Cited by 164Antioxidant Activity and Oxidative StressRetinoids in leukemia and cellular processesPhytochemicals and Antioxidant Activities

Effects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

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Albanes, D, Virtamo, J, Taylor, PR, Rautalahti, M, Pietinen, P, Heinonen, OP·1997·The American Journal of Clinical Nutrition

Abstract

We determined whether serum carotenoid or retinol concentrations were altered by beta-carotene supplementation in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and whether such effects were modified by alcohol consumption or cigarette use. Participants in this substudy were 491 randomly selected men aged 58-76 y from the metropolitan Helsinki study center [237 receiving supplemental beta-carotene (20 mg/d) and 254 not receiving such supplementation]. Dietary carotenoids, retinol, and alcohol, and serum beta-carotene, alpha-tocopherol, retinol, and cholesterol were assessed at baseline. After an average of 6.7 y of supplementation, serum was collected and carotenoid, retinol, and alpha-tocopherol concentrations were determined by HPLC. Serum carotenoid fractions were highly correlated with each other (P < or = 0.0001). Compared with the unsupplemented group, the beta-carotene group had significantly higher serum concentrations of beta-carotene (1483%), alpha-carotene (145%), and beta-cryptoxanthin (67%) (P < or = 0.0001). Retinol concentrations were 6% higher (P = 0.03) and lutein was 11% lower (P = 0.02) in the supplemented group. Serum lycopene, zeaxanthin, and alpha-tocopherol did not differ according to beta-carotene-supplementation status. Although these beta-carotene-group differences were not significantly altered by amount of alcohol consumption, higher consumption (> 12.9 g/d, median) was related to lower (10-38%) concentrations of carotenoids, particularly beta-carotene, alpha-carotene, and beta-cryptoxanthin, in both the supplemented and unsupplemented groups. Smoking status did not significantly influence the supplementation-related differences in serum carotenoid and retinol values but concentrations of carotenoids were generally highest in participants who quit smoking while in the study and lowest in current smokers of > or = 20 cigarettes/d. This study showed that serum concentrations of non-beta-carotene carotenoids are altered by long-term beta-carotene supplementation and confirms the adverse effects of alcohol and cigarette smoking on serum carotenoids.

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Crossref · 10.1093/ajcn/66.2.366

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  • Dietary biomarker concentrations can be altered by genetic factors, physiologic or health status, dietary factors, and lifestyle factors.

    “They may be altered because of possible interactions with genetic factors, physiologic or health status (ie, age or obesity) (30), dietary factors such as fats for lipophilic biomarkers (31), and lifestyle factors such as alcohol intake or smoking (32).”

    From The food metabolome: a window over dietary exposure (2014) · cites this paper as [32]

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Authors
Albanes, D., Virtamo, J., Taylor, P., Rautalahti, M., Pietinen, P., & Heinonen, O.
Affiliations
National Institutes of Health (US)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1997-08
Volume
66
Issue
2
Pages
366-372
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2101372924
Cited by
164
References
43
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 3 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 6
FWCI
8.62
Type
journal article
Language
en
Update notices
erratum (1997-12-01)
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
  • National Institutes of Health (n01cn045165-030)
  • National Cancer Institute (N01 CN 45165)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
beta-carotene supplementation, serum carotenoids, retinol, alcohol consumption, cigarette smoking, alpha-carotene, beta-cryptoxanthin, lutein, alpha-tocopherol, dietary carotenoids
MeSH terms
Aged, Alcohol Drinking, Carotenoids, Double-Blind Method, Humans, Male, Middle Aged, Placebos, Plants, Toxic, Smoking, Nicotiana, beta Carotene

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