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Cited by 178Folate and B Vitamins ResearchNutritional Studies and DietPorphyrin Metabolism and Disorders

The DOI matches its Crossref record; 32 of the 35 references it cites were found in a registry or an index.

Signs of impaired cognitive function in adolescents with marginal cobalamin status

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Louwman, Marieke WJ, van Dusseldorp, Marijke, van de Vijver, Fons JR, Thomas, Chris MG, Schneede, Jørn, Ueland, Per M, Refsum, Helga, van Staveren, Wija A·2000·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/72.3.762
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Abstract

Background Lack of cobalamin may lead to neurologic disorders, which have been reported in strict vegetarians.Objective The objective of this study was to investigate whether cognitive functioning is affected in adolescents (aged 10-16 y) with marginal cobalamin status as a result of being fed a macrobiotic diet up to an average age of 6 y.Design Data on dietary intake, psychological test performance, and biochemical variables of cobalamin status were collected from 48 adolescents who consumed macrobiotic (vegan type) diets up to the age of 6 y, subsequently followed by lactovegetarian or omnivorous diets, and from 24 subjects (aged 10-18 y) who were fed omnivorous diets from birth onward. Thirty-one subjects from the previously macrobiotic group were cobalamin deficient according to their plasma methylmalonic acid concentrations. Seventeen previously macrobiotic subjects and all control subjects had normal cobalamin status.Results The control subjects performed better on most psychological tests than did macrobiotic subjects with low or normal cobalamin status. A significant relation between test score and cobalamin deficiency (P: = 0.01) was observed for a test measuring fluid intelligence (correlation coefficient: -0.28; 95% CI: -0.48, -0.08). This effect became more pronounced (P: = 0.003) within the subgroup of macrobiotic subjects (correlation coefficient: -0.38; 95% CI: -0.62, - 0.14).Conclusion Our data suggest that cobalamin deficiency, in the absence of hematologic signs, may lead to impaired cognitive performance in adolescents.

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Metadata

Authors
Louwman, M. W., van Dusseldorp, M., van de Vijver, F. J., Thomas, C. M., Schneede, J., Ueland, P. M., Refsum, H., & van Staveren, W. A.
Affiliations
Wageningen University & Research (NL)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2000-09
Volume
72
Issue
3
Pages
762-769
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/72.3.762
OpenAlex
W2097021221
Cited by
178
References
35
Citations by year
2026: 5 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 15 · 2019: 13 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 9 · 2012: 9
FWCI
4.61
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • TNO Repository (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Keywords
vitamin B12 deficiency, cognitive function, fluid intelligence, macrobiotic diet, vegan diet, adolescents, methylmalonic acid
MeSH terms
Adolescent, Child, Cognition, Cognition Disorders, Female, Humans, Intelligence, Male, Psychological Tests, Psychomotor Performance, Reference Values, Vitamin B 12, Vitamin B 12 Deficiency, Cohort Studies, Diet, Macrobiotic

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