Glucoregulation is more precise in women than in men during postexercise recovery
Open accessAbstract
Background The regulation of glycemia is challenged in healthy men and women after exercise bouts of substantial energy expenditure.Objective We determined rates of glucose appearance (Ra), disappearance (Rd), and metabolic clearance (MCR) before, during, and after isoenergetic moderate and hard-intensity exercise.Design Ten men and 8 women received primed-continuous infusion of [6,6-(2)H(2)]glucose tracer to measure glucose kinetics. Participants were studied under 3 different conditions with diet unchanged between trials: 1) before, during, and 3 h after 90 min of exercise at 45% of peak oxygen consumption (VO(2)peak; E45); 2) before, during, and 3 h after 60 min of exercise at 65% VO(2)peak (E65), and 3) in a time-matched sedentary control trial.Results In men and women, Ra, Rd, and MCR increased above the control trial during exercise and were higher in E65 than in E45 (P < 0.05). Average Ra, Rd, and MCR remained elevated above the control over 3 h of postexercise recovery in men after exercise in E45 and E65 (P < 0.05), and blood glucose concentrations were depressed below the control during recovery (P < 0.05). Glucose concentrations were not depressed in women during 3 h of postexercise recovery, and in contrast with that in men, average Ra and Rd did not remain significantly elevated during postexercise recovery in women, although MCR did remain elevated in E65 (P < 0.05).Conclusions After exercise bouts, women are better able to maintain glucose concentrations at sedentary control levels, thus not requiring the counter-regulation of glucose production that is seen in men and requiring less accentuation of lipid metabolism.
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Nutrient timing has been proposed to have a significant impact on attenuating health, exercise training, and recovery implications.
“nutrient timing has been proposed to have a significant impact on attenuating increasing health, exercise training, and recovery implications [153].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [153]
The Experimental protocol describes a standardized breakfast three hours before exercise, and the Experimental design says participants ate no food during recovery. The Discussion reports sex differences in postexercise glucoregulation, but no passage found proposes that nutrient timing attenuates health, training, or recovery effects (searched: nutrient timing and timing of food intake). (LLM, conf=0.76)
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Cites
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078 · see citing works
Trumbo, P., Schlicker, S., Yates, A. A., & Poos, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90346-9 · Cited by 5,993 · see citing works
(1966) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(66)80573-4 · Cited by 4,287 · see citing works
Generalized equations for predicting body density of men
Jackson, A. S., & Pollock, M. L. (1978) · British Journal Of Nutrition · doi:10.1079/bjn19780152 · Cited by 3,205 · see citing works
Generalized equations for predicting body density of women
Jackson, A. S., Pollock, M. L., & Ward, A. (1980) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198023000-00009 · Cited by 1,853 · see citing works
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680 · see citing works
Balance of carbohydrate and lipid utilization during exercise: the "crossover" concept
Brooks, G. A., & Mercier, J. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.6.2253 · Cited by 862 · see citing works
Self-citationRadioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis
Wolfe, R. R. (1992) · Medical Entomology and Zoology · Cited by 617 · see citing works
Gender differences in substrate for endurance exercise
Tarnopolsky, L. J., MacDougall, J. D., Atkinson, S. A., Tarnopolsky, M. A., & Sutton, J. R. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.1.302 · Cited by 470 · see citing works
Tarnopolsky, M. A., Rennie, C. D., Robertshaw, H. A., Fedak-Tarnopolsky, S. N., Devries, M. C., & Hamadeh, M. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00472.2006 · Cited by 457 · see citing works
Fuel metabolism in men and women during and after long-duration exercise
Horton, T. J., Pagliassotti, M. J., Hobbs, K., & Hill, J. O. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.5.1823 · Cited by 370 · see citing works
Substrate utilization during endurance exercise in men and women after endurance training
Carter, S. L., Rennie, C., & Tarnopolsky, M. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.6.e898 · Cited by 329 · see citing works
Ballor, D. L., & Keesey, R. E. (1991) · PubMed · Cited by 324 · see citing works
Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis
Matthews, D. E. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.3.452 · Cited by 324 · see citing works
Gender differences in leucine kinetics and nitrogen balance in endurance athletes
Phillips, S. M., Atkinson, S. A., Tarnopolsky, M. A., & MacDougall, J. D. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.5.2134 · Cited by 281 · see citing works
Mammalian fuel utilization during sustained exercise
Brooks, G. A. (1998) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(98)00025-x · Cited by 253 · see citing works
Self-citationDevries, M. C., Hamadeh, M. J., Phillips, S. M., & Tarnopolsky, M. A. (2006) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00700.2005 · Cited by 202 · see citing works
Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period
Henderson, G. C., Fattor, J. A., Horning, M. A., Faghihnia, N., Johnson, M. L., Mau, T. L., Luke‐Zeitoun, M., & Brooks, G. A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.137331 · Cited by 193 · see citing works
Self-citationEffects of exercise intensity and training on lipid metabolism in young women.
Friedlander, A., Casazza, G., Horning, M., Buddinger, T. F., & Brooks, G. (1998) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e853 · Cited by 182 · see citing works
Self-citationDonnelly, J. E., & SMITH, B. K. (2005) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200510000-00004 · Cited by 172 · see citing works
Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases
Price, T. B., Rothman, D. L., Taylor, R., Avison, M. J., Shulman, G. I., & Shulman, R. G. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.1.104 · Cited by 168 · see citing works
Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work
Wasserman, D. H., Spalding, J. A., Lacy, D. B., Colburn, C. A., Goldstein, R. E., & Cherrington, A. D. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.1.e108 · Cited by 155 · see citing works
Gender differences in lipid and glucose kinetics during short-term fasting.
Mittendorfer, B., Horowitz, J. F., & Klein, S. (2001) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1333 · Cited by 129 · see citing works
Phelain, J. F., Reinke, E., Harris, M. A., & Melby, C. L. (1997) · Journal of the American College of Nutrition · doi:10.1080/07315724.1997.10718664 · Cited by 119 · see citing works
Endurance training increases fatty acid turnover, but not fat oxidation, in young men
Friedlander, A. L., Casazza, G. A., Horning, M. A., Ušaj, A., & Brooks, G. A. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.6.2097 · Cited by 117 · see citing works
Self-citationLipid oxidation in fit young adults during postexercise recovery
Kuo, C. C., Fattor, J. A., Henderson, G. C., & Brooks, G. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00997.2004 · Cited by 96 · see citing works
Self-citationGlycogen repletion following continuous and intermittent exercise to exhaustion
Gaesser, G. A., & Brooks, G. A. (1980) · Journal of Applied Physiology · doi:10.1152/jappl.1980.49.4.722 · Cited by 87 · see citing works
Self-citationDevries, M. C., Lowther, S. A., Glover, A. W., Hamadeh, M. J., & Tarnopolsky, M. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00510.2007 · Cited by 87 · see citing works
Luteal and follicular glucose fluxes during rest and exercise in 3-h postabsorptive women
Suh, S., Casazza, G. A., Horning, M. A., Miller, B. F., & Brooks, G. A. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01080.2001 · Cited by 80 · see citing works
Self-citationBenedict, F. G., & Cathcart, E. P. (1913) · Carnegie Institution of Washington eBooks · doi:10.5962/t.174876 · Cited by 75 · see citing works
Glucose kinetics differ between women and men, during and after exercise
Horton, T. J., Grunwald, G. K., Lavely, J., & Donahoo, W. T. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01431.2005 · Cited by 68 · see citing works
Decreased glucose oxidation during short-term starvation
Romijn, J. A., Godfried, M. H., Hommes, M. J. T., Endert, E., & Sauerwein, H. P. (1990) · Metabolism · doi:10.1016/0026-0495(90)90012-2 · Cited by 65 · see citing works
Glucose and fat metabolism during short-term starvation in cirrhosis
Romijn, J. A., Endert, E., & Sauerwein, H. P. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)80018-5 · Cited by 63 · see citing works
Boon, H., Blaak, E. E., Saris, W. H. M., KEIZER, H. A., Wagenmakers, A. J. M., & van Loon, L. J. C. (2006) · Diabetologia · doi:10.1007/s00125-006-0482-2 · Cited by 59 · see citing works
Regulation of glucose metabolism by norepinephrine in conscious dogs
Connolly, C. C., Steiner, K., Stevenson, R. W., Neal, D. W., Williams, P. E., Alberti, K. G., & Cherrington, A. D. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.6.e764 · Cited by 57 · see citing works
Horowitz, J. F., Coppack, S. W., & Klein, S. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.3.517 · Cited by 46 · see citing works
Gluconeogenic pathway in liver and muscle glycogen synthesis after exercise
Johnson, J. L., & Bagby, G. J. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.4.1591 · Cited by 39 · see citing works
Broeder, C. E., Brenner, M., Hofman, Z., Paijmans, I., Thomas, E. L., & Wilmore, J. H. (1991) · PubMed · Cited by 36 · see citing works
Role of the glucose cycle in control of net glucose flux in exercising humans
Weber, J., Klein, S. J., & Wolfe, R. R. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.5.1815 · Cited by 34 · see citing works
Henderson, G. C., Fattor, J. A., Horning, M. A., Faghihnia, N., Luke‐Zeitoun, M., & Brooks, G. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00309.2007 · Cited by 25 · see citing works
Self-citationHendrick, G. K., Wasserman, D. H., Frizzell, R. T., Williams, P. E., Lacy, D. B., Jaspan, J. B., & Cherrington, A. D. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.3.e541 · Cited by 20 · see citing works
Weststrate, J. A., Weys, P. J., Poortvliet, E., Deurenberg, P., & Hautvast, J. G. A. J. (1990) · PubMed · Cited by 14 · see citing works
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Hagobian, T. A., Sharoff, C. G., Stephens, B. R., Wade, G. N., Silva, J. E., Chipkin, S. R., & Braun, B. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90671.2008 · Cited by 173 · see citing works
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Brooks, G. A., Osmond, A. D., Arevalo, J. A., Duong, J. J., Curl, C. C., Moreno-Santillan, D. D., & Leija, R. G. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00497.2022 · Cited by 171 · see citing works
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Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 91 · see citing works
“intensity and the same duration, women display a greater capacity for lipid oxidation and regain control over glycemia and glucose flux more rapidly in recovery than do men [154,155].”
BackgroundChen, X., Huang, W., Zhang, J., Li, Y., Xing, Z., Guo, L., Jiang, H., & Zhang, J. (2023) · BMC Biology · doi:10.1186/s12915-023-01698-9 · Cited by 50 · see citing works
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- Authors
- Henderson, G. C., Fattor, J. A., Horning, M. A., Faghihnia, N., Johnson, M. L., Luke-Zeitoun, M., & Brooks, G. A.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Brooks, George A
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 87
- Issue
- 6
- Pages
- 1686-1694
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2187029953
- Cited by
- 49
- References
- 42
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AR42906)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR42906, R01AR042906)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- sex differences, post-exercise recovery, glucose kinetics, glucose appearance, glucose disappearance, metabolic clearance rate, exercise intensity, blood glucose, lipid metabolism, glucose production
- MeSH terms
- Adult, Blood Glucose, Energy Metabolism, Female, Homeostasis, Humans, Male, Metabolic Clearance Rate, Oxygen Consumption, Rest, Sex Characteristics, Exercise, Body Mass Index
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