The development of probiotic treatment in obesity: a review

Mekkes, M.C.; Weenen, T.C.; Brummer, R.J.; Claassen, E.

doi:10.3920/bm2012.0069

Cited by 87Probiotics and Fermented FoodsGut microbiota and healthInfant Nutrition and Health

The development of probiotic treatment in obesity: a review

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Mekkes, M.C., Weenen, T.C., Brummer, R.J., Claassen, E.·2014·Beneficial Microbes

DOI 10.3920/bm2012.0069

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Abstract

Recent studies suggested that manipulation of the composition of the microbial ecosystem in the gut might be a novel approach in the treatment of obesity. Such treatment might consist of altering the composition of the microbial communities of an obese individual by administration of beneficial microorganisms, commonly known as probiotics. Here, we intend to contribute to the developmental process of probiotic treatment of human obesity. The aim is to review the evidence regarding the potential effect of probiotic strains on reduction of weight and body fat. A literature study was conducted focusing on clinical trials that examined the effect of specific microorganisms on body weight control. Analysis of the eligible articles pointed out that Lactobacillus gasseri SBT 2055, Lactobacillus rhamnosus ATCC 53103, and the combination of L. rhamnosus ATCC 53102 and Bifidobacterium lactis Bb12 may reduce adiposity, body weight, and weight gain. This suggests that these microbial strains can be applied in the treatment of obesity. Furthermore, short chain fatty acid production and low grade inflammation were found as the underlying mechanisms of action that influence metabolism and affect body weight. These findings might contribute to the development of probiotic treatment of obesity. Further research should be directed to the most effective combination and dosage rate of probiotic microorganisms.

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Human and animal studies have established the ability to successfully populate the oral cavity or gastrointestinal tract with specific strains, combinations of bacteria, or bacteria genetically modified to produce enzymes or metabolites.
“While human and animal studies have established the ability to successfully populate the oral cavity or gastrointestinal tract with specific strains, combinations of bacteria, or bacteria genetically modified to produce enzymes or metabolites[74,404–407]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [405]
L. rhamnosus has been linked to beneficial effects in obesity and metabolic syndrome in humans.
“and beneficial effects in obesity and metabolic syndrome in humans[405,420].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [405]

Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Obesity and Overweight
Levesque, R. J. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-32132-5_447-2 · Cited by 4,059 · see citing works
National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants
Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050 · see citing works
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Human gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880 · see citing works
H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE
Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623 · see citing works
The Ribosomal Database Project (RDP-II): sequences and tools for high-throughput rRNA analysis
Cole, J. R. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki038 · Cited by 1,462 · see citing works
Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.
Roediger, W. E. (1980) · Gut · doi:10.1136/gut.21.9.793 · Cited by 1,310 · see citing works
The emerging epidemic of obesity in developing countries
Prentice, A. M. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi272 · Cited by 1,205 · see citing works
Glycan foraging in vivo by an intestine-adapted bacterial symbiont
Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1109051 · Cited by 1,184 · see citing works
Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
Kadooka, Y., Sato, M., Imaizumi, K., Ogawa, A., Ikuyama, K., Akai, Y., Okano, M., Kagoshima, M., & Tsuchida, T. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.19 · Cited by 700 · see citing works
The Epidemic of Obesity
Stein, C. J., & Colditz, G. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0288 · Cited by 635 · see citing works
Energy intake is associated with endotoxemia in apparently healthy men
Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 588 · see citing works
Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents
Santacruz, A., Marcos, A., Wärnberǵ, J., Martí, A., Martín‐Matillas, M., Campoy, C., Moreno, L. A., Veiga, Ó. L., Redondo-Figuero, C. G., Garagorri, J. M., et al. (2009) · Obesity · doi:10.1038/oby.2009.112 · Cited by 474 · see citing works
Gut microbiota: a potential new territory for drug targeting
Jia, W. P., Li, H., Zhao, L., & Nicholson, J. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2505 · Cited by 471 · see citing works
The gut microbiome as therapeutic target
Cani, P. D., & Delzenne, N. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.012 · Cited by 350 · see citing works
The environment within: how gut microbiota may influence metabolism and body composition
Vrieze, A., Holleman, F., Zoetendal, E. G., de Vos, W. M., Hoekstra, J. B. L., & Nieuwdorp, M. (2010) · Diabetologia · doi:10.1007/s00125-010-1662-7 · Cited by 347 · see citing works
Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans
Mehta, N. N., McGillicuddy, F. C., Anderson, P. D., Hinkle, C. C., Shah, R. D., Pruscino, L., Tabita‐Martinez, J., Sellers, K. F., Rickels, M. R., & Reilly, M. P. (2009) · Diabetes · doi:10.2337/db09-0367 · Cited by 347 · see citing works
Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents
Nadal, I., Santacruz, A., Marcos, A., Wärnberǵ, J., Garagorri, M., Moreno, L. A., Martín‐Matillas, M., Campoy, C., Martí, A., Moleres, A., et al. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.260 · Cited by 346 · see citing works
The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years
Luoto, R., Kalliomäki, M. A., Laitinen, K., & Isolauri, E. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.50 · Cited by 315 · see citing works
Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics
Geurts, L., Neyrinck, A. M., Delzenne, N. M., Knauf, C., & Cani, P. D. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0065 · Cited by 279 · see citing works
Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism
Caesar, R., Fåk, F., & Bäckhed, F. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02270.x · Cited by 253 · see citing works
Nutrient Utilization by Cells Isolated from Rat Jejunum, Cecum and Colon
Fleming, S. E., Fitch, M. D., DeVries, S. G., Liu, M., & Kight, C. E. (1991) · Journal of Nutrition · doi:10.1093/jn/121.6.869 · Cited by 168 · see citing works
Impact of dietary counselling and probiotic intervention on maternal anthropometric measurements during and after pregnancy: A randomized placebo-controlled trial
Ilmonen, J., Isolauri, E., Poussa, T., & Laitinen, K. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2010.09.009 · Cited by 144 · see citing works
Correspondence
Bukowska, H., Pieczul-Mróz, J., Jastrzebska, M. M., Chełstowski, K., & Naruszewicz, M. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00283-9 · Cited by 106 · see citing works
The randomized clinical trial: An unbeatable standard in clinical research?
Stel, V. S., Jager, K. J., Zoccali, C., Wanner, C., & Dekker, F. W. (2007) · Kidney International · doi:10.1038/sj.ki.5002354 · Cited by 44 · see citing works
Implication de la flore intestinale dans le métabolisme énergétique
Delzenne, N. M., & Cani, P. D. (2008) · médecine/sciences · doi:10.1051/medsci/2008245505 · Cited by 39 · see citing works
Effect of Weight Reduction on Cardiovascular Risk Factors and CD34-positive Cells in Circulation
Mikirova, N. A., Casciari, J. J., Hunninghake, R., & Beezley, M. M. (2011) · International Journal of Medical Sciences · doi:10.7150/ijms.8.445 · Cited by 35 · see citing works
A common core microbiota between obese individuals and their lean relatives? Evaluation of the predisposition to obesity on the basis of the fecal microflora profile
Elli, M., Colombo, O., & Tagliabue, A. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.03.022 · Cited by 33 · see citing works
Intestinal microbiota and overweight
Lyra, A., Lahtinen, S. J., Tiihonen, K., & Ouwehand, A. C. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0030 · Cited by 32 · see citing works
Economic consequences of overweight and obesity in Asia-Pacific
Reinhold, T., von Schultzendorff, A., & Müller‐Riemenschneider, F. (2011) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2011.02.004 · Cited by 8 · see citing works

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Belizário, J. E., & Napolitano, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01050 · Cited by 377 · see citing works
“The effect of the endogenous host microbiota on obesity and beneficial role of probiotics including L. rhamnosus and gasseri and Bifidobacterium lactis in the treatment of adiposity and obesity has been reviewed elsewhere (Mekkes et al., 2014).”
Background
Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases
Belizário, J. E., Faintuch, J., & Garay-Malpartida, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/2037838 · Cited by 341 · see citing works
“Lactobacillus rhamnosus in combination with Lactobacillus gasseri and Bifidobacterium lactis may reduce weight gain, in particular, fat tissue mass adiposity, in humans [87].”
Background
International Society of Sports Nutrition Position Stand: Probiotics
Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., Townsend, J. R., Lamprecht, M., West, N. P., Black, K., et al. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0329-0 · Cited by 277 · see citing works
Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice
Wang, Y., Dilidaxi, D., Wu, Y., Sailike, J., Sun, X., & Nabi, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109914 · Cited by 277 · see citing works
Microbiome and Gut Dysbiosis
Belizário, J. E., & Faintuch, J. (2018) · Experientia supplementum · doi:10.1007/978-3-319-74932-7_13 · Cited by 265 · see citing works
Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics
Evivie, S. E., Huo, G., Igene, J. O., & Bian, X. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1318034 · Cited by 189 · see citing works
Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
“It has also been linked to weight reduction, prevention of ischemia-reperfusion injury, and attenuation of cardiac hypertrophy and post-infarction heart failure in rodents [403,418,419], and beneficial effects in obesity and metabolic syndrome in humans [405,420].”
Background
Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial
Minami, J.-I., Kondo, S., Yanagisawa, N., Odamaki, T., Xiao, J., Abe, F., Nakajima, S., Hamamoto, Y., Saitoh, S., & Shimoda, T. (2015) · Journal of Nutritional Science · doi:10.1017/jns.2015.5 · Cited by 112 · see citing works
“Such treatment might consist of altering the composition of the microbial communities of an obese individual by administering beneficial micro-organisms, commonly known as probiotics((2)).”
Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group
Barazzoni, R., Deutz, N. E. P., Biolo, G., Bischoff, S., Boirie, Y., Cederholm, T., Cuerda, C., Delzenne, N., Leon Sanz, M., Ljungqvist, O., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.010 · Cited by 112 · see citing works
“In particular, dietary fibers interact with the gut microbiota and may reduce inflammation and unfavorable metabolic responses, thereby also reducing hepatic steatosis [41,62].”
Background
Potentiality of probiotic yoghurt as a functional food – a review
Sarkar, S. (2018) · Nutrition & Food Science · doi:10.1108/nfs-05-2018-0139 · Cited by 87 · see citing works
Lactobacillus casei loaded Soy Protein-Alginate Microparticles prepared by Spray-Drying
Hadzieva, J., Mladenovska, K., Crcarevska, M. S., Dodov, M. G., Dimchevska, S., Geškovski, N., Grozdanov, A., Popovski, E., Petrushevski, G., Chachorovska, M., et al. (2017) · Food Technology and Biotechnology · doi:10.17113/ftb.55.02.17.4991 · Cited by 68 · see citing works
Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice
Heo, J.-Y., Seo, M., Park, H., Lee, W. K., Guan, L. L., Yoon, J. H., Caetano-Anollés, K., Ahn, H., Kim, S., Kang, Y.-M., et al. (2016) · Scientific Reports · doi:10.1038/srep33566 · Cited by 55 · see citing works
“Some probiotic strains and probiotic mixtures were shown to be effective in weight loss, visceral adiposity, and related metabolic syndrome in animals 13,14,21 .”
Evaluation of immune response, microbiota, and blood markers after probiotic bacteria administration in obese mice induced by a high-fat diet
Núñez, I. N., Galdeano, C. M., de LeBlanc, A. D. M., & Perdigón, G. (2014) · Nutrition · doi:10.1016/j.nut.2014.03.025 · Cited by 53 · see citing works
Obesity increases the risk of small intestinal bacterial overgrowth ( SIBO )
Roland, B. C., Lee, D., Miller, L. S., Vegesna, A. K., Yolken, R. H., Severance, E. G., Prandovszky, E., Zheng, X., & Mullin, G. E. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13199 · Cited by 51 · see citing works
Antibiotic administration and the development of obesity in children
Principi, N., & Esposito, S. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2015.12.017 · Cited by 70 · see citing works
“Supplementation with Lactobacillus rhamnosus, Lactobacillus asseri, Bifidobacterium lactis, Lactobacillus curvatus HY7601 and actobacillus plantarum KY1032 in diet-induced obese mice was ound to be able to induce gut microbial changes, to reduce besity and to modulate genes associated with metabolism and nflammation i…”
Background
Awareness and Attitudes of Gut Health, Probiotics and Prebiotics in Australian Adults
Khalesi, S., Vandelanotte, C., Thwaite, T. L., Russell, A. M. T., Dawson, D. E., & Williams, S. L. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1783420 · Cited by 48 · see citing works
Probiotics
Mizock, B. A. (2015) · Disease-a-Month · doi:10.1016/j.disamonth.2015.03.011 · Cited by 40 · see citing works
The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., Nabi, X., Dilidaxi, D., Liu, L., & Sailike, J. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03303-4 · Cited by 39 · see citing works
“An increasing number of studies have shown that probiotics have enormous potential in treating metabolic diseases, such as diabetes and obesity [31, 32].”
Background
The association between antibiotics in the first year of life and child growth trajectory
Dawson-Hahn, E. E., & Rhee, K. E. (2019) · BMC Pediatrics · doi:10.1186/s12887-018-1363-9 · Cited by 36 · see citing works
Microbial Biosynthesis: A Repertory of Vital Natural Products
Abdel-Aziz, S. M., Elsoud, M. M. A., & Anise, A. A. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811372-1.00003-8 · Cited by 35 · see citing works
Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial
Sung, H.-K., Youn, S. J., Choi, Y., Eun, S., & Shin, S. M. (2022) · Nutrients · doi:10.3390/nu15010028 · Cited by 33 · see citing works
Gut carbohydrate metabolism instead of fat metabolism regulated by gut microbes mediates high-fat diet-induced obesity
Li, M., Gu, D., Xu, N., Lei, F., Du, L., Zhang, Y., & Xie, W. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0071 · Cited by 33 · see citing works
A combination of probiotics and whey proteins enhances anti-obesity effects of calcium and dairy products during nutritional energy restriction in aP2-agouti transgenic mice
Yoda, K., Sun, X., Kawase, M., Kubota, A., Miyazawa, K., Harata, G., Hosoda, M., Hiramatsu, M., He, F., & Zemel, M. B. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000914 · Cited by 33 · see citing works
“However, emerging data suggest that probiotics may also confer anti-obesity effects (19) .”
The effects of supplementation with blueberry, cyanidin-3-O-β-glucoside, yoghurt and its peptides on obesity and related comorbidities in a diet-induced obese mouse model
Shi, M. Y., Mathai, M. L., Xu, G., McAinch, A. J., & Su, X. Q. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.03.002 · Cited by 31 · see citing works
Natural Useful Therapeutic Products from Microbes
Gupta, C. (2014) · Journal of Microbiology & Experimentation · doi:10.15406/jmen.2014.01.00006 · Cited by 29 · see citing works
“presumably by breaking down bile in the gut, thus inhibiting its re-absorption (which enters the blood as cholesterol) [37].”
Background
Mouse Model of Anti-Obesity Effects of Blautia hansenii on Diet-Induced Obesity
Shibata, M., Ozato, N., TSUDA, H., Mori, K., Kinoshita, K., Katashima, M., Katsuragi, Y., Nakaji, S., & Maeda, H. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45090452 · Cited by 28 · see citing works
Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility
Henschel, A. M., Cabrera, S. M., Kaldunski, M. L., Jia, S., Geoffrey, R., Roethle, M. F., Lam, V., Chen, Y., Wang, X., Salzman, N. H., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190351 · Cited by 28 · see citing works
Influence of a multistrain probiotic on body composition and mood in female occupational shift workers
Smith‐Ryan, A. E., Mock, M. G., Trexler, E. T., Hirsch, K. R., & Blue, M. N. M. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0645 · Cited by 22 · see citing works
A 12-Week, Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial for the Evaluation of the Efficacy and Safety of Lactiplantibacillus plantarum SKO-001 in Reducing Body Fat
Shin, S. M., Park, J.-S., Kim, S., Cho, Y. H., Seo, H., & Lee, H. S. (2024) · Nutrients · doi:10.3390/nu16081137 · Cited by 21 · see citing works
Dose-dependent and strain-dependent anti-obesity effects of Lactobacillus sakei in a diet induced obese murine model
Ji, Y., Chung, Y. M., Park, S., Jeong, D., Kim, B., & Holzapfel, W. H. (2019) · PeerJ · doi:10.7717/peerj.6651 · Cited by 21 · see citing works
“Yet, the anti-obesity efficacy of probiotics has not been fully elucidated in spite of various clinical trials, and scientific evidence for a “minimal dose effect level” remains relatively sparse (Tanentsapf, Heitmann & Adegboye, 2011; Raoult, 2009; Mekkes et al., 2013).”
Background
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“Lactic acid bacteria (LAB), including lactobacilli and bifidobacteria, have been reported to support the maintenance of gut microbiota balance in humans and animals, regulate host immune response, and have hepatoprotective, anti-colitis, and anti-obesity activities [7-9].”
Background
Probiotic treatment (Bifidobacterium longum subsp. longum 35624™) affects stress responsivity in male rats after chronic corticosterone exposure
Haas, G. S., Wang, W., Saffar, M., Mooney‐Leber, S. M., & Brummelte, S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112718 · Cited by 21 · see citing works
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Kong, X., Wan, G., Tian, R., Liu, S., Liu, K., Clairmont, C. D., Lin, X., Zhang, X., Sherman, H. T., Zhu, J., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.587974 · Cited by 19 · see citing works
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Kouamé, K. J. E., Bora, A. F. M., Li, X., Liu, L., Coulibaly, I., Sun, Y., & Hussain, M. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102840 · Cited by 19 · see citing works
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Anti-obesity natural products
Arya, A., Nahar, L., Khan, H. U., & Sarker, S. D. (2020) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2020.02.006 · Cited by 15 · see citing works
Microbial metabolites and the vagal afferent pathway in the control of food intake
Raybould, H. E., & Zumpano, D. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113555 · Cited by 15 · see citing works
Oral and faecal microbiota in volunteers with hypertension in a double blind, randomised placebo controlled trial with probiotics and fermented bilberries
Xu, J., Ahrén, I. L., Olsson, C., Jeppsson, B. W., Ahrné, S., & Molin, G. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.07.005 · Cited by 15 · see citing works
Prevalence of Systemic Inflammation and Micronutrient Imbalance in Patients with Complex Abdominal Hernias
Geletzke, A. K., Rinaldi, J. M., Phillips, B. E., Mobley, S. B., Miller, J., Dykes, T., Hollenbeak, C., Kelleher, S. L., & Soybel, D. I. (2014) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-013-2431-y · Cited by 14 · see citing works
Mechanism of Action and Beneficial Effects of Probiotics in Amateur and Professional Athletes
Nami, Y., Barghi, A., Shahgolzari, M., Salehian, M., & Haghshenas, B. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4658 · Cited by 15 · see citing works
“…probiotic consumption and body weight adjustment in athletes is an evolving area of study, with potential mechanisms suggested by emerging evidence (Mekkes et al. 2014), including regulation of appetite, modulation of metabolism, influence on fat mass, anti-inflammatory effects, short-chain fatty…”
Transcriptome analysis of Lactobacillus rhamnosus GG strain treated with prebiotic - bovine lactoferrin under a cold environment
Liu, Z., Lin, C., & Chen, P. (2021) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.3369 · Cited by 14 · see citing works
“rhamnosus GG strain (ATCC 53103; LGG) was originally isolated from the human gastrointestinal tract as a probiotic bacterial strain [14,15], and it has been shown to exert a variety of biological activities including antibacterial activity against a variety of bacterial species [16,17], immune modulation activities [1…”
Background
Foreword
Venema, K. (2013) · Beneficial Microbes · doi:10.3920/bm2013.x001 · Cited by 12 · see citing works
Investigation of the probiotic supplement’s effect on obese adults demonstrated a reduction in fasting insulin levels: a double-blind randomized clinical trial
Hasani‐Ranjbar, S., Tavassol, Z. H., Malmir, H., Ejtahed, H., Ebrahimi, M. T., & Larijani, B. A. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01400-y · Cited by 11 · see citing works
“Here, the probiotics were selected based on review stud - ies on the probiotics’ effect on diabetes and obesity manage - ment [ 13 – 15 ].”
Study of Probiotic Effects of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus plantarum 299v Strains on Biochemical and Morphometric Parameters of Rabbits after Obesity Induction
Bouaziz, A., Dib, A. L., Lakhdara, N., Kadja, L., Espigares, E., Moreno, E., Bouaziz, O., & Gagaoua, M. (2021) · Biology · doi:10.3390/biology10020131 · Cited by 11 · see citing works
“Studies on animals have shown that the consumption of probiotics could treat and/or prevent obesity [90].”
BackgroundInfluential
Industry funding effect on positive results of probiotic use in the management of acute diarrhea: a systematized review
Saa, C., Bunout, D., & Hirsch, S. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001322 · Cited by 10 · see citing works
Correlation of Gut Microbiota with Children Obesity and Weight Loss
Peng, L., Chen, Y., Qu, F., Zhong, Y., & Jiang, Z. (2023) · Indian Journal of Microbiology · doi:10.1007/s12088-023-01088-3 · Cited by 9 · see citing works
Food Science without Borders
Knorr, D., & Khoo, C. S. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00033 · Cited by 8 · see citing works
Lactic Acid Bacteria as Potential Probiotics
Sadiq, M. B. (2022) · doi:10.1002/9781119702160.ch3 · Cited by 8 · see citing works
Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity
Tian, J., Liu, H., Guo, H., Han, W., Ding, H. J., & Chen, T. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9488 · Cited by 6 · see citing works
“Moreover, mouse experiments have reported that, treatments with lactic acid bacteria, Bifidobacteria, Lactobacillus rhamnosus and other probi‐ otics in food‐borne obese mice can produce changes in the gut microbial compositions, thereby decreasing the risk of overweight and obesity (30,31).”
Background
Gut Microbiota and Inflammatory Disorders
Krishna, V., Kumar, N., & Banerjee, S. (2021) · Current Drug Targets · doi:10.2174/1389450122666210623125603 · Cited by 6 · see citing works
Childhood Obesity
Koletzko, B. V. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2016.tb00031.x · Cited by 6 · see citing works
Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults–A Double‐Blind Trial
Santamarina, A. B., Filho, V. N., de Freitas, J. A., Franco, L. A. M., Martins, R. C. R., Fonseca, J. V. D. S., Turri, J. A. O., Hufnagel, M. T., Demarque, D. P., da Silva, B. F. R. B., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400806 · Cited by 5 · see citing works
“Lactobacilli are known for their probiotic activity, enhancing the production of lactic acid and other SCFAs like acetate and butyrate, which influence gut health and immune regulation [90].”
Antiobesity Effect of Dead Lactobacillus plantarum nF1 on High-Fat Diet-Induced C57BL/6 Mice
Lee, X., Hong, G.-H., Lee, S., Noh, H. C., & Park, K. (2022) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2022.51.11.1119 · Cited by 5 · see citing works
Microbes as a Source for the Production of Food Ingredients
Gupta, C., & Prakash, D. (2017) · doi:10.1002/9781119048961.ch6 · Cited by 4 · see citing works
Cost-benefit relation of diet and probiotics in iatrogenic bowel irregularity (IBI)
Claassen, E. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00014 · Cited by 3 · see citing works
“Here, we would like to put both the clinical and economic impact of this paper in a broader “state of the art” context, by adding alternative new insights and references not yet available to the Lenoir-Wijnkoop paper.”
Background
Gut Homeostasis; Microbial Cross Talks in Health and Disease Management
Khatri, G. S., Kurian, C., Anand, A., & Paari, K. A. (2021) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.9.3.28 · Cited by 3 · see citing works
Leuconostoc mesenteroides utilizes glucose fermentation to produce electricity and ameliorates high-fat diet-induced abdominal fat mass
Pham, M. T., Tran, T. D., & Zayabaatar, E. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03281-2 · Cited by 3 · see citing works
The Effects of Probiotic Supplementation in Active Men and Women
António, J., Leaf, A., Evans, C., Ellerbroek, A., Axelrod, C. H., Silver, T. A., Burgess, V., & Peacock, C. A. (2018) · Journal of Exercise and Nutrition · Cited by 3 · see citing works
Oat arabinoxylan promoted Lactobacillus gasseri to alleviate metabolic disorders in high-fat diet-induced obese mice
Zhang, Y., Zhou, M., Zhou, Y., & Guan, X. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250379 · Cited by 2 · see citing works
Перспективи використання пробіотиків якмодуляторів кишкової мікробіоти при ожирінні (оглядлітератури)
Miloslavsky, D. К., & Koval, S. M. (2022) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.18.6.2022.1207 · Cited by 2 · see citing works
Gastroenterology Disease and Lifestyle Medicine
FRIEDMAN, G. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-24687-1_30 · Cited by 2 · see citing works
Applications of Microbes in Human Health
Jasmine, S., Sankarapandian, V., Vijayakumar, N., Krishnamoorthy, R., & Thangavelu, A. (2022) · Environmental and microbial biotechnology · doi:10.1007/978-981-16-2225-0_11 · Cited by 2 · see citing works
Foreword
Venema, K. (2014) · Beneficial Microbes · doi:10.3920/bm2014.x001 · Cited by 2 · see citing works
Lactic Acid Bacteria in Fermented Foods
Cheng, Z., Li, H., Sun, J., Sun, B., & Wang, B. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1014577 · Cited by 1 · see citing works
Prebiotics and probiotics as novel therapeutic agents for obesity
Burton-Shepherd, A. (2015) · Nurse Prescribing · doi:10.12968/npre.2015.13.3.136 · Cited by 1 · see citing works
Control of Weight: How Do We Get Fat?
Sweeting, A., & Caterson, I. D. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch9 · Cited by 1 · see citing works
Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction studyPreprint
Liu, L., Cheng, B., Wen, Y. F., Jia, Y., Cheng, S., Liang, C., Chu, X., Ye, J., Yao, Y., Dai, X., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-113419/v1 · Cited by 1 · see citing works
“Various biological function of Lactobacillales has been explored, including treating obesity [43], enhancing muscle strength and function[37], improving insulin sensitivity[44].”
Background
Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico.
Nishiyama, S. A. B. (2013) · doi:10.11606/t.42.2013.tde-26062014-141424
Health Effects of Pro- and Prebiotics: Utilization of Sophisticated In Vitro Tools
Venema, K. (2015) · Microbiology monographs · doi:10.1007/978-3-319-23213-3_1
“2014), necrotizing enterocolitis in neonates (Parker 2014), obesity (Mekkes et al. 2014), and its associated diseases, such as nonalcoholic liver disease (Yasutake et al.”
Background
Machen Darmbakterien dick?
Schumacher, B. (2014) · Pädiatrie · doi:10.1007/s15014-014-0508-z
Machen Darmbakterien dick?
Schumacher, B. (2015) · gynäkologie + geburtshilfe · doi:10.1007/s15013-015-0648-4
A gut reaction
Hasan, D., & Reilly, K. (2016) · University of Western Ontario Medical Journal · doi:10.5206/uwomj.v85i1.4200
Peer Review #2 of "Dose-dependent and strain-dependent anti-obesity effects of Lactobacillus sakei in a diet induced obese murine model (v0.1)"
(2019) · PeerJ · doi:10.7287/peerj.6651v0.1/reviews/2
Peer Review #1 of "Dose-dependent and strain-dependent anti-obesity effects of Lactobacillus sakei in a diet induced obese murine model (v0.1)"
(2019) · PeerJ · doi:10.7287/peerj.6651v0.1/reviews/1
Effect of Probiotic Dairy Consumption on Obesity and Overweight: A Systematic Review and Meta-Analysis
Vafaei, A., Farid, M., Natanzi, M. M., & Khodaii, Z. (2022) · ملیون. · doi:10.61186/sjrm.7.4.259
Additional file 7 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471715
Additional file 2 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471700
Additional file 4 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471706
Additional file 9 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471721
Additional file 6 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471712
Additional file 3 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471703
Additional file 8 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471718
Additional file 5 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471709
Additional file 1 of The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
Manaer, T., Yu, L., 新华·那比, Dilidaxi, D., Liu, L., & Sailike, J. (2021) · Figshare · doi:10.6084/m9.figshare.14471697
Hypolipidemic activity of Limosilactobacillus fermentum SHY0004 from Miao sour soup
Ren, Z., Wang, J., Chen, J., Zhang, Y., Tong, T., Wang, F., Zhang, Z., Ouyang, Z., Li, Y., Liu, D., et al. (2026) · BMC Microbiology · doi:10.1186/s12866-026-04798-y
Mécanismes moléculaires régulant l'action du glucagon-like peptide one dans la physiopathologie du diabète de type 2
Grasset, E. (2016) · theses.fr (ABES) · doi:10.70675/e5821324ze30ez4b18z84d4zb8a6264141d3
Probiotics improve obesity development and modulate gut microbiota in rabbits and their offsprings
Bouaziz, A., Dib, A. L., Monnoye, M., Kadja, L., Espigares, E., & Gérard, P. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107344

Is It Time to Use Probiotics to Prevent or Treat Obesity?
Brusaferro, A., Cozzali, R., Orabona, C., Biscarini, A., Farinelli, E., Cavalli, E., Grohmann, U., Principi, N., & Esposito, S. (2018) · Nutrients · doi:10.3390/nu10111613 · Cited by 102 · see citing works
Probiotics and Its Application in Obesity as the Most Important Cardiovascular Risk: A Review
Pashapour, P. (2026) · Plant Biotechnology Persa · doi:10.66224/pbp.8.2.8
Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials
Crovesy, L., Ostrowski, M., Ferreira, D. M., Rosado, E. L., & Soares-Mota, M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.161 · Cited by 243 · see citing works
Efectividad de los probioticos como estrategia terapéutica para modificar la micro-biota intestinal en pacientes adultos obesos: Artículo de revisión
Guachi-Chango, T., & Aguilar-Salazar, A. F. (2023) · Ciencia Ecuador
Effect of probiotics on the obese patient. A review study
Crespata, M. A. M., & Robayo, C. P. V. (2023) · Salud Ciencia y Tecnología - Serie de Conferencias · doi:10.56294/sctconf2023549

Authors: Mekkes, M. C., Weenen, T. C., Brummer, R. J., & Claassen, E.
Affiliations: Vrije Universiteit Amsterdam (NL)
Erasmus MC (NL)
Örebro University (SE)
ORCID: Weenen, T.C.
Brummer, R.J.
Claassen, E.
Venue: Beneficial Microbes
Publisher: Walter de Gruyter GmbH
Published: 2014-03-01
Volume: 5
Issue: 1
Pages: 19-28
ISSN: 1876-2883 (ISSN-L)
1876-2891
DOI: 10.3920/bm2012.0069
OpenAlex: W1967724197
Cited by: 87
References: 37
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 16 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 6 · 2013: 3
FWCI: 1.20
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: Beneficial Microbes (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
VU Research Portal (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, obesity, gut microbiota, Lactobacillus gasseri, Lactobacillus rhamnosus, Bifidobacterium animalis subsp. lactis, weight loss, adiposity, short-chain fatty acids, low-grade inflammation, weight gain prevention, probiotic dosage
MeSH terms: Adipose Tissue, Bifidobacterium, Body Weight, Fatty Acids, Volatile, Humans, Inflammation, Lactobacillus, Obesity, Weight Loss, Probiotics, Gastrointestinal Tract, Adiposity, Microbiota

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The development of probiotic treatment in obesity: a review

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