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Cited by 22Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressNutrition and Health Studies

Effects of erythorbic acid on vitamin C metabolism in young women

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Sauberlich, HE, Tamura, T, Craig, CB, Freeberg, LE, Liu, T·1996·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/64.3.336
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Abstract

Erythorbic acid, an epimer of L-ascorbic acid, is used in the United States as a food additive. Studies were conducted to determine whether the ingestion of erythorbic acid in the diet had any beneficial or adverse effects on the human requirement for vitamin C. Young women were fed diets that contained controlled amounts of erythorbic acid and ascorbic acid. In pharmacokinetic evaluations, erythorbic acid and ascorbic acid were rapidly absorbed with little interaction. Erythorbic acid cleared from the body more rapidly than ascorbic acid. Some subjects received diets deficient in vitamin C for periods < or = 30 d. Increasing intakes of erythorbic acid or prolonged intakes of < or = 1 g erythorbic acid/d did not indicate any interactions with ascorbic acid. Consumption of erythorbic acid resulted in the presence of erythorbic acid in mononuclear leukocytes. Ascorbic acid concentrations in these cells were not affected by the presence of erythorbic acid. Erythorbic acid disappeared quickly from these cells with cessation of erythorbic acid supplements. Prolonged ingestion of erythrobic acid by young women neither antagonized nor spared their vitamin C status.

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  • Erythorbic acid and D-ascorbic acid are partly active as vitamin C but are poorly retained by tissues and more rapidly excreted from the human body.

    “Its epimer erythorbic acid (Figure 1B, also known as isoascorbic acid or D-araboascorbic acid), which is used as a food additive, and its enantiomer D-ascorbic acid (Figure 1C) are also partly active as vitamin C. However, they are only poorly retained by tissues and are more rapidly excreted from the human body [7,8,9,10].”

    From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [7]

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Authors
Sauberlich, H., Tamura, T., Craig, C., Freeberg, L., & Liu, T.
Affiliations
University of Alabama at Birmingham (US)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1996-09
Volume
64
Issue
3
Pages
336-346
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/64.3.336
OpenAlex
W1952867066
Cited by
22
References
36
Citations by year
2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1
FWCI
1.69
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r01dk036298-01a1)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 36298)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords
erythorbic acid, vitamin C metabolism, vitamin C, vitamin C requirement, scurvy, food additives, pharmacokinetics, mononuclear leukocytes, vitamin C status, young women
MeSH terms
Absorption, Adult, Ascorbic Acid, Chromatography, High Pressure Liquid, Drug Combinations, Female, Humans, Osmolar Concentration, Stereoisomerism, Treatment Outcome

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