The Effect of Lutein on Eye and Extra-Eye Health

Buscemi, Silvio; Corleo, Davide; Di Pace, Francesco; Petroni, Maria Letizia; Satriano, Angela; Marchesini, Giulio

doi:10.3390/nu10091321

Cited by 260Antioxidant Activity and Oxidative StressRetinal Diseases and TreatmentsPhytochemicals and Antioxidant Activities

The Effect of Lutein on Eye and Extra-Eye Health

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Buscemi, Silvio, Corleo, Davide, Di Pace, Francesco, Petroni, Maria Letizia, Satriano, Angela, Marchesini, Giulio·2018·Nutrients

DOI 10.3390/nu10091321PMC PMC6164534

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Abstract

Lutein is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. In particular, lutein is known to improve or even prevent age-related macular disease which is the leading cause of blindness and vision impairment. Furthermore, many studies have reported that lutein may also have positive effects in different clinical conditions, thus ameliorating cognitive function, decreasing the risk of cancer, and improving measures of cardiovascular health. At present, the available data have been obtained from both observational studies investigating lutein intake with food, and a few intervention trials assessing the efficacy of lutein supplementation. In general, sustained lutein consumption, either through diet or supplementation, may contribute to reducing the burden of several chronic diseases. However, there are also conflicting data concerning lutein efficacy in inducing favorable effects on human health and there are no univocal data concerning the most appropriate dosage for daily lutein supplementation. Therefore, based on the most recent findings, this review will focus on lutein properties, dietary sources, usual intake, efficacy in human health, and toxicity.

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Carotenoids such as lutein have shown health-promoting properties such as anti-inflammatory properties, and can promote or prevent age-related macular disease.
“Carotenoids such as lutein have also shown great health-promoting properties such as anti-inflammatory properties, and it has been shown that this bioactive pigment can promote or prevent age-related macular disease which is the leading cause of blindness and vision impairment [47].”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [47]
The Mechanisms of Action section reports anti-inflammatory effects, and section 4.1 discusses possible prevention or treatment of age-related macular degeneration, while acknowledging conflicting results. The claim that lutein can *promote* the disease says the opposite of what the paper reports; the paper says lutein may improve or prevent it. (LLM, conf=0.88)
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Authors: Buscemi, S., Corleo, D., Di Pace, F., Petroni, M. L., Satriano, A., & Marchesini, G.
Affiliations: Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), University of Palermo, Unit of Oculistica, Policlinico University Hospital, 90127 Palermo, Italy
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
IRCCS Policlinico San Donato (IT)
Corresponding author: Buscemi, Silvio
ORCID: Buscemi, Silvio
Corleo, Davide
Petroni, Maria Letizia
Marchesini, Giulio
Venue: Nutrients
Publisher: MDPI AG
Published: 2018-09-18
Volume: 10
Issue: 9
Pages: 1321
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu10091321
PMC: PMC6164534
OpenAlex: W2890633333
Cited by: 260
References: 209
Citations by year: 2026: 22 · 2025: 37 · 2024: 45 · 2023: 31 · 2022: 45 · 2021: 36 · 2020: 31 · 2019: 12 · 2018: 1
FWCI: 2.09
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: lutein, carotenoids, eye health, age-related macular degeneration, cognitive function, cancer risk, cardiovascular health, lutein supplementation, dietary intake, anti-inflammatory activity
MeSH terms: Animals, Diet, Eye, Eye Diseases, Humans, Nutritional Status, Nutritive Value, Prognosis, Risk Factors, Lutein, Dietary Supplements, Protective Factors

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