Cited by 485Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyInfant Nutrition and Health

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Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019

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Gill, Harsharnjit S, Rutherfurd, Kay J, Cross, Martin L, Gopal, Pramod K·2001·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/74.6.833

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Abstract

Background The aging process can lead to a decline in cellular immunity. Therefore, the elderly could benefit from safe and effective interventions that restore cellular immune functions.Objective We determined whether dietary supplementation with the known immunostimulating probiotic Bifidobacterium lactis HN019 could enhance aspects of cellular immunity in elderly subjects.Design Thirty healthy elderly volunteers (age range: 63-84 y; median: 69 y) participated in a 3-stage dietary supplementation trial lasting 9 wk. During stage 1 (run-in), subjects consumed low-fat milk (200 mL twice daily for 3 wk) as a base-diet control. During stage 2 (intervention), they consumed milk supplemented with B. lactis HN019 in a typical dose (5 x 10(10) organisms/d) or a low dose (5 x 10(9) organisms/d) for 3 wk. During stage 3 (washout), they consumed low-fat milk for 3 wk. Changes in the relative proportions of leukocyte subsets and ex vivo leukocyte phagocytic and tumor-cell-killing activity were determined longitudinally by assaying peripheral blood samples.Results Increases in the proportions of total, helper (CD4(+)), and activated (CD25(+)) T lymphocytes and natural killer cells were measured in the subjects' blood after consumption of B. lactis HN019. The ex vivo phagocytic capacity of mononuclear and polymorphonuclear phagocytes and the tumoricidal activity of natural killer cells were also elevated after B. lactis HN019 consumption. The greatest changes in immunity were found in subjects who had poor pretreatment immune responses. In general, the 2 doses of B. lactis HN019 had similar effectiveness.Conclusion B. lactis HN019 could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly.

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RETRACTED: Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects
Chandra, R. K. (1992) · The Lancet · doi:10.1016/0140-6736(92)93151-c · Cited by 523
Retracted
Enhancement of the Circulating Antibody Secreting Cell Response in Human Diarrhea by a Human Lactobacillus Strain
Kaila, M., Isolauri, E., Soppi, E. T., Virtanen, E., Laine, S., & Arvilommi, H. S. (1992) · Pediatric Research · doi:10.1203/00006450-199208000-00002 · Cited by 700
A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children.
Isolauri, E., Juntunen, M., Rautanen, T., Sillanaukee, P., & Koivula, T. (1991) · PubMed · Cited by 684
Letter: Hypoglycaemia in propranolol-treated dialysis patients.
Jensen, H. A., Bjaeldager, P., & Broch‐Møller, B. (1976) · PubMed · Cited by 649
Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bacteria
Schiffrin, E. J., Rochat, F., Link‐Amster, H., Aeschlimann, J., & Donnet‐Hughes, A. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76659-0 · Cited by 553
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535
AGEING, IMMUNE RESPONSE, AND MORTALITY
Roberts-Thomson, I., Youngchaiyud, U., Whittingham, S., & Mackay, I. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91755-3 · Cited by 477
SUCCESSFUL TREATMENT OF RELAPSING CLOSTRIDIUM DIFFICILE COLITIS WITH LACTOBACILLUS GG
Gorbach, S., Chang, T., & Goldin, B. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92646-8 · Cited by 467
Effect of age on human neutrophil function
Wenisch, C., Patruta, S., Daxböck, F., Krause, R., & Hörl, W. H. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.40 · Cited by 452
Preventive Effect of a Lactobacillus casei Preparation on the Recurrence of Superficial Bladder Cancer in a Double-Blind Trial
Aso, Y., Akaza, H., Kotake, T., Tsukamoto, T., Imai, K., Naito, S., & and the BLP Study Group (1995) · European Urology · doi:10.1159/000475138 · Cited by 373

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Prasanna, P. H. P., Grandison, A. S., & Charalampopoulos, D. (2014) · Food Research International · doi:10.1016/j.foodres.2013.11.013 · Cited by 135
Effect of Probiotics and Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lei, W.-T., Shih, P.-C., Liu, S.-J., Lin, C.-Y., & Yeh, T.-L. (2017) · Nutrients · doi:10.3390/nu9111175 · Cited by 134
“Probiotics induce cellular immunity in phagocyte and NK cells [33,41] and promote IgA secretion into saliva to enhance the vaccine effects [35,42].”
Background
Daily Intake of Heat-Killed Lactobacillus plantarum L-137 Augments Acquired Immunity in Healthy Adults
Hirose, Y., Murosaki, S., Yamamoto, Y., Yoshikai, Y., & Tsuru, T. (2006) · Journal of Nutrition · doi:10.1093/jn/136.12.3069 · Cited by 134
“Several lines of evidence show that dietary consumption of probiotic lactic acid bacteria can enhance the activity of NK cells in healthy adult subjects (19,20).”
Background
The Effects of Probiotic and Mannanoligosaccharide on some Haematological and Immunological Parameters in Turkeys
ÇEti̇n, N., Güçlü, B. K., & ÇEti̇n, E. (2005) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.2005.00736.x · Cited by 132
Quercetin improves gut dysbiosis in antibiotic-treated mice
Shi, T., Bian, X., Yao, Z., Wang, Y., Gao, W., & Guo, C. (2020) · Food & Function · doi:10.1039/d0fo01439g · Cited by 132
Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines
Lee, D. K., Jang, S., Kim, M. J., Kim, J. H., Chung, M. J., Kim, K. J., & Ha, N. J. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-310 · Cited by 130
“, and LAB, are probiotic organisms in humans and stimulate immune function and anti-tumor effects [19-45].”
Background
The interaction between gut microbiota and age-related changes in immune function and inflammation
Magrone, T., & Jirillo, E. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-31 · Cited by 124
“) lactis HN 019 to aged individuals led to the recovery of granulocyte and NK cell activities [43].”
Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers
Dong, H., Rowland, I., Thomas, L. V., & Yaqoob, P. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0487-1 · Cited by 127
“Decreases in the numbers of T cells in peripheral blood, decreased capacity of T cells to proliferate and secrete cytokines, poor contribution to effective delayed-type hypersensitivity responses in vivo, a decline in innate immunity, including phagocytic and NK cell activity [2], and a decrease in specific antibody r…”
Background
Role of Natural Killer and Dendritic Cell Crosstalk in Immunomodulation by Commensal Bacteria Probiotics
Rizzello, V., Bonaccorsi, I., Dongarrà, M. L., Fink, L. N., & Ferlazzo, G. (2011) · BioMed Research International · doi:10.1155/2011/473097 · Cited by 126
Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients
Roller, M., Clune, Y., Collins, K., Rechkemmer, G., & Watzl, B. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507450292 · Cited by 125
“Consumption of probiotics changed the relative proportions of leucocyte subsets and enhanced phagocytic activity as well as natural killer (NK) cell cytotoxicity (Gill et al. 2001; Olivares et al. 2006).”
Cheesomics: the future pathway to understanding cheese flavour and quality.
Afshari, R., Pillidge, C. J., Dias, D. A., Osborn, A. M., & Gill, H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1512471 · Cited by 126
“Indeed, several NSLAB isolated from cheese have been found to exhibit unique health-promoting properties and are currently being used as probiotics worldwide (Prasad et al. 1998; Gill et al. 2001; da Cruz et al. 2009; Settanni and Moschetti 2010).”
Background
Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota
Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 133
Prebiotic and Probiotic Fortified Milk in Prevention of Morbidities among Children: Community-Based, Randomized, Double-Blind, Controlled Trial
Sazawal, S., Dhingra, U., Hiremath, G. S., Sarkar, A., Dhingra, P., Dutta, A., Verma, P., Menon, V. P., & Black, R. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012164 · Cited by 124
“Immune-stimulant activity among healthy adult volunteers, with no notable adverse health events has been documented [31–33].”
Background
Innate mechanisms for Bifidobacterium lactis to activate transient pro‐inflammatory host responses in intestinal epithelial cells after the colonization of germ‐free rats
Ruiz, P. A., Hoffmann, M., Szcesny, S., Blaut, M., & Haller, D. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02176.x · Cited by 128
Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells
Hwang, P.-A., Phan, N. N., Lu, W.-J., Hieu, B. T. N., & Lin, Y.-C. (2016) · Food & Nutrition Research · doi:10.3402/fnr.v60.32033 · Cited by 120
“Among them, Bifidobacterium lactis is a probiotic strain that is consumed worldwide, which can reduce the severity of pathogen infection and enhance immunity in the elderly (9) and protect enterocytes from an acute inflammatory response induced by enteropathogen (10).”
Background
Gut changes attributed to ageing: effects on intestinal microflora
Hébuterne, X. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200301000-00008 · Cited by 120
Natural Health Products, Modulation of Immune Function and Prevention of Chronic Diseases
Haddad, P. S., Azar, G. A., Groom, S., & Boivin, M. (2005) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/neh125 · Cited by 119
The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans.
Olivares, M. M., Díaz-Ropero, M. P., Gómez, N., Lara‐Villoslada, F., Sierra, S., Maldonado, J. A., Martı́n, R., Rodríguez, J. M., & Xaus, J. (2006) · PubMed · Cited by 117
Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses
Fink, L. N., Zeuthen, L., Christensen, H. R., Morandi, B., Frøkiær, H., & Ferlazzo, G. (2007) · International Immunology · doi:10.1093/intimm/dxm103 · Cited by 115
Caseinomacropeptide and whey protein concentrate enhance Bifidobacterium lactis growth in milk
Janer, C., Peláez, C., & Requena, T. (2003) · Food Chemistry · doi:10.1016/j.foodchem.2003.09.034 · Cited by 112
Effects ofBifidobacterium longumBB536 Administration on Influenza Infection, Influenza Vaccine Antibody Titer, and Cell-Mediated Immunity in the Elderly
NAMBA, K., Hatano, M., Yaeshima, T., Takase, M., & Suzuki, K. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90749 · Cited by 111
Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression
Putaala, H., Salusjärvi, T., Nordström, M., Saarinen, M., Ouwehand, A. C., Hansen, E. B., & Rautonen, N. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2008.08.002 · Cited by 114
“lactis HN019 has been proven to be immunostimulatory, but not to induce pathological inflammation [12,39], which could explain the increased COX-2-to-COX-1 in the case of B.”
Background
Drinking yoghurts with berry polyphenols added before and after fermentation
Sun-Waterhouse, D., Zhou, J., & Wadhwa, S. (2013) · Food Control · doi:10.1016/j.foodcont.2013.01.011 · Cited by 109
African Traditional Fermented Foods and Probiotics
Anukam, K. C., & Reid, G. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0163 · Cited by 111
“36 It is surprising, though erroneous, to ﬁnd that Elie Metchnikoff noted a tendency to longer life in people who consumed fermented foods, 37 as recent medical science history has revealed that he later denied that he had ever inferred that drinking fermented milk would prolong life.”
Metabolic and Physiological Impact of Probiotics or Direct-Fed-Microbials on Poultry: A Brief Review of Current Knowledge
Chichlowski, M., Croom, J., McBride, B. W., HAVENSTEIN, G. B., & Koci, M. D. (2007) · International Journal of Poultry Science · doi:10.3923/ijps.2007.694.704 · Cited by 110
“This cell line principal end products of fermentation by Bifidobacteria spontaneously differentiates under standard culture are acetate and lactate which are produced in a 3:2 conditions and the differentiated cells then express molar ratio (Gill et al., 2001).”
Background
Probiotics, immunity and exercise: a review.
West, N. P., Pyne, D. B., Peake, J. M., & Cripps, A. W. (2009) · PubMed · Cited by 108
Mucosal Biofilm Communities in the Human Intestinal Tract
Macfarlane, S., Bahrami, B., & Macfarlane, G. T. (2011) · Advances in applied microbiology · doi:10.1016/b978-0-12-387046-9.00005-0 · Cited by 113
Review on Bifidobacterium bifidum BGN4: Functionality and Nutraceutical Applications as a Probiotic Microorganism
Ku, S., Park, M., Ji, G., & You, H. J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091544 · Cited by 110
“Multiple reports have shown a significantly promoted phagocytic capacity of phagocytes by probiotic supplementation as an immunomodulator [83].”
Background
Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials
Mazidi, M., Rezaie, P., Ferns, G. A., & Vatanparast, H. (2017) · Nutrients · doi:10.3390/nu9010020 · Cited by 107
“Several human studies have also recommended that lower doses of probiotics may be more effective and improve cellular immunity to the preferred extent [63].”
Background
Efficacy of Bifidobacterium longum alone or in multi-strain probiotic formulations during early life and beyond
Mills, S., Yang, B. K., Smith, G., Stanton, C., & Ross, R. P. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2186098 · Cited by 117
Effect of Lactobacillus plantarum enteral feeding on the gut permeability and septic complications in the patients with acute pancreatitis
Qin, H.-L., Zheng, J.-J., Tong, D.-N., Chen, W.-X., Fan, X.-B., Hang, X., & Jiang, Y.-Q. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602792 · Cited by 106
“One proposed mechanism is that probiotics initiate an immune response in the gut-associated lymphoid tissue, resulting in circulation of primed T and B cells and immune activation at distant mucosal surfaces (Perdigon et al., 1999; Gill et al., 2001).”
The inflammatory status of the elderly: The intestinal contribution
Schiffrin, E. J., Morley, J. E., Donnet‐Hughes, A., & Guigoz, Y. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.07.011 · Cited by 103
Antagonistic activity against pathogenic bacteria by human vaginal lactobacilli
Voravuthikunchai, S. P., Bilasoi, S., & Supamala, O. (2006) · Anaerobe · doi:10.1016/j.anaerobe.2006.06.003 · Cited by 104
Nutrition, geoepidemiology, and autoimmunity
Selmi, C. F., & Tsuneyama, K. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.12.001 · Cited by 100
“Cumulatively, it should be noted that the results of a human supplementation trial suggest that lower doses could be more effective immune modulators than higher doses [44].”
Background

Authors: Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K.
Affiliations: Massey University (NZ)
ORCID: Gopal, Pramod K
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2001-12
Volume: 74
Issue: 6
Pages: 833-839
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/74.6.833
OpenAlex: W1905558879
Cited by: 485
References: 40
Citations by year: 2026: 3 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 25 · 2021: 35 · 2020: 24 · 2019: 21 · 2018: 19 · 2017: 29 · 2016: 20 · 2015: 15 · 2014: 19 · 2013: 23 · 2012: 23
FWCI: 21.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7758 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, dietary supplementation, cell-mediated immunity, older adults, aging, T cells, natural killer cells, phagocytic activity, milk supplementation, immunosenescence
MeSH terms: Aged, Aged, 80 and over, Aging, Animals, Bifidobacterium, Female, Humans, Immunity, Cellular, Killer Cells, Natural, Leukocytes, Male, Middle Aged, Milk, Phagocytosis, Colony Count, Microbial, Dietary Supplements, Probiotics

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Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019

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