Prospective study of cured meats consumption and risk of chronic obstructive pulmonary disease in men
Open accessAbstract
Cured meats are high in nitrites. Nitrites generate reactive nitrogen species that may cause damage to the lung. The objective is to assess the relation between frequent consumption of cured meats and the risk of newly diagnosed chronic obstructive pulmonary disease (COPD). Between 1986 and 1998, the authors identified 111 self-reported cases of newly diagnosed COPD among 42,915 men from the Health Professionals Follow-up Study. The cumulative average intake of cured meats consumption (processed meats, bacon, hot dogs) was calculated from food frequency questionnaires administrated in 1986, 1990, and 1994 and divided according to servings per week (never/almost never, <1 serving/week, 1-3 servings/week, 4-6 servings/week, at least once/day). After adjustment for age, smoking status, pack-years, pack-years squared, energy intake, race/ethnicity, US region, body mass index, and physical activity, the consumption of cured meats was positively associated with the risk of newly diagnosed COPD (for highest vs. lowest intake: relative risk = 2.64, 95% confidence interval: 1.39, 5.00; p(trend) = 0.002). In contrast to these findings, the consumption of cured meats was not associated with the risk of adult-onset asthma. These data suggest that cured meat may worsen the adverse effects of smoking on risk of COPD.
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Because cured meats such as bacon, sausage, and ham contain high doses of nitrite for preservation, antimicrobial, and color fixation, epidemiological studies have demonstrated that consumption of cured meats is positively linked to the risk of newly diagnosed COPD.
“Because cured meats such as bacon, sausage and ham contain high doses of nitrite for preservation, antimicrobial and color fixation, epidemiological studies have demonstrated that the consumption of cured meats is positively linked to the risk of newly diagnosed COPD [109,110,111].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [111]
Nitrite generates reactive nitrogen species, which may cause nitrosative damage to the lungs, eventually leading to structural changes like emphysema.
“Nitrite generates reactive nitrogen species, which may cause nitrosative damage to the lungs, eventually leading to structural changes like emphysema [111].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [111]
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Research works printed but not linked: 1
- Jiang R, Paik DC, Hankinson J, et al. Consumption of cured meats, lung function and chronic obstructive pulmonary dis- ease among US adults. Am J Respir Crit Care Med 2007;175: 798-804.
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- Authors
- Varraso, R., Jiang, R., Barr, R. G., Willett, W. C., & Camargo, C. A.
- Affiliations
- Harvard University (US)
- Columbia University Irving Medical Center (US)
- Brigham and Women's Hospital (US)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09-06
- Volume
- 166
- Issue
- 12
- Pages
- 1438-1445
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC2573990
- OpenAlex
- W2106060081
- Cited by
- 84
- References
- 41
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 9 · 2018: 5 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- National Institutes of Health (CA55075)
- National Heart, Lung, and Blood Institute (HL60712, R01HL060712, RC1HL100543)
- National Cancer Institute (CA-55075, P01CA055075)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK040561)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Keywords
- cured meat, chronic obstructive pulmonary disease, nitrite, processed meat, bacon, hot dogs, smoking, adult-onset asthma, lung cancer risk, men, dietary intake
- MeSH terms
- Adult, Aged, Diet, Food Preservation, Humans, Life Style, Male, Meat Products, Middle Aged, Nitrites, Phenotype, Prospective Studies, Surveys and Questionnaires, Risk Factors, United States, Body Mass Index, Chi-Square Distribution, Proportional Hazards Models, Pulmonary Disease, Chronic Obstructive
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