Characterization of a Highly Evolved Vaccine-Derived Poliovirus Type 3 Isolated from Sewage in Estonia
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Two types of vaccine-derived polioviruses have been recently designated to emphasize the different origins of the evolved viruses: circulating vaccine-derived polioviruses (cVDPV) associated with outbreaks of paralytic disease and strains isolated from chronically infected immunodeficient individuals (iVDPV). We describe here a type 3 VDPV (PV3/EST/02/E252; later E252) isolated from sewage collected in Tallinn, Estonia, in October 2002. Due to aberrant properties in subtyping, the virus was subjected to detailed characterization. Partial genomic sequencing suggested that the closest relative was the oral vaccine strain PV3/Sabin, but the two virus strains shared only 86.7% of the 900 nucleotides (nt) coding for the capsid protein VP1. Phylogenetic analysis of the nearly complete genome [nt 19 to poly(A)] revealed multiple nucleotide substitutions throughout the genome and a possible Sabin 3/Sabin 1-recombination junction site in the 2C coding region. A calculation based on the estimated mutation frequency of the P1 region of polioviruses suggested that the E252 virus might have replicated in one or more individuals for approximately 10 years. No persons chronically excreting poliovirus are known in Estonia. Amino acid substitutions were seen in all known antigenic sites, which was consistent with the observed aberrant antigenic properties of the virus demonstrated by both monoclonal antibodies and human sera from vaccinated children. In spite of the apparent transmission potential, no evidence was obtained for circulation of the virus in the Estonian population.
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All VDPV isolates characterized so far have antigenic properties distinct from the original Sabin strains.
“Moreover, all VDPV isolates characterized so far have antigenic properties distinct from the original Sabin strains (12, 71, 84, 117, 177, 180, 226).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [12]
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VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION
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- Authors
- Blomqvist, S., Savolainen, C., Laine, P., Hirttiö, P., Lamminsalo, E., Penttilä, E., Jöks, S., Roivainen, M., & Hovi, T.
- Affiliations
- Department of Microbiology, Enterovirus Laboratory, National Public Health Institute (KTL), 00300 Helsinki, Finland
- Central Laboratory of Virology, Health Protection Inspectorate, 11315 Tallinn, Estonia
- Corresponding author
- Blomqvist, Soile
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2004-05
- Volume
- 78
- Issue
- 9
- Pages
- 4876-4883
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC387693
- OpenAlex
- W2121087154
- Cited by
- 104
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 11 · 2013: 11 · 2012: 5
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- circulating vaccine-derived poliovirus, wastewater, VP1 phylogeny, paralytic disease, oral polio vaccine, Estonia
- MeSH terms
- Amino Acid Sequence, Antibodies, Viral, Antigens, Viral, Child, Child, Preschool, Estonia, Humans, Infant, Molecular Sequence Data, Neutralization Tests, Poliovirus Vaccine, Oral, Serotyping, Sewage, Vaccination, Genome, Viral, Sequence Analysis, DNA, Poliovirus, Evolution, Molecular, Amino Acid Substitution
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