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Cited by 339Regulation of Appetite and ObesityDiet, Metabolism, and DiseaseMuscle metabolism and nutrition

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

Fat and carbohydrate overfeeding in humans: different effects on energy storage

Horton, TJ, Drougas, H, Brachey, A, Reed, GW, Peters, JC, Hill, JO·1995·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/62.1.19
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Abstract

Both the amount and composition of food eaten influence body-weight regulation. The purpose of this study was to determine whether and by what mechanism excess dietary fat leads to greater fat accumulation than does excess dietary carbohydrate. We overfed isoenergetic amounts (50% above energy requirements) of fat and carbohydrate (for 14 d each) to nine lean and seven obese men. A whole-room calorimeter was used to measure energy expenditure and nutrient oxidation on days 0, 1, 7, and 14 of each overfeeding period. From energy and nutrient balances (intake-expenditure) we estimated the amount and composition of energy stored. Carbohydrate overfeeding produced progressive increases in carbohydrate oxidation and total energy expenditure resulting in 75-85% of excess energy being stored. Alternatively, fat overfeeding had minimal effects on fat oxidation and total energy expenditure, leading to storage of 90-95% of excess energy. Excess dietary fat leads to greater fat accumulation than does excess dietary carbohydrate, and the difference was greatest early in the overfeeding period.

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Crossref · 10.1093/ajcn/62.1.19

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  1. Schwartz, 1993, Effect of oral fructose on lipolysis, fat oxidation, fractional and absolute de novo lipogenesis (DNL) using mass isotopomer distribution analysis (MIDA)., FASEB J, 7, A867

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Metadata

Authors
Horton, T., Drougas, H., Brachey, A., Reed, G., Peters, J., & Hill, J.
Affiliations
University of Colorado Health (US)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1995-07
Volume
62
Issue
1
Pages
19-29
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/62.1.19
OpenAlex
W1952443362
Cited by
339
References
38
Citations by year
2026: 7 · 2025: 1 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 14 · 2018: 7 · 2017: 16 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 11
FWCI
5.03
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-42549)
  • National Center for Research Resources (RR00095)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
energy storage, fat deposition, energy expenditure, carbohydrate oxidation, fat oxidation, nutrient oxidation, body weight regulation, obesity, lean men, energy balance
MeSH terms
Adolescent, Adult, Blood Glucose, Body Composition, Body Weight, Calorimetry, Dietary Carbohydrates, Dietary Fats, Energy Metabolism, Fasting, Fatty Acids, Nonesterified, Humans, Hyperphagia, Insulin, Male, Middle Aged, Obesity, Oxidation-Reduction, Cross-Over Studies

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