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Cited by 364Fatty Acid Research and HealthNutritional Studies and DietDiet, Metabolism, and Disease

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study

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Wang, Lu, Folsom, Aaron R, Zheng, Zhi-Jie, Pankow, James S, Eckfeldt, John H·2003·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/78.1.91
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Abstract

Background The results of some epidemiologic studies conducted by using questionnaires suggest that dietary fat composition influences diabetes risk. Confirmation of this finding with use of a biomarker is warranted.Objective We prospectively investigated the relation of plasma cholesterol ester (CE) and phospholipid (PL) fatty acid composition with the incidence of diabetes mellitus.Design In 2909 adults aged 45-64 y, plasma fatty acid composition was quantified by using gas-liquid chromatography and was expressed as a percentage of total fatty acids. Incident diabetes (n = 252) was identified during 9 y of follow-up.Results After adjustment for age, sex, baseline body mass index, waist-to-hip ratio, alcohol intake, cigarette smoking, physical activity, education, and parental history of diabetes, diabetes incidence was significantly and positively associated with the proportions of total saturated fatty acids in plasma CE and PL. The rate ratios of incident diabetes across quintiles of saturated fatty acids were 1.00, 1.36, 1.16, 1.60, and 2.08 (P = 0.0013) in CE and 1.00, 1.75, 1.87, 2.40, and 3.37 (P < 0.0001) in PL. In CE, the incidence of diabetes was also positively associated with the proportions of palmitic (16:0), palmitoleic (16:1n-7), and dihomo-gamma-linolenic (20:3n-6) acids and inversely associated with the proportion of linoleic acid (18:2n-6). In PL, incident diabetes was positively associated with the proportions of 16:0 and stearic acid (18:0).Conclusions The proportional saturated fatty acid composition of plasma is positively associated with the development of diabetes. Our findings with the use of this biomarker suggest indirectly that the dietary fat profile, particularly that of saturated fat, may contribute to the etiology of diabetes.

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Metadata

Authors
Wang, L., Folsom, A. R., Zheng, Z.-J., Pankow, J. S., & Eckfeldt, J. H.
Affiliations
Centers for Disease Control and Prevention (US)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2003-07
Volume
78
Issue
1
Pages
91-98
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/78.1.91
OpenAlex
W1955662609
Cited by
364
References
48
Citations by year
2026: 4 · 2025: 11 · 2024: 12 · 2023: 9 · 2022: 15 · 2021: 22 · 2020: 26 · 2019: 15 · 2018: 13 · 2017: 16 · 2016: 22 · 2015: 21 · 2014: 17 · 2013: 26 · 2012: 21
FWCI
8.77
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, 5r01hl040848-04, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
  • National Heart, Lung, and Blood Institute (N01-HC55022, N01-HC-55018, N01 HC 55020, N01 HC 55019, R01-HL-40848, ­N01-HC55016, N01‐HC‐55015)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
plasma fatty acid composition, diabetes incidence, saturated fatty acids, phospholipid fatty acids, dietary fat, middle-aged adults, linoleic acid, palmitic acid, stearic acid, dihomo-gamma-linolenic acid, palmitoleic acid
MeSH terms
Cholesterol Esters, Chromatography, Gas, Diabetes Mellitus, Dietary Fats, Fatty Acids, Female, Follow-Up Studies, Humans, Male, Middle Aged, Phospholipids, Prospective Studies, Incidence

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