

Esposito, G., Filippis, D. D., Carnuccio, R., Izzo, A. A., & Iuvone, T. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0025-1 · Cited by 252

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

Esposito, G., Scuderi, C., Valenza, M., Togna, G. I., Latina, V., De Filippis, D., Cipriano, M., Carratù, M. R., Iuvone, T., & Steardo, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028668 · Cited by 410

Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma

Vallée, A., & Lecarpentier, Y. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00459 · Cited by 147

Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease

Hickey, J. P., Collins, A. E., Nelson, M. L., Chen, H., & Kalisch, B. E. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050266 · Cited by 39

Understanding the Modulatory Effects of Cannabidiol on Alzheimer’s Disease

Xiong, Y., & Lim, C. (2021) · Brain Sciences · doi:10.3390/brainsci11091211 · Cited by 60