The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
The brain response to personally familiar faces in autism: findings of fusiform activity and beyond
Abstract
Past functional MRI (FMRI) studies of autism have reported reduced activation in response to the faces of strangers primarily in the 'fusiform face area' (FFA). An alternative and potentially stronger test of FFA function in autism is one that attempts to affect levels of FFA activity using factors believed to modulate function in this brain region, such as face familiarity and the perception of face identity. The current study presented personally meaningful faces, such as mother and co-worker, as well as stranger faces in a rapid event-related FMRI design. Seven autistic and nine normal control adults participated and pressed a button in response to all female faces. A deconvolution analysis revealed significant FFA activity in response to familiar and stranger faces in both autism and normal control groups. Individuals with autism also showed greater fusiform activity in response to familiar faces than stranger faces, as well as the prototypical right hemisphere dominance in response to both types of faces. Normal subjects showed additional activation to familiar faces in the posterior cingulate, amygdala and medial frontal lobes, including the anterior cingulate. Subjects with autism showed a similar, but more limited, network in response to familiar faces. This network included the amygdala and implies that this structure, involved in multiple socio-emotional functions, can be responsive in autism in the presence of stimuli that represent high reward value, such as mother's face. Furthermore, the presence of a distinct network to process familiar faces in autism, one that included limbic structures and was not found in response to the faces of strangers, suggests socio-emotional processing in autism. A potentially noteworthy trend, however, was evidence for a reduction in medial frontal lobe function in the autism group. The main finding of FFA activity in autism stands in contrast to most past FMRI studies of face processing in this disorder. This positive result may reflect the use of personally significant faces that enhanced attention and motivation in the autistic participants. Furthermore, given the proposed role of the FFA in establishing person identity, the use of almost a dozen different personally familiar faces for each participant (totalling 32 non-repeating faces) may have additionally maximized FFA involvement. Therefore, dysfunction in the FFA found in other studies of autism may reflect defects in systems that modulate the FFA, rather than the FFA itself.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, three studies, those of Ogai et al. (2003), Pierce et al. (2004) and Piggot et al. (2004), failed to find any significant differences in amygdala activation for the ASD samples compared to controls.”
From Vision in autism spectrum disorders (2009) · cites this paper as Pierce et al. (2004)
In the citing paper
“Dalton et al.'s (2005) study, together with Ogai et al. (2003), Pierce et al. (2004) and Piggot et al. (2004) suggest that it is possible to obtain functional activations of the amygdala in individuals with ASD, given appropriate control of the participant (with regard to fixation) and appropriate levels of stimulation (familiar or highly evocative faces).”
From Vision in autism spectrum disorders (2009) · cites this paper as Pierce et al. (2004)
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,842
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Thresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923
The distributed human neural system for face perception
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01482-0 · Cited by 4,891
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 431
Constellation autistique, mouvement, temps et pensée
Gepner, B. (2006) · Devenir · doi:10.3917/dev.064.0333 · Cited by 48
An image-invariant neural response to familiar faces in the human medial temporal lobe
Weibert, K., Harris, R. J., Mitchell, A. G., Byrne, H. R., Young, A. W., & Andrews, T. J. (2016) · Cortex · doi:10.1016/j.cortex.2016.08.014 · Cited by 37
“The MTL has previously been reported to respond more to familiar than to unfamiliar faces (Bar, Aminoff, & Ishai, 2008; Barense, Henson, & Graham, 2011; Eger et al., 2005; Elfgren et al., 2006; Ishai, Haxby, & Ungerleider, 2002; Leveroni et al., 2000; Nielson et al., 2010; Pierce et al., 2004; Sergent et al., 1992).”
PRANDOTA, J. (2009) · Research in Autism · doi:10.1016/j.rasd.2009.09.007 · Cited by 35
Autistic-spectrum disorders: lessons from neuroimaging
Toal, F., Murphy, D., & Murphy, K. C. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.187.5.395 · Cited by 35
“However, more recently it has been identified that this response can be modulated, depending on the familiarity and personal emotional content of the faces presented (Hadjikhani et al, 2004; Pierce et al, 2004).”
BackgroundAndrás, J., Emri, M., Spisák, T., Szemán-Nagy, A., Béresová, M., Kis, S. A., Molnár, P., & Berényi, E. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060982 · Cited by 36
“during performance of emotional, social and introspective tasks, such as the theory of mind [90], social perception, emotional processing, viewing familiar faces [91] and its impairments have been frequently linked with the autism spectrum disorder.”
BackgroundGhanouni, P., Jarus, T., Zwicker, J. G., & Lucyshyn, J. M. (2020) · Behaviour and Information Technology · doi:10.1080/0144929x.2020.1776770 · Cited by 40
“High resemblance of virtual settings to real environments help represent internal models or repertoire, which in turn may generate respective experiences (Crowder and Merritte 2013; Pierce et al. 2004; Wages, Grünvogel, and Grützmacher 2004; Wolpert, Miall, and Kawato 1998).”
BackgroundAhadullah, Yau, S., Lu, H., Lee, T. M. C., Guo, H., & Chan, C. C. H. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.043 · Cited by 33
Event-related oscillations in structural and semantic encoding of faces
Sakihara, K., Gunji, A., Furushima, W., & Inagaki, M. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.06.023 · Cited by 33
“Recent hemodynamic studies have reported that self-face perception activates inferior frontal and superior temporal areas, with right hemisphere dominance (Keenan et al., 2001; Pierce et al., 2004; Platek et al., 2004, 2006; Uddin et al., 2005b).”
BackgroundOverview and Introduction to Autism Spectrum Disorder (ASD)
Al-Dewik, N. I. E., Al‐Jurf, R., Styles, M., Tahtamouni, S., Al‐Sharshani, D., Alsharshani, M., Ahmad, A. I., Khattab, A., Rifai, H. A., & Qoronfleh, M. W. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_1 · Cited by 37
Grandgeorge, M., Bourreau, Y., Alavi, Z., Lemonnier, É., Tordjman, S., Deleau, M., & Hausberger, M. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0528-9 · Cited by 36
“Fusiform face area activation is normal when ASD children and TD children looked at familiar faces [66].”
BackgroundFrom Loci to Networks and Back Again
Müller, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1416.014 · Cited by 30
“Aside from some nonreplications (Hadjikhani et al., 2004; Pierce et al., 2004), such findings do not necessarily indicate locally compromised cortical function, but they may be indicative of experiential effects (as discussed in detail in Müller, 2007a, 2007b).”
BackgroundThe Implications of Social Neuroscience for Social Disability
McPartland, J. C., & Pelphrey, K. A. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1514-z · Cited by 33
“…replicated findings, such as atypical brain activation during face perception, are not evident in all samples of individuals with ASD (Hadjikhani et al. 2004; Jemel et al. 2006; Kemner et al. 2006; Kleinhans et al. 2008; Lahaie et al. 2006; Pierce et al. 2004; Senju et al. 2005; Webb et al. 2009).”
Gaze aversion during social style interactions in autism spectrum disorder and Williams syndrome
Doherty‐Sneddon, G., Whittle, L., & Riby, D. M. (2012) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2012.09.022 · Cited by 30
Kim, J. I., Bang, S., Yang, J., Kwon, H., Jang, S., Roh, S., Kim, S. H., Kim, M. J., Lee, H. J., Lee, J., et al. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05368-z · Cited by 31
Barman, A., Richter, S., Soch, J., Deibele, A., Richter, A., Assmann, A., Wüstenberg, T., Walter, H., Seidenbecher, C. I., & Schott, B. H. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv044 · Cited by 34
Autismus und soziale Kognition
Domes, G., Kumbier, E., Herpertz‐Dahlmann, B., & Herpertz, S. C. (2008) · Der Nervenarzt · doi:10.1007/s00115-008-2409-2 · Cited by 32
Boeschoten, M. A., Kenemans, J. L., van Engeland, H., & Kemner, C. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0780-y · Cited by 31
“These differences between the two groups of children in the frontal sources activated in response to face processing seem to be in line with recent fMRI results presented by Pierce et al. (2004) and Dalton et al. (2005).”
BackgroundResultInfluentialInvestigations of face expertise in the social developmental disorders
Barton, J. J. S., Hefter, R. L., Cherkasova, M. V., & Manoach, D. S. (2007) · Neurology · doi:10.1212/01.wnl.0000267842.85646.f2 · Cited by 29
Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder
Yerys, B. E., Herrington, J. D., Bartley, G. K., Liu, H. S., Detre, J. A., & Schultz, R. T. (2018) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-018-9250-0 · Cited by 33
Yang, J., Yang, C., & Yin, B.-Q. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113094 · Cited by 32
Functional Neuroimaging Studies of Autism Spectrum Disorders
Schultz, R. T., & Robins, D. L. (2005) · Wiley eBooks · doi:10.1002/9780470939345.ch19 · Cited by 29
Helt, M. S., FEIN, D. A., & Vargas, J. E. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000154 · Cited by 27
“These results align with previous research reporting normal neural responses to faces and actions in individuals with ASD only in studies in which the stimuli were composed of familiar individuals (Oberman et al., 2008; Pierce et al., 2004).”
ResultHappy and Angry Faces Elicit Atypical Neural Activation in Children With Autism Spectrum Disorder
Leung, R. C., Pang, E. W., Brian, J. A., & Taylor, M. J. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.03.013 · Cited by 28
Yan, X., & Rossion, B. (2020) · Cortex · doi:10.1016/j.cortex.2020.08.016 · Cited by 29
Helt, M. S., & FEIN, D. A. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2545-z · Cited by 26
“…with ASD are securely attached to their caregivers (Capps et al. 1994; Rogers et al. 1991) and tend to show more typical social and emotional processing with regard to people who are personally meaningful to them (Oberman et al. 2008; Pierce et al. 2004; Van Hecke et al. 2009; Wilson et al. 2007).”
BackgroundElectrodermal Response to Reward and Non‐Reward Among Children With Autism
Neuhaus, E., Bernier, R., & Beauchaine, T. P. (2015) · Autism Research · doi:10.1002/aur.1451 · Cited by 30
Responsivity to familiar versus unfamiliar social reward in children with autism
Pankert, A., Pankert, K., Herpertz‐Dahlmann, B., Konrad, K., & Kohls, G. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1210-6 · Cited by 30
Pereira, J. A., Sepúlveda, P., Rana, M., Montalba, C., Cristián Tejos, N., Torres, R., Sitaram, R., & Ruíz, S. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00446 · Cited by 27
Ammons, C. J., Winslett, M., Bice, J., Patel, P. H., May, K. E., & Kana, R. K. (2020) · Autism Research · doi:10.1002/aur.2425 · Cited by 27
Seri, S., Pisani, F., Thai, N. J., & Cerquiglini, A. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2006.03.013 · Cited by 25
Spatiotemporal changes in neural response patterns to faces varying in visual familiarity
Natu, V. S., & O’Toole, A. J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.027 · Cited by 25
“nt, Stanford University, 450 differences between neural responses to famous and/or personally familiar versus unfamiliar faces (e.g., Leveroni et al., 2000; Ishai et al., 2002; Elfgren et al., 2006; Sergent et al., 1992; Gorno-Tempini and Price, 2001; Ewbank and Andrews, 2008; Pourtois et al., 2005; Henson et al., 200…”
Skelly, L. R., & Jean Decety, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040371 · Cited by 23
“However, equivalent or increased fusiform activation was seen in ASD participants when the stimuli were faces that were familiar to them, indicating that interest in the stimuli might play a mediating role [22–24].”
BackgroundLiloia, D., Cauda, F., Uddin, L. Q., Manuello, J., Mancuso, L., Keller, R., Nani, A., & Costa, T. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.01.007 · Cited by 23
Moerkerke, M., Daniëls, N., der Donck, S. V., Tibermont, L., Tang, T., Debbaut, E., Bamps, A., Prinsen, J., Steyaert, J. G., Alaerts, K., et al. (2023) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13850 · Cited by 23
A multimodal neural signature of face processing in autism within the fusiform gyrus
Floris, D. L., Llera, A., Zabihi, M., Moessnang, C., Jones, E. J. H., Mason, L., Haartsen, R., Holz, N. E., Mei, T., Elleaume, C., et al. (2025) · Nature Mental Health · doi:10.1038/s44220-024-00349-4 · Cited by 27
“Many studies show that the FFG is hypoactive during face processing fMRI tasks 22,23 and functionally atypically connected 24,25 in autism.”
Schauder, K. B., Park, W. J., Tsank, Y., Eckstein, M. P., Tadin, D., & Bennetto, L. (2019) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-019-9303-z · Cited by 23
O’Hearn, K. M., & Lynn, A. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.957375 · Cited by 26
“However, FFA activation in ASD may be relatively typical with familiar faces (Pierce et al., 2004).”
BackgroundThreatening faces fail to guide attention for adults with autistic‐like traits
English, M. C. W., Maybery, M. T., & Visser, T. A. W. (2016) · Autism Research · doi:10.1002/aur.1658 · Cited by 22
Empathy: shared circuits and their dysfunctions
Thioux, M., & Keysers, C. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.4/mthioux · Cited by 21
“Two out of three studies did not find any group difference in premotor areas.(59,60) A single study with autistic adults documented a hypoactivation in this region.”
Ibrahim, K., Soorya, L. V., Halpern, D. B., Gorenstein, M., Siper, P. M., & Wang, A. T. (2021) · Autism Research · doi:10.1002/aur.2603 · Cited by 25
“, 2004), viewing a familiar or personally significant face (Pierce et al., 2004; Pierce & Redcay, 2008), and when prompting fixation to the eye region (Hadjikhani et al.”
BackgroundLarson, C., Thomas, H., Crutcher, J., Stevens, M. C. G., & Eigsti, I. (2023) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-023-00382-6 · Cited by 25
Peng, Z., Chen, J., Jin, L., Han, H., Dong, C., Guo, Y. Q., Kong, X., Wan, G., & Wei, Z. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111063 · Cited by 20
Recognition of Face and Non‐Face Stimuli in Autistic Spectrum Disorder
Arkush, L., Smith, A. P. R., Fiorentini, C., & Skuse, D. (2013) · Autism Research · doi:10.1002/aur.1318 · Cited by 21
Gunji, A., Goto, T., Kita, Y., Sakuma, R., Kokubo, N., Koike, T., Sakihara, K., Kaga, M., & Inagaki, M. (2013) · Brain and Development · doi:10.1016/j.braindev.2012.12.008 · Cited by 21
“These areas were reported to perform socioemotional memory retrieval [4].”
BackgroundFein, D., & Helt, M. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717001096 · Cited by 20
Sagehorn, M., Johnsdorf, M., Kisker, J., Sylvester, S., Gruber, T., & Schöne, B. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1050892 · Cited by 22
Autism spectrum disorders: autistic phenotypes and complicated mechanisms
Zhang, X.-C., Shu, L., Zhao, X., & Li, X. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-018-0210-2 · Cited by 22
Autism spectrum traits in normal individuals: a preliminary VBM analysis
Focquaert, F., & Vanneste, S. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00264 · Cited by 19
“…neuroimaging studies have shown that atypical temporal lobe functioning is implicated in abnormal face recognition and emotional face-based mindreading in individuals with ASD (Baron-Cohen et al., 1999; Critchley et al., 2000; Schultz et al., 2000; Pierce et al., 2004; Dalton et al., 2005).”
BackgroundVettori, S., Dzhelyova, M. P., der Donck, S. V., Jacques, C., Steyaert, J. G., Rossion, B., & Boets, B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00332 · Cited by 18
Vandewouw, M. M., Choi, E. J., Hammill, C. F., Lerch, J. P., Anagnostou, E. A., & Taylor, M. J. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.09.006 · Cited by 18
Helt, M. S., Sorensen, T. M., Scheub, R. J., Nakhle, M. B., & Luddy, A. C. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.645310 · Cited by 19
“(Pierce et al., 2004) or when explicitly instructed to attend to the eye region of the target (Hadjikhani et al.”
BackgroundTypical and Atypical Neurodevelopment for Face Specialization: An fMRI Study
Joseph, J. E., Zhu, X., Gundran, A., Davies, F., Clark, J. D., Ruble, L. A., Glaser, P. E. A., & Bhatt, R. S. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2330-4 · Cited by 20
Effect of Familiarity on Reward Anticipation in Children with and without Autism Spectrum Disorders
Stavropoulos, K. K. M., & Carver, L. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106667 · Cited by 18
Kemner, C., Schuller, A., & van Engeland, H. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01678.x · Cited by 18
(2012) · Frontiers research topics · doi:10.3389/978-2-88919-025-6 · Cited by 18
Kim, Y., Noh, Y. W., Kim, K., Yang, E., Kim, H., & Kim, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00023 · Cited by 18
Samaey, C., der Donck, S. V., van Winkel, R., & Boets, B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.592937 · Cited by 17
Rapid Neural Representations of Personally Relevant Faces
Bayer, M., Berhe, O., Dziobek, I., & Johnstone, T. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab116 · Cited by 18
Han, Y. M. Y., Chan, A. S.-Y., Sze, S. L., Cheung, M., Wong, C. K., Lam, J. M. K., & Poon, P. M. K. (2013) · Research in Autism · doi:10.1016/j.rasd.2013.02.011 · Cited by 18
Neuroimaging studies on recognition of personally familiar people
Sugiura, M. (2014) · Frontiers in bioscience · doi:10.2741/4235 · Cited by 19
Scherrer, B., Prohl, A. K., Taquet, M., Kapur, K., Peters, J. M., Tomas-Fernandez, X., Davis, P. E., Bebin, E. M., Krueger, D. A., Northrup, H., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz233 · Cited by 17
“Other experiments have failed to replicate the functional MRI (fMRI) findings (Hadjikhani et al. 2004; Pierce et al. 2004; Bird et al. 2006; Kleinhans et al. 2008).”
BackgroundSliwinska, M. W., Searle, L. R., Earl, M., O’Gorman, D., Pollicina, G., Burton, A. M., & Pitcher, D. (2022) · Perception · doi:10.1177/03010066221098728 · Cited by 18
“We identified four face-selective areas using anatomical landmarks, these were; the FFA, OFA, pSTS, and face-selective voxels in the amygdala.”
BackgroundResultInfluentialAutistic Traits Affect Reward Anticipation but not Reception
Matyjek, M., Bayer, M., & Dziobek, I. (2020) · Scientific Reports · doi:10.1038/s41598-020-65345-x · Cited by 17
Baduell, M. P., Salvadó, B. S., Clofent-Torrentó, M., & Santasusana, A. V. (2012) · Revista de Neurología · doi:10.33588/rn.54s01.2011711 · Cited by 20
A Nexus Model of Restricted Interests in Autism Spectrum Disorder
Carter, R., Jung, H., Reaven, J., Blakeley‐Smith, A., & Dichter, G. S. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00212 · Cited by 18
Autism from a Biometric Perspective
Kostyuk, N., Rajnarayanan, R. V., Isokpehi, R. D., & Cohly, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7051984 · Cited by 18
“There are numerous studies in the medical literature [23-30] that confirm cerebral hypoperfusion (decreased blood flow to the brain) in as many as 86% of individuals with autism [23].”
BackgroundStructural and Functional MRI Studies of Autism Spectrum Disorders
Stigler, K. A., & McDougle, C. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391924-3.00017-x · Cited by 18
Ross, D. A., Tamber-Rosenau, B. J., Palmeri, T. J., Zhang, J., Yaoda Xu, A., & Gauthier, L. (2018) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01256 · Cited by 16
D'Mello, A. M., Frosch, I. R., Meisler, S. L., Grotzinger, H., Perrachione, T. K., & Gabrieli, J. D. E. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.0608-22.2023 · Cited by 14
“Similarly, modulating familiarity of, or attention to, face stimuli in ASD can eliminate group differences in gaze duration (Dawson et al., 1990; Golarai et al., 2006) or FFA activation (Pierce et al., 2004; Bird et al., 2006; Pierce and Redcay, 2008).”
BackgroundSynthesis of Facial Expressions in Photographs
Testa, R. L., Corrêa, C. G., Machado‐Lima, A., & Nunes, F. L. S. (2019) · ACM Computing Surveys · doi:10.1145/3292652 · Cited by 14
“For example, people with an autism spectrum disorder have greater difficulty in identifying emotions in unfamiliar faces (Pierce et al. 2004).”
BackgroundOnline decoding of object‐based attention using real‐time f MRI
Niazi, A. M., van den Broek, P. L. C., Klanke, S., Barth, M., Poel, M., Desain, P., & van Gerven, M. A. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12405 · Cited by 15
“Previous studies have shown larger activations for familiar faces and places compared with unfamiliar faces and places, respectively (Shah et al., 2001; Pierce et al., 2004; Rosenbaum et al., 2004).”
BackgroundThe Early Start Denver Model Intervention and Mu Rhythm Attenuation in Autism Spectrum Disorders
Aaronson, B., Estes, A. M., Rogers, S. J., Dawson, G., & Bernier, R. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05190-7 · Cited by 13
Lv, H., Gu, X. Q., Shan, X., Zhu, T., Ma, B., Zhang, H.-T., Bambini-Júnior, V., Zhang, T., Li, W., Gao, X., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.870577 · Cited by 13
Barros, F., & Soares, S. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.008 · Cited by 14
Lu, J. T., Kishida, K. T., Asis‐Cruz, J. D., Lohrenz, T. M., Treadwell‐Deering, D., Beauchamp, M. S., & Montague, P. R. (2015) · Clinical Psychological Science · doi:10.1177/2167702614562042 · Cited by 13
Guided saccades modulate object and face‐specific activity in the fusiform gyrus
Morris, J. P., & McCarthy, G. (2006) · Human Brain Mapping · doi:10.1002/hbm.20301 · Cited by 13
“…tomographic (PET) imaging [Haxby et al., 1994; Sergent et al., 1992], and functional MRI (fMRI) [Kanwisher et al., 1997; McCarthy et al., 1997; Puce et al., 1995] studies in humans have identified a discrete region of the fusiform gyrus (FFG) that responds robustly for faces but not for other…”
BackgroundAmmons, C. J., Winslett, M., & Kana, R. K. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107694 · Cited by 12
Anatomical and Functional Connectivity in Autism Spectrum Disorders
Müller, R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-4788-7_192 · Cited by 13
“, 2001), but largely intact activity in another (Pierce et al., 2004).”
BackgroundThe Amygdala in Autism Spectrum Disorders
Morgan, J. T., Nordahl, C. W., & Schumann, C. M. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391924-3.00021-1 · Cited by 10
Déficit social en el autismo: un enfoque en la atención conjunta
Alessandri, M., Mundy, P. C., & Tuchman, R. F. (2005) · Revista de Neurología · doi:10.33588/rn.40s01.2004650 · Cited by 12
Matyjek, M., Bayer, M., & Dziobek, I. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103442 · Cited by 15
Face processing in a case of high functioning autism with developmental prosopagnosia
Cygan, H. B., Okuniewska, H., Jednoróg, K., Marchewka, A., Wypych, M., & Nowicka, A. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-011 · Cited by 10
“with data showing normal activation in these structures during recognition of familiar faces (Pierce et al. 2004).”
BackgroundInfluentialGhanouni, P., Jarus, T., Zwicker, J. G., Lucyshyn, J. M., Fenn, B., & Stokley, E. (2019) · Games for Health Journal · doi:10.1089/g4h.2019.0070 · Cited by 10
“23,42,43 However, there is always a trade-off between the game to be realistic and imaginary/simplistic.”
Functional Mri in Pediatric Neurobehavioral Disorders
Seyffert, M., & Castellanos, F. X. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)67008-0 · Cited by 10
Tardif, C., Lainé, F., Rodriguez, M., & Gepner, B. (2007) · HAL · Cited by 10
Karjalainen, S., Aro, T. I., & Parviainen, T. M. (2023) · Neuropsychology Review · doi:10.1007/s11065-023-09579-2 · Cited by 10
“However, both similar brain activation between ASD and comparison groups as well as opposing findings have been reported, and thus, current evidence is considered ambiguous and inconsistent (e.g., Dufour et al., 2013; Hadjikhani et al., 2004; Pierce et al., 2004).”
ResultThe modulatory effect of semantic familiarity on the audiovisual integration of face‐name pairs
Li, Y., Wang, F., Huang, B., Yang, W., Yu, T., & Talsma, D. (2016) · Human Brain Mapping · doi:10.1002/hbm.23312 · Cited by 9
The Neural Representational Space of Social Memory
Dziura, S. L., & Thompson, J. C. (2018) · Open Mind · doi:10.1162/opmi_a_00021 · Cited by 8
Anxiety in Children with Autism Spectrum Disorder
Jennett, H. K., Vasa, R. A., & Hagopian, L. P. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6599-7_16 · Cited by 9
Unfamiliar face recognition in children with autistic spectrum disorders
Wilson, R. R., Blades, M., Coleman, M., & Pascalis, O. (2009) · Infant and Child Development · doi:10.1002/icd.638 · Cited by 9
“The processing pattern displayed by the children with ASD in our study differed from Rondan et al. (2003) who found equal recognition performance for internal and external face parts in a matching task.”
From neuronal to human communication disorders: A novel approach to autism
Gepner, B. (2008) · HAL · Cited by 9
Sex-Specific Behavioral Features of the Prenatal Valproic Acid Rat Model of Autism Spectrum Disorder
Mamali, P. M., Dignon, C., Ngwenya, A., & Maseko, B. C. (2025) · Brain Sciences · doi:10.3390/brainsci15040388 · Cited by 9
Afzalian, N., & Rajimehr, R. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1580-20.2021 · Cited by 9
“Another study showed that abnormal behavior of autistic subjects in recognizing familiar faces was correlated to the lower extent of activity in this area (Pierce et al., 2004).”
BackgroundMarshall, N. A., Kaplan, J., Stoycos, S. A., Goldenberg, D., Khoddam, H., Cárdenas, S. I., Sellery, P., & Saxbe, D. (2022) · Social Neuroscience · doi:10.1080/17470919.2022.2029559 · Cited by 8
“Given the LOC’s involvement in functions related to social cognition (e.g., self-representation, face perception; Aleman & Swart, 2008; Cazzato et al., 2015; Gauthier et al., 2000; Gschwind et al., 2012; Pierce et al., 2004) and”
BackgroundAtypical Functional Connectivity During Unfamiliar Music Listening in Children With Autism
Freitas, C., Hunt, B. A. E., Wong, S. M., Ristic, L., Fragiadakis, S. D., Chow, S., Iaboni, A., Brian, J. A., Soorya, L. V., Chen, J. L., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.829415 · Cited by 9
Traitement de l’information faciale dans l’autisme
Labruyère, N., & Hubert, B. (2009) · L Évolution Psychiatrique · doi:10.1016/j.evopsy.2008.12.008 · Cited by 8
Conceptual and methodological challenges for neuroimaging studies of autistic spectrum disorders
Mazzone, L., & Curatolo, P. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-17 · Cited by 8
Cai, X., Wang, X., Guo, J.-W., Xu, F., Ma, K.-Y., Wang, Z., Zhao, Y., Xie, W., Schonewille, M., Zeeuw, C. I. D., et al. (2024) · Protein & Cell · doi:10.1093/procel/pwae040 · Cited by 7
HIV/AIDS: vaccines and alternate strategies for treatment and prevention
Voronin, Y., & Phogat, S. K. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05759.x · Cited by 7
Afzalian, N., & Rajimehr, R. (2021) · PubMed Central · doi:10.17863/cam.78751 · Cited by 7
Metadata
- Authors
- Pierce, K.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Pierce, K.
- ORCID
- Pierce, K.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-11-10
- Volume
- 127
- Issue
- 12
- Pages
- 2703-2716
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2025319978
- Cited by
- 432
- References
- 91
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 10 · 2022: 15 · 2021: 20 · 2020: 21 · 2019: 17 · 2018: 22 · 2017: 18 · 2016: 15 · 2015: 18 · 2014: 26 · 2013: 18 · 2012: 25
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01-MH36840, K01-MH01814, R01MH036840, K01MH001814)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- autism spectrum disorder, fusiform face area, face familiarity, face processing, face identity, amygdala, socio-emotional processing, right hemisphere dominance, medial frontal lobe, posterior cingulate cortex
- MeSH terms
- Adolescent, Adult, Amygdala, Autistic Disorder, Brain Mapping, Discrimination, Psychological, Face, Humans, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Photic Stimulation, Photography, Temporal Lobe, Case-Control Studies, Recognition, Psychology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
