Cited by 138Folate and B Vitamins ResearchChild Nutrition and Water AccessPorphyrin Metabolism and Disorders

Vitamin B-12 and Cognition in Children

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Venkatramanan, Sudha, Armata, Ilianna E, Strupp, Barbara J, Finkelstein, Julia L·2016·Advances in Nutrition

Abstract

Vitamin B-12 is essential for brain development, neural myelination, and cognitive function. Inadequate vitamin B-12 status during pregnancy and early childhood has been associated with adverse child health outcomes, including impaired cognitive development. However, the underlying mechanisms have not been elucidated. This review was conducted to examine the evidence that links vitamin B-12 and cognition in children. The search strategy resulted in 17 studies: 3 cross-sectional, 1 case-control, and 12 cohort studies, and 1 randomized trial. Cognitive processes assessed included attention, memory, and perception. Developmental outcomes, academic performance, and intelligence quotient were also considered. Despite the high prevalence of vitamin B-12 insufficiency and associated risk of adverse cognitive outcomes in children, to our knowledge, no studies to date have been conducted to examine the effects of vitamin B-12 supplementation on cognition in children. The role of vitamin B-12 in the etiology of child cognitive outcomes needs to be elucidated to inform public health interventions.

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  1. Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelop- ment in infants: current knowledge and possible mechanisms. Nutr Rev 2008;66:250-5.
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Authors
Venkatramanan, S., Armata, I. E., Strupp, B. J., & Finkelstein, J. L.
Affiliations
  • Cornell University (US)
  • St. John's Research Institute (IN)
Corresponding author
Finkelstein, Julia L
Venue
Advances in Nutrition
Publisher
Elsevier BV
Published
2016-09
Volume
7
Issue
5
Pages
879-888
ISSN
  • 2156-5376 (ISSN-L)
  • 2161-8313
OpenAlex
W2519961203
Cited by
138
References
69
Citations by year
2026: 15 · 2025: 16 · 2024: 20 · 2023: 14 · 2022: 19 · 2021: 16 · 2020: 15 · 2019: 9 · 2018: 10 · 2017: 3 · 2016: 1
FWCI
1.22
Type
journal article
Language
en
Open access
Locations
  • Advances in Nutrition (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Keywords
vitamin B12, cognitive development, children, attention, memory, academic performance, intelligence quotient, prenatal nutrition
MeSH terms
Attention, Child, Child Development, Child Nutritional Physiological Phenomena, Cognition, Cognition Disorders, Humans, Memory, Nutritional Status, Vitamin B 12, Vitamin B 12 Deficiency, Dietary Supplements

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