The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Effects of n−3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation
Open accessAbstract
Background Effects of fish oil supplements on metabolic variables are insufficiently clarified in type 2 diabetes.Objective We aimed to investigate short-term (1 wk) and longer-term (9 wk) effects of n-3 fatty acids.Design Twenty-six subjects with type 2 diabetes without hypertriacylglycerolemia participated in a double-blind controlled study. Median intake in the intervention group was 17.6 mL fish oil/d (1.8 g 20:5n-3, 3.0 g 22:6n-3, and 5.9 g total n-3 fatty acids). The control group received 17.8 mL corn oil/d (8.5 g 18:2n-6).Results Plasma phospholipid 20:5n-3 and 22:6n-3 increased, whereas 18:2n-6 decreased, in the fish oil group compared with the corn oil group after 1 wk. The two n-3 fatty acids also increased in adipose tissue biopsy samples taken after 9 wk in the fish oil group. Glucose concentrations (home-monitored) were approximately 1 mmol/L higher in the fish oil group than in the corn oil group at the end of the intervention (P = 0.035). Glucose utilization measured by using an isoglycemic clamp was lowered in the fish oil group compared with that in the corn oil group at the end of the intervention (P = 0.049), whereas glucagon-stimulated C-peptide tended to increase (P = 0.078). The fish oil group utilized less fat for oxidation after 1 wk, with a change to more fat and less carbohydrate oxidation after 9 wk (P = 0.040), than did the corn oil group.Conclusion A high intake of fish oil moderately increases blood glucose and decreases insulin sensitivity in persons with type 2 diabetes without hypertriacylglycerolemia and alters carbohydrate and fat utilization in a time-dependent manner.
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“rather, increased hepatic fatty acid oxidation is likely.”
In the citing paper
“Clinical studies have shown that OM3FA treatment increases fatty acid oxidation, as determined by indirect calorimetry [35, 36].”
In the citing paper
“Mostad and colleagues (2006) observed that the short term response to intake of omega-3 PUFAs was a decrease in fat oxidation but the opposite effect was observed after nine weeks [92].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [92]
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Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
Pocock, S. J., & Simon, R. (1975) · Biometrics · doi:10.2307/2529712 · Cited by 2,350
Omega-3 fatty acids in health and disease and in growth and development.
Simopoulos, A. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.438 · Cited by 2,162
Analysing controlled trials with baseline and follow up measurements
Vickers, A. J., & Altman, D. G. (2001) · BMJ · doi:10.1136/bmj.323.7321.1123 · Cited by 2,116
Davis, H. S. (1966) · JAMA · doi:10.1001/jama.1966.03100200106038 · Cited by 1,719
The theoretical bases of indirect calorimetry: A review
Ferrannini, E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90110-2 · Cited by 1,604
Vessby, B., Uusitupa, M., Hermansen, K., Riccardi, G., Rivellese, A. A., Tapsell, L. C., Nälsén, C., Berglund, L., Louheranta, A., Rasmussen, B. M., et al. (2001) · Diabetologia · doi:10.1007/s001250051620 · Cited by 1,119
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Hodson, L., Skeaff, C. M., & Fielding, B. A. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.03.003 · Cited by 1,344
“Although the evidence reporting changes in the fatty acid composition of adipose tissue is limited it does suggest that detectable changes can be measured, in weight stable individuals, within a few months of a change in PUFA intake [171,179].”
BackgroundInfluentialDietary fats and prevention of type 2 diabetes
Risérus, U., Willett, W. C., & Hu, F. B. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.002 · Cited by 753
“Moreover, a recent report indicated that high doses of n-3 FA (fish oil) may even impair insulin action in subjects with type 2 diabetes [57].”
BackgroundEFSA Panel on Dietetic Products, N. A. A. (. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2815 · Cited by 372
“3 g DPA) for nine weeks (Mostad et al., 2006) reported a marginal decrease in glucose utilisation during the euglycemic hyperinsulinaemic clamp in the fish oil group (n=13) compared to the maize oil group (n=14; p=0.”
BackgroundInfluentialMacronutrients, Food Groups, and Eating Patterns in the Management of Diabetes
Wheeler, M. L., Dunbar, S. A., Jaacks, L. M., Karmally, W., Mayer-Davis, E. J., Wylie-Rosett, J., & Yancy, W. S. (2012) · Diabetes Care · doi:10.2337/dc11-2216 · Cited by 357
The role of diet in the prevention of type 2 diabetes
Salas‐Salvadó, J., Martínez‐González, M. Á., Bulló, M., & Ros, E. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.03.009 · Cited by 357
“Regarding long-chain n-3 PUFA, supplementation with pharmacological doses based on fish oils consistently failed to improve insulin sensitivity [111,114e116] and even worsened it in one study [117].”
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Metadata
- Authors
- Mostad, I. L., Bjerve, K. S., Bjorgaas, M. R., Lydersen, S., & Grill, V.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Mostad, Ingrid L
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 84
- Issue
- 3
- Pages
- 540-550
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2151700012
- Cited by
- 152
- References
- 45
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 9 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 13 · 2012: 11
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Update notices
- erratum (2007-06-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- EkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam)
- Novo Nordisk
- Diabetesforbundet
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- omega-3 fatty acids, fish oil supplementation, type 2 diabetes, insulin sensitivity, glucose utilization, substrate oxidation, plasma phospholipids, adipose tissue fatty acids, corn oil, C-peptide, blood glucose
- MeSH terms
- Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Dietary Fats, Unsaturated, Double-Blind Method, Female, Fish Oils, Hemostasis, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Oxidation-Reduction, Oxygen Consumption, Phospholipids, Time Factors, Glucose Clamp Technique, Fatty Acids, Omega-3, Dietary Supplements, Carbohydrate Metabolism
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