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Physical Trauma and Amyotrophic Lateral Sclerosis: A Population-Based Study Using Danish National Registries

Seals, Ryan M., Hansen, Johnni, Gredal, Ole, Weisskopf, Marc G.·2016·American Journal of Epidemiology
DOI 10.1093/aje/kwv169
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  • Some studies have reported that multiple head injuries and age at first head injury were associated with ALS, which is consistent with the findings we observed in our study.

    “Some studies have reported that multiple head injuries and age at first head injury were associated with ALS, which is also consistent with the findings we observed in our study [18,20,61,62].”

    From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [61]

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Research works printed but not linked: 33

  1. Deapen DM, Henderson BE. A case-control study of amyotrophic lateral sclerosis. Am J Epidemiol. 1986;123(5): 790-799.
  2. Shlosberg D, Benifla M, Kaufer D, et al. Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury. Nat Rev Neurol. 2010;6(7):393-403.
  3. Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008;57(2):178-201.
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  5. Goldman SM, Tanner CM, Oakes D, et al. Head injury and Parkinson's disease risk in twins. Ann Neurol. 2006;60(1): 65-72.
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  7. Duffy LM, Chapman AL, Shaw PJ, et al. Review: the role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol. 2011;37(4):336-352.
  8. Paschen W, Mengesdorf T. Endoplasmic reticulum stress response and neurodegeneration. Cell Calcium. 2005;38(3-4): 409-415.
  9. Pupillo E, Messina P, Logroscino G, et al. Trauma and amyotrophic lateral sclerosis: a case-control study from a population-based registry. Eur J Neurol. 2012;19(12): 1509-1517.
  10. Armon C, Nelson LM. Is head trauma a risk factor for amyotrophic lateral sclerosis? An evidence based review. Amyotroph Lateral Scler. 2012;13(4):351-356.
  11. Kurtzke JF, Beebe GW. Epidemiology of amyotrophic lateral sclerosis: 1. A case-control comparison based on ALS deaths. Neurology. 1980;30(5):453-462.
  12. Kurland LT, Radhakrishnan K, Smith GE, et al. Mechanical trauma as a risk factor in classic amyotrophic lateral sclerosis: lack of epidemiologic evidence. J Neurol Sci. 1992;113(2): 133-143.
  13. Kioumourtzoglou M-A, Seals RM, Himmerslev L, et al. Comparison of diagnoses of amyotrophic lateral sclerosis by use of death certificates and hospital discharge data in the Danish population. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(3-4):224-229.
  14. Pedersen CB, Gøtzsche H, Møller JO, et al. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull. 2006;53(4):441-449.
  15. Lipsitch M, Tchetgen Tchetgen E, Cohen T. Negative controls: a tool for detecting confounding and bias in observational studies. Epidemiology. 2010;21(3):383-388.
  16. Harwood CA, McDermott CJ, Shaw PJ. Physical activity as an exogenous risk factor in motor neuron disease (MND): a review of the evidence. Amyotroph Lateral Scler. 2009;10(4): 191-204.
  17. Pupillo E, Messina P, Giussani G, et al. Physical activity and amyotrophic lateral sclerosis: a European population-based case-control study. Ann Neurol. 2014;75(5):708-716.
  18. Wicks P. Hypothesis: higher prenatal testosterone predisposes ALS patients to improved athletic performance and manual professions. Amyotroph Lateral Scler. 2012;13(3):251-253.
  19. Glass CK, Saijo K, Winner B, et al. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010;140(6): 918-934.
  20. Liu B, Gao H-M, Hong J-S. Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect. 2003;111(8):1065-1073.
  21. Jensen AB, Moseley PL, Oprea TI, et al. Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients. Nat Commun. 2014;5:4022.
  22. Weisskopf MG, McCullough ML, Calle EE, et al. Prospective study of cigarette smoking and amyotrophic lateral sclerosis. Am J Epidemiol. 2004;160(1):26-33.
  23. Alonso A, Logroscino G, Hernán MA. Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta- analysis. J Neurol Neurosurg Psychiatry. 2010;81(11): 1249-1252.
  24. O'Reilly ÉJ, Wang H, Weisskopf MG, et al. Premorbid body mass index and risk of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013; 14(3):205-211.
  25. Fang F, Bellocco R, Hernán MA, et al. Smoking, snuff dipping and the risk of amyotrophic lateral sclerosis-a prospective cohort study. Neuroepidemiology. 2006;27(4):217-221.
  26. Alonso A, Logroscino G, Jick SS, et al. Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective study. BMC Neurol. 2010; 10:6.
  27. Guerriero RM, Proctor MR, Mannix R, et al. Epidemiology, trends, assessment and management of sport-related concussion in United States high schools. Curr Opin Pediatr. 2012;24(6): 696-701.
  28. Marar M, McIlvain NM, Fields SK, et al. Epidemiology of concussions among United States high school athletes in 20 sports. Am J Sports Med. 2012;40(4):747-755.
  29. Meehan WP 3rd, Mannix RC, O'Brien MJ, et al. The prevalence of undiagnosed concussions in athletes. Clin J Sport Med. 2013;23(5):339-342.
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  31. Haley RW. Excess incidence of ALS in young Gulf War veterans. Neurology. 2003;61(6):750-756.
  32. Horner RD, Kamins KG, Feussner JR, et al. Occurrence of amyotrophic lateral sclerosis among Gulf War veterans. Neurology. 2003;61(6):742-749.
  33. Lehman EJ, Hein MJ, Baron SL, et al. Neurodegenerative causes of death among retired National Football League players. Neurology. 2012;79(19):1970-1974.

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Authors
Seals, R. M., Hansen, J., Gredal, O., & Weisskopf, M. G.
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2016-01-28
Volume
183
Issue
4
Pages
294-301
ISSN
  • 0002-9262
  • 1476-6256
DOI
10.1093/aje/kwv169
Cited by
38
References
3
Language
en
Funders
  • National Institute of Environmental Health Sciences (5R01ES019188-02)
  • National Research Service Award (T32 ES 07069)

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