Association of intentional changes in body weight with coronary heart disease event rates in overweight subjects who have an additional coronary risk factor
Abstract
Despite evidence that weight loss improves the severity of coronary heart disease (CHD) risk factors, a direct association between weight loss and CHD incidence has not been demonstrated. In 1994-2001, the authors conducted an observational study of intentional weight loss as related to CHD incidence among patients recruited from a network of clinics in Israel who received nutritional counseling from a dietitian to support the medical recommendation to lose weight. Subjects were outpatients aged 50-75 years with a body mass index of > or =27 kg/m(2), without CHD or cancer but with at least one risk factor for CHD in addition to overweight. Outcomes were documented over 4 years by repeated weight measurements and by medical record verification. Among 1,669 patients, 224 (13.4%) incidents of CHD were recorded. For subjects who underwent at least 6 months of dietetic counseling, the risk-factor-adjusted odds ratio for CHD incidence associated with a weight loss of 4.5 kg (the median level of weight loss) was 0.57 (95% confidence interval: 0.39, 0.84). In this, the largest known study of its type reported to date, intentional weight loss from a 6-month diet predicted lower incidence of CHD over 4 years.
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In a study of more than 1,500 coronary heart disease patients, intentional weight loss from a 6-month dietary program lowered the incidence of coronary heart disease events over 4 years.
“Likewise, in a study of over 1,500 CHD patients, intentional weight loss from a 6-month dietary program also produced a lower incidence of CHD events over 4 years (78).”
From Obesity and Cardiovascular Disease (2009) · cites this paper as [78]
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- Authors
- Eilat-Adar, S.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Eilat-Adar, S.
- ORCID
- Eilat-Adar, S.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-15
- Volume
- 161
- Issue
- 4
- Pages
- 352-358
- ISSN
- 0002-9262 (ISSN-L)
- OpenAlex
- W2125288612
- Cited by
- 109
- References
- 43
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 4 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 10 · 2013: 15 · 2012: 8
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Danone
- Hebrew University of Jerusalem
- Tel Aviv University
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- intentional weight loss, coronary heart disease incidence, overweight, nutrition counseling, coronary risk factors, weight change, middle-aged and older adults, cardiovascular risk reduction
- MeSH terms
- Aged, Coronary Disease, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Prospective Studies, Risk Factors, Cardiovascular Surgical Procedures, Weight Loss, Body Mass Index, Incidence, Directive Counseling
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