Greater skeletal muscle fat infiltration is associated with higher all-cause mortality among men of African ancestry
Open accessAbstract
BACKGROUND: fat infiltration within and around skeletal muscle (i.e. myosteatosis) increases with ageing, is greater in African versus European ancestry men and is associated with poor health. Myosteatosis studies of mortality are lacking, particularly among African ancestry populations. METHODS: in the Tobago Health study, a prospective longitudinal study, we evaluated the association of all-cause mortality with quantitative computed tomography (QCT) measured lower leg myosteatosis (intermuscular fat (IM fat) and muscle density) in 1,652 African ancestry men using Cox proportional hazards models. Date of death was abstracted from death certificates and/or proxy. RESULTS: one hundred and twelve deaths occurred during follow-up (mean 5.9 years). In all men (age range 40-91 years), higher all-cause mortality was associated with greater IM fat (HR (95% CI) per SD: 1.29 (1.06-1.57)) and lower muscle density (HR (95% CI) per SD lower: 1.37 (1.08-1.75)) in fully adjusted models. Similar mortality hazard rates were seen in the subset of elderly men (aged ≥65 years) with greater IM fat (1.40 (1.11-1.78) or lower muscle density (1.66 (1.24-2.21)) in fully adjusted models. CONCLUSIONS: our study identified a novel, independent association between myosteatosis and all-cause mortality in African ancestry men. Further studies are needed to establish whether this association is independent of other ectopic fat depots and to identify possible biological mechanisms underlying this relationship.
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Myosteatosis is associated with greater risk of mortality, even after adjusting for muscle mass.
“Myosteatosis’ association with greater risk of mortality has been observed in several large studies, even after adjusting for muscle mass.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Zhao et al., 2016
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Cites
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · cited 1× · see citing works
“In particular, myosteatosis may play an important role in the development of insulin resistance and type 2 diabetes (T2D) [1, 2, 5, 7–10], decreased muscle strength [11, 12] and mobility loss [3, 13].”
BackgroundMitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403 · see citing works
Skeletal Muscle Strength as a Predictor of All-Cause Mortality in Healthy Men
Metter, E. J., Talbot, L. A., Schrager, M., & CONWIT, R. A. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.10.b359 · Cited by 843 · see citing works
Etiology of Insulin Resistance
Petersen, K. F., & Shulman, G. I. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.01.009 · Cited by 825 · cited 1× · see citing works
“Additionally, the accumulation of intramuscular fat may impair the glucose metabolism via the insulin receptor substrate 1/phosphatidylinositol 3-kinase and growth-factorregulated protein kinase B pathways [24] and eventually lead to impaired insulin signalling and insulin resistance [25].”
BackgroundGoodpaster, B. H., Thaete, F. L., & Kelley, D. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.885 · Cited by 707 · cited 1× · see citing works
“The accumulation of intermuscular fat may impair nutritive blood flow to muscles and lead to impaired insulin action and insulin diffusion capacity [1].”
BackgroundGoodpaster, B. H., Krishnaswami, S., Resnick, H., Kelley, D. E., Haggerty, C., Harris, T. B., Schwartz, A. V., Kritchevsky, S., & Newman, A. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.372 · Cited by 619 · see citing works
The Molecular Basis for Oxidative Stress-Induced Insulin Resistance
Evans, J. L., Maddux, B. A., & Goldfine, I. D. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1040 · Cited by 587 · see citing works
A Pooled Analysis of Waist Circumference and Mortality in 650,000 Adults
Cerhan, J. R., Moore, S. C., Jacobs, E. J., Kitahara, C. M., Rosenberg, P. S., Adami, H.-O., Ebbert, J. O., English, D. R., Gapstur, S. M., Giles, G. G., et al. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.11.011 · Cited by 443 · see citing works
Study, F. T. H. A., Snijder, M. B., Visser, M., Dekker, J. M., Goodpaster, B. H., Harris, T. B., Kritchevsky, S. B., de Rekeneire, N., Kanaya, A. M., Newman, A. B., et al. (2005) · Diabetologia · doi:10.1007/s00125-004-1637-7 · Cited by 412 · see citing works
Lang, T., Cauley, J. A., Tylavsky, F., Bauer, D., Cummings, S., & Harris, T. B. (2010) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090807 · Cited by 371 · see citing works
Skeletal muscle and mortality results from the InCHIANTI study
Cesari, M., Pahor, M., Lauretani, F., Zamboni, V., Bandinelli, S., Bernabei, R., Guralnik, J. M., & Ferrucci, L. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln031 · Cited by 346 · see citing works
Intramuscular adipose tissue, sarcopenia, and mobility function in older individuals
Marcus, R. L., Addison, O., Dibble, L. E., Foreman, K. B., Morrell, G., & LaStayo, P. (2012) · Journal of Aging Research · doi:10.1155/2012/629637 · Cited by 296 · see citing works
Inflammation and Race and Gender Differences in Computerized Tomography‐measured Adipose Depots
Beasley, L. E., Koster, A., Newman, A. B., Javaid, M. K., Ferrucci, L., Kritchevsky, S. B., Kuller, L. H., Pahor, M., Schaap, L. A., Visser, M., et al. (2009) · Obesity · doi:10.1038/oby.2008.627 · Cited by 234 · see citing works
Boettcher, M., Machann, J., Stefan, N., Thamer, C., Häring, H., Claussen, C. D., Fritsche, A., & Schick, F. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21754 · Cited by 214 · see citing works
Adipose tissue distribution is different in type 2 diabetes
Gallagher, D., Kelley, D. E., Yim, J., Spence, N., Albu, J., Boxt, L. M., Pi‐Sunyer, F. X., & Heshka, S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26955 · Cited by 201 · see citing works
Intermuscular adipose tissue is muscle specific and associated with poor functional performance
Tuttle, L. J., Sinacore, D. R., & Mueller, M. J. (2012) · Journal of Aging Research · doi:10.1155/2012/172957 · Cited by 193 · see citing works
Bunker, C. H., Patrick, A. L., Konety, B. R., Dhir, R., Brufsky, A., Vivas, C., Becich, M. J., Trump, D. L., & Kuller, L. H. (2002) · PubMed · Cited by 172 · see citing works
Yim, J.-E., Heshka, S., Albu, J., Heymsfield, S. B., Kuznia, P., Harris, T. B., & Gallagher, D. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803621 · Cited by 147 · see citing works
Miljkovic, I., Kuipers, A. L., Cauley, J. A., Prasad, T., Lee, C. G., Ensrud, K. E., Cawthon, P. M., Hoffman, A. R., Dam, T.-T., Gordon, C. L., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv027 · Cited by 144 · see citing works
Calf Muscle Characteristics, Strength Measures, and Mortality in Peripheral Arterial Disease
McDermott, M. M., Liu, K., Tian, L., Guralnik, J. M., Criqui, M. H., Liao, Y., & Ferrucci, L. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.12.019 · Cited by 127 · see citing works
Miljkovic-Gacic, I., Gordon, C. L., Goodpaster, B. H., Bunker, C. H., Patrick, A. L., Kuller, L. H., Wheeler, V. W., Evans, R. W., & Zmuda, J. M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1590 · Cited by 122 · see citing works
Simonsick, E. M., Maffeo, C. E., Rogers, S. K., Skinner, E. A., Davis, D., Guralnik, J. M., & Fried, L. P. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.5.m264 · Cited by 115 · see citing works
Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy
Larson‐Meyer, D. E., Smith, S. R., Heilbronn, L. K., Kelley, D. E., Ravussin, E., Newcomer, B. R., & The Look AHEAD Adipose Research Group (2006) · Obesity · doi:10.1038/oby.2006.10 · Cited by 111 · see citing works
Miljkovic, I., Cauley, J. A., Wang, P. Y., Holton, K. F., Lee, C. G., Sheu, Y., Barrett-Connor, E. L., Hoffman, A. R., Lewis, C. E., ORWOLL, E. S., et al. (2013) · Obesity · doi:10.1002/oby.20346 · Cited by 107 · see citing works
Fat distribution and mortality: The AGES‐Reykjavik study
Koster, A., Murphy, R. A., Eiríksdóttir, G., Aspelund, T., Sigurdsson, S. O., Lang, T., Gudnason, V. G., Launer, L. J., & Harris, T. B. (2015) · Obesity · doi:10.1002/oby.21028 · Cited by 107 · see citing works
Miljkovic-Gacic, I., Ferrell, R., Patrick, A., Kammerer, C., & Bunker, C. (2006) · Human Heredity · doi:10.1159/000089553 · Cited by 105 · see citing works
Thinggaard, M., Lindahl‐Jacobsen, R., Jeune, B., Martinussen, T., & Christensen, K. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp214 · Cited by 101 · see citing works
Wong, A. K. O., Hummel, K., Moore, C., BEATTIE, K. A., Shaker, S., Craven, B. C., Adachi, J. D., Παπαϊωάννου, Α., & Giangregorio, L. (2014) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2014.04.124 · Cited by 42 · see citing works
Racial differences in fat distribution: the importance of intermuscular fat1,2
Torriani, M., & Grinspoon, S. K. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.4.731 · Cited by 24 · see citing works
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Correa-de-Araujo, R., Addison, O., Miljkovic, I., Goodpaster, B. H., Bergman, B. C., Clark, R. V., Elena, J. W., Esser, K. A., Ferrucci, L., Harris-Love, M. O., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00963 · Cited by 468 · see citing works
Jayedi, A., Soltani, S., Zargar, M. S., Khan, T. A., & Shab‐Bidar, S. (2020) · BMJ · doi:10.1136/bmj.m3324 · Cited by 404 · see citing works
Implications of low muscle mass across the continuum of care: a narrative review
Prado, C. M., Purcell, S. A., Alish, C., Pereira, S. L., Deutz, N. E., Heyland, D. K., Goodpaster, B. H., Tappenden, K. A., & Heymsfield, S. B. (2018) · Annals of Medicine · doi:10.1080/07853890.2018.1511918 · Cited by 286 · see citing works
Body weight and body composition in old age and their relationship with frailty
Reinders, I., Visser, M., & Schaap, L. S. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000332 · Cited by 96 · see citing works
Sex and population-specific cutoff values of muscle quality index: Results from NHANES 2011–2014
Lopes, L. C. C., Vaz-Gonçalves, L., Schincaglia, R. M., González, M. C., Prado, C. M. M., de Oliveira, E. P., & Mota, J. F. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.04.026 · Cited by 83 · see citing works
Lenchik, L., Barnard, R., Boutin, R. D., Kritchevsky, S. B., Chen, H., Tan, J., Cawthon, P. M., Weaver, A. A., & Hsu, F. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa141 · Cited by 56 · see citing works
Ballin, M., Nordström, P., Niklasson, J., & Nordström, A. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020065 · Cited by 50 · see citing works
Baker, J. F., Mostoufi‐Moab, S., Long, J., Zemel, B. S., Ibrahim, S. A., Taratuta, E., & Leonard, M. B. (2018) · Arthritis Care & Research · doi:10.1002/acr.23550 · Cited by 44 · see citing works
Perkisas, S., Cock, A. D., Verhoeven, V., & Vandewoude, M. F. J. (2017) · Geriatrics · doi:10.3390/geriatrics2010011 · Cited by 42 · see citing works
Fukumoto, Y., Yamada, Y., Ikezoe, T., Watanabe, Y., Taniguchi, M., Sawano, S., Minami, S., Asai, T., Kimura, M., & Ichihashi, N. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00317.2018 · Cited by 42 · see citing works
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging
Lim, J., & Frontera, W. R. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04924-4 · Cited by 40 · see citing works
Poor muscle quality: A hidden and detrimental health condition in obesity
Vieira, F. T., Cai, Y., González, M. C., Goodpaster, B. H., Prado, C. M. M., & Haqq, A. M. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09941-0 · Cited by 43 · see citing works
Pacifico, L., Perla, F. M., Andreoli, G. M., Grieco, R., Pierimarchi, P., & Chiesa, C. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00158 · Cited by 37 · see citing works
Keddar, M., Muylle, T., Carrie, E., Tréfois, P., Nachit, M., Crott, R., Christiaens, C., Bammens, B., Jadoul, M. Y., Goffin, E. J., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00130 · Cited by 35 · see citing works
Baker, J. F., Mostoufi‐Moab, S., Long, J., Taratuta, E., Leonard, M. B., & Zemel, B. S. (2019) · Arthritis Care & Research · doi:10.1002/acr.24126 · Cited by 28 · see citing works
Rossi, A. P., Gottin, L., Donadello, K., Schweiger, V., Brandimarte, P., Zamboni, G. A., Florio, A., BOETTI, R. P., Pavan, G., Zamboni, M. M., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.651167 · Cited by 28 · see citing works
Murea, M., Lenchik, L., Register, T. C., Russell, G. B., Xu, J., Smith, S. C., Bowden, D. W., Divers, J., & Freedman, B. I. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.03.004 · Cited by 22 · see citing works
Bergia, R. E., Kim, J. E., & Campbell, W. W. (2018) · International Journal of Endocrinology · doi:10.1155/2018/2751250 · Cited by 18 · see citing works
Oh, E., Cho, N., Kang, H., Kim, S. H., Park, H. K., & Kwon, S. H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0296073 · Cited by 15 · see citing works
Tucker, B. M., Hsu, F., Register, T. C., Xu, J., Smith, S. C., Murea, M., Bowden, D. W., Freedman, B. I., & Lenchik, L. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.5 · Cited by 13 · see citing works
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Pacicco, T., Ratner, S., Xi, Y., Yokoo, T., Fetzer, D. T., Öz, O. K., Rubin, C. D., & Chhabra, A. B. (2019) · Indian journal of radiology and imaging - new series/Indian journal of radiology and imaging/Indian Journal of Radiology & Imaging · doi:10.4103/ijri.ijri_414_18 · Cited by 11 · see citing works
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Haffer, H. P. H., Muellner, M., Chiapparelli, E. A., Dodo, Y., Zhu, J., Han, Y. X., Donnelly, E. L., Tan, E. T., Shue, J., Sama, A. A., et al. (2023) · Spine · doi:10.1097/brs.0000000000004683 · Cited by 9 · see citing works
Sheean, P., O'Connor, P., Joyce, C., Vasilopoulos, V., Badami, A., & Stolley, M. R. (2022) · Prostate Cancer · doi:10.1155/2022/9242243 · Cited by 8 · see citing works
Association of physical activity with fatty infiltration of muscles after total hip arthroplasty
Kawano, T., Nankaku, M., Murao, M., Yuri, T., Kitamura, G., Goto, K., Kuroda, Y., Kawai, T., Okuzu, Y., Ikeguchi, R., et al. (2023) · Skeletal Radiology · doi:10.1007/s00256-023-04516-z · Cited by 4 · see citing works
Miranda-Ferrúa, E., Cadenas‐Sánchez, C., Medrano, M., Ruiz, J. R., Idoate, F., Osés, M., Alavarez, M. C., Cabeza, R., & Labayen, I. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01903-5 · Cited by 3 · see citing works
Jammy, G. R., Boudreau, R. M., Miljkovic, I., Sharma, P. K., Reddy, S. P., Greenspan, S. L., Newman, A. B., & Cauley, J. A. (2022) · PLOS Global Public Health · doi:10.1371/journal.pgph.0000333 · Cited by 2 · see citing works
Age-related change in skeletal muscle strength, size, and adiposity over 18 years in Caribbean men
Roe, L. S., Cvejkus, R., Wheeler, V. W., Gordon, C. L., Kenkre, T. S., Zmuda, J. M., & Miljkovic, I. (2025) · GeroScience · doi:10.1007/s11357-025-02023-8 · Cited by 1 · see citing works
Liu, C.-H., Sularz, A., Saleh, G., Korfiatis, P., Collins, J. D., & Alkhouli, M. A. (2026) · Mayo Clinic Proceedings Digital Health · doi:10.1016/j.mcpdig.2026.100346 · Cited by 1 · see citing works
Hepatic Fat Fraction is Independently Associated with Myosteatosis: Insights from Chemical Shift MRI
Konukoğlu, O., Kaya, M., & Arslan, B. C. (2026) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-026-00577-3 · Cited by 1 · see citing works
Tilves, C. (2017) · D-Scholarship@Pitt (University of Pittsburgh)
Skeletal and muscle health among rural south indian older population
Jammy, G. R. (2020) · D-Scholarship@Pitt (University of Pittsburgh)
Kwon, S. H., Oh, E., Cho, N., Kang, H., Kim, S. H., & Park, H. K. (2022) · Research Square · doi:10.21203/rs.3.rs-1552951/v1
Hou, S., Li, M., Cao, J., Wang, Y., Yang, M., Tian, L., Ni, Y.-H., Yang, B.-X., Hao, L.-R., Hao, J., et al. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1687179
Kim, K., Chang, Y., Jang, H.-M., Kim, H., Yoon, S. H., & Ryu, S. (2026) · GeroScience · doi:10.1007/s11357-026-02420-7
Myosteatosis: an emerging biomarker of aging
Roe, L. S., Zmuda, J. M., & Miljkovic, I. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1868010
- Authors
- Zhao, Q., Zmuda, J. M., Kuipers, A. L., Jonnalagadda, P., Bunker, C. H., Patrick, A. L., Youk, A. O., & Miljkovic, I.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Zhao, Qian
- ORCID
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-04-13
- Volume
- 45
- Issue
- 4
- Pages
- 529-534
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- PMC
- PMC4916343
- OpenAlex
- W2339507627
- Cited by
- 38
- References
- 31
- Citations by year
- 2026: 4 · 2025: 4 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 1
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Age and Ageing (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-DK097084, K01-DK083029)
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- myosteatosis, skeletal muscle fat infiltration, intermuscular fat, muscle density, all-cause mortality, lower leg muscles, aging, older men, ectopic fat
- MeSH terms
- Aged, Black or African American, Cause of Death, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Muscular Diseases, Prognosis, Prospective Studies, Risk Factors, Sex Factors, Time Factors, Tomography, X-Ray Computed, Trinidad and Tobago, Comorbidity, Multivariate Analysis, Chi-Square Distribution, Proportional Hazards Models, Muscle, Skeletal, Lower Extremity, Black People, Adiposity
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