Cited by 364Fatty Acid Research and HealthNutritional Studies and DietDiet, Metabolism, and Disease

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study

Open access

Wang, Lu, Folsom, Aaron R, Zheng, Zhi-Jie, Pankow, James S, Eckfeldt, John H·2003·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/78.1.91

Open this paper in CoChat — free account

Abstract

Background The results of some epidemiologic studies conducted by using questionnaires suggest that dietary fat composition influences diabetes risk. Confirmation of this finding with use of a biomarker is warranted.Objective We prospectively investigated the relation of plasma cholesterol ester (CE) and phospholipid (PL) fatty acid composition with the incidence of diabetes mellitus.Design In 2909 adults aged 45-64 y, plasma fatty acid composition was quantified by using gas-liquid chromatography and was expressed as a percentage of total fatty acids. Incident diabetes (n = 252) was identified during 9 y of follow-up.Results After adjustment for age, sex, baseline body mass index, waist-to-hip ratio, alcohol intake, cigarette smoking, physical activity, education, and parental history of diabetes, diabetes incidence was significantly and positively associated with the proportions of total saturated fatty acids in plasma CE and PL. The rate ratios of incident diabetes across quintiles of saturated fatty acids were 1.00, 1.36, 1.16, 1.60, and 2.08 (P = 0.0013) in CE and 1.00, 1.75, 1.87, 2.40, and 3.37 (P < 0.0001) in PL. In CE, the incidence of diabetes was also positively associated with the proportions of palmitic (16:0), palmitoleic (16:1n-7), and dihomo-gamma-linolenic (20:3n-6) acids and inversely associated with the proportion of linoleic acid (18:2n-6). In PL, incident diabetes was positively associated with the proportions of 16:0 and stearic acid (18:0).Conclusions The proportional saturated fatty acid composition of plasma is positively associated with the development of diabetes. Our findings with the use of this biomarker suggest indirectly that the dietary fat profile, particularly that of saturated fat, may contribute to the etiology of diabetes.

Integrity signals

Registry

Crossref · 10.1093/ajcn/78.1.91

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,325
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220
A short questionnaire for the measurement of habitual physical activity in epidemiological studies
Baecke, J. A. H., BUREMA, J., & Frijters, J. E. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.5.936 · Cited by 3,950
THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES
THE ARIC INVESTIGATORS (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115184 · Cited by 3,510
Untitled work
(1989) · PubMed · Cited by 3,139
Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974.
Kromann, N., & Green, A. (1980) · PubMed · Cited by 854
Dietary fat intake and risk of type 2 diabetes in women
Salmerón, J., Hu, F. B., Manson, J. E., Stampfer, M. J., Colditz, G. A., Rimm, E. B., & Willett, W. C. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1019 · Cited by 818
Epidemiological Studies in the Upernavik District, Greenland: Incidence of Some Chronic Diseases 1950–1974
Kromann, N., & Green, A. (1980) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1980.tb01221.x · Cited by 713
Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats
Storlien, L. H., Kraegen, E. W., Chisholm, D. J., Ford, G. L., Bruce, D. G., & Pascoe, W. S. (1987) · Science · doi:10.1126/science.3303333 · Cited by 648
Dietary Fat and Meat Intake in Relation to Risk of Type 2 Diabetes in Men
van Dam, R. M., Willett, W. C., Rimm, E. B., Stampfer, M. J., & Hu, F. B. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.417 · Cited by 593

Show all 48 references

Sorted by citations

Omega-3 Fatty Acids and Cardiovascular Disease
Mozaffarian, D., & Wu, J. H. Y. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.063 · Cited by 1,771
Omega-3 polyunsaturated fatty acids and their health benefits
Shahidi, F., & Ambigaipalan, P. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-111317-095850 · Cited by 1,390
Functional Roles of Fatty Acids and Their Effects on Human Health
Calder, P. C. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115595980 · Cited by 1,276
Dietary fats and prevention of type 2 diabetes
Risérus, U., Willett, W. C., & Hu, F. B. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.002 · Cited by 753
“In phospholipids, there was a positive association between SFA (palmitic and stearic acid) and diabetes risk [25].”
Background
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
Rhee, E. P., Cheng, S., Larson, M. G., Walford, G. A., Lewis, G. D., McCabe, E., Yang, E., Farrell, L., Fox, C. S., O’Donnell, C. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44442 · Cited by 647
“These data are consistent with prior studies of diabetes prediction, which have relied on the measurement of derivatized fatty acids, following hydrolysis of plasma lipids (19–22).”
Result
Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study
Forouhi, N. G., Koulman, A., Sharp, S. J., Imamura, F., Kröger, J., Schulze, M. B., Crowe, F. L., Huerta, J. M., Guevara, M., Beulens, J. W., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70146-9 · Cited by 557
Self-citation
Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations
Astrup, A. V., Magkos, F., Bier, D. M., Brenna, J. T., Otto, M. C. D. O., Hill, J. O., King, J. C., Mente, A., Ordovás, J. M., Volek, J. S., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.05.077 · Cited by 581
“Beyond its importance as a surrogate for de novo lipogenesis, palmitoleic acid levels in blood and adipose tissue are consistently and strongly linked to obesity and hypertriglyceridemia (67), hyperglycemia and type 2 diabetes (59,68,69), heart failure (60,70), and CVD mortality (61,70).”
Background
Japanese clinical practice guideline for diabetes 2019
Araki, E., Goto, A., Kondo, T., Noda, M., Noto, H., Origasa, H., Osawa, H., Taguchi, A., Tanizawa, Y., Tobe, K., et al. (2020) · Diabetology International · doi:10.1007/s13340-020-00439-5 · Cited by 545
The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling
Fu, S., Watkins, S. M., & Hotamışlıgil, G. S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.007 · Cited by 554
Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus
Mann, J. I., Leeuw, I. D., Hermansen, K., Karamanos, B. G., Karlström, B., Katsilambros, N. L., Riccardi, G., Rivellese, A. A., Rizkalla, S. W., Slama, G., et al. (2004) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/s0939-4753(04)80028-0 · Cited by 524
A European Evidence-Based Guideline for the Prevention of Type 2 Diabetes
Paulweber, B., Valensi, P. E., Lindström, J., Lalic, N. M., Greaves, C. J., McKee, M., Kissimova‐Skarbek, K., Liatis, S., Cosson, E., Szendroedi, J., et al. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0029-1240928 · Cited by 485
“However, the evidence for an increased risk associated with high glycemic index and high glycemic load diets is mixed [98 – 100 , 103 Low unsaturated/saturated fat ratio [105 – 107].”
A Review of Odd-Chain Fatty Acid Metabolism and the Role of Pentadecanoic Acid (C15:0) and Heptadecanoic Acid (C17:0) in Health and Disease
Jenkins, B., West, J. A., & Koulman, A. (2015) · Molecules · doi:10.3390/molecules20022425 · Cited by 455
Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study
Tanaka, T., Shen, J., Abecasis, G. R., Kisialiou, A., Ordovas, J. M., Guralnik, J. M., Singleton, A., Bandinelli, S., Cherubini, A., Arnett, D., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000338 · Cited by 418
“Epidemiological studies have shown that fatty acid consumption and plasma levels, in particular of the n-3 family, are associated with reduced risk of cardiovascular disease [5–7], diabetes [8–10], depression [11,12], and dementia [13].”
Background
Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes
Lytrivi, M., Castell, A., Poitout, V., & Cnop, M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.09.016 · Cited by 434
Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review
Schwab, U., Lauritzen, L., Tholstrup, T., Halldorsson, T. I., Risérus, U., Uusitupa, M. I. J., & Becker, W. (2014) · Food & Nutrition Research · doi:10.3402/fnr.v58.25145 · Cited by 408
Omega-3 fatty acids and incident type 2 diabetes: A systematic review and meta-analysis
Wu, J. H. Y., Micha, R., Imamura, F., Pan, A., Biggs, M. L., Ajaz, O., Djousse, L., B. Hu, F., & Mozaffarian, D. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001602 · Cited by 340
“However, EPA and DHA were not associated with risk of diabetes ((44)), and inclusion of this”
Influential
Japanese Clinical Practice Guideline for Diabetes 2019
Araki, E., Goto, A., Kondo, T., Noda, M., Noto, H., Origasa, H., Osawa, H., Taguchi, A., Tanizawa, Y., Tobe, K., et al. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13306 · Cited by 346
The role of diet in the prevention of type 2 diabetes
Salas‐Salvadó, J., Martínez‐González, M. Á., Bulló, M., & Ros, E. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.03.009 · Cited by 357
Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men
Warensjö, E., Risérus, U., & Vessby, B. (2005) · Diabetologia · doi:10.1007/s00125-005-1897-x · Cited by 344
“The serum fatty acid composition has been shown to predict the risk of diabetes and cardiovascular disease [10, 11] and recently it was closely related to components of the metabolic syndrome in a cross-sectional study [12].”
Background
Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes
Schröder, H. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.05.006 · Cited by 347
“[151] Wang L, Folsom AR, Zheng ZJ, Pankow JS, Eckfeldt JH.”
Background
Dietary fatty acids and cardiovascular disease: An epidemiological approach
Erkkilä, A. T., de Mello, V. D., Risérus, U., & Laaksonen, D. E. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.01.004 · Cited by 309
Metabolic Profiling of Plasma in Overweight/Obese and Lean Men using Ultra Performance Liquid Chromatography and Q-TOF Mass Spectrometry (UPLC−Q-TOF MS)
Kim, J. Y., Park, J. Y., Kim, O. Y., Ham, B. M., Kim, H., Kwon, D. Y., Jang, Y., & Lee, J. H. (2010) · Journal of Proteome Research · doi:10.1021/pr100101p · Cited by 292
Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid
Hodge, A. M., English, D. R., O’Dea, K., Sinclair, A. J., Makrides, M., Gibson, R. A., & Giles, G. G. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.1.189 · Cited by 287
Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study
Warensjö, E., Sundström, J., Vessby, B. O., Cederholm, T., & Risérus, U. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.203 · Cited by 281
Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam Study
Kröger, J., Zietemann, V., Enzenbach, C., Weikert, C., Jansen, E. H., Döring, F., Joost, H.-G., Boeing, H., & Schulze, M. B. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005447 · Cited by 270
Curcuminoids exert glucose‐lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double‐blind, placebo‐controlled trial
Na, L., Li, Y., Pan, H., Zhou, X., Sun, D., Meng, M., Li, X., & Sun, C. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200131 · Cited by 281
Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells
POWELL, D. J., TURBAN, S., GRAY, A., HAJDUCH, E., & HUNDAL, H. S. (2004) · Biochemical Journal · doi:10.1042/bj20040139 · Cited by 267
Plasma fatty acid composition is associated with the metabolic syndrome and low-grade inflammation in overweight adolescents
Platat, C., Drai, J., Oujaa, M., Schlienger, J.-L., & Simon, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.6.1178 · Cited by 263
“This contrasts with several studies in adults that related serum phospholipid SFAs to incident diabetes and to increased fasting and meal-induced insulinemia in healthy, obese, or diabetic adults (12, 32, 33).”
Result
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
Dimopoulos, N., Watson, M., Sakamoto, K., & Hundal, H. S. (2006) · Biochemical Journal · doi:10.1042/bj20060244 · Cited by 247
Fatty Acid Desaturation and the Regulation of Adiposity in Caenorhabditis elegans
Brock, T., Browse, J., & Watts, J. L. (2007) · Genetics · doi:10.1534/genetics.107.071860 · Cited by 234
“In humans, alterations in ratios of saturated to unsaturated fatty acids are associated with various diseases including diabetes, atherosclerosis, cancer, and obesity (Wang et al. 2003a,b; Warensjo et al. 2005; Bougnoux et al. 2006).”
Background
Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Norfolk cohort
Patel, P. S., Sharp, S. J., Jansen, E. H. J. M., Luben, R., Khaw, K., Wareham, N. J., & Forouhi, N. G. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29182 · Cited by 229
Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss
Hyde, P. N., Sapper, T. N., Crabtree, C. D., LaFountain, R. A., Bowling, M. L., Buga, A., Fell, B., McSwiney, F. T., Dickerson, R. M., Miller, V. J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.128308 · Cited by 210
“We therefore determined traits strongly linked to MetS including LDL subclass phenotype (12), accumulation of circulating SFAs (13, 14), palmitoleic acid (16:1n7) (15–17), and other fatty acid species associated with diabetes, CVD, and mortality (18, 19).”
BackgroundInfluential
Nutritional challenges and health implications of takeaway and fast food
Jaworowska, A., Blackham, T., Davies, I. G., & Stevenson, L. (2013) · Nutrition Reviews · doi:10.1111/nure.12031 · Cited by 230
“These findings were similar to those of 19 Wang et al.62 who in a 9 year follow up study of 2909 American participants (45 – 64 years of 20 age) showed the positive association between diabetes incidence and the proportion of total 21 SFAs in plasma cholesterol esters and phospholipids, which reflects dietary intake o…”
Result
Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus
Kaushik, M., Mozaffarian, D., Spiegelman, D. L., Manson, J. E., Willett, W. C., & Hu, F. B. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27424 · Cited by 210
Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study
Forouhi, N. G., Imamura, F., Sharp, S. J., Koulman, A., Schulze, M. B., Zheng, J., Ye, Z., Sluijs, I., Guevara, M., Huerta, J. M., et al. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002094 · Cited by 208
Self-citation
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
Demirkan, A., van Duijn, C. M., Ugocsai, P., Isaacs, A., Pramstaller, P. P., Liebisch, G., Wilson, J. F., Johansson, Å., Rudan, I., Aulchenko, Y. S., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002490 · Cited by 205
“Altered concentrations of circulating phospholipids have been implicated in the pathology of type 2 diabetes, dyslipidemia and cardiovascular disease [10–15], as well as a wide range of other common diseases including dementia and depression [16].”
Background
Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes
Cnop, M. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360348 · Cited by 207
Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance
Warensjö, E., Rosell, M., Hellénius, M.-L., Vessby, B. O., Fairé, U. D., & Risérus, U. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-37 · Cited by 212
“Serum fatty acids and desaturase indices have been related to obesity [7], insulin resistance [8], type-2-diabetes [9] and the metabolic syndrome [10].”
Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations
Kotronen, A., Velagapudi, V. R., Yetukuri, L., Westerbacka, J., Bergholm, R., Ekroos, K., Makkonen, J., Taskinen, M.-R., Orešič, M., & Yki-Järvinen, H. (2009) · Diabetologia · doi:10.1007/s00125-009-1282-2 · Cited by 198
Interorgan Metabolic Crosstalk in Human Insulin Resistance
Gancheva, S., Jeleník, T., Álvarez-Hernández, E., & Roden, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00015.2017 · Cited by 194
Diet composition and the risk of type 2 diabetes: epidemiological and clinical evidence
Parillo, M., & Riccardi, G. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041117 · Cited by 183
“…fat, has been recently conﬁrmed in a cross-sectional study on a European population (Thanopoulou et al. 2003) and is further supported by evidence from studies where dietary fat composition was assessed by objective markers of fat intake (Vessby et al. 1994; Laak-sonen, 2002; Wang et al. 2003).”
Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes
Djoussé, L., Gaziano, J. M., Buring, J. E., & Lee, I.-M. M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005603 · Cited by 186
“These results were similar to those from the ARIC study (16) and the Kouopio study (17) that also showed no association between marine omega-3 fatty acids or polyunsaturated fatty acids and T2D risk, respectively.”
BackgroundResult
Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra‐abdominal Adipose Tissue, and Serum
Kotronen, A., Seppänen‐Laakso, T., Westerbacka, J., Kiviluoto, T. A., Arola, J. T., Ruskeepää, A., Yki‐Järvinen, H., & Orešič, M. (2009) · Obesity · doi:10.1038/oby.2009.326 · Cited by 184
Nutrient Modification of the Innate Immune Response
Schwartz, E. A., Zhang, W.-Y., Karnik, S. K., Borwege, S., Anand, V. R., Laine, P. S., Su, Y., & Reaven, P. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.201681 · Cited by 180
Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study
Lemaître, R. N., Yu, C., Hoofnagle, A. N., Nair, H., Jensen, P. N., Fretts, A. M., Umans, J. G., Howard, B. V., Sitlani, C. M., Siscovick, D. S., et al. (2018) · Diabetes · doi:10.2337/db17-1449 · Cited by 184
International Analysis of the Nutritional Content and a Review of Health Benefits of Non-Dairy Plant-Based Beverages
Craig, W. J., & Fresán, U. (2021) · Nutrients · doi:10.3390/nu13030842 · Cited by 186
Dietary Fat Is Associated With Metabolic Syndrome in Japanese Brazilians
Freire, R. D., Cardoso, M. A., Gimeno, S. G. A., Ferreira, S. R. G., & for the Japanese-Brazilian Diabetes Study Group (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1779 · Cited by 169
Omega-3 polyunsaturated fatty acid and insulin sensitivity: A meta-analysis of randomized controlled trials
Akinkuolie, A. O., Ngwa, J. S., Meigs, J. B., & Djoussé, L. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.08.013 · Cited by 167
Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study
Ma, W., Wu, J. H. Y., Wang, Q., Lemaître, R. N., Mukamal, K. J., Djoussé, L., King, I. B., Song, X., Biggs, M. L., Delaney, J. A., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092601 · Cited by 166
sRAGE and Risk of Diabetes, Cardiovascular Disease, and Death
Selvin, E., Halushka, M. K., Rawlings, A. M., Hoogeveen, R. C., Ballantyne, C. M., Coresh, J., & Astor, B. C. (2013) · Diabetes · doi:10.2337/db12-1528 · Cited by 173
“standard time-to-diabetes definition based on the visit-based information (30,31) and self-reported information on diagnosed diabetes or glucose-lowering medication use obtained during a median of 12 years of annual telephone calls after visit 4 (32).”
Fasting Plasma Free Fatty Acids and Risk of Type 2 Diabetes
Pankow, J. S., Duncan, B. B., Schmidt, M. I., Ballantyne, C. M., Couper, D. J., Hoogeveen, R. C., & Golden, S. H. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.77 · Cited by 166
Self-citation
Glycerol and Fatty Acids in Serum Predict the Development of Hyperglycemia and Type 2 Diabetes in Finnish Men
Mahendran, Y., Cederberg, H., Vangipurapu, J., Kangas, A. J., Soininen, P., Kuusisto, J., Uusitupa, M. I. J., Ala‐Korpela, M., & Laakso, M. (2013) · Diabetes Care · doi:10.2337/dc13-0800 · Cited by 164
Plasma fatty acid composition and incident heart failure in middle-aged adults: The Atherosclerosis Risk in Communities (ARIC) Study
Yamagishi, K., Nettleton, J. A., & Folsom, A. R. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.06.017 · Cited by 155
“We have previously reported their associations with carotid artery intima-media thickness (11), hypertension (12), diabetes (13), CHD (14) and cognitive decline (15).”
Self-citation
Fatty acid profile of the erythrocyte membrane preceding development of Type 2 diabetes mellitus
Krachler, B., Norberg, M., Eriksson, J. W., Hallmans, G., Johansson, I., Vessby, B. O., Weinehall, L., & Lindahl, B. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.04.005 · Cited by 159
The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes
Ha, C. Y., Kim, J. Y., Paik, J. K., Kim, O. Y., Paik, Y., Lee, E. J., & Lee, J. H. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04244.x · Cited by 161
Investigating Potential Mechanisms of Obesity by Metabolomics
Xie, B., Waters, M. J., & Schirra, H. J. (2012) · BioMed Research International · doi:10.1155/2012/805683 · Cited by 152
“Furthermore, the serum FFA composition, especially the proportion of saturated fatty acids (SFAs), has been found to be positively associated with the development of obesity and diabetes [43].”
Background
Fatty acids and insulin sensitivity
Risérus, U. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f52708 · Cited by 149
Organic Production Enhances Milk Nutritional Quality by Shifting Fatty Acid Composition: A United States–Wide, 18-Month Study
Benbrook, C. M., Butler, G., Latif, M. A., Leifert, C., & Davis, D. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082429 · Cited by 155
Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals
Ni, Y., Zhao, L., Yu, H., Ma, X., Bao, Y., Rajani, C., Loo, L. W. M., Shvetsov, Y. B., Yu, H., Chen, T., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.09.004 · Cited by 139
“Palmitate in plasma phospholipid and erythrocyte membranes phospholipid was prospectively associated with higher diabetes risk in several longitudinal studies (Ma et al., 2015; Wang et al., 2003; Patel et al., 2010).”
Background
Dietary stearic acid and risk of cardiovascular disease: Intake, sources, digestion, and absorption
Kris‐Etherton, P. M., Griel, A. E., Psota, T., Gebauer, S. K., Zhang, J., & Etherton, T. D. (2005) · Lipids · doi:10.1007/s11745-005-1485-y · Cited by 137
Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention
Warensjö, E., Risérus, U., Gustafsson, I., Mohsen, R., Cederholm, T., & Vessby, B. O. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.11.002 · Cited by 139
Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men
Warensjö, E., Sundström, J., Lind, L., & Vessby, B. O. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.442 · Cited by 143
Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study
Corpeleijn, E., Feskens, E. J. M., Jansen, E. H. J. M., Mensink, M., Saris, W. H. M., de Bruin, T. W., & Blaak, E. E. (2006) · Diabetologia · doi:10.1007/s00125-006-0383-4 · Cited by 132
“In addition, prospective studies in healthy subjects have shown that a serum fatty acid profile of high saturated fatty acids or low unsaturated fatty acids can predict the development of type 2 diabetes [1, 6, 7].”
Background
Marine N-3 Polyunsaturated Fatty Acids Are Inversely Associated with Risk of Type 2 Diabetes in Asians: A Systematic Review and Meta-Analysis
Zheng, J.-S., Huang, T., Yang, J., Fu, Y.-Q., & Li, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044525 · Cited by 126
“Literature Search Twenty-four published studies [3,5–11,14–22,27,29–34] including 24,509 T2D patients and 545,275 participants were identified from a full-text examination of 97 potentially relevant studies (Figure 1), 1 study from Australia [5], 1 study from Cuba [19], 7 studies from Europe [7,14,17,21,22,27,33], 8 s…”
Background
Causes and cures for endoplasmic reticulum stress in lipotoxic β ‐cell dysfunction
Cnop, M., Ladrière, L., Igoillo‐Esteve, M., Moura, R. F., & Cunha, D. A. (2010) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01279.x · Cited by 150
“High circulating levels of saturated FFAs are predictive of later development of type 2 diabetes [11–13].”
Background
Enhancing Omega-3 Long-Chain Polyunsaturated Fatty Acid Content of Dairy-Derived Foods for Human Consumption
Nguyen, Q. V., Malau‐Aduli, B. S., Cavalieri, J., Nichols, P. D., & Malau‐Aduli, A. E. O. (2019) · Nutrients · doi:10.3390/nu11040743 · Cited by 129
“While some authors have recognised that n-3 PUFA intake can reduce the incidence of diabetes [79,80], the findings from a systematic review and meta-analysis reported by Wu et al.”
Background
Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets
Due, A., Larsen, T. M., Hermansen, K., Stender, S., Holst, J. J., Toubro, S., Martinussen, T., & Astrup, A. V. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.855 · Cited by 122
SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors
Sun, Q., Xing, X., Wang, H., Wan, K., Fan, R., Liu, C., Wang, Y., Wu, W., Wang, Y., & Wang, R. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115586 · Cited by 125
Metabolomics – the complementary field in systems biology: a review on obesity and type 2 diabetes
Bakar, M. H. A., Sarmidi, M. R., Cheng, K., Khan, A. A., Suan, C. L., Huri, H. Z., & Yaakob, H. (2015) · Molecular BioSystems · doi:10.1039/c5mb00158g · Cited by 120
Plasma omega-3 fatty acids and incident diabetes in older adults
Djoussé, L., Biggs, M. L., Lemaître, R. N., King, I. B., Song, X., Ix, J. H., Mukamal, K. J., Siscovick, D. S., & Mozaffarian, D. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.013334 · Cited by 120
Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study
Lemaitre, R. N., Fretts, A. M., Sitlani, C. M., Biggs, M. L., Mukamal, K., King, I. B., Song, X., Djoussé, L., Siscovick, D. S., McKnight, B., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.101857 · Cited by 117
Omega-3 polyunsaturated fatty acid biomarkers and risk of type 2 diabetes, cardiovascular disease, cancer, and mortality
Jiang, H., Wang, L., Wang, D., Yan, N., Li, C., Wu, M., Wang, F., Mi, B., Chen, F., Jia, W., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.06.034 · Cited by 120
Self-citation
Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway
Wu, J. H. Y., Lemaître, R. N., Manichaikul, A. W., Guan, W., Tanaka, T., Foy, M., Kabagambe, E. K., Djoussé, L., Siscovick, D. S., Fretts, A. M., et al. (2013) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.112.964619 · Cited by 113
Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications
Khan, I. R., Hussain, M., Jiang, B., Zheng, L., Pan, Y., Hu, J., Khan, A., Ashraf, A., & Zou, X. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101255 · Cited by 123
Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro
Moffitt, J. H., Fielding, B. A., Evershed, R. P., Berstan, R., Currie, J. M., & Clark, A. (2005) · Diabetologia · doi:10.1007/s00125-005-1861-9 · Cited by 114
“[22], this condition is not invariably linked to the onset of type 2 diabetes; fewer than 12% of obese subjects with elevated lipid profiles have diabetes [23, 24].”
Background
Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome
Volk, B. M., Kunces, L. J., Freidenreich, D. J., Kupchak, B. R., Saenz, C., Artistizabal, J. C., Fernandez, M. L., Bruno, R. S., Maresh, C. M., Kraemer, W. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113605 · Cited by 112
Plasma fatty acids as predictors of glycaemia and type 2 diabetes
Lankinen, M. A., Stančáková, A., Uusitupa, M. I. J., Ågren, J., Pihlajamäki, J., Kuusisto, J., Schwab, U., & Laakso, M. (2015) · Diabetologia · doi:10.1007/s00125-015-3730-5 · Cited by 115
Intake of jaboticaba peel attenuates oxidative stress in tissues and reduces circulating saturated lipids of rats with high-fat diet-induced obesity
Batista, Â. G., Lenquiste, S. A., Cazarin, C. B. B., da Silva-Maia, J. K., Luiz-Ferreira, Â., Bogusz, S., Hantao, L. W., Souza, R., Augusto, F., Prado, M. A., et al. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2013.11.011 · Cited by 114
Polymorphisms in the SCD1 Gene: Associations With Body Fat Distribution and Insulin Sensitivity
Warensjö, E., Ingelsson, E., Lundmark, P., Lannfelt, L., Syvänen, A., Vessby, B. O., & Risérus, U. (2007) · Obesity · doi:10.1038/oby.2007.206 · Cited by 107
Fish Consumption and Incidence of Diabetes
Xun, P., & He, K. (2012) · Diabetes Care · doi:10.2337/dc11-1869 · Cited by 114
Omega-3 fatty acids and incident type 2 diabetes: the Singapore Chinese Health Study
Brostow, D. P., Odegaard, A., Koh, W., Duval, S., Gross, M. D., Yuan, J., & Pereira, M. A. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.009357 · Cited by 105
“The ARIC study of cholesterol ester and phospholipid FA concentrations yielded a similar result (10).”
Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation
Çimen, İ., Kocatürk, B., Koyuncu, S., Tufanlı, Ö., Onat, U. İ., Yıldırım, A., Apaydın, O., Demirsoy, Ş., Aykut, G., Nguyen, U. T., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf9087 · Cited by 103
Review: The epidemiology of lifestyle and risk for type 2 diabetes
van Dam, R. M. (2003) · European Journal of Epidemiology · doi:10.1023/b:ejep.0000006612.70245.24 · Cited by 103
“Two studies examined the association between the fatty acid composition of serum cholesterol esters in relation to risk for type 2 diabetes [35, 36].”
Free Fatty Acids-Sensing G Protein-Coupled Receptors in Drug Targeting and Therapeutics
Yonezawa, T., Kurata, R., Yoshida, K., Murayama, M. A., Cui, X., & Hasegawa, A. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990168 · Cited by 104
Diet quality, change in diet quality and risk of incident CVD and diabetes
Xu, Z., Steffen, L. M., Selvin, E., & Rebholz, C. M. (2019) · Public Health Nutrition · doi:10.1017/s136898001900212x · Cited by 103
“For participants with self-reported newly diagnosed diabetes, the diagnosis date was assigned to the midpoint between the last visit without diabetes and the next visit with diabetes; for diabetes defined by blood glucose levels, the diagnosis date was estimated as the point when the serum glucose concentration crosse…”
Background
High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance
Kurotani, K., Sato, M., Ejima, Y., Nanri, A., Yi, S., Pham, N. M., Akter, S., Poudel‐Tandukar, K., Kimura, Y., Imaizumi, K., et al. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.07.004 · Cited by 101
Biosynthesis and metabolic engineering of palmitoleate production, an important contributor to human health and sustainable industry
Wu, Y., Li, R., & Hildebrand, D. F. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.05.001 · Cited by 97
“Non-esterified fatty acids (NEFAs) have been implicated strongly in diabetes development in tissues such as skeletal muscle [21,22].”
Evidence-based guideline of the German Nutrition Society: fat intake and prevention of selected nutrition-related diseases
Wolfram, G., Bechthold, A., Boeing, H., Ellinger, S., Hauner, H., Kroke, A., Leschik-Bonnet, E., Linseisen, J., Lorkowski, S., Schulze, M., et al. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000437243 · Cited by 94
Plasma Phospholipid Fatty Acid Biomarkers of Dietary Fat Quality and Endogenous Metabolism Predict Coronary Heart Disease Risk: A Nested Case‐Control Study Within the Women's Health Initiative Observational Study
Matthan, N. R., Ooi, E. M. M., Horn, L. V., Neuhouser, M. L., Woodman, R. J., & Lichtenstein, A. H. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000764 · Cited by 91
Saturated fatty acid biomarkers and risk of cardiometabolic diseases: A meta-analysis of prospective studies
Li, Z., Lei, H., Jiang, H., Fan, Y., Shi, J., Li, C., Chen, F., Mi, B., Ma, M., Lin, J., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.963471 · Cited by 90
Plasma metabolomics identified novel metabolites associated with risk of type 2 diabetes in two prospective cohorts of Chinese adults
Qiu, G., Zheng, Y., Wang, H., Sun, J., Ma, H., Xiao, Y., Li, Y., Yuan, Y. L., Yang, H., Li, X., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw221 · Cited by 89
The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population
Lee, T. C., Ivester, P., Hester, A. G., Sergeant, S., Case, L. D., Morgan, T. M., Kouba, E. O., & Chilton, F. H. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-196 · Cited by 93
“Discussion To date, randomized controlled and prospective population-based trials [32-35] that have assessed the impact of n-3 PUFAs on T2D and insulin sensitivity have provided inconsistent results regarding their effectiveness in preventing or treating T2D.”
Result
Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese
Zong, G., Zhu, J., Sun, L., Ye, X., Lu, L., Jin, Q., He, Z., Yu, Z., Zhu, Z., Li, H., et al. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.061218 · Cited by 87
Assessment of erythrocyte phospholipid fatty acid composition as a biomarker for dietary MUFA, PUFA or saturated fatty acid intake in a controlled cross-over intervention trial
Poppitt, S. D., Kilmartin, P. A., Butler, P. A. G., & Keogh, G. F. (2005) · Lipids in Health and Disease · doi:10.1186/1476-511x-4-30 · Cited by 93
Serum n–6 polyunsaturated fatty acids, Δ5- and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
Yary, T., Voutilainen, S., Tuomainen, T., Ruusunen, A. A., Nurmi, T., & Virtanen, J. K. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.128629 · Cited by 87
DEHP and DINP Induce Tissue- and Gender-Specific Disturbances in Fatty Acid and Lipidomic Profiles in Neonatal Mice: A Comparative Study
Huang, Y., Sun, F., Tan, H., Deng, Y., Sun, Z., Chen, H., Li, J., & Chen, D. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b04369 · Cited by 83
Longitudinal associations of serum fatty acid composition with type 2 diabetes risk and markers of insulin secretion and sensitivity in the Finnish Diabetes Prevention Study
the DPS Study Group, Takkunen, M. J., Schwab, U., de Mello, V. D., Eriksson, J. G., Lindström, J., Tuomilehto, J. O., & Uusitupa, M. I. J. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0911-4 · Cited by 83
The optimal diet for women with polycystic ovary syndrome?
Marsh, K. A., & Brand-Miller, J. C. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051475 · Cited by 79
“…have been found to have changes in the fatty acid pattern in serum cholesteryl esters (a marker of dietary fat intake) with a higher proportion of saturated fatty acids and lower proportions of linoleic acid (Salomaa et al. 1990; Vessby et al. 1994a,b; Öhrvall et al. 1996; Wang et al. 2003).”
Background
Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies
Mousavi, S. M., Jalilpiran‬, Y., Karimi, E., Aune, D., Larijani, B. A., Mozaffarian, D., Willett, W. C., & Esmaillzadeh, A. (2021) · Diabetes Care · doi:10.2337/dc21-0438 · Cited by 85
Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate
Ortega, Á., Berná, G., Rojas, A., Martín, F., & Soria, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061188 · Cited by 87
“In vitro approaches indicated that cis-palmitoleic acid can influence pancreatic β-cell survival, insulin secretion, skeletal muscle insulin response and adipocyte metabolism, On the other hand, prospective studies have shown a positive association between higher circulating palmitoleic acid and improved insulin sensi…”
Background

Authors: Wang, L., Folsom, A. R., Zheng, Z.-J., Pankow, J. S., & Eckfeldt, J. H.
Affiliations: Centers for Disease Control and Prevention (US)
ORCID: Wang, Lu
Folsom, Aaron R
Zheng, Zhi-Jie
Pankow, James S
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2003-07
Volume: 78
Issue: 1
Pages: 91-98
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/78.1.91
OpenAlex: W1955662609
Cited by: 364
References: 48
Citations by year: 2026: 4 · 2025: 11 · 2024: 12 · 2023: 9 · 2022: 15 · 2021: 22 · 2020: 26 · 2019: 15 · 2018: 13 · 2017: 16 · 2016: 22 · 2015: 21 · 2014: 17 · 2013: 26 · 2012: 21
FWCI: 8.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7168 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, 5r01hl040848-04, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
National Heart, Lung, and Blood Institute (N01-HC55022, N01-HC-55018, N01 HC 55020, N01 HC 55019, R01-HL-40848, N01-HC55016, N01‐HC‐55015)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: plasma fatty acid composition, diabetes incidence, saturated fatty acids, phospholipid fatty acids, dietary fat, middle-aged adults, linoleic acid, palmitic acid, stearic acid, dihomo-gamma-linolenic acid, palmitoleic acid
MeSH terms: Cholesterol Esters, Chromatography, Gas, Diabetes Mellitus, Dietary Fats, Fatty Acids, Female, Follow-Up Studies, Humans, Male, Middle Aged, Phospholipids, Prospective Studies, Incidence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks