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Cited by 123Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

The DOI matches its Crossref record; 35 of the 37 references it cites were found in a registry or an index.

Metabolic advantages of spreading the nutrient load: effects of increased meal frequency in non-insulin-dependent diabetes

Jenkins, DJ, Ocana, A, Jenkins, AL, Wolever, TM, Vuksan, V, Katzman, L, Hollands, M, Greenberg, G, Corey, P, Patten, R·1992·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/55.2.461
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Abstract

The acute effect of increasing meal frequency as a model of slow absorption was studied for 1 d in 11 patients with non-insulin-dependent diabetes. On 1 d they took 13 snacks (the nibbling diet) and on another day the same diet was taken as three meals and one snack (the three-meal diet). The nibbling diet reduced mean blood glucose, serum insulin, and C peptide concentrations over the 9.5 h of observation and 24-h urinary C peptide output by 12.7 +/- 3.7% (mean +/- SE) (P = 0.0062), 20.1 +/- 5.8% (P = 0.0108), 9.2 +/- 2.6% (P = 0.0073), and 20.37 +/- 8.12% (P = 0.039), respectively, compared with the three-meal diet. Serum triglyceride concentrations were lower by 8.5 +/- 3.2% (P = 0.037). Despite lower insulin concentrations on the nibbling diet, the concentrations of free fatty acids, 3-hydroxybutyrate, and the insulin-sensitive branched-chain amino acids responded similarly on both treatments. Metabolic benefits seen with increased meal frequency may explain the success of similar agents that prolong absorption, including fiber and enzyme inhibitors.

Overview

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Crossref · 10.1093/ajcn/55.2.461

Cites

35 of 35 references verified0 citation errors · 0 not checkable

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Citations

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2 of the 37 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

  1. 1981, Guidelines for the nutritional management of diabetes mellitus: a special report from the Canadian Diabetes Association., J Can Diet Assoc, 42, 110
  2. Southgate, 1990, Editorial, Nibbiers, gorgers, snackers and grazers. Br Med J, 300, 136
  3. Adrian, 1977, Mechanisms of pancreatic polypeptide release in man, Lancet, 1, 101
  4. Pringle, 1976, Influence of frequency of eating low energy diets on insulin response in women during weight reduction, Nutr Rep Int, 13, 337
  5. Besterman, 1975, Gut hormone profile in celiac disease, Lancet, 1, 785
  6. Fontvieille, 1988, A moderate switch from high to low glycemic index foods for three weeks improves the metabolic control in type I (IDDM) diabetic subjects, Diabetes Nutr Metab, 1, 139

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Metadata

Authors
Jenkins, D., Ocana, A., Jenkins, A., Wolever, T., Vuksan, V, Katzman, L., Hollands, M., Greenberg, G., Corey, P., & Patten, R.
Affiliations
St. Michael's Hospital (CA)
Corresponding author
Jenkins, DJ
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1992-02
Volume
55
Issue
2
Pages
461-467
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/55.2.461
OpenAlex
W2105262749
Cited by
123
References
37
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 5
FWCI
2.82
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
type 2 diabetes, blood glucose, serum insulin, C-peptide, urinary C-peptide, serum triglycerides, free fatty acids, beta-hydroxybutyrate, branched-chain amino acids, dietary fiber, enzyme inhibitors
MeSH terms
Adult, Aged, Aged, 80 and over, Amino Acids, Blood Glucose, C-Peptide, Creatinine, Diabetes Mellitus, Type 2, Fasting, Feeding Behavior, Female, Hormones, Humans, Male, Middle Aged, Nutritional Physiological Phenomena, Osmolar Concentration, Time Factors

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