Dementia and survival in Parkinson disease: A 12-year population study
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BACKGROUND: The risk for dementia in Parkinson disease (PD) is high, with important clinical consequences for patients with PD. However, the absolute risk of dementia and how it affects survival in PD are not known. Such questions are important for patients, their families, and service providers but require long-term studies. METHODS: This study is a prospective longitudinal cohort study with patients from a prevalence study of PD in Norway. Patients were reassessed 4, 8, 9, 10, 11, and 12 years after prevalence day. A dementia diagnosis according to Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, criteria was based on a semistructured caregiver interview, cognitive rating scales, and neuropsychological tests. Progression from PD to PD with dementia and death was modeled using a continuous-time three-state irreversible Markov model. RESULTS: A total of 233 PD patients were included, and 140 patients (60%, 95% CI 54% to 66%) had developed dementia by the end of the study period. The cumulative incidence of dementia steadily increases with age and duration of PD and, conditional on survival, increases to 80% to 90% by age 90 years. Women live with PD longer than men and spend more years with dementia. At age 70 years, a man with PD but no dementia has a life expectancy of 8 years, of which 5 years would be expected to be dementia free and 3 years would be expected to be with dementia. CONCLUSION: Dementia is a key part of survival in Parkinson disease and must be planned for in services for this condition.
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Dementia eventually develops in most patients with Parkinson disease with long-term follow-up.
“Dementia eventually develops in most patients with PD with long-term follow-up.15,16”
From Does vigorous exercise have a neuroprotective effect in Parkinson disease? (2011) · cites this paper as [16]
Cites
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107 · see citing works
Population-Based Norms for the Mini-Mental State Examination by Age and Educational Level
Crum, R. M. (1993) · JAMA · doi:10.1001/jama.1993.03500180078038 · Cited by 2,906 · see citing works
Prevalence and Characteristics of Dementia in Parkinson Disease
Aarsland, D., Andersen, K., Larsen, J. O., & Lolk, A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.387 · Cited by 1,403 · see citing works
Self-citationThe question of familial meningiomas and schwannomas:
King, A. A., & Gutmann, D. H. (2000) · Neurology · doi:10.1212/wnl.54.1.4 · Cited by 814 · see citing works
The incidence of dementia: A meta-analysis
Jorm, A. F., & Jolley, D. (1998) · Neurology · doi:10.1212/wnl.51.3.728 · Cited by 705 · see citing works
Risk of dementia in Parkinson’s disease: A community-based, prospective study
Aarsland, D., Andersen, K., Larsen, J. P., Lolk, A., Nielsen, H., & Kragh–Sørensen, P. (2001) · Neurology · doi:10.1212/wnl.56.6.730 · Cited by 576 · see citing works
Self-citationAarsland, D., Brønnick, K., Ehrt, U., Deyn, P. P. D., Tekin, S., Emre, M., & Cummings, J. L. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.083113 · Cited by 519 · see citing works
Self-citationMental symptoms in Parkinson's disease are important contributors to caregiver distress
Aarsland, D., Larsen, J. P., Karlsen, K., Lim, N. G., & Tandberg, E. (1999) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199910)14:10 · Cited by 484 · see citing works
Self-citationAge-specific incidence rates of Alzheimer’s disease: The Baltimore Longitudinal Study of Aging
Kawas, C., Gray, S., Brookmeyer, R., Fozard, J., & Zonderman, A. (2000) · Neurology · doi:10.1212/wnl.54.11.2072 · Cited by 472 · see citing works
Prevalence of Dementia in Older Japanese-American Men in Hawaii: The Honolulu-Asia Aging Study
White, L. (1996) · JAMA · doi:10.1001/jama.1996.03540120033030 · Cited by 437 · see citing works
A 10-year study of the incidence of and factors predicting dementia in Parkinson’s disease
Hughes, T. A., Ross, H., Musa, S., Bhattacherjee, S., Nathan, R. N., Mindham, R. H. S., & SPOKES, E. G. S. (2000) · Neurology · doi:10.1212/wnl.54.8.1596 · Cited by 368 · see citing works
Neuropathology of dementia in Parkinson's disease: A prospective, community‐based study
Aarsland, D., Perry, R., Brown, A. D., Larsen, J. O., & Ballard, C. G. (2005) · Annals of Neurology · doi:10.1002/ana.20635 · Cited by 347 · see citing works
Self-citationTuokko, H. A., Hadjistavropoulos, T., Miller, J., & Beattie, B. L. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb02106.x · Cited by 302 · see citing works
The association of incident dementia with mortality in PD
Levy, G., Tang, M. ‐., Louis, E. D., Cote, L. J., Alfaro, B., Mejía, H., Stern, Y., & Marder, K. S. (2002) · Neurology · doi:10.1212/01.wnl.0000036610.36834.e0 · Cited by 300 · see citing works
Multistate Markov models for disease progression with classification error
Jackson, C. H., Sharples, L. D., Thompson, S. G., et al. (2003) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.1111/1467-9884.00351 · Cited by 280 · see citing works
Frequency of Dementia in Parkinson Disease
Aarsland, D., Tandberg, E., Larsen, J. O., & Cummings, J. L. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550060082020 · Cited by 276 · see citing works
Self-citationThe Frequency and Associated Risk Factors for Dementia in Patients With Parkinson's Disease
Marder, K. S., Tang, M. X., Cote, L. M., Stern, Y., & Mayeux, R. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540310069018 · Cited by 268 · see citing works
Prevalence of dementia in the elderly in Europe
Berr, C., Wancata, J., & Ritchie, K. A. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.04.003 · Cited by 241 · see citing works
Mortality in Parkinson's disease and its association with dementia and depression
Hughes, T. A., Ross, H., Mindham, R. H. S., & SPOKES, E. G. S. (2004) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2004.00292.x · Cited by 219 · see citing works
Neuropsychological Profile of Patients with Parkinson’s Disease without Dementia
Janvin, C. C., Aarsland, D., Larsen, J. O., & Hugdahl, K. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000068483 · Cited by 212 · see citing works
Self-citationRisk factors for dementia, depression and psychosis in long-standing Parkinson's disease
Giladi, N., Treves, T. A., Paleacu, D., Shabtai, H., Orlov, Y., Kandinov, B., Simon, E. S., & Korczyn, A. D. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050005 · Cited by 211 · see citing works
Prognosis of Parkinson Disease
de Lau, L. M. L., Schipper, C. M. A., Albert Hofman, D., Koudstaal, P. J., & Breteler, M. M. B. (2005) · Archives of Neurology · doi:10.1001/archneur.62.8.1265 · Cited by 211 · see citing works
Combined effect of age and severity on the risk of dementia in Parkinson's disease
Levy, G., Schupf, N., Tang, M., COTE, L. J., Louis, E. D., Mejia‐Santana, H., Stern, Y., & Marder, K. S. (2002) · Annals of Neurology · doi:10.1002/ana.10219 · Cited by 209 · see citing works
Fratiglioni, L., Launer, L. J., Andersen, K., Breteler, M. M. B., Copeland, J., Dartigues, J., Lobo, A., Martinez-Lage, J., Soininen, H., & Albert Hofman, D. (2000) · EUR Research Repository (Erasmus University Rotterdam) · Cited by 203 · see citing works
Ten-year incidence of dementia in a rural elderly US community population: the MoVIES Project
Ganguli, M., Dodge, H. H., Chen, P., Belle, S., & DeKosky, S. T. (2000) · Neurology · doi:10.1212/wnl.54.5.1109 · Cited by 196 · see citing works
The Mattis Dementia Rating Scale
Schmidt, R., Freidl, W., Fazekas, F., Reinhart, B., Grieshofer, P., Koch, M., Eber, B., Schumacher, M., Polmin, K., & Lechner, H. (1994) · Neurology · doi:10.1212/wnl.44.5.964 · Cited by 185 · see citing works
THE ESTIMATION OF HEALTH EXPECTANCIES FROM CROSS-LONGITUDINAL SURVEYS
Lièvre, A., Brouard, N., & Heathcote, C. R. (2003) · Mathematical Population Studies · doi:10.1080/713644739 · Cited by 180 · see citing works
The epidemiology of Parkinson's disease in the county of Rogaland, Norway
Tandberg, E., Larsen, J. O., Nessler, E. G., Riise, T., & Aarli, J. A. (1995) · Movement Disorders · doi:10.1002/mds.870100503 · Cited by 177 · see citing works
Self-citationLarsen, J. O., Dupont, E., & Tandberg, E. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb01674.x · Cited by 176 · see citing works
Self-citationThe effect of age of onset of PD on risk of dementia
Aarsland, D., Kvaløy, J. T., Andersen, K., Larsen, J. P., Tang, M. X., Lolk, A., Kragh-Sørensen, P., & Marder, K. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0234-8 · Cited by 162 · see citing works
Self-citationQuality of life of caregivers in Parkinson?s disease
Mart�nez-Mart�n, P., Benito‐León, J., Alonso, F., Catal�n, M. J., Pondal, M., Zamarbide, I., Tobı́as, A., & de Pedro, J. (2005) · Quality of Life Research · doi:10.1007/s11136-004-6253-y · Cited by 159 · see citing works
Cost of Illness and its Predictors for Parkinson??s Disease in Germany
Spottke, A. E., Reuter, M., Machat, O., Bornschein, B., von Campenhausen, S., Berger, K., Köhne-Volland, R., Rieke, J., Simonow, A., Brandstädter, D., et al. (2005) · PharmacoEconomics · doi:10.2165/00019053-200523080-00007 · Cited by 144 · see citing works
Medical Services Utilization and Prognosis in Parkinson Disease: A Population-Based Study
Parashos, S. A., Maraganore, D. M., O'Brien, P. C., & Rocca, W. A. (2002) · Mayo Clinic Proceedings · doi:10.4065/77.9.918 · Cited by 90 · see citing works
Dementia in Parkinson's disease
Tison, F., Dartigues, J.-F., Auriacombe, S., et al. (1995) · Neurology · doi:10.1212/wnl.45.4.705 · Cited by 90 · see citing works
The present state of people who survived the holocaust as children
Robinson, S., Rapaport‐Bar‐Sever, M., & Rapaport, J. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb01508.x · Cited by 87 · see citing works
Rates and risk factors for dementia and Alzheimer's disease. Results from EURODEM pooled analyses
Launer, L. J., Andersen, K., Dewey, M., Letenneur, L., Ott, A., Amaducci, L. A., Brayne, C., Copeland, J., Dartigues, J., Kragh-Sorensen, P., et al. (1999) · EUR Research Repository (Erasmus University Rotterdam) · Cited by 36 · see citing works
Self-citationMigraine and autonomic nervous system function: A population-based, case-control study
Marinis, M. D. (2003) · Neurology · doi:10.1212/wnl.61.3.424-a · Cited by 23 · see citing works
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Davis, E. J., Broestl, L., Abdulai-Saiku, S., Worden, K., Bonham, L. W., Miñones-Moyano, E., Moreno, A. J., Wang, D., Chang, K., Williams, G., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz5677 · Cited by 176 · see citing works
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- Authors
- Buter, T. C., van den Hout, A., Matthews, F. E., Larsen, J. P., Brayne, C., & Aarsland, D.
- Affiliations
- University of Cambridge (GB)
- From the Norwegian Centre for Movement Disorders (T.C.B., J.P.L., D.A.), Stavanger University Hospital, Stavanger, Norway; Institute of Clinical Medicine (J.P.L., D.A.), University of Bergen, Norway; MRC Biostatistics Unit (A.v.d.H., F.E.M.), Institute of Public Health, University of Cambridge; and Department of Public Health and Primary Care (C.B.), University of Cambridge, UK.
- Venue
- Neurology
- Published
- 2008-03-25
- Volume
- 70
- Issue
- 13
- Pages
- 1017-1022
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2000216201
- Cited by
- 451
- References
- 37
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 24 · 2023: 12 · 2022: 25 · 2021: 26 · 2020: 25 · 2019: 21 · 2018: 26 · 2017: 34 · 2016: 29 · 2015: 27 · 2014: 22 · 2013: 27 · 2012: 23
- FWCI
- 22.63
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
- Repository@Hull (Worktribe) (University of Hull) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, dementia, survival, dementia risk, life expectancy, dementia incidence, sex differences, disease progression, Markov model, cognitive decline
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Dementia, Female, Humans, Life Expectancy, Longitudinal Studies, Male, Middle Aged, Norway, Parkinson Disease, Prospective Studies, Risk Factors, Sex Factors, Cohort Studies, Comorbidity, Incidence, Survival Rate, Age Distribution, Sex Distribution
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