Consumption of sucrose and high-fructose corn syrup does not increase liver fat or ectopic fat deposition in muscles

Bravo, Stephen; Lowndes, Joshua; Sinnett, Stephanie; Yu, Zhiping; Rippe, James

doi:10.1139/apnm-2012-0322

Cited by 86Diet, Metabolism, and DiseaseLiver Disease Diagnosis and TreatmentAdipokines, Inflammation, and Metabolic Diseases

Consumption of sucrose and high-fructose corn syrup does not increase liver fat or ectopic fat deposition in muscles

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Bravo, Stephen, Lowndes, Joshua, Sinnett, Stephanie, Yu, Zhiping, Rippe, James·2013·Applied Physiology, Nutrition, and Metabolism

DOI 10.1139/apnm-2012-0322

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Abstract

It has been postulated that fructose-induced triglyceride synthesis is augmented when accompanied by glucose. Chronic elevations could lead to excess fat accumulation in the liver and ectopic fat deposition in muscles, which in turn could contribute to the induction of abnormalities in glucose homeostasis, insulin resistance, and the subsequent development of type 2 diabetes. Our objective was to evaluate the effect of the addition of commonly consumed fructose- and (or) glucose-containing sugars in the usual diet on liver fat content and intramuscular adipose tissue. For 10 weeks, 64 individuals (mean age, 42.16 ± 11.66 years) consumed low-fat milk sweetened with either high-fructose corn syrup (HFCS) or sucrose; the added sugar matched consumption levels of fructose in the 25th, 50th, and 90th percentiles of the population. The fat content of the liver was measured with unenhanced computed tomography imaging, and the fat content of muscle was assessed with magnetic resonance imaging. When the 6 HFCS and sucrose groups were averaged, there was no change over the course of 10 weeks in the fat content of the liver (13.32% ± 10.49% vs. 13.21% ± 10.75%; p > 0.05), vastus lateralis muscle (3.07 ± 0.74 g per 100 mL vs. 3.15 ± 0.84 g per 100 mL; p > 0.05), or gluteus maximus muscle (4.08 ± 1.50 g per 100 mL vs. 4.24 ± 1.42 g per 100 mL; p > 0.05). Group assignment did not affect the result (interaction > 0.05). These data suggest that when fructose is consumed as part of a typical diet in normally consumed sweeteners, such as sucrose or HFCS, ectopic fat storage in the liver or muscles is not promoted.

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The literature is not in agreement that HFCS consumption leads to fat accumulation.
“However, it should be noted that the literate is not in agreement that HFCS consumption leads to fat accumulation [23].”
From In a single-blind, matched group design: Branched-chain amino acid supplementation and resistance training maintains lean body mass during a caloric restricted diet (2016) · cites this paper as [23]

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Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: A scoping review of lateral hip musculaturePreprint
Perraton, Z., Lawrenson, P. R., Mosler, A., Elliott, J. M., Weber, K. A., II, Flack, N., Cornwall, J., Crawford, R. J., Stewart, C., & Semciw, A. I. (2022) · Research Square · doi:10.21203/rs.3.rs-1320324/v1
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Additional file 3 of Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: a scoping review of lateral hip musculature
Perraton, Z., Lawrenson, P. R., Mosler, A., Elliott, J. M., Weber, K. A., II, Flack, N. A. M. S., Cornwall, J., Crawford, R. J., Stewart, C., & Semciw, A. I. (2022) · Figshare · doi:10.6084/m9.figshare.20004660
Additional file 2 of Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: a scoping review of lateral hip musculature
Perraton, Z., Lawrenson, P. R., Mosler, A., Elliott, J. M., Weber, K. A., II, Flack, N. A. M. S., Cornwall, J., Crawford, R. J., Stewart, C., & Semciw, A. I. (2022) · Figshare · doi:10.6084/m9.figshare.20004657
Additional file 1 of Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: a scoping review of lateral hip musculature
Perraton, Z., Lawrenson, P. R., Mosler, A., Elliott, J. M., Weber, K. A., II, Flack, N. A. M. S., Cornwall, J., Crawford, R. J., Stewart, C., & Semciw, A. I. (2022) · Figshare · doi:10.6084/m9.figshare.20004654

Abstract P062: Ten Weeks of Daily Consumption of Common Fructose Containing Sugars Does Not Increase Liver Fat Content
Bravo, S. M., Lowndes, J., Yu, Z., & Rippe, J. M. (2013) · Circulation · doi:10.1161/circ.127.suppl_12.ap062
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No effect of the type of sugar on ectopic fat storage (1039.1)
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Research in brief
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Distinct impacts of fat and fructose on the liver, muscle, and adipose tissue metabolome: An integrated view
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Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver
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Authors: Bravo, S., Lowndes, J., Sinnett, S., Yu, Z., & Rippe, J.
Affiliations: University of Central Florida (US)
Rippe Health (US)
ORCID: Yu, Zhiping
Rippe, James
Venue: Applied Physiology, Nutrition, and Metabolism
Publisher: Canadian Science Publishing
Published: 2013-06
Volume: 38
Issue: 6
Pages: 681-688
ISSN: 1715-5312 (ISSN-L)
1715-5320
DOI: 10.1139/apnm-2012-0322
OpenAlex: W2031820227
Cited by: 86
References: 66
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 10 · 2021: 6 · 2020: 2 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 16 · 2013: 3
FWCI: 10.74
Type: journal article
Language: en
Open access: green
stars.library.ucf.edu
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Applied Physiology Nutrition and Metabolism (publishedVersion)
PubMed (publishedVersion)
Journal of International Crisis and Risk Communication Research (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: high fructose corn syrup, sucrose, fructose, liver fat, ectopic fat deposition, intramuscular fat, glucose homeostasis, insulin resistance, type 2 diabetes, dietary sugar, triglyceride synthesis
MeSH terms: Zea mays, Diabetes Mellitus, Type 2, Fructose, Humans, Liver, Obesity, Sucrose, Sweetening Agents, High Fructose Corn Syrup

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Consumption of sucrose and high-fructose corn syrup does not increase liver fat or ectopic fat deposition in muscles

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