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Effects of n−3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation
Open accessAbstract
Background Effects of fish oil supplements on metabolic variables are insufficiently clarified in type 2 diabetes.Objective We aimed to investigate short-term (1 wk) and longer-term (9 wk) effects of n-3 fatty acids.Design Twenty-six subjects with type 2 diabetes without hypertriacylglycerolemia participated in a double-blind controlled study. Median intake in the intervention group was 17.6 mL fish oil/d (1.8 g 20:5n-3, 3.0 g 22:6n-3, and 5.9 g total n-3 fatty acids). The control group received 17.8 mL corn oil/d (8.5 g 18:2n-6).Results Plasma phospholipid 20:5n-3 and 22:6n-3 increased, whereas 18:2n-6 decreased, in the fish oil group compared with the corn oil group after 1 wk. The two n-3 fatty acids also increased in adipose tissue biopsy samples taken after 9 wk in the fish oil group. Glucose concentrations (home-monitored) were approximately 1 mmol/L higher in the fish oil group than in the corn oil group at the end of the intervention (P = 0.035). Glucose utilization measured by using an isoglycemic clamp was lowered in the fish oil group compared with that in the corn oil group at the end of the intervention (P = 0.049), whereas glucagon-stimulated C-peptide tended to increase (P = 0.078). The fish oil group utilized less fat for oxidation after 1 wk, with a change to more fat and less carbohydrate oxidation after 9 wk (P = 0.040), than did the corn oil group.Conclusion A high intake of fish oil moderately increases blood glucose and decreases insulin sensitivity in persons with type 2 diabetes without hypertriacylglycerolemia and alters carbohydrate and fat utilization in a time-dependent manner.
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“rather, increased hepatic fatty acid oxidation is likely.”
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“Clinical studies have shown that OM3FA treatment increases fatty acid oxidation, as determined by indirect calorimetry [35, 36].”
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“Mostad and colleagues (2006) observed that the short term response to intake of omega-3 PUFAs was a decrease in fat oxidation but the opposite effect was observed after nine weeks [92].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [92]
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Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
Pocock, S. J., & Simon, R. (1975) · Biometrics · doi:10.2307/2529712 · Cited by 2,350
Omega-3 fatty acids in health and disease and in growth and development.
Simopoulos, A. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.438 · Cited by 2,162
Analysing controlled trials with baseline and follow up measurements
Vickers, A. J., & Altman, D. G. (2001) · BMJ · doi:10.1136/bmj.323.7321.1123 · Cited by 2,116
Davis, H. S. (1966) · JAMA · doi:10.1001/jama.1966.03100200106038 · Cited by 1,719
The theoretical bases of indirect calorimetry: A review
Ferrannini, E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90110-2 · Cited by 1,604
Vessby, B., Uusitupa, M., Hermansen, K., Riccardi, G., Rivellese, A. A., Tapsell, L. C., Nälsén, C., Berglund, L., Louheranta, A., Rasmussen, B. M., et al. (2001) · Diabetologia · doi:10.1007/s001250051620 · Cited by 1,119
Groop, L. C., Bonadonna, R. C., DelPrato, S., Ratheiser, K., Zyck, K., Ferrannini, E., & DeFronzo, R. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114142 · Cited by 812 · cited 3×
“There were no differences in the concentrations of FFAs between samples with and without paraoxon .”
BackgroundHow to measure insulin sensitivity
Ferrannini, E., & Mari, A. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816070-00001 · Cited by 510
Effect of Eicosapentaenoic and Docosahexaenoic Acids on Blood Pressure in Hypertension
Bønaa, K. H., Bjerve, K. S., Straume, B., Gram, I. T., & Thelle, D. S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003223221202 · Cited by 411
Self-citationDietary fats and insulin action
Storlien, L. H., Baur, L. A., Kriketos, A. D., Pan, D. A., Cooney, G. J., Jenkins, A. B., Calvert, G. D., & Campbell, L. V. (1996) · Diabetologia · doi:10.1007/bf00418533 · Cited by 354
Grimsgaard, S., Bonaa, K., Hansen, J., & Nordøy, A. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.3.649 · Cited by 300
Fish oil supplementation in type 2 diabetes: a quantitative systematic review.
Montori, V. M., Farmer, A. A., Wollan, P. C., & Dinneen, S. F. (2000) · Diabetes Care · doi:10.2337/diacare.23.9.1407 · Cited by 241
Beynen, A., & Katan, M. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.2.317 · Cited by 206
Very-long-chain n−3 fatty acids as biomarkers for intake of fish and n−3 fatty acid concentrates
Andersen, L., Solvoll, K., & Drevon, C. A. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.3.305 · Cited by 182
Effects of Fish Oil Supplementation on Glucose and Lipid Metabolism in NIDDM
Borkman, M., Chisholm, D. J., Furler, S. M., Storlien, L. H., Kraegen, E. W., Simons, L. A., & Chesterman, C. N. (1989) · Diabetes · doi:10.2337/diab.38.10.1314 · Cited by 159
Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans
Bonadonna, R. C., Groop, L. C., Zych, K., Shank, M., & DeFronzo, R. A. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.5.e736 · Cited by 149 · cited 1×
“However, plasma FFA concentrations generally reflect the rate of generation of fatty acids rather than their rate of removal (46).”
BackgroundAnalysis of techniques to obtain plasma for measurement of levels of free fatty acids
Zambon, A., Hashimoto, S., & Brunzell, J. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39687-5 · Cited by 143
Evaluation of an electrochemical sensor for measuring blood ketones.
Byrne, H. A., Tieszen, K. L., Hollis, S., Dornan, T., & New, J. P. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.500 · Cited by 138
Davis, T. M. E., Wright, A. D., Mehta, Z., Cull, C. A., STRATTON, I. M., Bottazzo, G. F., Bosi, E., Mackay, I. R., & Holman, R. R. (2005) · Diabetologia · doi:10.1007/s00125-005-1690-x · Cited by 118
Luo, J., Rizkalla, S. W., Vidal, H., Oppert, J., Colas, C., Boussairi, A., Guerre-Millo, M., Chapuis, A.-S., Chevalier, A., Durand, G., et al. (1998) · Diabetes Care · doi:10.2337/diacare.21.5.717 · Cited by 114
Adipose tissue fatty acids and risk of myocardial infarction—a case-control study
Pedersen, J., Ringstad, J., Almendingen, K., Haugen, T. S., Stensvold, I., & Thelle, D. S. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601064 · Cited by 105
McManus, R. M., Jumpson, J., Finegood, D. T., Clandinin, M. T., & Ryan, E. A. (1996) · Diabetes Care · doi:10.2337/diacare.19.5.463 · Cited by 103
Effect of Fish Oil Concentrate on Lipoprotein Composition in NIDDM
Schectman, G., Kaul, S., & Kissebah, A. H. (1988) · Diabetes · doi:10.2337/diab.37.11.1567 · Cited by 102
Annuzzi, G., Rivellese, A. A., Capaldo, B., Marino, L., Iovine, C., Marotta, G., & Riccardi, G. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90233-s · Cited by 96
Sirtori, C., Paoletti, R., Mancini, M., Crepaldi, G., Manzato, E., Rivellese, A. A., Pamparana, F., & Stragliotto, E. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.6.1874 · Cited by 89
Boberg, M., Pollare, T., Siegbahn, A., & Vessby, B. (1992) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1992.tb01424.x · Cited by 81
Effects of fish oil on metabolic responses to oral fructose and glucose loads in healthy humans
Delarue, J., Couet, C., Cohen, R., Bréchot, J.-F., Antoine, J. M., & Lamisse, F. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e353 · Cited by 80
The Hypotriglyceridemic Effect of Fish Oil in Adult‐Onset Diabetes without Adverse Glucose Control a
Connor, W. E., PRINCE, M. J., Ullmann, D., Riddle, M. C., Hatcher, L. F., SMITH, F. E., & Wilson, D. A. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35725.x · Cited by 79
Effects of Fish Oil Supplements in NIDDM Subjects: Controlled Study
Hendra, T. J., Britton, M. E., Roper, D. R., Wagaine‐Twabwe, D., Jeremy, J., Dandona, P., Haines, A., & Yudkin, J. S. (1990) · Diabetes Care · doi:10.2337/diacare.13.8.821 · Cited by 77
Puhakainen, I., Ahola, I., & Yki‐Järvinen, H. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.1.121 · Cited by 76
Axelrod, L., Camuso, J. M., Williams, E., KLEINMAN, K. P., BRIONES, E. R., & Schoenfeld, D. (1994) · Diabetes Care · doi:10.2337/diacare.17.1.37 · Cited by 69
Quality of dietary fatty acids, insulin sensitivity and type 2 diabetes
Rivellese, A. A., & Lilli, S. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00003-9 · Cited by 67
Vessby, B., & Boberg, M. (1990) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1990.tb00211.x · Cited by 64
Westerveld, H. T., de Graaf, J. C., van Breugel, H. H. F. I., Akkerman, J. W. N., Sixma, J. J., Erkelens, D. W., & Banga, J. D. (1993) · Diabetes Care · doi:10.2337/diacare.16.5.683 · Cited by 64
A computer program for randomizing patients with near-even distribution of important parameters
Jensen, C. V. (1991) · Computers and Biomedical Research · doi:10.1016/0010-4809(91)90018-r · Cited by 45
A Comparison of Fish Oil or Corn Oil Supplements in Hyperlipidemic Subjects with NIDDM
Morgan, W. A., Raskin, P., & Rosenstock, J. (1995) · Diabetes Care · doi:10.2337/diacare.18.1.83 · Cited by 41
Omega‐3 and Omega‐6 Fatty Acids in the Insulin Resistance Syndrome
Rustan, A. C., Nenseter, M. S., & Drevon, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51844.x · Cited by 34
Genotypic and phenotypic fatty acid composition in the tissues of salmon, Salmo salar
Viga, A., & Grahl‐Nielsen, O. (1990) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(90)90220-n · Cited by 34
Gottsäter, A., Landin‐Olsson, M., Fernlund, P., Gullberg, B., Lernmark, Å., & Sundkvist, G. (1992) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519209115506 · Cited by 34
Metabolic Effects of Omega‐3 Fatty Acids in Type 2 (Non‐Insulin‐Dependent) Diabetic Patients
Pelikánová, T., Kohout, M., Válek, J., Kazdová, L., & Baše, J. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35716.x · Cited by 33
Popp‐Snijders, C., & Blonk, M. C. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.2.360 · Cited by 25
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Hodson, L., Skeaff, C. M., & Fielding, B. A. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.03.003 · Cited by 1,344
“Although the evidence reporting changes in the fatty acid composition of adipose tissue is limited it does suggest that detectable changes can be measured, in weight stable individuals, within a few months of a change in PUFA intake [171,179].”
BackgroundInfluentialDietary fats and prevention of type 2 diabetes
Risérus, U., Willett, W. C., & Hu, F. B. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.002 · Cited by 753
“Moreover, a recent report indicated that high doses of n-3 FA (fish oil) may even impair insulin action in subjects with type 2 diabetes [57].”
BackgroundEFSA Panel on Dietetic Products, N. A. A. (. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2815 · Cited by 372
“3 g DPA) for nine weeks (Mostad et al., 2006) reported a marginal decrease in glucose utilisation during the euglycemic hyperinsulinaemic clamp in the fish oil group (n=13) compared to the maize oil group (n=14; p=0.”
BackgroundInfluentialMacronutrients, Food Groups, and Eating Patterns in the Management of Diabetes
Wheeler, M. L., Dunbar, S. A., Jaacks, L. M., Karmally, W., Mayer-Davis, E. J., Wylie-Rosett, J., & Yancy, W. S. (2012) · Diabetes Care · doi:10.2337/dc11-2216 · Cited by 357
The role of diet in the prevention of type 2 diabetes
Salas‐Salvadó, J., Martínez‐González, M. Á., Bulló, M., & Ros, E. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.03.009 · Cited by 357
“Regarding long-chain n-3 PUFA, supplementation with pharmacological doses based on fish oils consistently failed to improve insulin sensitivity [111,114e116] and even worsened it in one study [117].”
Background
Metadata
- Authors
- Mostad, I. L., Bjerve, K. S., Bjorgaas, M. R., Lydersen, S., & Grill, V.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Mostad, Ingrid L
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 84
- Issue
- 3
- Pages
- 540-550
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2151700012
- Cited by
- 152
- References
- 45
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 9 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 13 · 2012: 11
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Update notices
- erratum (2007-06-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- EkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam)
- Novo Nordisk
- Diabetesforbundet
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- omega-3 fatty acids, fish oil supplementation, type 2 diabetes, insulin sensitivity, glucose utilization, substrate oxidation, plasma phospholipids, adipose tissue fatty acids, corn oil, C-peptide, blood glucose
- MeSH terms
- Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Dietary Fats, Unsaturated, Double-Blind Method, Female, Fish Oils, Hemostasis, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Oxidation-Reduction, Oxygen Consumption, Phospholipids, Time Factors, Glucose Clamp Technique, Fatty Acids, Omega-3, Dietary Supplements, Carbohydrate Metabolism
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