Differential impairment of source memory in progressive versus non-progressive behavioral variant frontotemporal dementia
Abstract
Episodic memory has recently been shown to be impaired in the behavioral variant of frontotemporal dementia (bvFTD) when so-called non-progressive cases are excluded. Such non-progressive cases present with the behavioral features of bvFTD, but show no evidence of cognitive decline over time. To date, evidence regarding episodic memory performance in bvFTD subgroups on more stringent tasks is lacking. We investigated temporal and spatial source memory in progressive (n = 7) versus non-progressive (n = 12) bvFTD. BvFTD cases were retrospectively classified based on general cognitive decline on the Addenbrooke's Cognitive Examination Revised, and the presence of atrophy on structural neuroimaging, over 3 years following diagnosis. Progressors showed impaired temporal and spatial source retrieval. Non-progressors displayed temporal source deficits only. These differential source memory profiles point to the variability of episodic memory performance in bvFTD, and underscore the importance of differential diagnosis of bvFTD subgroups using longitudinal and neuroimaging data.
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Studies reported specific patterns of episodic memory impairment, with temporal and spatial memory deficits in progressive bvFTD.
“Studies reported specific patterns of (episodic) memory impairment, with temporal and spatial memory deficits in progressive bvFTD (Irish et al., 2012), and a vulnerability for recent autobiographical memory over time, likely to reflect an encoding deficit rather than retrieval deficit (Irish et al., 2018).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Irish et al., 2012
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- Authors
- Irish, M., Graham, A., Graham, K. S., Hodges, J. R., & Hornberger, M.
- Affiliations
- UNSW Sydney (AU)
- MRC Cognition and Brain Sciences Unit (GB)
- Cardiff University (GB)
- Corresponding author
- Irish, M.
- Venue
- Archives of Clinical Neuropsychology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-13
- Volume
- 27
- Issue
- 3
- Pages
- 338-347
- ISSN
- 0887-6177 (ISSN-L)
- 1873-5843
- OpenAlex
- W2155256837
- Cited by
- 20
- References
- 52
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Clinical Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- behavioral variant frontotemporal dementia, source memory, episodic memory, cognitive decline, disease progression, differential diagnosis, frontal lobe atrophy
- MeSH terms
- Aged, Cognition Disorders, Diagnosis, Differential, Female, Humans, Male, Memory Disorders, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Case-Control Studies, Disease Progression, Statistics, Nonparametric, Frontotemporal Dementia, Memory, Episodic
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