Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study

Vasilopoulou, Dafni; Markey, Oonagh; Kliem, Kirsty E; Fagan, Colette C; Grandison, Alistair S; Humphries, David J; Todd, Susan; Jackson, Kim G; Givens, David I; Lovegrove, Julie A

doi:10.1093/ajcn/nqz344

Cited by 50Fatty Acid Research and HealthNutritional Studies and DietLipoproteins and Cardiovascular Health

Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study

Open access

Vasilopoulou, Dafni, Markey, Oonagh, Kliem, Kirsty E, Fagan, Colette C, Grandison, Alistair S, Humphries, David J, Todd, Susan, Jackson, Kim G +2 more·2020·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/nqz344PMC PMC7138681

Open this paper in CoChat — free account

Abstract

BACKGROUND: Modifying dairy fat composition by increasing the MUFA content is a potential strategy to reduce dietary SFA intake for cardiovascular disease (CVD) prevention in the population. OBJECTIVES: To determine the effects of consuming SFA-reduced, MUFA-enriched (modified) dairy products, compared with conventional dairy products (control), on the fasting cholesterol profile (primary outcome), endothelial function assessed by flow-mediated dilatation (FMD; key secondary outcome), and other cardiometabolic risk markers. METHODS: A double-blind, randomized, controlled crossover 12-wk intervention was conducted. Participants with a 1.5-fold higher (moderate) CVD risk than the population mean replaced habitual dairy products with study products (milk, cheese, and butter) to achieve a high-fat, high-dairy isoenergetic daily dietary exchange [38% of total energy intake (%TE) from fat: control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA) diet]. RESULTS: Fifty-four participants (57.4% men; mean ± SEM age: 52 ± 3 y; BMI: 25.8 ± 0.5 kg/m2) completed the study. The modified diet attenuated the rise in fasting LDL cholesterol observed with the control diet (0.03 ± 0.06 mmol/L and 0.19 ± 0.05 mmol/L, respectively; P = 0.03). Relative to baseline, the %FMD response increased after the modified diet (0.35% ± 0.15%), whereas a decrease was observed after the control diet (-0.51% ± 0.15%; P< 0.0001). In addition, fasting plasma nitrite concentrations increased after the modified diet, yet decreased after the control diet (0.02 ± 0.01 μmol/L and -0.03 ± 0.02 μmol/L, respectively; P = 0.01). CONCLUSIONS: In adults at moderate CVD risk, consumption of a high-fat diet containing SFA-reduced, MUFA-enriched dairy products for 12 wk showed beneficial effects on fasting LDL cholesterol and endothelial function compared with conventional dairy products. Our findings indicate that fatty acid modification of dairy products may have potential as a public health strategy aimed at CVD risk reduction. This trial was registered at clinicaltrials.gov as NCT02089035.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/ajcn/nqz344

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A recent study in 53 subjects at moderate risk of CVD observed an increase in FMD when consuming dairy products fortified with MUFA for 12 weeks.
“This is in line with results from a recent study in 53 subjects at moderate risk of CVD, where an increase in FMD was observed when consuming dairy products fortified with MUFA for 12 weeks [45].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [45]
The Introduction describes a 12-week study of MUFA-enriched dairy products in adults at moderate CVD risk, and the Results report increased FMD after the modified diet compared with the control diet. However, the Results section on study participants says 54 participants completed both arms, not 53. Our copy provides no page numbers for these passages. (LLM, conf=0.88)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Prediction of coronary heart disease using risk factor categories
Wilson, P. W. F., D’Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H., & Kannel, W. B. (1998) · Circulation · doi:10.1161/01.cir.97.18.1837 · Cited by 9,581 · see citing works
Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats
Marella, S., Maddirela, D. R., Badri, K. R., Kumar, M. V. J., & Chippada, A. R. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373954 · Cited by 5,938 · see citing works
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606 · see citing works
Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials
Mensink, R. P., Zock, P. L., Kester, A. D., & Katan, M. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1146 · Cited by 2,811 · see citing works
Endothelial Dysfunction
Bonetti, P. O., Lerman, L. O., & Lerman, A. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000051384.43104.fc · Cited by 2,199 · see citing works
Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004–2006–2011)
Touboul, P., Hennerici, M. G., Meairs, S. P., Adams, H., Amarenco, P., Bornstein, N. M., Csiba, L., Desvarieux, M., Ebrahim, S. B. J., Hernandez, R. H., et al. (2012) · Cerebrovascular Diseases · doi:10.1159/000343145 · Cited by 1,818 · see citing works
Quantitative Effects of Dietary Fat on Serum Cholesterol in Man
Hegsted, D. M., McGandy, R. B., Myers, M. L., & Stare, F. J. (1965) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/17.5.281 · Cited by 1,589 · see citing works
Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials
Mensink, R. P., & Katan, M. B. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.8.911 · Cited by 1,477 · see citing works
Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies
de Souza, R. J., Mente, A., Maroleanu, A., Cozma, A. I., Ha, V., Kishibe, T., Uleryk, E., Budylowski, P., Schünemann, H., Beyene, J., et al. (2015) · BMJ · doi:10.1136/bmj.h3978 · Cited by 1,424 · see citing works
Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
Siri-Tarino, P. W., Sun, Q., Hu, F. B., & Krauss, R. M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27725 · Cited by 1,253 · see citing works
Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis
Chowdhury, R., Warnakula, S., Kunutsor, S., Crowe, F., Ward, H. A., Johnson, L., Franco, O. H., Butterworth, A. S., Forouhi, N. G., Thompson, S. G., et al. (2014) · Annals of Internal Medicine · doi:10.7326/m13-1788 · Cited by 1,139 · see citing works
Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies
Jakobsen, M. U., O’Reilly, E. J., Heitmann, B. L., Pereira, M. A., Bälter, K., Fraser, G. E., Goldbourt, U., Hallmans, G., Knekt, P., Liu, S., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27124 · Cited by 1,026 · see citing works
Methods to detect nitric oxide and its metabolites in biological samples
Bryan, N. S., & Grisham, M. B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.026 · Cited by 1,005 · see citing works
Serum cholesterol response to changes in the diet
Keys, A. B., Anderson, J. T., & Grande, F. (1965) · Metabolism · doi:10.1016/0026-0495(65)90002-8 · Cited by 969 · see citing works
Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
Soininen, P., Kangas, A. J., Würtz, P., Suna, T., & Ala‐Korpela, M. (2015) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000216 · Cited by 890 · see citing works
Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis
Inaba, Y., Chen, J. A., & Bergmann, S. R. (2010) · The International Journal of Cardiovascular Imaging · doi:10.1007/s10554-010-9616-1 · Cited by 820 · see citing works
Serum cholesterol response to changes in the diet
Keys, A., Anderson, J. T., & Grande, F. (1965) · Metabolism · doi:10.1016/0026-0495(65)90004-1 · Cited by 803 · see citing works
Reduction in saturated fat intake for cardiovascular disease
Hooper, L., Martin, N., Abdelhamid, A., & Davey Smith, G. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011737 · Cited by 704 · see citing works
Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies
Clarke, R. C., Frost, C. D., Collins, R., Appleby, P. N., & Peto, R. (1997) · BMJ · doi:10.1136/bmj.314.7074.112 · Cited by 645 · see citing works
Mechanisms by which Dietary Fatty Acids Modulate Plasma Lipids
Fernandez, M. L., & West, K. L. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.9.2075 · Cited by 469 · see citing works
National Diet and Nutrition Survey : results from years 7 and 8 (combined) of the Rolling Programme (2014/2015 – 2015/2016)
Roberts, C., Steer, T. E., Maplethorpe, N., Cox, L., Meadows, S. O., Nicholson, S. K., Page, P., & Swan, G. (2018) · Digital Education Resource Archive (University College London) · Cited by 389 · see citing works
Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps ,
Thorning, T. K., Bertram, H. C., Bonjour, J., de Groot, C. P. G. M., Dupont, D., Feeney, E. L., Ipsen, R., Lecerf, J. M., Mackie, A. R., McKinley, M. C., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.151548 · Cited by 380 · see citing works
Self-citation
Best (but oft-forgotten) practices: the multiple problems of multiplicity—whether and how to correct for many statistical tests
Streiner, D. L. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.113548 · Cited by 344 · see citing works
Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis
Howell, W., McNamara, D., Tosca, M., Smith, B., & Gaines, J. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.6.1747 · Cited by 343 · see citing works
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341 · see citing works
Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men
Fuentes, F. J., López‐Miranda, J., Sánchez, E., Sánchez, F., Paez, J., Paz-Rojas, E., Marı́n, C., Gómez, P., Jiménez-Perepérez, J., Ordovás, J. M., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00011 · Cited by 260 · see citing works
Olive Oil Polyphenols Decrease Blood Pressure and Improve Endothelial Function in Young Women with Mild Hypertension
Moreno‐Luna, R., Múñoz‐Hernández, R., Miranda, M. L., Costa, A. F., Jiménez-Jiménez, L., Vallejo‐Vaz, A. J., Muriana, F. J. G., Villar, J. R., & Stiefel, P. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.128 · Cited by 243 · see citing works
Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin, and blood pressure: results from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study
Vafeiadou, K., Weech, M., Altowaijri, H., Todd, S., Yaqoob, P., Jackson, K. G., & Lovegrove, J. A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.097089 · Cited by 178 · see citing works
Self-citation
Flow-Mediated Dilatation Is Impaired by a High–Saturated Fat Diet but Not by a High-Carbohydrate Diet
Keogh, J. B., Grieger, J. A., Noakes, M., & Clifton, P. M. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000163185.28245.a1 · Cited by 160 · see citing works
Within-subject variability of flow-mediated vasodilation of the brachial artery in healthy men and women: implications for experimental studies
de Roos, N. M., Bots, M. L., Schouten, E. G., & Katan, M. (2003) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(02)00709-3 · Cited by 148 · see citing works
Convenience food with environmentally-sustainable attributes: A consumer perspective
Stranieri, S., Ricci, E. C., & Banterle, A. (2017) · Appetite · doi:10.1016/j.appet.2017.04.015 · Cited by 130 · see citing works
Guidelines for the design, conduct and reporting of human intervention studies to evaluate the health benefits of foods
Welch, R., Antoine, J., Berta, J.-L., Bub, A., de Vries, J., Guarner, F., Hasselwander, O., Hendriks, H., Jäkel, M., Koletzko, B. V., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003606 · Cited by 123 · see citing works
Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with α-linolenic acid on postprandial endothelial function in healthy men
Fuentes, F. J., López‐Miranda, J., Pérez‐Martínez, P., Jiménez, Y., Marı́n, C., Gómez, P., Fernández, J. M., Caballero‐Villarraso, J., Delgado‐Lista, J., & Pérez‐Jiménez, F. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508888708 · Cited by 113 · see citing works
The impact of substituting SFA in dairy products with MUFA or PUFA on CVD risk: evidence from human intervention studies
Livingstone, K. M., Lovegrove, J. A., & Givens, D. I. (2012) · Nutrition Research Reviews · doi:10.1017/s095442241200011x · Cited by 111 · see citing works
Self-citation
Dairy matrix effects: response to consumption of dairy fat differs when eaten within the cheese matrix—a randomized controlled trial
Feeney, E. L., Barron, R. E., Dible, V. A., Hamilton, Z., Power, Y., Tanner, L., Flynn, C., Bouchier, P., Beresford, T. P. J., Noronha, N., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy146 · Cited by 92 · see citing works
Is there a linear relationship between the dose of ruminant trans -fatty acids and cardiovascular risk markers in healthy subjects: results from a systematic review and meta-regression of randomised clinical trials
Boyer, C., Tenenhaus‐Aziza, F., Prunet, C., Marmonier, C., Malpuech‐Brugère, C., Lamarche, B., & Chardigny, J. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002578 · Cited by 79 · see citing works
Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids
Silva, R., Kelly, C. N. M., Jones, A. E., Smith, R. D., Wootton, S. A., Miller, G. J., & Williams, C. M. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00306-4 · Cited by 77 · see citing works
Role of cis-Monounsaturated Fatty Acids in the Prevention of Coronary Heart Disease
Joris, P. J., & Mensink, R. P. (2016) · Current Atherosclerosis Reports · doi:10.1007/s11883-016-0597-y · Cited by 77 · see citing works
Serum cholesterol predictive equations with special emphasis on Trans and saturated fatty acids. An analysis from designed controlled studies
Müller, H., Kirkhus, B., & Pedersen, J. I. (2001) · Lipids · doi:10.1007/s11745-001-0785-6 · Cited by 66 · see citing works
Dairy food products: good or bad for cardiometabolic disease?
Lovegrove, J. A., & Givens, D. I. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000160 · Cited by 58 · see citing works
Self-citation
Dairy and cardiovascular health: Friend or foe?
Markey, O., Vasilopoulou, D., Givens, D. I., & Lovegrove, J. A. (2014) · Nutrition Bulletin · doi:10.1111/nbu.12086 · Cited by 54 · see citing works
Self-citation
Innovation to Create a Healthy and Sustainable Food System: A Science Advisory From the American Heart Association
Anderson, C. A. M., Thorndike, A. N., Lichtenstein, A. H., Horn, L. V., Kris‐Etherton, P. M., Foraker, R. E., & Spees, C. (2019) · Circulation · doi:10.1161/cir.0000000000000686 · Cited by 50 · see citing works
Saturated fat-induced changes in Sf 60–400 particle composition reduces uptake of LDL by HepG2 cells
Jackson, K. G., Maitin, V., Leake, D. S., Yaqoob, P., & Williams, C. M. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500382-jlr200 · Cited by 48 · see citing works
Self-citation
Revised QUICKI provides a strong surrogate estimate of insulin sensitivity when compared with the minimal model
Brady, L. M., Gower, B. A., Lovegrove, S. S., Williams, C. M., & Lovegrove, J. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802547 · Cited by 43 · see citing works
Self-citation
Differential Effects of Two Isoenergetic Meals Rich in Saturated or Monounsaturated Fat on Endothelial Function in Subjects With Type 2 Diabetes
Tentolouris, N., Arapostathi, C., Perrea, D. N., Kyriaki, D., Revenas, C., & Katsilambros, N. L. (2008) · Diabetes Care · doi:10.2337/dc08-0924 · Cited by 33 · see citing works
Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial
Markey, O., Vasilopoulou, D., Kliem, K. E., Koulman, A., Fagan, C. C., Summerhill, K., Wang, L. Y., Grandison, A. S., Humphries, D. J., Todd, S., et al. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0249-2 · Cited by 29 · see citing works
Self-citation
Consumer acceptance of dairy products with a saturated fatty acid–reduced, monounsaturated fatty acid–enriched content
Markey, O., Souroullas, K., Fagan, C. C., Kliem, K. E., Vasilopoulou, D., Jackson, K. G., Humphries, D. J., Grandison, A. S., Givens, D. I., Lovegrove, J. A., et al. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-12057 · Cited by 29 · see citing works
Self-citation
Diet and low-density lipoprotein particle size
Desroches, S., & Lamarche, B. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0086-6 · Cited by 17 · see citing works
Food chain approach to lowering the saturated fat of milk and dairy products
Kliem, K. E., Humphries, D. J., Markey, O., Vasilopoulou, D., Fagan, C. C., Grandison, A. S., Jackson, K. G., Todd, S., Givens, D. I., & Lovegrove, J. A. (2018) · International Journal of Dairy Technology · doi:10.1111/1471-0307.12564 · Cited by 16 · see citing works
Self-citation

Flagged first, then by citations

1 of the 51 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

[10]World Health Organization. Draft Guidelines on Saturated Fatty Acid and trans-fatty Acid Intake for Adults and Children [Internet]. Geneva: WHO; 2018; [cited 29 April 2019]. Available from: https://extranet.who.int/dataform/upload/surveys/666752/files/Draft WHO SFA-TFA guidelines_04052018 Public Consultation(1).pdf. 37490572

Sorted by citations

Inulin‐type fructans and short‐chain fructooligosaccharides—their role within the food industry as fat and sugar replacers and texture modifiers—what needs to be considered!
Jackson, P. P. J., Wijeyesekera, A., & Rastall, R. A. (2022) · Food Science & Nutrition · doi:10.1002/fsn3.3040 · Cited by 73 · see citing works
Saturated fats, dairy foods and cardiovascular health: No longer a curious paradox?
Givens, D. I. (2022) · Nutrition Bulletin · doi:10.1111/nbu.12585 · Cited by 52 · see citing works
Self-citation
Controlled lipid digestion in the development of functional and personalized foods for a tailored delivery of dietary fats
Kupikowska-Stobba, B., Niu, H., Klojdová, I., Agregán, R., Lorenzo, J. M., & Kasprzak, M. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142151 · Cited by 51 · see citing works
Dairy Consumption and Metabolic Health
Timon, C., O’Connor, A., Bhargava, N., Gibney, E. R., & Feeney, E. L. (2020) · Nutrients · doi:10.3390/nu12103040 · Cited by 39 · see citing works
Replacement of dietary saturated with unsaturated fatty acids is associated with beneficial effects on lipidome metabolites: a secondary analysis of a randomized trial
Sellem, L., Eichelmann, F., Jackson, K. G., Wittenbecher, C., Schulze, M. B., & Lovegrove, J. A. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.03.024 · Cited by 39 · see citing works
Self-citation
Evaluating the effects of high-oil rapeseed cake or natural additives on methane emissions and performance of dairy cows
Bayat, A. R., Vilkki, J., Razzaghi, A., Leskinen, H. M., Kettunen, H., Khurana, R., Brand, T., & Ahvenjärvi, S. A. (2021) · Journal of Dairy Science · doi:10.3168/jds.2021-20537 · Cited by 39 · see citing works
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
Ruocco, C., Ragni, M., Rossi, F., Carullo, P., Ghini, V., Piscitelli, F., Cutignano, A., Manzo, E., Ioris, R. M., Bontems, F., et al. (2020) · Diabetes · doi:10.2337/db20-0489 · Cited by 36 · see citing works
Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders
Jia, X., Chen, Q., Wu, H., Liu, H., Jing, C., Gong, A., & Zhang, Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1291853 · Cited by 33 · see citing works
Dietary fat quality, plasma atherogenic lipoproteins, and atherosclerotic cardiovascular disease: An overview of the rationale for dietary recommendations for fat intake
Christensen, J. J., Arnesen, E., Rundblad, A., Telle‐Hansen, V. H., Narverud, I., Blomhoff, R., Bogsrud, M. P., Retterstøl, K., Ulven, S. M., & Holven, K. B. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117433 · Cited by 31 · see citing works
A genomics perspective of personalized prevention and management of obesity
Gkouskou, K. K., Grammatikopoulou, M. G., Lazou, E., Vasilogiannakopoulou, T., Sanoudou, D., & Eliopoulos, A. G. (2024) · Human Genomics · doi:10.1186/s40246-024-00570-3 · Cited by 30 · see citing works
Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers
González-Rámila, S., Sarriá, B., Seguido, M. A., García-Cordero, J., Mateos, R., & Bravo, L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03001-y · Cited by 24 · see citing works
Dairy foods and cardiometabolic diseases: an update and a reassessment of the impact of SFA
Givens, D. I. (2023) · Proceedings of The Nutrition Society · doi:10.1017/s0029665123000083 · Cited by 18 · see citing works
Self-citation
Consumers’ valuation for low - carbon emission and low – saturated fat butter
Asioli, D., Zhou, X., Halmemies‐Beauchet‐Filleau, A., Vanhatalo, A., Givens, D. I., Rondoni, A., & Turpeinen, A. M. (2023) · Food Quality and Preference · doi:10.1016/j.foodqual.2023.104859 · Cited by 15 · see citing works
Self-citation
Postprandial Fatty Acid Profile, but Not Cardiometabolic Risk Markers, Is Modulated by Dairy Fat Manipulation in Adults with Moderate Cardiovascular Disease Risk: The Randomized Controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) Study
Markey, O., Vasilopoulou, D., Kliem, K. E., Fagan, C. C., Grandison, A. S., Sutton, R., Humphries, D. J., Todd, S., Jackson, K. G., Givens, D. I., et al. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab050 · Cited by 14 · see citing works
Self-citation
Natural ingredients and probiotics for lowering cholesterol and saturated fat in dairy products
Chailangka, A., Leksawasdi, N., Ruksiriwanich, W., Jantanasakulwong, K., Rachtanapun, P., Sommano, S. R., Khaneghah, A. M., Castagnini, J. M., Barba, F. J., Kumar, A., et al. (2023) · Quality Assurance and Safety of Crops & Foods · doi:10.15586/qas.v15i2.1269 · Cited by 13 · see citing works
Enrichment of Ewe’s Milk with Dietary n-3 Fatty Acids from Palm, Linseed and Algae Oils in Isoenergetic Rations
Manso, T., Gallardo, B., Lavín, P., Mantecón, Á. R., Cejudo, C., Gómez‐Cortés, P., & de la Fuente, M. Á. (2022) · Animals · doi:10.3390/ani12131716 · Cited by 12 · see citing works
Role of food matrix in modulating dairy fat induced changes in lipoprotein particle size distribution in a human intervention
Dunne, S., McGillicuddy, F. C., Gibney, E. R., & Feeney, E. L. (2022) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2022.10.002 · Cited by 12 · see citing works
Variation of LDL cholesterol in response to the replacement of saturated with unsaturated fatty acids: a nonrandomized, sequential dietary intervention; the Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention (“RISSCI”-1) study
Koutsos, A., Griffin, B. A., Antoni, R., Ozen, E., Sellem, L., Wong, G. H. Y., Ayyad, H., Fielding, B. A., Robertson, M. D., Swann, J. R., et al. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.07.032 · Cited by 11 · see citing works
Self-citation
Molecular and metabolic effects of extra-virgin olive oil on the cardiovascular gene signature in rodents
Ruocco, C., Ragni, M., Tedesco, L., Segala, A., Servili, M., Riccardi, G., Carruba, M. O., Valerio, A., Nisoli, E., & Visioli, F. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.03.020 · Cited by 11 · see citing works
Metabolic effects of milk fatty acids: A literature review
Muñoz‐Alvarez, K. Y., Gutiérrez‐Aguilar, R., & Frigolet, M. E. (2024) · Nutrition Bulletin · doi:10.1111/nbu.12657 · Cited by 11 · see citing works
Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial
Pushpass, R.-A. G., Alzoufairi, S., Mancini, A., Quilter, K., Fava, F., Delaiti, S., Vrhovšek, U., Christensen, C., Joyce, S. A., Tuohy, K. M., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2022.10.013 · Cited by 10 · see citing works
Self-citation
Identification of High and Low Branched-Chain Fatty Acid–Producing Phenotypes in Holstein Cows following High-Forage and Low-Forage Diets in a Crossover Designed Trial
Picklo, M. J., Kalscheur, K. F., Magnuson, A., Bukowski, M. R., Harnly, J. M., Fukagawa, N. K., & Finley, J. W. (2022) · Current Developments in Nutrition · doi:10.1093/cdn/nzab154 · Cited by 10 · see citing works
Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats
Domínguez-Vías, G., Segarra, A. B., Ramírez‐Sánchez, M., & Prieto, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105388 · Cited by 9 · see citing works
The impact of pasture-fed versus total mixed ration derived whole milk powder (WMP) on circulating fatty acid concentrations and cardiometabolic health in healthy adults: Results from a randomized controlled crossover trial
Rooney, M. L., O’Connor, A., Gollogly, C., Mills, A., Dunne, S., Chonnacháin, C. N., Timlin, M., Brodkorb, A., O’Callaghan, T. F., Magan, J. B., et al. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110004 · Cited by 6 · see citing works
Bovine dairy products and flow mediated dilation (FMD): a systematic review of the published evidence
Rooney, M. L., Lambe, J., O’Connor, A., Dunne, S., Mills, A., Feeney, E. L., & Gibney, E. R. (2025) · European Journal of Nutrition · doi:10.1007/s00394-024-03574-w · Cited by 6 · see citing works
The effect of pasture-fed vs total mixed ration (TMR)-fed cheese on circulating fatty acid concentrations in middle-aged, overweight adults
Rooney, M. L., O’Connor, A., Dunne, S., Timlin, M., Brodkorb, A., Sheehan, J. J., O’Callaghan, T. F., O’Donovan, M., Hennessy, D., Pierce, K. M., et al. (2025) · International Dairy Journal · doi:10.1016/j.idairyj.2025.106246 · Cited by 6 · see citing works
Effect of fat-reformulated dairy food consumption on postprandial flow-mediated dilatation and cardiometabolic risk biomarkers compared with conventional dairy: a randomized controlled trial
Markey, O., Vasilopoulou, D., Kliem, K. E., Fagan, C. C., Grandison, A. S., Sutton, R., Humphries, D. J., Todd, S., Jackson, K. G., Givens, D. I., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab428 · Cited by 6 · see citing works
Self-citation
Dietary fats and cardiometabolic health—from public health to personalised nutrition: ‘One for all’ and ‘all for one’
Lovegrove, J. A. (2025) · Nutrition Bulletin · doi:10.1111/nbu.12722 · Cited by 5 · see citing works
Self-citation
The effects of whole foods and dietary patterns on flow-mediated dilation: a systematic review and meta-analysis of randomized controlled trials
Trinquet, N. M., Kellow, N. J., Eviana, R., Williamson, G., & Dordevic, A. L. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.09.020 · Cited by 5 · see citing works
The Effect of Short-Wavelength White LED Illumination throughout the Night on the Milk Fatty Acid Profile of High-Yielding Dairy Cows
Asher, A., Fialko, M., Fares, F., Moallem, U., Jacoby, S., & Gutman, R. (2022) · Biology · doi:10.3390/biology11121799 · Cited by 10 · see citing works
High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats
Domínguez-Vías, G., Segarra, A. B., Ramírez‐Sánchez, M., & Prieto, I. (2021) · Biomedicines · doi:10.3390/biomedicines9091149 · Cited by 5 · see citing works
Association between empirically driven dietary patterns and cardiometabolic disease risk factors: a cross-sectional analysis in disease-free adults
Yilmaz, A., Weech, M., Bountziouka, V. P., Jackson, K. G., & Lovegrove, J. A. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00965-6 · Cited by 4 · see citing works
Self-citation
Association between body composition and cardiometabolic disease risk: role of dietary fat intake and APOLIPOPROTEIN E genotype on this relationship
Ozen, E., Lovegrove, J. A., & Jackson, K. G. (2024) · Proceedings of The Nutrition Society · doi:10.1017/s0029665124000053 · Cited by 3 · see citing works
Self-citation
Milled rapeseeds and oats decrease milk saturated fatty acids and ruminal methane emissions in dairy cows without changes in product sensory quality
Halmemies‐Beauchet‐Filleau, A., Jaakkola, S., Kokkonen, T., Turpeinen, A. M., Givens, D. I., & Vanhatalo, A. (2023) · Frontiers in Animal Science · doi:10.3389/fanim.2023.1278495 · Cited by 3 · see citing works
Self-citation
A natural and safe diglyceride (DAG)‐MFGM reconstituted milk: preparation, physiochemical, in‐vitro digestion, and sterilisation safety
Xu, J., Lu, Y., Nie, X., Yu, N., & Meng, X. (2023) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16454 · Cited by 2 · see citing works
Inflammatory Cytokine Responses to 6 Wks of Increased Dairy Intake in Individuals with Overweight and Obesity–A Randomized Crossover Trial
Prowting, J. L., Fraschetti, E. C., Pereira, T. J., Tucker, J. A. L., Gagnon, S., Cheng, N., Edgell, H., Wright, D. C., Klentrou, P., Perry, C. G. R., et al. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.10.040 · Cited by 2 · see citing works
Lipids and Cardiovascular Disease Risks with a Focus on Dairy Foods
Givens, D. I. (2021) · Springer eBooks · doi:10.1007/978-3-030-56909-9_6 · Cited by 2 · see citing works
Self-citation
POTENSI MINUMAN FUNGSIONAL BERBASIS SUSU DENGAN ISOLAT BIJI ATAU KECAMBAH KORO PEDANG DALAM PENCEGAHAN PENYAKIT KARDIOVASKULAR
Kanetro, B., Slamet, A., & Budiyanto, C. (2021) · Jurnal Teknologi Pertanian · doi:10.21776/ub.jtp.2021.022.03.4 · Cited by 1 · see citing works
A Pumpkin Seed Oil and Orange Peel Flour Gelled Emulsion as a Novel Fat Replacer in English Breakfast Sausages: Effects on Composition, Quality, and Sensory Acceptance
Botella-Martínez, C. M., López-Córdoba, A., Lucas‐González, R., Fernández‐López, J., Pérez‐Álvarez, J. Á., & Viuda‐Martos, M. (2025) · Applied Sciences · doi:10.3390/app152312488 · Cited by 1 · see citing works
Trans fatty acids from dairy foods do not affect risk of cardiometabolic diseases: Systematic review and meta-analysis of evidence from randomized controlled trials and systematic review of prospective cohort studies
Boyer, C., Tenenhaus-Aziza, F., Torres‐Gonzalez, M., Givens, D. I., & Schweitzer, C. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.03.009 · Cited by 1 · see citing works
Self-citation
Impact of saturated fat absorption on serum low density lipoprotein-cholesterol response to the replacement of saturated with unsaturated fats in healthy males. The ‘Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention-2 (RISSCI-2)’ non-randomised sequential dietary intervention study
Fielding, B. A., Koutsos, A., Antoni, R., Ozen, E., Ayyad, H., Robertson, M. D., Swann, J. R., Jackson, K. G., Lovegrove, J. A., & Griffin, B. A. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.121884 · Cited by 1 · see citing works
Self-citation
The Impact of Carbohydrate Restriction and Nutritional Ketosis on Cardiovascular Health
Lowe, D. A., Corbit, K. C., & Weiss, E. J. (2021) · Contemporary cardiology · doi:10.1007/978-3-030-78177-4_5 · Cited by 1 · see citing works
Efecto de la suplementación lipídica en vacas Holstein lactantes, sobre el perfil de ácidos grasos de la leche, perfil metabólico y su asociación con la expresión génica en tejido mamario
Grajales, B., & Grajales, S. M. B. (2020)
Modification of the fatty acid composition of animal-derived foods: Does it enhance their healthiness?
Givens, D. I. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15327-3.00004-5
Self-citation
Fat reduction and profile improvement in food products
Campagnol, P. C. B., Eid, N. M. S., Fernández‐López, J., & Rosmini, M. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15346-4.00005-7
Impact of dairy fat manipulation on endothelial function and lipid regulation in human aortic endothelial cells exposed to human plasma samples: an in vitro investigation from the RESET study
Markey, O., Garcimartín, A., Vasilopoulou, D., Kliem, K. E., Fagan, C. C., Humphries, D. J., Todd, S., Givens, D. I., Lovegrove, J. A., & Jackson, K. G. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03284-9
Self-citation
A food-exchange model for achieving the recommended dietary intakes for saturated fat in Irish children: analysis from the cross-sectional National Children’s Food Survey II
O’Connor, A., Buffini, M., Nugent, A. P., Kehoe, L., Flynn, A., Walton, J., Kearney, J. M., & McNulty, B. A. (2024) · Public Health Nutrition · doi:10.1017/s1368980024000971
Applications of Emerging Technologies in Traditional Chinese Medicine of Chronic Liver Disease: Nanotherapy Integration with Relevance to Artificial Intelligence and Genomics
Jiang, Z., & Xing, F. (2025) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-025-00696-y
Bovine Leukemia Virus as a One Health Challenge in Nutrition, Food Security, and Public Health: A Narrative Review
Scull, T. F., & Benitez, O. J. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101654
Effect of dairy intake and fat composition on fasting plasma branched-chain amino acids in adults at moderate cardiovascular risk: secondary analysis of the replacement of saturated fat in dairy on total cholesterol study
Bell, H. E., Jackson, K. G., Markey, O., Crompton, L., Givens, I. D., & Lovegrove, J. A. (2026) · Proceedings of The Nutrition Society · doi:10.1017/s0029665126102468
Self-citation

Effect of fat-reformulated dairy food consumption on postprandial flow-mediated dilatation and cardiometabolic risk biomarkers compared with conventional dairy: a randomized controlled trial
Markey, O., Vasilopoulou, D., Kliem, K. E., Fagan, C. C., Grandison, A. S., Sutton, R., Humphries, D. J., Todd, S., Jackson, K. G., Givens, D. I., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab428 · Cited by 6 · see citing works
Self-citation
Impact of partial replacement of saturated with monounsaturated fatty acids in dairy foods on markers of cardiovascular risk
Vasilopoulou, D. (2018) · CentAUR (University of Reading)
Self-citation
Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial
Markey, O., Vasilopoulou, D., Kliem, K. E., Koulman, A., Fagan, C. C., Summerhill, K., Wang, L. Y., Grandison, A. S., Humphries, D. J., Todd, S., et al. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0249-2 · Cited by 29 · see citing works
Self-citation
The impact of substituting SFA in dairy products with MUFA or PUFA on CVD risk: evidence from human intervention studies
Livingstone, K. M., Lovegrove, J. A., & Givens, D. I. (2012) · Nutrition Research Reviews · doi:10.1017/s095442241200011x · Cited by 111 · see citing works
Self-citation
Postprandial Fatty Acid Profile, but Not Cardiometabolic Risk Markers, Is Modulated by Dairy Fat Manipulation in Adults with Moderate Cardiovascular Disease Risk: The Randomized Controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) Study
Markey, O., Vasilopoulou, D., Kliem, K. E., Fagan, C. C., Grandison, A. S., Sutton, R., Humphries, D. J., Todd, S., Jackson, K. G., Givens, D. I., et al. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab050 · Cited by 14 · see citing works
Self-citation

Authors: Vasilopoulou, D., Markey, O., Kliem, K. E., Fagan, C. C., Grandison, A. S., Humphries, D. J., Todd, S., Jackson, K. G., Givens, D. I., & Lovegrove, J. A.
Affiliations: University of Reading (GB)
Corresponding author: Markey, Oonagh
Lovegrove, Julie A
ORCID: Vasilopoulou, Dafni
Markey, Oonagh
Kliem, Kirsty E
Fagan, Colette C
Todd, Susan
Jackson, Kim G
Givens, David I
Lovegrove, Julie A
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2020-04
Volume: 111
Issue: 4
Pages: 739-748
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/nqz344
PMC: PMC7138681
OpenAlex: W3004500872
Cited by: 50
References: 51
Citations by year: 2026: 4 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 3
FWCI: 4.90
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: American Journal of Clinical Nutrition (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
CentAUR (University of Reading) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: Medical Research Council (MR/K020218/1)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords: unsaturated fatty acids, monounsaturated fatty acids, dairy products, LDL cholesterol, flow-mediated dilation, endothelial function, nitrite, cardiovascular risk, cheese, butter, milk, cardiometabolic risk markers, cardiovascular disease prevention
MeSH terms: Cardiovascular Diseases, Dietary Fats, Dilatation, Double-Blind Method, Fats, Unsaturated, Fatty Acids, Unsaturated, Female, Humans, Cholesterol, LDL, Male, Middle Aged

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review