Adipose tissue infiltration in skeletal muscle: age patterns and association with diabetes among men of African ancestry
Open accessAbstract
Background Although obesity is strongly associated with diabetes, the greater prevalence of diabetes in persons of African ancestry than in those of other ancestries cannot be explained simply by differences in total or central adiposity.Objective We examined whether skeletal muscle composition is associated with diabetes in 1249 men of African ancestry aged >or=40 y.Design Anthropometry and fasting serum glucose were measured, and lower-leg skeletal muscle composition was assessed with peripheral quantitative computerized tomography (pQCT).Results The prevalence of diabetes in this population was high (21%). We observed an age-associated adipose tissue remodeling in skeletal muscle and greater intermuscular (IMAT) and lesser subcutaneous (SAT) adipose tissue area with advancing age (P < 0.0001). Multivariate stepwise logistic regression identified more IMAT and less SAT to be significantly associated with a greater prevalence of diabetes. Even among normal-weight men [body mass index (BMI; in kg/m(2)) < 25], diabetic men had significantly (P = 0.01) more IMAT than did those without diabetes. Greater IMAT was also associated with a greater prevalence of hyperglycemia in men with a family history of diabetes than in those without such history (P for interaction = 0.02).Conclusions These findings underscore the independent associations of subcutaneous and intermuscular fat among men of African ancestry, an effect that may be modified by a family history of diabetes. Further studies are needed to identify the genetic and physiologic mechanisms that influence the distribution and remodeling of adipose tissue in skeletal muscle with aging.'
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Greater IMAT was observed in men with T2D and is associated with greater prevalence of hyperglycemia.
“However, greater IMAT was observed in men with T2D and has been associated with greater prevalence of hyperglycemia (45).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [45]
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- Authors
- Miljkovic-Gacic, I., Gordon, C. L., Goodpaster, B. H., Bunker, C. H., Patrick, A. L., Kuller, L. H., Wheeler, V. W., Evans, R. W., & Zmuda, J. M.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 87
- Issue
- 6
- Pages
- 1590-1595
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC2532786
- OpenAlex
- W2127537627
- Cited by
- 122
- References
- 39
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 11 · 2013: 7 · 2012: 5
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (F32HL083641)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049747)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- intermuscular adipose tissue, subcutaneous adipose tissue, skeletal muscle composition, diabetes mellitus, aging, hyperglycemia, family history of diabetes, peripheral quantitative computed tomography, obesity, adipose tissue remodeling
- MeSH terms
- Adipose Tissue, Adult, Aged, Aging, Blood Glucose, Diabetes Mellitus, Humans, Male, Middle Aged, Regression Analysis, Trinidad and Tobago, Body Mass Index, Muscle, Skeletal, Black People
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