Protein consumption is an important predictor of lower limb bone mass in elderly women
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Background The effect of protein intake on bone density is uncertain, and evidence exists for beneficial effects of both low and high protein intakes. Objective The objective was to study the relation between protein consumption and bone mass in elderly women with allowance for other lifestyle factors affecting bone metabolism. Design We conducted a cross-sectional and longitudinal study of a population-based sample of 1077 women aged 75 +/- 3 y. At baseline, protein consumption was measured with a food-frequency questionnaire, and bone mass and structure were measured by using quantitative ultrasound of the heel. One year later, hip bone mineral density (BMD) was measured by using dual-energy X-ray absorptiometry. Results Subjects consumed a mean (+/-SD) of 80.5 +/- 27.8 g protein/d (1.19 +/- 0.44 g protein/kg body wt). Regression analysis showed a positive correlation between protein intake and qualitative ultrasound of the heel and BMD after adjustment for age, body mass index, and other nutrients. The dose-response effect was best characterized by protein consumption expressed in tertiles, such that subjects in the lowest tertile (<66 g protein/d) had significantly lower qualitative ultrasound of the heel (1.3%) and hip BMD (2.6%) than did the subjects in the higher tertiles (>87 g protein/d). Conclusion These data suggest that protein intakes for elderly women above current recommendations may be necessary to optimize bone mass.
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In older people with osteoporosis, a systematic review, prospective cohort studies, and a randomized controlled trial found higher bone mineral density when protein intake was higher than 0.8 g/kg body weight per day or was 24% of total energy intake.
“In older people with osteoporosis, findings from a systematic review, 88 several prospective cohort studies, 89,90 and a randomized, controlled trial 91 (RCT) all found higher bone mineral density when protein intake was at levels higher than 0.8 g/kg BW/d or was 24% of total energy intake (Table 4).”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [89]
A 1-year prospective cohort study showed higher BMD with higher protein intake (>0.84 vs <0.84 g/kg BW/d).
“Devine 2005 89 >0.84 g/kg BW/d vs <0.84 g/kg BW/d 1-year prospective cohort study showing higher BMD with higher protein intake”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as Devine 2005
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- Authors
- Devine, A., Dick, I. M., Islam, A. F., Dhaliwal, S. S., & Prince, R. L.
- Affiliations
- Edith Cowan University (AU)
- Corresponding author
- Devine, Amanda
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 81
- Issue
- 6
- Pages
- 1423-1428
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1960408684
- Cited by
- 110
- References
- 56
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 8 · 2012: 11
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Australasian Journal of Paramedicine (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- Healthway (254627)
- Medical Research Council
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- protein intake, bone mass, bone mineral density, older women, hip bone density, bone metabolism, dose-response relationship
- MeSH terms
- Aged, Aging, Analysis of Variance, Bone and Bones, Calcaneus, Cross-Sectional Studies, Diet, Dietary Proteins, Dose-Response Relationship, Drug, Female, Humans, Longitudinal Studies, Nutritional Requirements, Pelvic Bones, Predictive Value of Tests, Surveys and Questionnaires, Ultrasonography, Cohort Studies, Absorptiometry, Photon, Bone Density, Osteoporosis, Postmenopausal, Body Mass Index
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