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Cited by 70Viral Infections and Immunology ResearchViral gastroenteritis research and epidemiologyFecal contamination and water quality

Prolonged Detection of Indigenous Wild Polioviruses in Sewage from Communities in Egypt

El Bassioni, L.·2003·American Journal of Epidemiology
DOI 10.1093/aje/kwg202
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Abstract

Environmental surveillance for polioviruses has been implemented in Egypt. This paper reports on a study in which 130 sewage samples were collected between January 2001 and December 2001 from eight provinces of Egypt. Samples were analyzed by virus isolation in L20B and RD cell cultures, and wild polioviruses were characterized by sequencing of the VP1 protein coding region. Wild type 1 polioviruses were detected in 57% of the sewage samples and 91% of the study sites, only two of which reported paralytic poliomyelitis cases in 2001. Three genetic lineages of a single indigenous type 1 poliovirus genotype were detectable in sewage, and only one lineage was also detected through surveillance for acute flaccid paralysis. Wild polioviruses persisted in the environment despite implementation of oral poliovirus vaccine immunization campaigns. Continued analysis of sewage samples, critical evaluation of immunization coverage, and performance of surveillance for acute flaccid paralysis are proposed as follow-up activities.

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Crossref · 10.1093/aje/kwg202

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21 of 21 references verified0 citation errors · 0 not checkable

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  • In India, sewage sampling helped describe poliovirus circulation epidemiology in places with high vaccination coverage but continuing paralytic polio.

    “In India, sampling of sewage helped to characterize the epidemiology of poliovirus circulation, as previously described [2,4].”

    From Environmental surveillance for polioviruses in the Global Polio Eradication Initiative. (2014) · cites this paper as [2]

  • Sewage or wastewater sampling for programmatically relevant polioviruses has long been used to supplement AFP surveillance in many countries.

    “Sampling of environmental sewage or wastewater for programmatically relevant polioviruses has been used for many years to supplement AFP surveillance in many countries [2].”

    From Environmental surveillance for polioviruses in the Global Polio Eradication Initiative. (2014) · cites this paper as [2]

  • In suspected high-risk areas lacking effective AFP surveillance, supplementary surveillance activities, such as sampling community contacts of AFP cases, stool surveys of healthy children, or environmental sampling, have been implemented to increase sensitivity for detecting wild polioviruses.

    “In suspected high-risk areas lacking effective AFP surveillance, supplementary surveillance activities, such as sampling community contacts of AFP cases, stool surveys of healthy children, or environmental sampling, have been implemented to increase sensitivity for detecting wild polioviruses (39, 48, 116, 131, 155, 190, 197).”

    From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [48]

  • Sequence relationships are generally summarized in the form of phylogenetic trees and lineage maps.

    “Sequence relationships are generally summarized in the form of phylogenetic trees and lineage maps (10, 12, 48, 84, 87, 118, 177, 179, 226).”

    From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [48]

  • Although the Israel and Slovakia isolates each comprise several distinct lineages derived from a common ancestor, this may indicate excellent sensitivity of environmental surveillance for wild polioviruses and VDPVs rather than wider VDPV circulation.

    “Although the Israel and Slovakia isolates each comprise several distinct lineages derived from a common ancestor, this may be an indication of the excellent sensitivity of environmental surveillance for wild polioviruses and VDPVs (48, 115), rather than of wider VDPV circulation.”

    From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [48]

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Authors
El Bassioni, L.
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2003-10-15
Volume
158
Issue
8
Pages
807-815
ISSN
0002-9262 (ISSN-L)
DOI
10.1093/aje/kwg202
OpenAlex
W2169363084
Cited by
70
References
20
Citations by year
2026: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 9 · 2013: 4 · 2012: 4
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
  • Physical Sciences › Environmental Science › Water Science and Technology › Fecal contamination and water quality
Keywords
poliovirus type 1, wastewater surveillance, environmental surveillance, Egypt, VP1 gene sequencing, oral polio vaccine, acute flaccid paralysis surveillance, vaccination coverage
MeSH terms
Adolescent, Child, Egypt, Environmental Microbiology, Humans, Poliomyelitis, Sewage, Water Microbiology, Poliovirus, Reverse Transcriptase Polymerase Chain Reaction

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