The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019
Open accessAbstract
Background The aging process can lead to a decline in cellular immunity. Therefore, the elderly could benefit from safe and effective interventions that restore cellular immune functions.Objective We determined whether dietary supplementation with the known immunostimulating probiotic Bifidobacterium lactis HN019 could enhance aspects of cellular immunity in elderly subjects.Design Thirty healthy elderly volunteers (age range: 63-84 y; median: 69 y) participated in a 3-stage dietary supplementation trial lasting 9 wk. During stage 1 (run-in), subjects consumed low-fat milk (200 mL twice daily for 3 wk) as a base-diet control. During stage 2 (intervention), they consumed milk supplemented with B. lactis HN019 in a typical dose (5 x 10(10) organisms/d) or a low dose (5 x 10(9) organisms/d) for 3 wk. During stage 3 (washout), they consumed low-fat milk for 3 wk. Changes in the relative proportions of leukocyte subsets and ex vivo leukocyte phagocytic and tumor-cell-killing activity were determined longitudinally by assaying peripheral blood samples.Results Increases in the proportions of total, helper (CD4(+)), and activated (CD25(+)) T lymphocytes and natural killer cells were measured in the subjects' blood after consumption of B. lactis HN019. The ex vivo phagocytic capacity of mononuclear and polymorphonuclear phagocytes and the tumoricidal activity of natural killer cells were also elevated after B. lactis HN019 consumption. The greatest changes in immunity were found in subjects who had poor pretreatment immune responses. In general, the 2 doses of B. lactis HN019 had similar effectiveness.Conclusion B. lactis HN019 could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Therefore, the administration of specific strains of Lactobacilli and Bifidobacteria as probiotics as well as fructooligosaccharides, galactooligosaccharides, and other prebiotics, or the combination of both might constitute a benefit for immunocompromised people (118–122).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [119]
Citations
Cites
1 retracted
Chandra, R. K. (1992) · The Lancet · doi:10.1016/0140-6736(92)93151-c · Cited by 523
RetractedKaila, M., Isolauri, E., Soppi, E. T., Virtanen, E., Laine, S., & Arvilommi, H. S. (1992) · Pediatric Research · doi:10.1203/00006450-199208000-00002 · Cited by 700
Isolauri, E., Juntunen, M., Rautanen, T., Sillanaukee, P., & Koivula, T. (1991) · PubMed · Cited by 684
Letter: Hypoglycaemia in propranolol-treated dialysis patients.
Jensen, H. A., Bjaeldager, P., & Broch‐Møller, B. (1976) · PubMed · Cited by 649
Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bacteria
Schiffrin, E. J., Rochat, F., Link‐Amster, H., Aeschlimann, J., & Donnet‐Hughes, A. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76659-0 · Cited by 553
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535
AGEING, IMMUNE RESPONSE, AND MORTALITY
Roberts-Thomson, I., Youngchaiyud, U., Whittingham, S., & Mackay, I. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91755-3 · Cited by 477
SUCCESSFUL TREATMENT OF RELAPSING CLOSTRIDIUM DIFFICILE COLITIS WITH LACTOBACILLUS GG
Gorbach, S., Chang, T., & Goldin, B. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92646-8 · Cited by 467
Effect of age on human neutrophil function
Wenisch, C., Patruta, S., Daxböck, F., Krause, R., & Hörl, W. H. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.40 · Cited by 452
Aso, Y., Akaza, H., Kotake, T., Tsukamoto, T., Imai, K., Naito, S., & and the BLP Study Group (1995) · European Urology · doi:10.1159/000475138 · Cited by 373
Improved immunogenicity of oral D x RRV reassortant rotavirus vaccine by Lactobacillus casei GG
Isolauri, E., Joensuu, J., Suomalainen, H., Luomala, M., & Vesikari, T. (1995) · Vaccine · doi:10.1016/0264-410x(95)93319-5 · Cited by 370
Prevention of Travellers Diarrhoea by Lactobacillus GG
Oksanen, P. J., Salminen, S., Saxelin, M., Hämäläinen, P., Ihantola-Vormisto, A., Muurasniemi-Isoviita, L., Nikkari, S. T., Oksanen, T., Pörsti, I. H., Salminen, E. K., et al. (1990) · Annals of Medicine · doi:10.3109/07853899009147242 · Cited by 362
Schiffrin, E., Brassart, D., Servin, A., Rochat, F., & Donnet-Hughes, A. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.515s · Cited by 354
Gill, H. S., Rutherfurd, K. J., Prasad, J., & Gopal, P. K. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000210 · Cited by 351
Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019)
Arunachalam, K. D., Gill, H., & Chandra, R. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600938 · Cited by 336
Cell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60
Wayne, S. J., Rhyne, R. L., Garry, P. J., & Goodwin, J. S. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.2.m45 · Cited by 303
Antioxidants and immune response in aged persons: overview of present evidence
Meydani, S. N., Wu, D., Santos, M., & Hayek, M. G. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1462s · Cited by 298
Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments
Lesourd, B. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.478s · Cited by 285
NK and NK/T cells in human senescence
Solana, R., & Mariani, E. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00495-8 · Cited by 279
Chiang, B., Sheih, Y.-H., Wang, L. H., Liao, C., & Gill, H. S. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601093 · Cited by 238
Modulation of Nonspecific Mechanisms of Defense by Lactic Acid Bacteria: Effective Dose
Donnet‐Hughes, A., Rochat, F., Serrant, P., Aeschlimann, J., & Schiffrin, E. J. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75304-x · Cited by 215
Ageing and the neutrophil: no appetite for killing?
Butcher, S. K., Chahel, H., & Lord, J. M. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00079.x · Cited by 200
The Effect of Zinc and Vitamin A Supplementation on Immune Response in an Older Population
Fortes, C., Forastiere, F., Agabiti, N., Fano, V., Pacifici, R., Virgili, F., Piras, G., Guidi, L., Bartoloni, C., Tricerri, A., et al. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01008.x · Cited by 164
Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation
Santos, M., Meydani, S., Leka, L., Wu, D., Fotouhi, N., Meydani, M., Hennekens, C., & Gaziano, J. (1996) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.772 · Cited by 163
Bogden, J. D., Oleske, J. M., Lavenhar, M. A., Munves, E. M., Kemp, F. W., Bruening, K. S., Holding, K. J., Denny, T. N., Guarino, M. A., & Holland, B. K. (1990) · Journal of the American College of Nutrition · doi:10.1080/07315724.1990.10720372 · Cited by 156
Zhou, J. S., Shu, Q., Rutherfurd, K. J., Prasad, J., Birtles, M. J., Gopal, P. K., & Gill, H. S. (2000) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(00)00219-1 · Cited by 142
PENN, N. D., Purkins, L., Kelleher, J., Heatley, R. V., Mascie‐Taylor, B. H., & Belfield, P. W. (1991) · Age and Ageing · doi:10.1093/ageing/20.3.169 · Cited by 142
Zhou, J. S., Shu, Q., Rutherfurd, K. J., Prasad, J., Gopal, P. K., & Gill, H. S. (2000) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(99)00154-4 · Cited by 131
Lesourd, B. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb01523.x · Cited by 120
Hodes, R. J. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01022.x · Cited by 106
The Role of Nutrition in Immunity in the Aged
Lesourd, B., Mazari, L., & Ferry, M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01628.x · Cited by 92
Lesourd, B., & Meaume, S. (1994) · Immunology Letters · doi:10.1016/0165-2478(94)00062-x · Cited by 86
Ligthart, G. J., Schuit, H. R. E., & Hijmans, W. (1989) · PubMed Central · Cited by 82
Active ageing makes the difference
Kalache, A. (1999) · Current Opinion in Psychiatry · doi:10.1097/00001504-199907000-00012 · Cited by 79
Decreased Immunity and Increased Morbidity in the Elderly
Goodwin, J. S. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb01515.x · Cited by 67
Immunological Functions of Aged Human Monocytes
McLachlan, J. A., Serkin, C. D., Morrey, K. M., & Bakouche, O. (2008) · Pathobiology · doi:10.1159/000163946 · Cited by 50
Optimizing immunity and gut function in the elderly.
Gill, H. S., Darragh, A. J., & Cross, M. L. (2001) · PubMed · Cited by 42
Patterns of Age-Related Immunologic Changes
Makinodan, T. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb01512.x · Cited by 34
Reversing and restoring immune functions
Hirokawa, K. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01828-3 · Cited by 32
Myśliwska, J. M., Myśliwski, A., Romanowski, P., Bigda, J., Sosnowska, D., & Foerster, J. (2009) · Gerontology · doi:10.1159/000213305 · Cited by 27
Flagged first, then by citations
Cited by
Sorted by citations
Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322
Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
Servin, A. L. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.01.003 · Cited by 1,267
Probiotics, Prebiotics, and Synbiotics
de Vrese, M., & Schrezenmeir, J. (2008) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2008_097 · Cited by 1,061
Enaud, R., Prével, R., Ciarlo, E., Beaufils, F., Wieërs, G., Guery, B. P., & Delhaès, L. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00009 · Cited by 786
“increased phagocytic and lytic activity after treatment with Bifidobacterium lactis HN019 probiotics (Gill et al., 2001).”
BackgroundAiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Metadata
- Authors
- Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K.
- Affiliations
- Massey University (NZ)
- ORCID
- Gopal, Pramod K
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 74
- Issue
- 6
- Pages
- 833-839
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1905558879
- Cited by
- 485
- References
- 40
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 25 · 2021: 35 · 2020: 24 · 2019: 21 · 2018: 19 · 2017: 29 · 2016: 20 · 2015: 15 · 2014: 19 · 2013: 23 · 2012: 23
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, dietary supplementation, cell-mediated immunity, older adults, aging, T cells, natural killer cells, phagocytic activity, milk supplementation, immunosenescence
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Bifidobacterium, Female, Humans, Immunity, Cellular, Killer Cells, Natural, Leukocytes, Male, Middle Aged, Milk, Phagocytosis, Colony Count, Microbial, Dietary Supplements, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
