Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China
Open accessAbstract
Background In vitro and in vivo studies suggest that selected strains of probiotic bacteria can form tight complexes with aflatoxin B(1) and other carcinogens.Objective The aim of the present study was to determine whether administration of probiotic bacteria could block the intestinal absorption of aflatoxin B(1) and thereby lead to reduced urinary excretion of aflatoxin B(1)-N(7)-guanine (AFB-N(7)-guanine), a marker for a biologically effective dose of aflatoxin exposure. Elevated urinary excretion of this aflatoxin-DNA adduct is associated with an increased risk of liver cancer.Design Ninety healthy young men from Guangzhou, China, were randomly assigned to 2 groups; one group received a mixture of Lactobacillus rhamnosus LC705 and Propionibacterium freudenreichii subsp. shermanii strains 2 times/d for 5 wk, and the other group received a placebo preparation. The subjects provided 4 urine samples: at baseline, at 3 and 5 wk after starting the supplementation, and at the end of the 5-wk postintervention period.Results The percentage of samples with negative AFB-N(7)-guanine values tended to be higher in the probiotic group than in the placebo group during the 5-wk intervention period (odds ratio: 2.63, P = 0.052), and a statistically significant decrease in the concentration of urinary AFB-N(7)-guanine was observed in the probiotic group. The reduction was 36% at week 3 and 55% at week 5. The geometric means for the probiotic and placebo groups were 0.24 and 0.49 ng AFB-N(7)-guanine/mL, respectively, during the intervention period (P = 0.005).Conclusion A probiotic supplement reduces the biologically effective dose of aflatoxin exposure and may thereby offer an effective dietary approach to decrease the risk of liver cancer.
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The beneficial effect of bacteria is explained by increasing the amount of enzymes in food, which facilitates digestion and chelating of mycotoxins.
“The beneficial effect of bacteria is explained by increasing the amount of enzymes in food, which facilitates digestion and chelating of mycotoxins (El-Nezami et al. 2006).”
From Trends in designing microbial silage quality by biotechnological methods using lactic acid bacteria inoculants: a minireview. (2019) · cites this paper as El-Nezami et al. 2006
Use of feed contaminated with fungi mixed with bacterial cultures isolated from the gastrointestinal tract of poultry reduced deoxynivalenol by 55%.
“The use of feed contaminated with fungi mixed with bacterial cultures isolated from the gastrointestinal tract of poultry reduced deoxynivalenol by 55%.”
From Trends in designing microbial silage quality by biotechnological methods using lactic acid bacteria inoculants: a minireview. (2019) · cites this paper as El-Nezami et al. 2006
Two other lactobacilli strains in the form of a probiotic preparation reduced the absorption of AFB1.
“Two other lactobacilli strains in the form of a probiotic preparation reduced the absorption of AFB1.”
From Trends in designing microbial silage quality by biotechnological methods using lactic acid bacteria inoculants: a minireview. (2019) · cites this paper as El-Nezami et al. 2006
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- Authors
- El-Nezami, H. S., Polychronaki, N. N., Ma, J., Zhu, H., Ling, W., Salminen, E. K., Juvonen, R. O., Salminen, S. J., Poussa, T., & Mykkänen, H. M.
- Affiliations
- University of Turku (FI)
- Corresponding author
- El-Nezami, Hani S
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 83
- Issue
- 5
- Pages
- 1199-1203
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2164252115
- Cited by
- 184
- References
- 33
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 9 · 2023: 14 · 2022: 7 · 2021: 5 · 2020: 15 · 2019: 11 · 2018: 13 · 2017: 10 · 2016: 8 · 2015: 16 · 2014: 7 · 2013: 6 · 2012: 9
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, aflatoxin B1, liver cancer risk, Propionibacterium freudenreichii subsp. shermanii, dietary cancer prevention, young men
- MeSH terms
- China, Double-Blind Method, Guanine, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Placebos, Propionibacterium, Risk Factors, Biomarkers, Tumor, Aflatoxin B1, DNA Adducts, Probiotics, Lacticaseibacillus rhamnosus
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